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A case report of cutaneous Langerhans cell Histiocytosis in an infant: a therapeutic challenge. 婴儿皮肤朗格汉斯细胞组织细胞增多症一例报告：一个治疗挑战。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf112
Linda Khanje, Khaled Khanje, Shahd Alqato
{"title":"A case report of cutaneous Langerhans cell Histiocytosis in an infant: a therapeutic challenge.","authors":"Linda Khanje, Khaled Khanje, Shahd Alqato","doi":"10.1093/omcr/omaf112","DOIUrl":"10.1093/omcr/omaf112","url":null,"abstract":"<p><p>Langerhans Cell Histiocytosis (LCH) is a rare clonal disorder of immature CD1a-positive dendritic cells, most commonly affecting children, with peak incidence between ages 1 and 3. This report presents a unique case of multifocal cutaneous LCH with cervical lymphadenopathy in a 7-month-old infant. The patient exhibited an unusual pattern of treatment resistance, failing to respond adequately to corticosteroids and vinblastine-prednisone, before achieving remission with methotrexate. This highlights the therapeutic challenges in managing refractory pediatric LCH and the need for alternative treatment approaches in such cases. This case emphasizes the importance of early diagnosis, tailored treatment regimens, and the potential utility of methotrexate in refractory cases. Comprehensive evaluation and multidisciplinary care are critical for managing this rare disease and minimizing its impact on quality of life.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf112"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seamless meningioma resection in a patient with coexisting myoclonic epilepsy and sporadic Pick's disease. 肌阵挛性癫痫并发散发性匹克病的无缝脑膜瘤切除术1例。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf116
Jose Maaz, Carlos Diaz, Marcos Orellana, Ricardo A Caravantes
{"title":"Seamless meningioma resection in a patient with coexisting myoclonic epilepsy and sporadic Pick's disease.","authors":"Jose Maaz, Carlos Diaz, Marcos Orellana, Ricardo A Caravantes","doi":"10.1093/omcr/omaf116","DOIUrl":"10.1093/omcr/omaf116","url":null,"abstract":"<p><p>We report the case of a 62-year-old male presenting with progressive gait disturbances, recurrent syncope, and episodes of myoclonic epilepsy over three months, with underlying sporadic Pick's disease diagnosed clinically. Imaging revealed a well-defined, extra-axial tumor in the right parietal region, consistent with a meningioma. Surgical intervention using neuronavigation technology facilitated a complete tumor resection. The patient's postoperative course was stable, with a resolution of syncope and improvement in gait. This case underscores the importance of interdisciplinary management in patients with overlapping neurological conditions and highlights the challenges posed by multifaceted clinical presentations.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf116"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffuse alveolar Hemorrhage as the initial presentation of systemic lupus erythematosus in a 57-year-old patient: a case report. 弥漫性肺泡出血作为系统性红斑狼疮的初始表现在一个57岁的病人：一个病例报告。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf115
Ahmed Abdulhussain Shahatta, Omar Radhwan Mohammed, Sajjad Ghanim Al-Badri, Muntadher Yousif Hasan Al Gehadi, Khadija Naeem, Aditya Duhan
{"title":"Diffuse alveolar Hemorrhage as the initial presentation of systemic lupus erythematosus in a 57-year-old patient: a case report.","authors":"Ahmed Abdulhussain Shahatta, Omar Radhwan Mohammed, Sajjad Ghanim Al-Badri, Muntadher Yousif Hasan Al Gehadi, Khadija Naeem, Aditya Duhan","doi":"10.1093/omcr/omaf115","DOIUrl":"10.1093/omcr/omaf115","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is an autoimmune systemic disease that presents a diagnostic challenge due to a wide range of clinical manifestations affecting multiple organs. Particularly rare is its presentation with diffuse alveolar hemorrhage (DAH), a severe complication that arises from the disruption of the capillary-alveolar barrier and can rapidly progress to a life-threatening condition. We report a case of a 57-year-old female who presented to the emergency department experiencing dyspnea and hemoptysis. Her initial evaluations revealed anemia and thrombocytopenia, with high-resolution computed tomography scans showing diffuse bilateral infiltrates indicative of DAH. The findings led to the diagnosis of previously unrecognized SLE. This case underscores the importance of considering SLE in the differential diagnosis of DAH, emphasizing the necessity for prompt diagnostic workup and aggressive treatment in such critical presentations to improve patient outcomes.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf115"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactivation of BCG vaccination SCAR after influenza vaccination: a case report. 流感疫苗接种后卡介苗SCAR再激活：1例报告。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf122
Augustinas Stasiūnas, Jurgita Stasiūnienė, Enrika Didžiulienė
