Shaun Abid, Anton Stolear, Maxim Dulgher, Samdish Sethi, Stuart Zarich
{"title":"When the farm turns fatal: a rare infection causing heart block.","authors":"Shaun Abid, Anton Stolear, Maxim Dulgher, Samdish Sethi, Stuart Zarich","doi":"10.1093/omcr/omaf010","DOIUrl":"10.1093/omcr/omaf010","url":null,"abstract":"<p><p>Brucellosis, a zoonotic infection typically presenting with nonspecific symptoms, rarely leads to cardiac complications, particularly conduction abnormalities. We report a unique case of an 84-year-old female who presented with dizziness, bradycardia, and hypotension, ultimately diagnosed with complete heart block. On admission, blood cultures and further diagnostic workup identified <i>Brucella</i> bacteremia as the underlying cause, with further history revealing that she had recently traveled from a farm in Colombia, a brucellosis-endemic area. The patient underwent dual-chamber pacemaker implantation to stabilize her heart rhythm and was initiated on a three-month antibiotic regimen of doxycycline and rifampin. This case highlights the importance of considering brucellosis as a differential diagnosis for heart block in patients with recent travel from endemic regions. Early recognition and intervention, including antibiotic therapy and pacemaker placement when necessary, are essential for achieving favorable outcomes in brucellosis-related cardiac complications.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf010"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fenna Ahsino, Mouad Al Moudni, Jamal Eddine Bourkadi, Karima Marc
{"title":"Pulmonary amyloidosis: a case report.","authors":"Fenna Ahsino, Mouad Al Moudni, Jamal Eddine Bourkadi, Karima Marc","doi":"10.1093/omcr/omaf007","DOIUrl":"10.1093/omcr/omaf007","url":null,"abstract":"<p><p>Amyloidosis is a rare disease in which abnormally folded proteins form accumulations called amyloid fibrils that accumulate in different tissues and organs, sometimes leading to organ dysfunction, organ failure and death. Rarely, pulmonary involvement can take one of three forms: nodular, diffuse alveolar-septal, or tracheobronchial. We report the case of a 60-year-old woman previously treated for confirmed pleural tuberculosis. She was admitted with progressive dyspnea for three months and a chest CT scan revealed a pulmonary nodule in the middle lobe. She underwent CT-guided biopsy and diagnosis of pulmonary amyloidosis was retained by histology. Follow up has been unremarkable.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf007"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of selegiline on <sup>123</sup>I-meta-iodobenzylguanidine myocardial scintigraphy.","authors":"Katsuya Nishida","doi":"10.1093/omcr/omae212","DOIUrl":"10.1093/omcr/omae212","url":null,"abstract":"","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omae212"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term follow-up of vasculitis with metal allergy after cerebrovascular coil embolization.","authors":"Yukiko Takakuwa, Seido Ooka, Nobuyuki Endo, Hisao Nakamura, Tatsuro Okano, Tomomitsu Miyagaki, Takafumi Kadono, Kimito Kawahata","doi":"10.1093/omcr/omaf004","DOIUrl":"10.1093/omcr/omaf004","url":null,"abstract":"<p><p>Interventional treatment using catheters, particularly coil embolization, is a common therapy for cerebral aneurysms. While generally safe, complications such as allergic vasculitis due to metal allergies can occur. We report the case of a 57-year-old Japanese woman who developed vasculitis after undergoing coil embolization for a cerebral aneurysm. Two days post-procedure, she presented with left-sided facial paralysis, paresis, and hearing loss. MRI revealed multiple small lesions, and vasculitis due to metal allergy was suspected. Treatment with steroids led to improvement, and steroid therapy was tapered off within a year. Allergy tests performed post-treatment identified a positive reaction to the GDC coil and potassium dichromate but not to nickel or platinum. Unfortunately, recurrent vasculitis lesions were detected following the patch test. This case highlights the importance of considering metal allergies before coil embolization and the potential risks of allergy testing after the procedure.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf004"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gordon P Bensen, Matthew R Bryan, Esther Nishimwe, Bao Sean Nguyen, Kenechukwu Chudy-Onwugaje
