Autopsy and Case Reports最新文献

Mucosal melanoma of hard palate. 硬腭粘膜黑色素瘤

Autopsy and Case Reports Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.522

Zahed Ali Qamer, Monika Maharjan, Kranthi Kumar Jandrasupalli, Bommisetty Lokesh, Amit Tyagi, Ravi Hari Phulware

{"title":"Mucosal melanoma of hard palate.","authors":"Zahed Ali Qamer, Monika Maharjan, Kranthi Kumar Jandrasupalli, Bommisetty Lokesh, Amit Tyagi, Ravi Hari Phulware","doi":"10.4322/acr.2024.522","DOIUrl":"10.4322/acr.2024.522","url":null,"abstract":"Melanoma arising in the hard palate is an exceedingly rare entity, comprising a minute fraction of all melanoma cases. The absence of specific clinical signs often leads to delayed diagnosis and subsequent challenges in treatment planning. We discussed the existing literature to elucidate the epidemiology, risk factors, and molecular pathways associated with melanoma of the hard palate. Additionally, we discuss the importance of a multidisciplinary approach involving dermatologists, otolaryngologists, oncologists, and pathologists in diagnosing and managing this condition. A 62-year-old male patient presented with a pigmented lesion on the hard palate mucosa, which was initially asymptomatic but gradually increased in size. Biopsy revealed melanoma, confirmed through immunohistochemical staining. Staging investigations indicated a metastatic disease. Surgery followed by adjuvant therapy was planned; however, he was lost for the follow-up. Melanoma originating from the hard palate mucosa is exceedingly rare, posing diagnostic and therapeutic challenges. Early detection, accurate diagnosis, and prompt multidisciplinary management are crucial for optimal outcomes. This case underscores the importance of comprehensive evaluation and tailored treatment strategies in patients with uncommon mucosal melanomas.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024522"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explant pathology in Biliary Atresia post Kasai procedure: a tale of two livers. 卡萨伊手术后胆道闭锁的切口病理：两个肝脏的故事。

Autopsy and Case Reports Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.521

Sunayana Misra, Sonia Badwal, Shashi Dhawan, Arpita Mittal, Naimish Mehta, Nishant Wadhwa, Arjun Maria

{"title":"Explant pathology in Biliary Atresia post Kasai procedure: a tale of two livers.","authors":"Sunayana Misra, Sonia Badwal, Shashi Dhawan, Arpita Mittal, Naimish Mehta, Nishant Wadhwa, Arjun Maria","doi":"10.4322/acr.2024.521","DOIUrl":"10.4322/acr.2024.521","url":null,"abstract":"Biliary atresia (BA) is a progressive inflammatory cholangiopathy of infancy that results in fibrous obliteration of the extrahepatic and intrahepatic bile ducts. In untreated patients, this leads to biliary-type cirrhosis within the first two years of life. Timely diagnosis of BA with a lack of significant hepatic fibrosis is critical and surgical drainage (Kasai procedure) within the first two months of life is the initial treatment modality with the highest success rate. Ultimately, liver transplantation is required due to surgical drainage complications, such as recurrent cholangitis, failure to thrive, and portal hypertension (PHTN). Histopathological findings of hepatectomy specimens after failed and successful Kasai procedures are vastly different depending on the subsequent course of liver disease. Bile flow is inadequate following a failed Kasai procedure with rapid development of biliary cirrhosis. Explants from patients with successful Kasai procedure may show cholestatic (recurrent cholangitis), vascular (obliterative venopathy, regenerative hyperplasia, and PHTN), or an interplay of both cholestatic and vascular abnormalities. Pathologists need to be aware of explant histopathology (post-successful Kasai procedures) with a clinical course dominated by PHTN for precise documentation of vascular abnormalities.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024521"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallbladder schistosomiasis. 胆囊血吸虫病。

Autopsy and Case Reports Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.516

Gabriela Del Angel-Millán, José Jukemura, Júlia Bragion Bicudo, Ricardo Jureidini, André Luís Montagnini, Vanderlei Segatelli, Thiago Costa Ribeiro, Guilherme Naccache Namur, Thiago Nogueira Costa, Lucas Cata Preta Stolzemburg, Emilio Elias Abdo, Ulysses Ribeiro, Paulo Herman, Estela Regina Ramos Figueira

{"title":"Gallbladder schistosomiasis.","authors":"Gabriela Del Angel-Millán, José Jukemura, Júlia Bragion Bicudo, Ricardo Jureidini, André Luís Montagnini, Vanderlei Segatelli, Thiago Costa Ribeiro, Guilherme Naccache Namur, Thiago Nogueira Costa, Lucas Cata Preta Stolzemburg, Emilio Elias Abdo, Ulysses Ribeiro, Paulo Herman, Estela Regina Ramos Figueira","doi":"10.4322/acr.2024.516","DOIUrl":"10.4322/acr.2024.516","url":null,"abstract":"Schistosomiasis is an infectious disease caused by parasitic flatworms of the genus Schistosoma. The species Schistosoma mansoni is associated with hepatosplenic disease. Schistosomiasis involving the gallbladder alone is highly unusual, with a few cases reported. Herein, we present the case of a woman from a region with endemic schistosomiasis who presented with a painless solid lesion and wall thickening of the gallbladder. She underwent an uneventful laparoscopic cholecystectomy. Microscopic examination of the surgical specimen revealed Schistosoma mansoni eggs associated with granulomatous reaction, leading to the diagnosis of schistosomiasis of the gallbladder, prompting subsequent treatment with praziquantel and follow-up. This case illustrates the importance of suspicion for this diagnosis in endemic areas, as it can be misdiagnosed with malignancy if not examined microscopically. Complications and treatment strategies are poorly characterized for the few cases of schistosomiasis; reporting this case can serve as a helpful reminder of a rare presentation of this disease.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024516"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stealth cryptococcus in an immunocompetent patient. 一名免疫功能正常患者体内的隐球菌。

