{"title":"An elderly patient with dementia presenting euglycaemic ketoacidosis due to oesophageal stricture-associated eating habits.","authors":"Hiroaki Iwasaki, Seie Morita","doi":"10.1093/omcr/omae187","DOIUrl":"10.1093/omcr/omae187","url":null,"abstract":"<p><p>An 85-year-old man with dementia was referred to our department because of problematic eating habits, which made it difficult to manage his diabetes mellitus. The patient exhibited euglycaemic ketoacidosis, with a clinical course and biochemical parameters more indicative of starvation ketoacidosis rather than diabetic ketoacidosis. After correcting the acid-base imbalance with dextrose-containing fluids, he attempted to resume oral intake; however, throat noises consistent with reflux were noted during food ingestion. Imaging and pathological studies revealed a stricture with wall thickening in the mid-oesophagus attributed to non-specific chronic oesophagitis. After receiving hypercaloric fluids to calm oesophageal inflammation, an endoscopic bougienage was performed, enabling oral intake and achieving appropriate glycaemic control with oral glucose-lowering agents. This case illustrates the importance of closely monitoring eating behaviours, which is crucial for identifying comorbid organic abnormalities, without being limited by cognitive bias in clinical reasoning that problematic dietary changes are highly prevalent in dementia patients.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae187"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maciej Bąk, Artur Oręziak, Ewa Świerżyńska-Wodarska, Maciej Sterliński, Łukasz Szumowski
{"title":"(Non) twiddler syndrome in a subcutaneous implantable cardioverter-defibrillator patient-fixation first?","authors":"Maciej Bąk, Artur Oręziak, Ewa Świerżyńska-Wodarska, Maciej Sterliński, Łukasz Szumowski","doi":"10.1093/omcr/omae188","DOIUrl":"10.1093/omcr/omae188","url":null,"abstract":"","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae188"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Statin-induced immune mediated necrotising myopathy presenting with a markedly elevated cardiac troponin T in the absence of myocardial injury.","authors":"David Hall, Goodness Mbonu, Zulakha Nadeem","doi":"10.1093/omcr/omae190","DOIUrl":"10.1093/omcr/omae190","url":null,"abstract":"<p><p>Cardiac troponin (cTn) is a sensitive test to assess for myocardial injury. However certain clinical situations can result in a raised cTn in the absence of cardiac involvement. Here we present a case of a 65-year-old woman on long term atorvastatin who presented with generalised weakness, non-specific chest pain, and a persistently elevated high sensitivity cardiac troponin T. Upon further investigation acute myocardial injury was excluded and a diagnosis of statin-induced immune mediated necrotising myopathy (IMNM) was made. The patient improved with cessation of atorvastatin and initiation of immunosuppressive therapy with mycophenolate, intravenous immunoglobulin, and steroids. The mechanism for cTn elevation in skeletal myopathies without cardiac damage and the presentation and treatment of statin-induced IMNM are reviewed. We highlight the importance that in these cases the true cause of the raised cTn is recognised to allow prompt diagnosis and treatment of the underlying myopathy.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae190"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Upadacitinib in refractory Polyarteritis Nodosa: a case report.","authors":"Akihiko Nakabayashi, Erika Iguchi, Dong Seop Kim, Yanakawee Siripongvutikorn, Akira Nishigaichi, Maiko Yoshimura, Hyota Takamatsu, Shiro Ohshima","doi":"10.1093/omcr/omae199","DOIUrl":"10.1093/omcr/omae199","url":null,"abstract":"<p><p>Polyarteritis nodosa (PAN) is systemic vasculitis, typically treated with a combination of glucocorticoids and immunosuppressants. Changing the immunosuppressant is recommended if remission cannot be achieved with these treatments. However, there is a lack of further treatment options for patients who are unresponsive to all immunosuppressants. We report a 44-year-old Japanese man with refractory PAN who was unresponsive to various immunosuppressants (including tocilizumab). Upadacitinib treatment led to relatively rapid symptom improvement, allowing for tapering and eventual discontinuation of immunosuppressants, including prednisolone. During his 1-year follow-up, no relapse or side effects were noted. This case suggests that Janus kinase inhibitors may provide a breakthrough for patients with refractory PAN.