{"title":"Reactivation of BCG vaccination SCAR after influenza vaccination: a case report.","authors":"Augustinas Stasiūnas, Jurgita Stasiūnienė, Enrika Didžiulienė","doi":"10.1093/omcr/omaf122","DOIUrl":"10.1093/omcr/omaf122","url":null,"abstract":"<p><p>The Bacillus Calmette-Guerin (BCG) vaccine, a live attenuated vaccine derived from <i>Mycobacterium bovis</i>, is widely used for tuberculosis prevention and has been linked to various immunological responses beyond its intended purpose. A 23-years-old healthy and allergy-free man was vaccinated for the current year's influenza on his left arm. Two days after inoculation, the patient's BCG scar on his left arm was erythematous, while the influenza vaccination site (located 3 cm from the BCG scar) remained unchanged. A possible ipsilateral relationship between the BCG scar and the influenza vaccine site is suggested. BCG vaccination influences the increase in TNF-α and IL-6 production following influenza vaccination. In BCG-vaccinated subjects, hemagglutinin-inhibition antibody responses against the A(H1N1)pdm09 vaccine strain is markedly enhanced, with a trend toward more-rapid seroconversion. Understanding this BCG and influenza vaccines interaction is crucial for healthcare providers to differentiate between benign post-vaccination reactions and those that may require further clinical evaluation.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf122"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Pediatric Ehlers-Danlos syndrome VI with retroperitoneal Hemorrhage: case report and management strategy'. 儿童ehers - danlos综合征伴腹膜后出血：病例报告及处理策略。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf119
Aimen Yunus, Mudassir Khan, Abid Ali Jamali, Ghazala Kazi
{"title":"'Pediatric Ehlers-Danlos syndrome VI with retroperitoneal Hemorrhage: case report and management strategy'.","authors":"Aimen Yunus, Mudassir Khan, Abid Ali Jamali, Ghazala Kazi","doi":"10.1093/omcr/omaf119","DOIUrl":"10.1093/omcr/omaf119","url":null,"abstract":"<p><p>Ehlers-Danlos syndrome (EDS) encompasses a spectrum of heritable connective tissue disorders, with the Kyphoscoliotic variant representing a rare manifestation. We present a case of an 11-year-old male diagnosed with Ehlers-Danlos Syndrome VI (Kyphoscoliotic Variant) who presented with an acute onset of symptoms suggestive of vascular hemorrhage. Despite the rarity of such presentations in pediatric populations, a multidisciplinary team swiftly intervened and thoroughly evaluated the emergent situation. Imaging studies revealed a retroperitoneal hemorrhage extending from the T10 to lower sacral vertebra, along with a sizable aneurysm closely juxtaposed to the celiac artery. After evaluation, the team opted for conservative management, emphasizing vigilant monitoring and pain management in the intensive care unit. This case underscores the significance of tailored management and research to optimize outcomes and reduce complications in pediatric patients with kyphoscoliotic variant of Ehlers-Danlos syndrome presenting with vascular hemorrhage.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf119"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RET-fusion metastatic colon cancer responding to selpercatinib-a case report. ret融合转移性结肠癌对赛尔珀卡替尼有应答- 1例报告。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf120
William J Mullally, Michael Huo, Kenneth J O'Byrne
{"title":"RET-fusion metastatic colon cancer responding to selpercatinib-a case report.","authors":"William J Mullally, Michael Huo, Kenneth J O'Byrne","doi":"10.1093/omcr/omaf120","DOIUrl":"10.1093/omcr/omaf120","url":null,"abstract":"<p><p>We present the case of a gentleman who developed oligometastatic colon cancer in his brain one year after completing adjuvant chemotherapy. Subsequent dural metastasis necessitated whole brain radiation therapy (WBRT). Whole exome sequencing (WES) identified a <i>NCOA4-RET</i> fusion and high tumor mutation burden. Treatment with selpercatinib following WBRT for multifocal dural metastases led to an initial treatment response, interrupted by grade 3 transaminitis for two weeks, during which dural metastases progressed. Resuming selpercatinib at 50% dose led to a rapid treatment response and maintained for four months until further brain metastases. Our patient survived 21 months following initial diagnoses of metastatic recurrence including nine months of selpercatinib. This case underscores the importance of molecular tumor board meetings and the use of next-generation sequencing WES to detect rare and targetable mutations, ultimately improving patient outcomes.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf120"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catastrophic cerebral venous sinus thrombosis secondary to fulminant invasive otomastoiditis. 暴发性侵袭性耳乳突炎继发的灾难性脑静脉窦血栓形成。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf111
Nilesh Anand Devanand, Krishnaswamy Sundararajan