Autopsy and Case Reports Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.520

Emily Ryan, Gia Jackson, Larry Nichols

引用次数: 0

Multicystic encephalopathy: an ultimate manifestation of ischemic-hypoxic injury. 多囊性脑病：缺血缺氧损伤的最终表现。

Autopsy and Case Reports Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.517

Vielka Fernandez Aragones, Amilcar Castellano-Sanchez, Gabriel Chamyan, Darline Santana-Acosta

引用次数: 0

Cytological diagnosis of hyaline-vascular type of Castleman disease. 卡斯特曼病透明血管型的细胞学诊断。

Autopsy and Case Reports Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.519

Deepa Rani, Anupam Varshney, Kanika Rastogi

引用次数: 0

Systemic amyloidosis: an aggressive evolution in a patient with relapsing polychondritis and monoclonal gammopathy of undetermined significance (MGUS) undergoing peritoneal dialysis. 系统性淀粉样变性：一名正在接受腹膜透析的复发性多软骨炎和意义未定的单克隆丙种球蛋白病（MGUS）患者的侵袭性演变。

Autopsy and Case Reports Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.518

Thiago Cavalcanti Matos, William George Giusti Fischer, Rosa Maria Rodrigues Pereira, Andre Silva Franco

{"title":"Systemic amyloidosis: an aggressive evolution in a patient with relapsing polychondritis and monoclonal gammopathy of undetermined significance (MGUS) undergoing peritoneal dialysis.","authors":"Thiago Cavalcanti Matos, William George Giusti Fischer, Rosa Maria Rodrigues Pereira, Andre Silva Franco","doi":"10.4322/acr.2024.518","DOIUrl":"10.4322/acr.2024.518","url":null,"abstract":"Herein, we report the case of primary amyloidosis with multi-organ involvement in a female patient in her 50s. The patient had a history of relapsing polychondritis, chronic kidney disease, and monoclonal gammopathy of undetermined significance (MGUS). The clinical manifestations included neuropathic pain, sensorimotor polyneuropathy, intrahepatic cholestatic liver injury, gastrointestinal symptoms, dysautonomia, and myocardial thickening. Initial histologic evaluations of the abdominal fat pad aspirate and bone marrow biopsy were negative for amyloid deposition. However, due to a high index of suspicion, a second bone marrow biopsy was performed, confirming the presence of the amyloid protein. Given the patient's complex medical history, other types of amyloidosis, such as AA amyloidosis, AL amyloidosis, and ß2-microglobulin amyloidosis, should also be considered as differential diagnoses. The type of amyloid protein was subsequently identified through laser microdissection of amyloid fibrils followed by liquid chromatography-tandem mass spectrometry as AL-lambda (amyloid light-chain) amyloidosis. The patient presented unfavorable evolution, with progressive dysautonomia, being admitted to the ICU, culminating in refractory circulatory shock, and undergoing an empirical broad-spectrum antibiotic therapy. After a few days, she presented pulseless ventricular tachycardia, culminating in her death, before undergoing specific treatment. This article highlights the crucial role of precise identification in guiding appropriate therapeutic strategies for this complex, yet potentially severe, diseases.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024518"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chondroblastic Osteosarcoma of proximal tibia. 胫骨近端软骨骨肉瘤

Autopsy and Case Reports Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.515

Ravi Hari Phulware, Kaashvi Gupta, Gaurav Rajendra Shirsath, Mohit Dhingra

引用次数: 0

Large atypical parathyroid tumor - a diagnostic conundrum. 大型非典型甲状旁腺瘤--诊断难题。

Autopsy and Case Reports Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.514

Saikat Mitra, Shouvanik Satpathy, Devmalya Banerjee, Sugat Sanyal

{"title":"Large atypical parathyroid tumor - a diagnostic conundrum.","authors":"Saikat Mitra, Shouvanik Satpathy, Devmalya Banerjee, Sugat Sanyal","doi":"10.4322/acr.2024.514","DOIUrl":"10.4322/acr.2024.514","url":null,"abstract":"Atypical parathyroid tumor (APT) is a rare neoplasm of the parathyroid gland, which shows atypical cytological or architectural features and lacks definite diagnosis criteria for malignancy. These cases can cause diagnostic challenges owing to their rarity and similarity with thyroid neoplasm on imaging and fine needle aspiration cytology. Also, differentiating APT from giant parathyroid adenoma or parathyroid carcinoma can be challenging based on clinical, imaging or cytological features. A 49-year-old male presented with clinical features of hyperparathyroidism. On laboratory evaluation, his serum calcium and serum parathyroid hormone was elevated. Imaging studies suggested a possibility of left inferior parathyroid neoplasm, and fine needle aspiration cytology showed features suggestive of parathyroid neoplasm. However, exact categorization of parathyroid tumor was difficult in pre-operative work-up. Possibilities of giant parathyroid adenoma as well as parathyroid carcinoma were considered. A final diagnosis of an atypical parathyroid tumor was made after detailed histopathological evaluation given focal capsular invasion but lack of unequivocal evidence of malignancy in the resected specimen. APT is a rare neoplasm of uncertain malignant potential. Knowledge of the radiological and pathological features will be helpful in accurately identifying the lesion and avoiding misdiagnosis.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024514"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mönckeberg calcified sclerosis preventing the use of radial artery in myocardial revascularization surgery. 防止在心肌血管重建手术中使用桡动脉的门克伯格钙化硬化症。

Autopsy and Case Reports Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.513

Luiz Alberto Benvenuti

引用次数: 0