Dermatopathology最新文献_第4页

Enhancing Melanoma Diagnosis with Advanced Deep Learning Models Focusing on Vision Transformer, Swin Transformer, and ConvNeXt. 以 Vision Transformer、Swin Transformer 和 ConvNeXt 为重点，利用先进的深度学习模型加强黑色素瘤诊断。

IF 1.6

Dermatopathology Pub Date : 2024-08-15 DOI: 10.3390/dermatopathology11030026

Serra Aksoy, Pinar Demircioglu, Ismail Bogrekci

{"title":"Enhancing Melanoma Diagnosis with Advanced Deep Learning Models Focusing on Vision Transformer, Swin Transformer, and ConvNeXt.","authors":"Serra Aksoy, Pinar Demircioglu, Ismail Bogrekci","doi":"10.3390/dermatopathology11030026","DOIUrl":"10.3390/dermatopathology11030026","url":null,"abstract":"Skin tumors, especially melanoma, which is highly aggressive and progresses quickly to other sites, are an issue in various parts of the world. Nevertheless, the one and only way to save lives is to detect it at its initial stages. This study explores the application of advanced deep learning models for classifying benign and malignant melanoma using dermoscopic images. The aim of the study is to enhance the accuracy and efficiency of melanoma diagnosis with the ConvNeXt, Vision Transformer (ViT) Base-16, and Swin Transformer V2 Small (Swin V2 S) deep learning models. The ConvNeXt model, which integrates principles of both convolutional neural networks and transformers, demonstrated superior performance, with balanced precision and recall metrics. The dataset, sourced from Kaggle, comprises 13,900 uniformly sized images, preprocessed to standardize the inputs for the models. Experimental results revealed that ConvNeXt achieved the highest diagnostic accuracy among the tested models. Experimental results revealed that ConvNeXt achieved an accuracy of 91.5%, with balanced precision and recall rates of 90.45% and 92.8% for benign cases, and 92.61% and 90.2% for malignant cases, respectively. The F1-scores for ConvNeXt were 91.61% for benign cases and 91.39% for malignant cases. This research points out the potential of hybrid deep learning architectures in medical image analysis, particularly for early melanoma detection.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 3","pages":"239-252"},"PeriodicalIF":1.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Challenge: A New Article Type in Dermatopathology. 临床病理挑战：皮肤病理学的新文章类型。

IF 1.6

Dermatopathology Pub Date : 2024-08-14 DOI: 10.3390/dermatopathology11030025

Gürkan Kaya

引用次数: 0

Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome. 两名奈瑟顿综合征患者的皮肤活检组织中白细胞介素-36高度表达

IF 1.6

Dermatopathology Pub Date : 2024-08-12 DOI: 10.3390/dermatopathology11030024

Johannes Pawlowski, Tatsiana Pukhalskaya, Kelly Cordoro, Marina Kristy Ibraheim, Jeffrey P North

{"title":"Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome.","authors":"Johannes Pawlowski, Tatsiana Pukhalskaya, Kelly Cordoro, Marina Kristy Ibraheim, Jeffrey P North","doi":"10.3390/dermatopathology11030024","DOIUrl":"10.3390/dermatopathology11030024","url":null,"abstract":"Netherton syndrome (NS) is a rare autosomal recessive disorder that occurs due to a loss-of-function mutation in SPINK5; this loss results in significant inflammation, as well as perturbations of the skin barrier's integrity and functionality. While it is unclear which inflammatory pathways contribute to the development of NS, recent studies have demonstrated the expression of interleukin (IL)-17/IL-36, as well as several Th2 cytokines. Consequently, immunohistochemistry (IHC) with IL-36 may serve as a potential tool for aiding the histopathological diagnosis of this condition. In this case series, we present two cases of NS and capture their immunostaining pattern with IL-36. Both cases demonstrated robust expression of IL-36. This finding bolsters the hypothesis that NS is partially driven by Th17 activation and suggests the potential utility of IL-36 IHC as part of the workup for this rare and diagnostically elusive entity. LEKTI IHC was negative in one biopsy, revealing a limitation of this stain in diagnosing NS.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 3","pages":"230-237"},"PeriodicalIF":1.6,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases. 数字乳头状腺癌：在部分病例中检测到低风险人类乳头状瘤病毒和 BRAF p.V600E 突变。

