Dermatopathology最新文献_第10页

Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses? 痣相关性黑色素瘤与新生黑色素瘤:它们有不同的特征和预后吗?

IF 1.9

Dermatopathology Pub Date : 2015-04-01 DOI: 10.1159/000375490

Nilay Duman, G. Erkin, Ö. Gököz, S. Karahan, A. Kayıkçıoğlu, I. Çelik

{"title":"Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses?","authors":"Nilay Duman, G. Erkin, Ö. Gököz, S. Karahan, A. Kayıkçıoğlu, I. Çelik","doi":"10.1159/000375490","DOIUrl":"https://doi.org/10.1159/000375490","url":null,"abstract":"Aim: The aim of this study was to determine if nevus-associated melanoma differs in characteristics and prognosis from de novo melanoma. Patients and Methods: The study included 118 melanoma patients. Clinical findings were retrospectively evaluated. For histopathological parameters, HE sections were reexamined. The differentiation between de novo and nevus-associated melanoma was based on the histopathological evidence of a precursor nevus. In addition, all analyses were repeated in all cases in which nevus-associated melanoma was defined based on patient anamnesis. Results: Among all patients, 28 (23.7%) had nevus-associated melanoma. Nevus-associated melanoma was most commonly located on the extremities (50%), followed by the trunk (25%), whereas de novo melanoma was most commonly located in the head and neck region (32.2%), followed by the acral region (31.1%). Other clinical findings and histopathological parameters did not differ significantly between the two groups (p > 0.05). The findings remained consistent following the repeated analysis of all cases in which nevus-associated melanoma was defined based on patient anamnesis. Conclusions: Nevus-associated melanoma was most commonly located on the extremities and the trunk, whereas de novo melanoma was most commonly located in the head and neck and the acral region. Furthermore, nevus-associated melanoma was similar to de novo melanoma in terms of prognosis and other disease characteristics.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"2 1","pages":"46 - 51"},"PeriodicalIF":1.9,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000375490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64772200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Porokeratoma: A Possible Association with Human Papillomavirus Infection 角化孔瘤:可能与人乳头瘤病毒感染有关

IF 1.9

Dermatopathology Pub Date : 2015-04-01 DOI: 10.1159/000379745

Patricia Caseiro Silverio, X. Pham, G. Kaya

引用次数: 10

Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature 皮肤肌外皮细胞瘤3例报告并文献复习

IF 1.9

Dermatopathology Pub Date : 2015-02-11 DOI: 10.1159/000371875

P. Aung, L. Goldberg, M. Mahalingam, J. Bhawan

引用次数: 20

Wong-Type Dermatomyositis Showing Porokeratosis-Like Changes (Columnar Dyskeratosis): A Case Report and Review of the Literature 表现为角化孔样改变的wong型皮肌炎(柱状角化不良病):1例报告及文献复习

