Autopsy and Case Reports最新文献_第2页

Anti MDA-5 associated rapidly progressive interstitial lung disease complicated by viral pneumonia - a fatal outcome. 抗 MDA-5 导致的快速进展性间质性肺病并发病毒性肺炎--致命结局。

Autopsy and Case Reports Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.511

Saikat Mitra, Nithye Parvathy, Mandeep Garg, Shritik Devkota, Sandeep Bansal, Inderpaul Singh Sehgal, Kirti Gupta

{"title":"Anti MDA-5 associated rapidly progressive interstitial lung disease complicated by viral pneumonia - a fatal outcome.","authors":"Saikat Mitra, Nithye Parvathy, Mandeep Garg, Shritik Devkota, Sandeep Bansal, Inderpaul Singh Sehgal, Kirti Gupta","doi":"10.4322/acr.2024.511","DOIUrl":"10.4322/acr.2024.511","url":null,"abstract":"Dermatomyositis is a heterogeneous systemic disease, with 7% to 10% of the individuals presenting the Anti MDA-5 antibody. This subset of patients has clinically amyotropic dermatomyositis, presenting with cutaneous ulcer and rapidly progressive interstitial lung disease. We report the case of a 22-year-old male with a six-month history of low-grade fever associated with myalgia, polyarthralgia, and marked weight loss. He had a history of shortness of breath and high-grade fever 15 days before admission. His clinical features and imaging workup were consistent with acute respiratory distress syndrome. A nasal swab was positive for H1N1 influenza virus infection. During the disease investigation, he succumbed after nine days of admission. The autopsy examination showed diffuse alveolar damage on a background of non-specific interstitial pattern of injury in the lungs. His postmortem muscle biopsy revealed subtle changes of inflammatory myopathy. The brain showed diffuse subarachnoid hemorrhage. Evaluation of postmortem serum sample revealed positivity for Anti MDA-5 and Ro-52 antibodies. This was a case of Anti MDA-5 and Ro-52 associated dermatomyositis with non-specific interstitial pneumonia pattern of lung injury complicated with H1N1 influenza pneumonia, leading to diffuse alveolar damage and subsequent respiratory failure and death. Serum Anti MDA-5 antibodies represent an important biomarker for diagnosing and predicting prognosis for patients with idiopathic inflammatory myopathies, especially clinically amyopathic dermatomyositis. Anti-Ro-52 has been reported in a wide variety of autoimmune diseases, particularly in myositis, scleroderma, and autoimmune liver diseases. Ro-52 autoantibodies are associated with interstitial lung disease (ILD), and their presence should encourage the clinician's curiosity to search for ILD.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024511"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 shed light on Virchow's law of thrombosis. COVID-19 揭示了维尔霍血栓形成定律。

Autopsy and Case Reports Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.512

Hubert Daisley, Oneka Acco, Martina Daisley, Dennecia George, Lilly Paul, Arlene Rampersad, Johann Daisley

引用次数: 0

Unravelling the mystery of the central dentinogenic ghost cell tumor- a rare case report and recurrent insights. 揭开中枢性牙本质鬼细胞瘤的神秘面纱--罕见病例报告和反复发作的启示。

Autopsy and Case Reports Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.510

Jagveer Yadav, Mala Kamboj, Anju Devi, Anjali Narwal, Deepti Chhikara, Bhawna Saini

引用次数: 0

The need for mandatory autopsy teaching in Forensic Medicine for medical students. 为医科学生开设法医学解剖必修课的必要性。

Autopsy and Case Reports Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.509

Nurul Kharmila Abdullah, Nur Arina Ahmad, Shalinawati Binti Ramli, Nadiawati Abdul Razak

{"title":"The need for mandatory autopsy teaching in Forensic Medicine for medical students.","authors":"Nurul Kharmila Abdullah, Nur Arina Ahmad, Shalinawati Binti Ramli, Nadiawati Abdul Razak","doi":"10.4322/acr.2024.509","DOIUrl":"10.4322/acr.2024.509","url":null,"abstract":"The effectiveness of the autopsy as an educational tool in forensic medicine courses has been widely acknowledged, and medical students were expected to attend regularly. Nevertheless, the use of autopsies for teaching has dramatically declined in recent years and worldwide despite their high-value benefits. This study aims to understand the importance and relevance of attending autopsies during forensic teaching sessions and identify any challenges that may impede attendance. A self-administered online questionnaire that assesses the knowledge, attitudes, and practices related to autopsies attendance was distributed to fourth-year medical students at the National Defence University of Malaysia and Universiti Sains Islam Malaysia. A total of 99 respondents were involved in this study. Our findings indicate that most respondents (over 85%) demonstrated good knowledge of forensic medicine. Pearson's statistical test revealed a significant correlation between the knowledge and students' attitudes toward autopsy. This study demonstrates the need to strategically integrate autopsy attendance into medical curricula to encourage constructive attitudes and practices among medical students. Students gain the most benefits from frequently attending autopsies. Passionate educators can conduct preparatory sessions to set expectations and address concerns, encourage students to process their experiences, and reinforce learning outcomes in the mortuary setting. Mandatory autopsy teaching should be integrated into the curriculum to ensure medical students have the necessary skills and knowledge to become competent doctors.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024509"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholangiocarcinoma in early childhood. 幼儿胆管癌

