{"title":"Massive Extraluminal gastrointestinal stromal tumour with pelvic extension: case report and mini-review of the literature.","authors":"Yasir Alshareefy, Ali Alshareefy","doi":"10.1093/omcr/omaf093","DOIUrl":"10.1093/omcr/omaf093","url":null,"abstract":"<p><p>Large extraluminal gastrointestinal stromal tumours (GISTs) are rare, with varied presentations and patient profiles. This report discusses the case of a 22-year-old female presenting with a 4-month history of lower abdominal pain, weight loss, and recurrent urinary tract infections. Imaging revealed a large intra-abdominal mass (9.3 × 15.3 × 18.9 cm) originating from the stomach, extending into the pelvis, and compressing adjacent structures. During surgery, the mass was found to arise from the lesser curvature of the stomach and adhered to the transverse colon, with non-adherent extension into the pelvis and compression of adjacent organs. A gastric wedge resection and transverse colectomy were performed with aim of achieving a R0 resection. Histopathological analysis confirmed a GIST and positive resection margins. A plan for adjuvant imatinib was initiated in accordance with the European Society for Medical Oncology (ESMO) guidelines. This article details the challenges faced in the management of such a rare presentation and highlights similar reports.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf093"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ocular complications of tussock moth cocoon associated injury.","authors":"Henry Zou, Thomas Aaberg, Brooke Geddie","doi":"10.1093/omcr/omaf099","DOIUrl":"10.1093/omcr/omaf099","url":null,"abstract":"<p><p>Insect-associated intraocular foreign body (IOFB) is a rare etiology of ocular injury. Ocular exposure to tussock moth hairs, or setae, have been associated with ophthalmia nodosa, endophthalmitis, cataracts, and long-term vision loss. We present a case of a vitreous hemorrhage and tractional retinal detachment induced by Tussock moth cocoon setae. A 12-year-old male suffered a left eye injury induced by Tussock moth cocoon setae, causing vitreous hemorrhage and tractional retinal detachment. He underwent pars plana vitrectomy with removal of IOFB, endolaser, fluid-air exchange, and injection of 14% C3F8 gas. He subsequently developed a visually significant cataract treated with lensectomy, intraocular lens implantation, and yttrium-aluminum-garnet laser capsulotomy, after which he regained 20/20 vision. This case demonstrates a rare occurrence of intraocular moth cocoon setae penetration with severe ocular complications. It also demonstrates the challenges of identifying intraocular setae penetration and treatment approach for successful vision rehabilitation despite delayed IOFB recognition.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf099"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meryeme Boutaarourt, Ouiame El Jouari, Salim Gallouj
{"title":"A case of an eccrine spiradenoma in an elderly patient mimicking an epidermoid cyst.","authors":"Meryeme Boutaarourt, Ouiame El Jouari, Salim Gallouj","doi":"10.1093/omcr/omaf103","DOIUrl":"10.1093/omcr/omaf103","url":null,"abstract":"<p><p>Eccrine spiradenoma is one of the rarest benign adnexal tumors. Its clinical presentation is nonspecific, often necessitating a differential diagnosis with other benign cutaneous tumors, highlighting the crucial role of histological examination. The literature provides limited descriptions of this tumor, particularly in elderly patients, emphasizing the significance of our case. Our patient, a 61-year-old man with no significant medical history, presented with a painless cutaneous lesion on his back that had been progressively enlarging over six years. Clinical examination revealed a subcutaneous nodule with a firm consistency, measuring 2 cm in its largest dimension. Complete excision of the lesion was performed for pathological examination. Clinical findings, combined with histology and immunohistochemistry, confirmed the diagnosis of eccrine spiradenoma. This is a benign tumor of the eccrine sweat glands, rarely reported in the literature, typically presenting as a solitary nodule, sometimes multiple, with its primary clinical feature being paroxysmal tenderness. Early and complete surgical excision serves both diagnostic and therapeutic purposes. In addition to its rarity, the occurrence in an elderly patient and its painless nature make our publication particularly noteworthy. This article reports a case of eccrine spiradenoma identified in an elderly patient initially suspected of having an epidermoid cyst, underscoring the importance of histopathological examination for any cutaneous tumor.