{"title":"Oral contraceptive pill-induced esophagitis: a rare cause of pill esophagitis in a Rwandan woman.","authors":"Gordon P Bensen, Matthew R Bryan, Esther Nishimwe, Bao Sean Nguyen, Kenechukwu Chudy-Onwugaje","doi":"10.1093/omcr/omaf001","DOIUrl":"10.1093/omcr/omaf001","url":null,"abstract":"<p><p>We describe a case of oral contraceptive pill (OCP)-induced esophagitis in a 43-year-old Rwandan woman. She presented with epigastric and retrosternal pain and reported daily use of a combined OCP containing ethinyl estradiol and levonorgestrel. Upper endoscopy revealed a solitary, clean-based esophageal ulcer. Histopathologic evaluation excluded infectious causes, and she improved with proton pump inhibitor therapy and modification of pill consumption habits. This is the first reported case of OCP-induced esophagitis on the African continent and the fifth case overall, and it highlights the importance of awareness of this rare gastrointestinal adverse effect of a commonly used class of drugs, particularly in an area of the world that is promoting the increased uptake of female contraception as a tool for family planning.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf001"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Aljarad, Ahmad Alhamid, Hamdah Hanifa, Obada Zayegh, Jamal Ataya, Ziad Aljarad
{"title":"Aase-Smith syndrome type 2 with new neurological findings.","authors":"Sarah Aljarad, Ahmad Alhamid, Hamdah Hanifa, Obada Zayegh, Jamal Ataya, Ziad Aljarad","doi":"10.1093/omcr/omaf006","DOIUrl":"10.1093/omcr/omaf006","url":null,"abstract":"<p><p>Aase-Smith syndrome type 2 is a rare genetic disorder that affects erythropoiesis and bone development, causing hypoplastic anemia and abnormalities in the fingers and toes, specifically triphalangeal thumbs. While there is no cure, treatment involves managing symptoms through blood transfusions, surgical intervention, and genetic counselling. A 15-year-old student presented with an unmeasured fever for two months, recurrent lung infections, difficulty in speech, and impaired gait. The patient had multiple congenital malformations including triphalangeal thumbs and a history of mild anemia. Bone marrow biopsy revealed an isolated slowing of erythroid lineage maturation. Radiology studies showed scoliosis, hand deformities, and multiple calcified lesions in the brain. The patient's fever exacerbated, and oxygen saturation deteriorated, necessitating tracheal intubation. Several hours later, the patient passed away.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf006"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boujguenna Imane, Mohammed Essaid Ramraoui, Fatima Boukis, Faisal ElMouhafid
{"title":"Unmasking the uncommon: retroperitoneal Leiomyosarcoma case report.","authors":"Boujguenna Imane, Mohammed Essaid Ramraoui, Fatima Boukis, Faisal ElMouhafid","doi":"10.1093/omcr/omaf002","DOIUrl":"10.1093/omcr/omaf002","url":null,"abstract":"<p><p>Leiomyosarcoma is a rare subtype of soft tissue sarcoma originating from smooth muscle cells. The clinical presentation varies based on the tumor's location. We report the case of a 63-year-old woman with no significant medical history, who presented with persistent epigastric pain. A suspected lymphadenopathy was found on a CT scan. Following surgical excision, histopathology and immunohistochemistry confirmed the diagnosis of leiomyosarcoma, negative for CD117 and Dog1, but positive for H-Caldesmon. Retroperitoneal leiomyosarcoma is aggressive and rare, making diagnosis difficult prior to histopathology. Complete surgical resection with negative margins is the gold standard of treatment, though it can be challenging to achieve. A multidisciplinary approach is crucial to improve survival and quality of life. The patient is under regular follow-up and remains free of recurrence six months post-operatively.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf002"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isaac K S Ng, Christopher Thong, Gaurav Deep Singh, Peter Daniel, Kei Jun Poon, Ching Ching Ong, Adrian C L Kee