Autopsy and Case Reports Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.504

Amrit Kaur, Prakruthi S Kaushik, Suma Mysore Narayana, Arun Kumar Ajjapanahalli Rajanna, Aruna Kumari Bandagadde Sreenivasa Bhat, Lingegowda Appaji

引用次数: 0

Laryngeal plasmacytoma in a patient with Down's syndrome. 一名唐氏综合征患者的喉浆细胞瘤。

Autopsy and Case Reports Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.508

Hassan Hodroj, Zahraa Saker, Zahraa Al Najjar, Hassane Choukr, Mohamad Reda Noureddine El Moussaoui

{"title":"Laryngeal plasmacytoma in a patient with Down's syndrome.","authors":"Hassan Hodroj, Zahraa Saker, Zahraa Al Najjar, Hassane Choukr, Mohamad Reda Noureddine El Moussaoui","doi":"10.4322/acr.2024.508","DOIUrl":"10.4322/acr.2024.508","url":null,"abstract":"Extramedullary plasmacytoma is a rare localized plasma cell neoplasm typically found in soft tissues outside the bone marrow. Predominantly occurring in the head and neck region, particularly in the sinonasal and nasopharyngeal areas, it presents a diagnostic challenge due to its uncommon nature. Herein, we report a 38-year-old female patient with Down's syndrome with a 2-year complaint of intermittent dysphonia, hoarseness, and progressive respiratory distress, including dyspnea, fatigue, and biphasic stridor. Examination via flexible laryngoscopy revealed a white lesion, prompting direct microscopic laryngeal surgery to excise a 1x1 cm mass. Histological findings confirmed the diagnosis as solitary extramedullary plasmacytoma. Notably, this represented the first documented case of laryngeal solitary extramedullary plasmacytoma in a patient with Down's syndrome. This case underscores the importance of considering tumor development in the larynx among individuals with Down's syndrome, highlighting the necessity for tailored management strategies to address such occurrences effectively. Increasing awareness of this association can aid in early detection and appropriate treatment of tumors in this population.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024508"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traveling together! - Intrathymic thyroid tissue in a patient with Graves' disease. 一起旅行- 一名巴塞杜氏病患者的病理内甲状腺组织

Autopsy and Case Reports Pub Date : 2024-07-30 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.506

Hugh Ellis McCormick, Sidrah Khawar, Ameer Hamza

引用次数: 0

Unilateral testicular metastasis of prostate cancer. 前列腺癌单侧睾丸转移。

Autopsy and Case Reports Pub Date : 2024-07-12 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.507

Ravi Hari Phulware, Gayathri K S, Gaurav Rajendra Shirsath, Amit Gupta

引用次数: 0

Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology. 经细胞学诊断为复发于左侧颌下淋巴结病的双侧原发性卵巢尤文肉瘤。

Autopsy and Case Reports Pub Date : 2024-07-12 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.499

Shaivy Malik, Neha Kawatra Madan, Meetu Agrawal, Rajni Yadav, Adarsh Barwad

{"title":"Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology.","authors":"Shaivy Malik, Neha Kawatra Madan, Meetu Agrawal, Rajni Yadav, Adarsh Barwad","doi":"10.4322/acr.2024.499","DOIUrl":"10.4322/acr.2024.499","url":null,"abstract":"Ewing sarcoma (ES) is a highly malignant and aggressive small round-cell tumor originating from primitive neuroepithelium and mesenchymal stem cells. It is usually seen in children and adolescents with a male predilection and a preponderance to occur in long bones. Although skeletal/soft tissue ES is encountered in clinical practice, primary ES of the genital tract, particularly bilateral primary ovarian ES, is highly uncommon, with only a handful of cases reported worldwide. Ovarian ES is occasionally reported to involve para-aortic and pelvic lymph nodes in advanced stages. Still, cervical lymph node metastasis from ovarian ES is an infrequent clinical occurrence and, when present, indicates a worse prognosis. Here, we present an intriguing case of bilateral peripheral primary ovarian ES in an adult female, recurring as metastasis in the left submandibular lymph node. This case underlines the importance of keeping metastasis from ES as a possible differential while diagnosing metastatic small round cell tumors in peripheral lymph nodes. It also highlights the usefulness of a minimally invasive diagnostic modality of fine needle aspiration cytology and cell block preparation with applied ancillary techniques of immunohistochemistry and confirmatory molecular testing by fluorescence in-situ hybridization (FISH), for an accurate and quick diagnosis of such entities. The cytological diagnosis of our patient helped in the prompt and early initiation of chemotherapy without requiring any invasive procedure.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"14 ","pages":"e2024499"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-functioning parathyroid cyst presenting as a neck mass. 表现为颈部肿块的非功能性甲状旁腺囊肿。

Autopsy and Case Reports Pub Date : 2024-07-12 eCollection Date: 2024-01-01 DOI: 10.4322/acr.2024.505

Sangamitra Rajasekaran, Adarsh Barwad, Suvradeep Mitra

引用次数: 0