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf103"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A multidisciplinary approach to eosinophilic esophagitis presenting with feeding dysfunction.","authors":"Emily Sitner-Medvedovsky, Nina Gabriella Sparacio, Bibiana Bernal, Ankita Prasad, Hillary Polk, Oksana Nulman, Shuchi Jani, Cathy Fan, Brande Brown, Kenny Castro Ochoa","doi":"10.1093/omcr/omaf096","DOIUrl":"10.1093/omcr/omaf096","url":null,"abstract":"<p><p>Eosinophilic Esophagitis (EoE) is a chronic, immune-mediated disorder characterized by eosinophilic infiltration of the esophageal mucosa. EoE presents a clinical challenge as the underlying esophageal dysfunction results in diverse symptomatology, ranging from feeding difficulties and failure to thrive in infants to dysphagia and food impaction in older children. The treatment and long-term management of EoE involves a multidisciplinary approach that may include topical glucocorticosteroids, diet therapy and other evolving pharmacotherapies. We present a case of a 12-month-old previously healthy female with a 3-week history of illness followed by an acute presentation of feeding intolerance and hypersensitivity reactions who was subsequently diagnosed with EoE.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf096"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Large hand mass due to poor primary care access in an internally displaced person in the DRC: a case report.","authors":"Rory Marples, Bavon Baruti Murakirwa, Charles Luhombo Kataala, Phanny Kambere Simisi","doi":"10.1093/omcr/omaf094","DOIUrl":"10.1093/omcr/omaf094","url":null,"abstract":"<p><p>We report a woman in her twenties from a displaced persons camp in the Democratic Republic of Congo (DRC) who presented to our medical clinic with a large exophytic tumour from the palm of her right hand. Examination revealed a 100 x 80 x 50 mm tender, necrotic mass, with no associated lymphadenopathy or metastases. Excision and histopathological analysis confirmed the tumour as a myxoma. This case underscores the rarity of palmar myxomas and highlights the impact of armed conflict on healthcare access. Delayed diagnosis and treatment were attributed to disrupted local health infrastructure and poor access to primary care due to the ongoing conflict in the eastern DRC between the Congolese Army and the M23 paramilitary group. The case emphasises the critical role of primary healthcare in conflict zones for timely diagnosis and referral, which is needed to reduce morbidity from neglected surgical diseases.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf094"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samantha Melanie Armendariz-Pineda, Andres Manuel Vargas-Beltran, Maria Juliana Corredor-Nassar, Armando Gamboa-Domínguez, David Arturo Santos-Reyes, Jacqueline Cordova-Gallardo
{"title":"Drug-induced liver injury secondary to rituximab use.","authors":"Samantha Melanie Armendariz-Pineda, Andres Manuel Vargas-Beltran, Maria Juliana Corredor-Nassar, Armando Gamboa-Domínguez, David Arturo Santos-Reyes, Jacqueline Cordova-Gallardo","doi":"10.1093/omcr/omaf003","DOIUrl":"10.1093/omcr/omaf003","url":null,"abstract":"<p><strong>Abbreviations: </strong>DILI: drug-induced liver injury, HBV: Hepatitis B virus, LFT: liver function test, RRMS: Relapsing-remitting multiple sclerosis, UDCA: ursodeoxycholic acid. Rituximab is a human chimeric monoclonal antibody that targets CD20 on B cells. The incidence of rituximab-associated drug-induced liver injury (DILI) is 19 cases per 100 000 people annually. This condition is characterized by a rapid increase in aminotransferase levels and hepatocellular injury, primarily due to reactivation of the hepatitis B virus (HBV). Nevertheless, there have been rare cases of DILI occurring in the absence of HBV reactivation. This case presents a 25-year-old male with relapsing-remitting multiple sclerosis (RRMS) that was treated with rituximab. After treatment, the patient demonstrated a hepatocellular damage pattern and biopsy confirmed the diagnosis. Following the administration of ursodeoxycholic acid (UDCA), the patient's liver function tests (LFTs) returned to normal levels, demonstrating that DILI from rituximab can occur after any infusion, regardless of therapy duration or dosage.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf003"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meryeme Boutaarourt, Ouiame El Jouari, Salim Gallouj
