Dermatopathology最新文献_第10页

Reliability of Histopathology for the Early Recognition of Fibrosis in Traction Alopecia: Correlation with Clinical Severity 牵引性脱发纤维化早期识别的组织病理学可靠性:与临床严重程度的相关性

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000500509

R. M. Ngwanya, H. Adeola, Renée A Beach, N. Gantsho, C. Walker, K. Pillay, R. Prokopetz, F. Gumedze, N. Khumalo

{"title":"Reliability of Histopathology for the Early Recognition of Fibrosis in Traction Alopecia: Correlation with Clinical Severity","authors":"R. M. Ngwanya, H. Adeola, Renée A Beach, N. Gantsho, C. Walker, K. Pillay, R. Prokopetz, F. Gumedze, N. Khumalo","doi":"10.1159/000500509","DOIUrl":"https://doi.org/10.1159/000500509","url":null,"abstract":"Traction alopecia (TA) is hair loss caused by prolonged pulling or repetitive tension on scalp hair; it belongs to the biphasic group of primary alopecia. It is non-scarring, typically with preservation of follicular stem cells and the potential for regrowth of early lesions especially if traction hairstyles are stopped. However, the alopecia may become permanent (scarring) and fail to respond to treatment if the traction is excessive and prolonged. Hence, the ability to detect fibrosis early in these lesions could predict patients who respond to treatment. Histopathological diagnosis based on scalp biopsies has been used as a gold standard to delineate various forms of non-scarring alopecia and to differentiate them from scarring ones. However, due to potential discrepant reporting as a result of the type of biopsy, method of sectioning, and site of biopsy, histopathology often tends to be unreliable for the early recognition of fibrosis in TA. In this study, 45 patients were assessed using the marginal TA severity scoring system, and their biopsies (both longitudinal and transverse sections) were systematically assessed by three dermatopathologists, the aim being to correlate histopathological findings with clinical staging. Intraclass correlation coefficients were used to determine the level of agreement between the assessors. We found poor agreement of the identification and grading of perifollicular and interfollicular fibrosis (0.55 [0.23–0.75] and 0.01 [2.20–0.41], respectively), and no correlation could be drawn with the clinical severity score. Better methods of diagnosis are needed for grading and for recognition of early fibrosis in TA.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"6 1","pages":"170 - 181"},"PeriodicalIF":1.9,"publicationDate":"2019-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000500509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43620318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

South African Tick Bite Fever: An Overview 南非蜱叮咬热:概述

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000495475

J. Frean, W. Grayson

引用次数: 9

Emergomyces africanus: The Mimicking Fungus 非洲新兴菌:模仿真菌

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000497608

Ameshin Moodley, A. Mosam, N. Govender, Y. Mahabeer, A. Chateau

引用次数: 9

Report of 2 Novel Presentations of Subcutaneous Fat Necrosis of the Newborn 新生儿皮下脂肪坏死2例新病例报告

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000497176

Susanna M H Kannenberg, H. Jordaan, W. Visser, Fatima H. Ahmed, A. Bezuidenhout

引用次数: 10

Induction of Hyalurosome by Topical Hyaluronate Fragments Results in Superficial Filling of the Skin Complementary to Hyaluronate Filler Injections 局部透明质酸片段诱导透明质体导致皮肤表面填充与透明质酸填充物注射互补

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000500493

G. Kaya, A. Kaya, J. Saurat

引用次数: 5

Primary Cutaneous Anaplastic Large-Cell Lymphoma 原发性皮肤变性大细胞淋巴瘤

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000500259

N. Moodley, Patiswa Nombona, A. Mosam

引用次数: 8

Keratolytic Winter Erythema: An Update 角膜溶解性冬季红斑:最新进展

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000496338

M. Ramsay, Thandiswa Ngcungcu, W. Grayson

{"title":"Keratolytic Winter Erythema: An Update","authors":"M. Ramsay, Thandiswa Ngcungcu, W. Grayson","doi":"10.1159/000496338","DOIUrl":"https://doi.org/10.1159/000496338","url":null,"abstract":"Keratolytic winter erythema (KWE) is a rare autosomal dominant keratoderma affecting primarily the palms and soles, manifesting with recurrent waves of erythema followed by epidermal peeling. The condition is so named in view of its anecdotal worsening during the winter months. It is highly penetrant but shows considerable individual clinical variability, waning and reappearing throughout the life course. Histologically, early established lesions of KWE manifest with degenerative changes involving the Malpighian layer, with associated absence of the stratum granulosum. The damaged zone undergoes parakeratotic transformation and subsequent centrifugal ejection. Thick peeling occurs when the stratum corneum eventually separates off as a result of a keratolytic split occurring above, through or below the parakeratotic zone. Reconstitution of the stratum granulosum ensues. KWE is caused by a duplication of an intergenic enhancer element upstream of the cathepsin B gene on chromosome 8. This leads to the upregulation of cathepsin B in the stratum granulosum and subsequent peeling of the epidermis as the end result. With elucidation of the molecular pathology of KWE, new therapeutic approaches to KWE may be considered.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"6 1","pages":"126 - 132"},"PeriodicalIF":1.9,"publicationDate":"2019-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000496338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48374146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Carcinoid Syndrome-Induced Scleroderma-Like Disease 类癌综合征诱发硬皮病样疾病

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000496388

K. Koch, W. Grayson

引用次数: 3

Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component 恶性软骨腔瘤：两例肉瘤性间充质成分的报告

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000495610

C. Nel, Dawn van der Byl, W. Grayson

引用次数: 7

β-Catenin Expression and Activation in Conjunctival Melanoma β-儿茶素在结膜黑色素瘤中的表达和激活

IF 1.9

Dermatopathology Pub Date : 2019-06-26 DOI: 10.1159/000500682

E. Larivé, M. Nicolas, G. Kaya, Nicolò Riggi, A. Moulin

{"title":"β-Catenin Expression and Activation in Conjunctival Melanoma","authors":"E. Larivé, M. Nicolas, G. Kaya, Nicolò Riggi, A. Moulin","doi":"10.1159/000500682","DOIUrl":"https://doi.org/10.1159/000500682","url":null,"abstract":"Purpose: To assess the role of the canonical Wnt pathway via activation of β-catenin in tumor progression of conjunctival melanoma. Methods: β-Catenin localization was assessed by immunohistochemistry in 43 conjunctival nevi, 48 primary acquired melanoses (PAM; conjunctival melanocytic intraepithelial neoplasia), and 44 conjunctival melanomas. Activation of the canonical or the noncanonical Wnt pathway was tested in vitro in 4 conjunctival melanoma cell lines with stimulation of either Wnt5a or Wnt3a. Wound healing assays were performed with Wnt5a. Results: Nuclear β-catenin expression was found in 16% of the nevi, in 15% of the melanomas, and in 4% of the PAM. Membranous β-catenin expression was identified in all the nevi and PAM and in 97.7% of the melanomas. In vitro, Wnt5a stimulation in the 4 conjunctival melanomas and in 1 skin melanoma cell line did not induce nuclear translocation of β-catenin, nor did it increase cell motility in the wound healing assays. Wnt3a stimulation did not induce nuclear localization of β-catenin in any of the cell lines tested. Conclusions: In conjunctival melanoma, nuclear localization and activation of β-catenin appear to be limited, suggesting that inhibition of ARF6, responsible for β-catenin activation, in subsets of skin melanoma may not represent a treatment option for this tumor. In vitro, Wnt3a or Wnt5a did not induce nuclear β-catenin localization.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"6 1","pages":"50 - 62"},"PeriodicalIF":1.9,"publicationDate":"2019-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000500682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47177966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3