{"title":"Catastrophic cerebral venous sinus thrombosis secondary to fulminant invasive otomastoiditis.","authors":"Nilesh Anand Devanand, Krishnaswamy Sundararajan","doi":"10.1093/omcr/omaf111","DOIUrl":"10.1093/omcr/omaf111","url":null,"abstract":"<p><p>A previously healthy, middle-aged immunocompetent man presented to a regional hospital with a 12-h history of right ear pain and discharge following a mild flu-like illness. He rapidly deteriorated neurologically, developing dilated pupils and seizures requiring intubation. Following urgent transfer to a quaternary ICU, multidisciplinary assessment (ENT and Neurosurgery), neuroimaging, and right ear myringotomy confirmed Otomastoiditis with catastrophic cerebral venous sinus thrombosis. CT venography demonstrated extensive thrombosis involving the right sigmoid, transverse, and superior sagittal sinuses. Myringotomy revealed culture-negative blood-stained pus. Pulmonary microbiology results were positive for Influenzae B and the Aspergillus fumigatus complex. Despite maximal medical management, the patient developed bilateral venous infarctions, cerebral edema, and cerebellar tonsillar herniation, progressing to brain death within 48 h. Organ donation proceeded in accordance with his prior wishes. Otomastoiditis can cause rapid, fatal intracranial complications even in healthy individuals, highlighting the need for early imaging, specialist input, and vigilance for neurological decline.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf111"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute spasticity in malignant MCA stroke: a case report and review of literature. 恶性MCA脑卒中急性痉挛1例报告及文献复习。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf114
Muhammad Faizan, Azza Halfawi, Alreem Alkuwari, Mohamad Ali, Mohamed Elgassim, Shahzad Anjum
{"title":"Acute spasticity in malignant MCA stroke: a case report and review of literature.","authors":"Muhammad Faizan, Azza Halfawi, Alreem Alkuwari, Mohamad Ali, Mohamed Elgassim, Shahzad Anjum","doi":"10.1093/omcr/omaf114","DOIUrl":"10.1093/omcr/omaf114","url":null,"abstract":"<p><p>Malignant Middle cerebral artery (MCA) infarction is characterized by rapid neurological deterioration due to cerebral edema. Spasticity, a common sequela of stroke, typically occurs days to weeks after the initial event. However, an acute onset of spasticity at presentation is extremely rare. We report a case of a 40-year-old male patient who presented with spasticity accompanied by aphasia and decreased consciousness. Left MCA occlusion was demonstrated on Computed tomography (CT) angiography. Cerebral edema developed rapidly, requiring decompressive hemicraniectomy (DH). The patient was a known smoker with androgenic anabolic steroid use. This case represents a rare presentation of malignant MCA infarction with acute spasticity and adds a unique aspect to the clinical spectrum of stroke presentation. This case emphasizes the need for awareness of atypical stroke presentation and the potential role of anabolic steroids in stroke risk.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf114"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bright kidney: a sign of contrast induced nephropathy after percutaneous coronary intervention. 亮肾：经皮冠状动脉介入治疗后造影剂肾病的征象。
IF 0.4
Oxford Medical Case Reports Pub Date : 2025-07-27 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf110
Kazunori Omote, Tadao Aikawa, Daisuke Sunaga, Naohiro Funayama
{"title":"Bright kidney: a sign of contrast induced nephropathy after percutaneous coronary intervention.","authors":"Kazunori Omote, Tadao Aikawa, Daisuke Sunaga, Naohiro Funayama","doi":"10.1093/omcr/omaf110","DOIUrl":"10.1093/omcr/omaf110","url":null,"abstract":"","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf110"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive Extraluminal gastrointestinal stromal tumour with pelvic extension: case report and mini-review of the literature. 伴盆腔扩张的巨大腔外胃肠道间质瘤：病例报告及文献回顾。
IF 0.5
Oxford Medical Case Reports Pub Date : 2025-07-14 eCollection Date: 2025-07-01 DOI: 10.1093/omcr/omaf093
Yasir Alshareefy, Ali Alshareefy
{"title":"Massive Extraluminal gastrointestinal stromal tumour with pelvic extension: case report and mini-review of the literature.","authors":"Yasir Alshareefy, Ali Alshareefy","doi":"10.1093/omcr/omaf093","DOIUrl":"10.1093/omcr/omaf093","url":null,"abstract":"<p><p>Large extraluminal gastrointestinal stromal tumours (GISTs) are rare, with varied presentations and patient profiles. This report discusses the case of a 22-year-old female presenting with a 4-month history of lower abdominal pain, weight loss, and recurrent urinary tract infections. Imaging revealed a large intra-abdominal mass (9.3 × 15.3 × 18.9 cm) originating from the stomach, extending into the pelvis, and compressing adjacent structures. During surgery, the mass was found to arise from the lesser curvature of the stomach and adhered to the transverse colon, with non-adherent extension into the pelvis and compression of adjacent organs. A gastric wedge resection and transverse colectomy were performed with aim of achieving a R0 resection. Histopathological analysis confirmed a GIST and positive resection margins. A plan for adjuvant imatinib was initiated in accordance with the European Society for Medical Oncology (ESMO) guidelines. This article details the challenges faced in the management of such a rare presentation and highlights similar reports.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf093"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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