IF 1.9

Dermatopathology Pub Date : 2015-01-27 DOI: 10.1159/000371573

Nicole Umanoff, A. Fisher, J. Carlson

{"title":"Wong-Type Dermatomyositis Showing Porokeratosis-Like Changes (Columnar Dyskeratosis): A Case Report and Review of the Literature","authors":"Nicole Umanoff, A. Fisher, J. Carlson","doi":"10.1159/000371573","DOIUrl":"https://doi.org/10.1159/000371573","url":null,"abstract":"Background: Wong-type dermatomyositis (DM) exhibits simultaneous pityriasis rubra pilaris (PRP) features. Case Report: A 50-year-old woman presented with a heliotrope rash, Gottron's papules, and a poikilodermic, erythematous rash in shawl distribution without evidence of muscle weakness. Despite topical corticosteroids, the eruption progressed 9 months later to include generalized hyperkeratotic follicular papules, islands of sparing, and atrophic macules with a collarette of scale suggestive of porokeratosis. Mild dysphonia was the only sign of muscle weakness. Serology showed positive ANA. Histopathology revealed interface dermatitis with dermal mucin and melanophages, irregular psoriasiform hyperplasia, alternating mounds of para- and orthokeratosis, and tiers of dyskeratotic cells (columnar dyskeratosis). Systemic corticosteroid therapy was not tolerated; acitretin diminished the hyperkeratosis. While hyperpigmentation persisted, no progression of cutaneous or muscular symptoms has occurred after 22 months of follow-up and cessation of the therapy. Overall, her course did not differ from the natural history documented in the literature review of Wong-type DM. The most similar case also exhibited pseudocornoid lamella changes. Conclusion: Wong-type DM is a clinicopathologic DM-PRP hybrid that can also exhibit porokeratosis-like features best described as columnar dyskeratosis. Recognizing these types of lesions in DM is warranted in order to make an accurate assessment of their prognostic significance.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"2 1","pages":"1 - 8"},"PeriodicalIF":1.9,"publicationDate":"2015-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000371573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64766615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Modulation of MCP-1, TGF-β1, and α-SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study 局部维生素B复合物对皮肤创面肉芽组织中MCP-1、TGF-β1和α-SMA表达调节的实验研究

IF 1.9

Dermatopathology Pub Date : 2014-11-27 DOI: 10.1159/000369163

C. Martinelli-Kläy, L. O. Lunardi, C. Martinelli, T. Lombardi, E. G. Soares, C. Martinelli

{"title":"Modulation of MCP-1, TGF-β1, and α-SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study","authors":"C. Martinelli-Kläy, L. O. Lunardi, C. Martinelli, T. Lombardi, E. G. Soares, C. Martinelli","doi":"10.1159/000369163","DOIUrl":"https://doi.org/10.1159/000369163","url":null,"abstract":"Vitamin B complex can modulate the inflammatory response and activate wound healing. However, the action mechanisms involved in this process are still unclear. The aim of this study was to evaluate the effects of vitamin B complex on the modulation of monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-β1, and α-smooth muscle actin (α-SMA) in granulation tissue growth. Cutaneous ulcers on Wistar rats were topically treated with vitamin B complex. MCP-1, TGF-β1, and α-SMA expressions were evaluated 24, 72, and 168 h after the treatment. Inflammatory cells were counted and collagen fibril staining was performed. After 24 h, more mononuclear cells (p ≤ 0.01) and a higher MCP-1 (p ≤ 0.05) and TGF-β1 (p ≤ 0.01) expression were observed. After 72 h, the number of fibroblasts and mononuclear cells (p ≤ 0.05) was elevated. After 168 h, an increased number of fibroblasts, myofibroblasts, and blood vessels (p ≤ 0.01) as well as a strong intensity of collagen fibril staining were seen. At that point, the cells presented a higher TGF-β1 expression (p ≤ 0.05), and the size of the ulcer area was decreased (p ≤ 0.01). We can conclude that vitamin B complex may stimulate a positive modulation of MCP-1, TGF-β1, and α-SMA expressions in granulation tissue of cutaneous ulcers. © 2014 S. Karger AG, Basel","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"1 1","pages":"98 - 107"},"PeriodicalIF":1.9,"publicationDate":"2014-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000369163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64751229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cellular Neurothekeoma in a Female with Guillain-Barré Syndrome: A Case Report and Review of the Literature 女性格林-巴勒综合征的细胞性神经瘤1例报告及文献复习

IF 1.9

Dermatopathology Pub Date : 2014-11-20 DOI: 10.1159/000369162

D. Sachdev, R. Barnhill, E. Taylor, S. Worswick

引用次数: 3

Cervicofacial Botryomycosis: Is Atopic Dermatitis a Predisposing Factor? 颈面孢菌病:特应性皮炎是诱发因素吗?

IF 1.9

Dermatopathology Pub Date : 2014-11-08 DOI: 10.1159/000368667

M. Heppt, J. Kamarashev

引用次数: 3

Perineural Invasion in the Absence of Malignancy: Report of Two Cases and Review of the Literature 无恶性肿瘤时的周围神经侵犯:两例报告及文献复习