{"title":"Diagnostic evaluation and management of pulmonary hypertension with concomitant incidental partial anomalous pulmonary venous return.","authors":"Isaac K S Ng, Christopher Thong, Gaurav Deep Singh, Peter Daniel, Kei Jun Poon, Ching Ching Ong, Adrian C L Kee","doi":"10.1093/omcr/omae214","DOIUrl":"10.1093/omcr/omae214","url":null,"abstract":"<p><p>Partial anomalous pulmonary venous return (PAPVR) is a rare congenital heart condition which is often asymptomatic and hence remains undiagnosed, but could occasionally be detected on thoracic imaging as an incidental finding. For rare cases of newly diagnosed pulmonary hypertension with concurrent PAPVRs, the diagnostic workup and subsequent management are more complicated, requiring a thorough evaluation of secondary causes of pulmonary hypertension, and assessing relative PAPVR shunt contribution to the pulmonary hypertension. We herein report a case of a 74-year-old Chinese male patient, a chronic smoker of 50 pack-years, and past medical history of hypertension and diabetes mellitus, who was admitted to our intensive care unit with acute decompensated type 2 respiratory failure, and subsequently found to have newly diagnosed pulmonary hypertension with right heart failure and an incidental PAPVR identified on inadvertent central venous cannulation (CVC) of the anomalous pulmonary vein draining into the left internal jugular vein. There are a few key learning points from this case study: firstly, we profile the characteristics and clinical outcomes of cases of incidental CVC cannulation of undiagnosed PAPVR from a literature review; and secondly, we discuss the diagnostic and management approach to newly diagnosed pulmonary hypertension with concomitant, incidental PAPVR that may be useful for internists and critical care physicians.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omae214"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emad A Odeh, Jaber H Jaradat, Raghad Amro, Seif Jankhout, Abdulqadir J Nashwan
{"title":"Case report of atypical presentation of Bartter's syndrome: hypertension and Hypokalemic nephropathy in a female patient.","authors":"Emad A Odeh, Jaber H Jaradat, Raghad Amro, Seif Jankhout, Abdulqadir J Nashwan","doi":"10.1093/omcr/omae215","DOIUrl":"10.1093/omcr/omae215","url":null,"abstract":"<p><p>Bartter's syndrome (BS) is a rare hereditary disorder characterized by tubulopathies that affect salt reabsorption in the thick ascending limb of the Henle's loop. While BS typically presents with electrolyte imbalances and normal blood pressure, atypical presentations can complicate its diagnosis and management. We report the case of a 21-year-old female with BS diagnosed clinically at birth who presented with cough, vomiting, and elevated blood pressure. Despite a positive family history of BS, her presentation was unique with hypertension and hypokalemic nephropathy. Diagnostic evaluations during hospital admission revealed electrolyte imbalances, kidney dysfunction, and renal histopathological findings that were consistent with hypokalemic nephropathy. This case highlights the diverse clinical manifestations and potential complications of BS and emphasizes the importance of thorough evaluation and multidisciplinary management. Further research is needed to elucidate the underlying mechanisms linking BS with hypertension and hypokalemic nephropathy, and to guide targeted therapeutic strategies for complex presentations.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omae215"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard Shamoon, Osman Elhassan, Lujain Al-Emadi, Abdulwahab Zabara, Mahir A Petkar, Sarah Sayed, Osama H Mohammad
{"title":"Neuroendocrine carcinoma causing common bile duct obstruction: a case report.","authors":"Richard Shamoon, Osman Elhassan, Lujain Al-Emadi, Abdulwahab Zabara, Mahir A Petkar, Sarah Sayed, Osama H Mohammad","doi":"10.1093/omcr/omaf011","DOIUrl":"10.1093/omcr/omaf011","url":null,"abstract":"<p><p>A 46-year-old male with no comorbidities was referred to our hospital because of jaundice and elevated LFT markers. After further investigations, he underwent magnetic resonance cholangiopancreatography (MRCP), which revealed a hypo-enhancing periampullary mass measuring 15 mm in size causing common bile duct (CBD) dilatation of 12 mm in cross diameter with intrahepatic biliary obstruction, which explained the patient's symptoms. Side-view endoscopy was performed to obtain a specimen of the mass. Further histopathological workup revealed poorly differentiated neuroendocrine carcinoma (NEC). A multidisciplinary team (MDT) was conducted, and the patient was planned to undergo positron emission tomography-computed tomography (PET-CT) scan to investigate any further organ metastasis. Unfortunately, the patient missed his upcoming appointments and was lost to follow-up. Nevertheless, more research is needed to understand pathogenesis and the best course of management for small periampullary NETs.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 4","pages":"omaf011"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}