{"title":"A case of classic epidermodysplasia verruciformis associated with elephantiasis: an atypical presentation.","authors":"Meryeme Boutaarourt, Ouiame El Jouari, Salim Gallouj","doi":"10.1093/omcr/omaf104","DOIUrl":"10.1093/omcr/omaf104","url":null,"abstract":"<p><p>Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder characterized by increased susceptibility to human papillomavirus infections (HPV) and a high risk of cutaneous carcinomas. We report the case of a 30-year-old female patient presenting with diffuse verrucous lesions, predominantly affecting the extremities, associated with unilateral elephantiasis. The diagnosis was histologically confirmed, revealing vulgar warts consistent with EV. HIV serology was negative, and systemic retinoid therapy was initiated. EV is linked to mutations in the EVER1 and EVER2 genes, predisposing patients to chronic infections with specific HPV types. Close monitoring is crucial to prevent malignant transformation. This case highlights the diagnostic and therapeutic challenges of EV, emphasizing the importance of an appropriate management strategy to control lesions and prevent complications.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf104"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fikri Chaimaa, Lalla Safia Echarif, Maryam Aboudourib, Layla Bendaoud, Ouafa Hocar, Said Amal
{"title":"When Pityriasis Versicolor wears a vitiligo mask: a puzzle in an immunocompromised patient.","authors":"Fikri Chaimaa, Lalla Safia Echarif, Maryam Aboudourib, Layla Bendaoud, Ouafa Hocar, Said Amal","doi":"10.1093/omcr/omaf105","DOIUrl":"10.1093/omcr/omaf105","url":null,"abstract":"<p><p>A 47-year-old male with a history of colonic adenocarcinoma and recent chemotherapy presented with persistent hyperpigmentation of the trunk, initially thought to be vitiligo due to the striking hyperpigmented lesions and well-demarcated hypopigmented skin. Histological examination of the hyperpigmented lesions, originally thought to represent normal skin, revealed findings consistent with lichen planus pigmentosus. Due to the clinical-histological discordance, a Scotch test was performed, which identified fungal elements consistent with pityriasis versicolor (PV). Treatment with oral fluconazole resulted in rapid resolution of symptoms, highlighting the importance of reconsidering initial diagnoses when clinical and investigative findings are discordant and the efficacy of timely antifungal therapy.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf105"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahzaib Siddiqui, Shayan Ali Irfan, Shahrukh Ahmed, Mirza Mehmood Ali Baig, Jawad Ahmed, Jawed Iqbal
{"title":"A case of adult-onset Bartter syndrome with transient paraplegia.","authors":"Shahzaib Siddiqui, Shayan Ali Irfan, Shahrukh Ahmed, Mirza Mehmood Ali Baig, Jawad Ahmed, Jawed Iqbal","doi":"10.1093/omcr/omaf100","DOIUrl":"10.1093/omcr/omaf100","url":null,"abstract":"<p><p>Bartter syndrome is a rare inherited renal tubular disorder characterised by metabolic alkalosis, hyperaldosteronism, and salt wasting due to defective salt reabsorption in the ascending loop of Henle. The disease is dominant in the antenatal and neonatal populations and rare in adults. Only a small number of studies present adult-onset Bartter syndrome. We present a case of an adult with transient paraplegia diagnosed with Bartter syndrome. A 22-year-old man presented with sudden bilateral lower limb weakness and cramps for two days, with no history of diarrhoea, vomiting, diuretics, laxatives, or addiction. Biochemical studies revealed hypokalemia, metabolic alkalosis, raised urinary potassium levels and raised serum renin. The potassium replacement therapy was initially ineffective in improving symptoms. The raised urinary calcium to creatinine ratio and normal serum magnesium level were noted. There was no nephrocalcinosis, unlike previously reported cases.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf100"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celina R Andonie, Saja I AbuGhannam, Shadi M A Ruzayqat
{"title":"Apple Cider Vinegar-Induced Hepatotoxicity: A Rare Case Report.","authors":"Celina R Andonie, Saja I AbuGhannam, Shadi M A Ruzayqat","doi":"10.1093/omcr/omaf097","DOIUrl":"10.1093/omcr/omaf097","url":null,"abstract":"<p><p>Apple cider vinegar is a ubiquitous ingredient that has been used for many years. There are not many reports in the literature of idiosyncratic drug-induced liver damage linked to apple cider vinegar in people. As far as we are aware, liver damage is an uncommon side effect of long-term apple cider vinegar use. We describe the case of a 60-year-old man who had a long history of vinegar consumption and now had vinegar-induced hepatotoxicity. After the patient stopped using vinegar, his condition improved. This case emphasizes how important it is to take into account conventional substances like vinegar as possible causes of liver damage.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 7","pages":"omaf097"},"PeriodicalIF":0.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}