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae199"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prolonged extrapyramidal syndrome due to metoclopramide overdose: a rare case report.","authors":"Abdollah Malakian, Alireza Omrani, Arshia Omrani, Yasin Ramzani, Zakaria Zakariaei","doi":"10.1093/omcr/omae217","DOIUrl":"10.1093/omcr/omae217","url":null,"abstract":"<p><p>Metoclopramide is a useful antiemetic drug that is widely used in medical emergencies. This drug can cause extrapyramidal side effects that are worrying. An 18-year-old girl student unintentionally consumed a large dose (60 mg) of metoclopramide, exceeding the recommended therapeutic dose, for the management of nausea and vomiting. Approximately six hours after the ingestion of the medication, she developed neck dystonia and upward deviation of the eyes. Seeing these symptoms and worrying about their child's physical condition, the parents took her to the local medical center in northern Iran. With the diagnosis of the extrapyramidal syndrome and intramuscular administration of biperiden 5 mg ampoule twice at 12-h intervals, unfortunately, the symptoms did not improve and finally he was referred to our hospital. Dystonic reactions caused by metoclopramide can be misdiagnosed and it is necessary to be monitored and treated appropriately to reduce the family's concern about its unpleasant side effects.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae217"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An incidental finding of Cor Triatriatum in an adult with left ventricular dysfunction and atrial flutter.","authors":"Ruchika Meel, Keitumetsi Lucy Sothoane, Ebrahim Variava","doi":"10.1093/omcr/omae189","DOIUrl":"10.1093/omcr/omae189","url":null,"abstract":"<p><p>The global incidence of Cor Triatriatum ranges from 0.1% to 0.4 globally. It is a rare diagnosis, with only a few cases reported in Africa. This case report outlines the first presentation of Cor Triatriatum in a 34-year-old female previously diagnosed with post-partum cardiomyopathy. The purpose of this case report was to raise awareness about the presence of congenital heart disease in adulthood as a potential cause of heart failure. Additionally, it emphasizes the importance of detailed echocardiography using advanced imaging techniques for evaluating defects and co-existing lesions.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae189"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lekhya Raavi, Nafiye Busra Celik, Pankaj Garg, John Haney
{"title":"ALCAPA: A Giant Right Coronary Artery Aneurysm.","authors":"Lekhya Raavi, Nafiye Busra Celik, Pankaj Garg, John Haney","doi":"10.1093/omcr/omae186","DOIUrl":"10.1093/omcr/omae186","url":null,"abstract":"","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae186"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir El Rahal, Katharina Wolf, Florian Volz, Jürgen Beck
{"title":"An arachnoid bleb and weeping dura-a persistent low flow CSF-leak after lumbar puncture.","authors":"Amir El Rahal, Katharina Wolf, Florian Volz, Jürgen Beck","doi":"10.1093/omcr/omae182","DOIUrl":"10.1093/omcr/omae182","url":null,"abstract":"<p><strong>Background and importance: </strong>Post-dural puncture headache (PDPH) is a well-recognized and frequently encountered complaint of Lumbar puncture. It usually resolves spontaneously over two weeks or with an epidural blood patch. Although known for a long time, PPDH could be linked to an arachnoidal bleb as a cause of cerebrospinal fluid (CSF) leakage. We report on surgical findings and impressive findings with low-flow CSF leakage in the context of an arachnoidal bleb.</p><p><strong>Clinical presentation: </strong>We report a 42-year-old Neuroscientist with a 23-month history of positional headaches after a lumbar puncture (LP). Multiple Sclerosis was ruled out, but chronic orthostatic headache and tinnitus developed. Bed rest, caffeine tablets, IV hydration, and five high-volume epidural blood patches did not lead to improvement. However, brain fog and reduced ability to work ensued. A dynamic myelography did not reveal a CSF leak or a CSF-venous fistula, but a high-resolution T2Space Fat-saturated MRI detected an arachnoidal bleb at the alleged L3-L4 level. Microsurgical exploration identified the arachnoid bleb as a low-flow CSF leak. The video depicts Neomenbranes overlaying the dura mater appearing as a web and CSF oozing, washing a layer of blood away. CSF was leaking like a tear, and we had the impression of a weeping dura. Treatment involved bipolar shrinking, reinforcement of the dura and fibrin glue. The patient's symptoms improved slowly post-surgery.</p><p><strong>Conclusion: </strong>This case emphasises the importance of considering atypical causes of post-lumbar puncture complications, such as arachnoid blebs, and the role of surgery in identifying and treating these rare conditions.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 2","pages":"omae182"},"PeriodicalIF":0.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}