IF 1.6

Dermatopathology Pub Date : 2024-06-28 DOI: 10.3390/dermatopathology11030018

Feifan Chen, Priyadharsini Nagarajan, Phyu P Aung

{"title":"Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases.","authors":"Feifan Chen, Priyadharsini Nagarajan, Phyu P Aung","doi":"10.3390/dermatopathology11030018","DOIUrl":"10.3390/dermatopathology11030018","url":null,"abstract":"Digital papillary adenocarcinoma (DPA) is a rare malignant neoplasm which arises from the sweat glands and has metastatic potential. DPA exhibits a wide range of architectural features and exhibits low-grade to high-grade features, so distinguishing DPA from benign skin neoplasms, including acral hidradenoma, poses significant diagnostic challenges. The recent literature suggests a strong association between DPA and human papillomavirus (HPV) 42, a low-risk HPV (LR-HPV) subtype, and a possible association between DPA and BRAF p.V600E. To explore these associations, we assessed the utility of in situ hybridization (ISH) for LR-HPV (types 6, 11, 40, 42, 43, 44) and immunohistochemistry (IHC) for BRAF p.V600E in diagnosing DPA and distinguishing DPA from acral hidradenoma. With institutional review board approval, we retrospectively identified 15 specimens of DPA (from 13 patients) and 3 cases of acral hidradenoma. Of the 13 DPA cases, 6 were negative for LR-HPV and BRAF p.V600E; 6 were positive for only LR-HPV; and 1 was positive for only BRAF p.V600E but negative for LR-HPV. All three cases of acral hidradenoma were negative for LR-HPV and BRAF p.V600E. As our sample size is limited, larger studies are needed to assess the value of detecting LR-HPV and BRAF p.V600E in the distinction of DPA and acral hidradenoma. However, our findings indicate a stronger association of DPA with LR-HPV than with BRAF p.V600E.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 3","pages":"177-183"},"PeriodicalIF":1.6,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Value of Histopathological Features in Early-Stage Mycosis Fungoides: Insights from a Retrospective-Prospective Cohort Study. 早期真菌病组织病理学特征的预后价值：一项回顾性-前瞻性队列研究的启示

IF 1.6

Dermatopathology Pub Date : 2024-06-14 DOI: 10.3390/dermatopathology11020017

Sandra Jerkovic Gulin, Ivana Ilic, Romana Ceovic

{"title":"The Prognostic Value of Histopathological Features in Early-Stage Mycosis Fungoides: Insights from a Retrospective-Prospective Cohort Study.","authors":"Sandra Jerkovic Gulin, Ivana Ilic, Romana Ceovic","doi":"10.3390/dermatopathology11020017","DOIUrl":"10.3390/dermatopathology11020017","url":null,"abstract":"Primary cutaneous lymphomas (PCLs), especially mycosis fungoides (MF), pose significant diagnostic and therapeutic challenges. This study aims to correlate initial histological features with the disease course and survival in MF patients. A retrospective-prospective cohort study was conducted on 83 patients diagnosed with early-stage MF at the Departments of Dermatovenerology and Pathology, UHC Zagreb, from January 2003 to December 2012. The analyzed histopathological parameters included lichenoid dermal lymphocyte infiltrate, Pautrier microabscesses, and lymphocyte atypia. Patients with more than 30 guardian lymphocytes per 100 keratinocytes exhibited worse overall and progression-free survival. Furthermore, those with over 50% atypical lymphocytes demonstrated a faster progression rate. A dense lichenoid dermal infiltrate and a high count of lymphocyte \"keepers\" significantly increased the mortality risk within five years of diagnosis. This study did not fully confirm the hypothesis regarding the prognostic value of large Pautrier microabscesses but highlighted the importance of dense lichenoid infiltrates. The study identified new potential histopathological prognostic factors in early-stage MF, suggesting the need for larger studies to confirm these findings. The identification of such predictors could enhance the prognostic stratification and guide more tailored therapeutic approaches for MF patients.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 2","pages":"161-176"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Histopathology of Leg Ulcers. 腿部溃疡的组织病理学。

IF 1.9

Dermatopathology Pub Date : 2024-01-29 DOI: 10.3390/dermatopathology11010007

Amun Georg Hofmann, Julia Deinsberger, André Oszwald, Benedikt Weber

引用次数: 0

Diagnosing Cutaneous Melanocytic Tumors in the Molecular Era: Updates and Review of Literature. 分子时代的皮肤黑色素细胞肿瘤诊断：最新进展和文献综述。

IF 1.6

Dermatopathology Pub Date : 2024-01-18 DOI: 10.3390/dermatopathology11010005

Chelsea Huang, Tiffany Wing-See Lau, Bruce R Smoller

引用次数: 0

Giant Folliculosebaceous Cystic Hamartoma of the Face 面部巨型毛囊囊性脂肪瘤

IF 1.9

Dermatopathology Pub Date : 2023-12-31 DOI: 10.3390/dermatopathology11010004

Ramona Tasar, Melanie Peckruhn, Jörg Tittelbach

{"title":"Giant Folliculosebaceous Cystic Hamartoma of the Face","authors":"Ramona Tasar, Melanie Peckruhn, Jörg Tittelbach","doi":"10.3390/dermatopathology11010004","DOIUrl":"https://doi.org/10.3390/dermatopathology11010004","url":null,"abstract":"Folliculosebaceous cystic hamartoma (FSCH) is a rare and benign form of cutaneous hamartomas. These skin lesions often lead to clinical and histopathological misdiagnosis due to their similarities to cutaneous lesions with overproduction of clustered sebaceous glands. Clinically, the lesions often present as solitary, skin-colored, pedunculated warts to cauliflower-like, exophytic papules and nodules, usually with a diameter ranging 0.5–1.5 cm that rarely exceed 2 cm in size. Only a small number of giant variants are reported in the literature with a diameter in the range of 5–23 cm. The vast majority of the lesions appear in the central face and show a striking predilection for the nose, ears, and scalp, but also emerge on the nipples, extremities, and genitals. Histologically, the epithelial components of folliculosebaceous cystic hamartoma comprise dilated infundibular cystic proliferation with surrounding mesenchymal components, which commonly include fibroplasia and vascular and adipose tissue proliferation. These histological characteristics were coined by Kimura and colleagues (1991). To the best of our knowledge, our case represents the biggest variant of giant folliculosebaceous cystic hamartoma.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"6 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139135862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus 一例多形性真皮肉瘤：内侧鱼尾纹巨型外生瘤

IF 1.9

Dermatopathology Pub Date : 2023-12-29 DOI: 10.3390/dermatopathology11010003

Rylee Moody, Kavita Darji, Tricia A Missall, Peter Chow, R. Behshad

{"title":"A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus","authors":"Rylee Moody, Kavita Darji, Tricia A Missall, Peter Chow, R. Behshad","doi":"10.3390/dermatopathology11010003","DOIUrl":"https://doi.org/10.3390/dermatopathology11010003","url":null,"abstract":"We present the case of a 99-year-old Caucasian female who was referred for treatment of a painless, 8.0 cm × 7.8 cm exophytic, pedunculated, ulcerated tumor of the left medial canthus. Pathology showed spindled, oval, and polygonal cells with pleomorphic nuclei. Many multinuclear giant cells and mitotic figures were also noted. The tumor was highlighted with CD10, showed focal positivity with actin, desmin, and CD68, and had increased Ki67 immunohistochemical staining. The tumor was negative for pancytokeratin, CK5/6, p63, MART-1/MelanA, S100, Sox10, p40, CD34, and CD23. Based on clinicopathologic correlation, the diagnosis of pleomorphic dermal sarcoma (PDS) was made. Pleomorphic dermal sarcoma (PDS) refers to a deep, histologically high-grade tumor that often resembles other tumors clinically and histologically. As PDS is frequently aggressive and related to adverse outcomes, it is important to recognize its distinguishing features in comparison to other similar entities, including atypical fibroxanthoma (AFX) and pleomorphic leiomyosarcoma (PLMS). To our knowledge, there is only one other reported case in the literature of PDS occurring on the eye. By reviewing and understanding characteristic etiologies, locations of presentation, histopathological features, and management techniques, pathologists can make a more accurate diagnosis and dermatologists can provide more effective patient care in a timely manner.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":" 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139142604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perforating Fibrous Histiocytoma Mimicking Keratoacanthoma: A Case Report 模仿角化棘皮瘤的穿孔性纤维组织细胞瘤：病例报告

IF 1.9

Dermatopathology Pub Date : 2023-12-25 DOI: 10.3390/dermatopathology11010002

Alina Lungu, Aurélie Hsieh, Gürkan Kaya, S. Menzinger

引用次数: 0