Dermatopathology最新文献_第9页

Hypertrophic Lichen Planus and Hypertrophic Skin Lesions Associated with Histological Lichenoid Infiltrate: A Case Report and Literature Review. 增生性扁平苔藓和增生性皮肤病变与组织学类地衣浸润：1例报告并文献复习。

IF 1.6

Dermatopathology Pub Date : 2025-02-25 DOI: 10.3390/dermatopathology12010008

Biagio Scotti, Cosimo Misciali, Federico Bardazzi, Bianca Maria Piraccini, Michelangelo La Placa

{"title":"Hypertrophic Lichen Planus and Hypertrophic Skin Lesions Associated with Histological Lichenoid Infiltrate: A Case Report and Literature Review.","authors":"Biagio Scotti, Cosimo Misciali, Federico Bardazzi, Bianca Maria Piraccini, Michelangelo La Placa","doi":"10.3390/dermatopathology12010008","DOIUrl":"10.3390/dermatopathology12010008","url":null,"abstract":"Hypertrophic lichen planus (HLP) is a chronic inflammatory skin condition defined by verrucous, pruritic, papules and plaques usually affecting the lower limbs. The diagnosis of HLP is primarily clinical. However, due to its feasible generalized presentation and similarities with other hypertrophic cutaneous disorders, histological evaluation is often necessary. Many dermatological conditions that present with a hypertrophic clinical appearance can arise from a histological lichenoid infiltrate (HCLI). Hence, we provide an overview of the clinical, histopathological, and prognostic features of selected HCLI, including HLP, hypertrophic lichenoid dermatitis, hypertrophic lichen sclerosus (HLS), lichen simplex chronicus (LSC), squamous cell carcinoma (SCC), keratoacanthoma (KA), pseudoepitheliomatous hyperplasia (PEH), viral warts, and lupus erythematosus/lichen planus (LE/LP) overlap. Choosing the appropriate procedure and the anatomical site for an incisional biopsy requires thoughtful consideration to ensure sufficient depth and improve diagnostic accuracy by identifying the histological features specific to each hypertrophic condition.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Kikuchi-Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood. 儿童菊池-藤本病：儿童皮肤和组织病理学特征的病例报告和回顾。

IF 1.6

Dermatopathology Pub Date : 2025-02-13 DOI: 10.3390/dermatopathology12010007

Alberto Soto-Moreno, Francisco Vílchez-Márquez, María Narváez-Simón, Julia Castro-Martín, Francisco Manuel Ramos-Pleguezuelos, Agustín Soto-Díaz, Jesús Tercedor-Sánchez, Salvador Arias-Santiago

{"title":"Pediatric Kikuchi-Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood.","authors":"Alberto Soto-Moreno, Francisco Vílchez-Márquez, María Narváez-Simón, Julia Castro-Martín, Francisco Manuel Ramos-Pleguezuelos, Agustín Soto-Díaz, Jesús Tercedor-Sánchez, Salvador Arias-Santiago","doi":"10.3390/dermatopathology12010007","DOIUrl":"10.3390/dermatopathology12010007","url":null,"abstract":"Kikuchi-Fujimoto disease (KFD) is a rare condition characterized by necrotizing lymphadenitis and fever, often associated with immune dysregulation. Histologically, it features necrotic foci with abundant histiocytes and plasmacytoid dendritic cells but notably lacks neutrophils and eosinophils. Recent evidence reveals a notable prevalence among pediatric patients, who may exhibit distinct features compared to adults. We reported the case of an 11-year-old girl presenting with persistent fever, cervical adenopathy, and a malar rash, leading to a diagnosis of KFD following lymph node biopsy, which revealed non-suppurative necrosis and histiocytic infiltration. Empirical treatment with antivirals and antibiotics was ineffective, but corticosteroid therapy achieved symptom remission. A literature review identified 48 relevant studies involving 386 pediatric cases, with histopathological findings consistent with classical descriptions of KFD. Cutaneous involvement was reported in 11.14% of cases, ranging from maculopapular rashes to lupus-like eruptions. Notable complications included the development of systemic lupus erythematous, Sjögren syndrome, and rare instances of hemophagocytic syndrome or central nervous system involvement. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of pediatric patients presenting with fever and lymphadenopathy, taking into account a higher frequency of cutaneous manifestations in pediatric cases. A skin biopsy may be helpful in diagnosing KFD and provide valuable information regarding the potential risk of developing systemic lupus erythematosus in the future.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11860556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histologic and Immunohistochemical Patterns in Lymphomatoid Papulosis: A Systematic Review of Published Cases. 淋巴瘤样丘疹病的组织学和免疫组织化学模式：对已发表病例的系统回顾。

IF 1.6

Dermatopathology Pub Date : 2025-02-12 DOI: 10.3390/dermatopathology12010006

Torben Fricke, Werner Kempf, Michael P Schön, Christina Mitteldorf

{"title":"Histologic and Immunohistochemical Patterns in Lymphomatoid Papulosis: A Systematic Review of Published Cases.","authors":"Torben Fricke, Werner Kempf, Michael P Schön, Christina Mitteldorf","doi":"10.3390/dermatopathology12010006","DOIUrl":"10.3390/dermatopathology12010006","url":null,"abstract":"Based on histologic and genetic patterns, the current World Health Organization (WHO) classification distinguishes six subtypes of lymphomatoid papulosis (Lyp). The aim of our article was to analyze the frequency of histologic and immunohistochemical features of different Lyp subtypes reported in the literature. We used PubMed advanced search builder to systematically review and evaluate English and German literature of Lyp from 1968 to April 2022. We considered only papers in which histopathologic features were mentioned in detail. We identified 48 publications with a total of 518 cases. The diagnoses were based on the diagnostic criteria at the time of publication. In Lyp A and Lyp B a CD8+ phenotype was more often reported than expected (53% and 52%, respectively). A double positive phenotype (CD4+/CD8+) was found in 28% of Lyp E and a double negative (CD4-/CD8-) in 50% of Lyp with 6p25.3 rearrangement. High rates of folliculo- and syringotropism were reported in both Lyp A and B. Surprisingly, strong epidermotropism occurred in 20/38 (53%) cases reported as Lyp B and in 43/64 (67%) of Lyp D cases. The predominating phenotype in Lyp D was CD8+, while TIA-1/granzymeB/perforin expression was reported in 37/46 (80%), and CD56 was expressed in 13/47 (28%) of the investigated cases. The limitation of the data is due to the retrospective approach with diagnostic criteria changing over time and on a case selection in some publications. However, the data indicate that the Lyp subtypes overlap more than assumed. They also show that a prospective study is needed to obtain valid data on the frequency distribution of certain histopathologic criteria.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming. 丙酮-醚-水小鼠持续瘙痒模型完全解决，无潜伏性瘙痒或跨模态启动。

IF 1.6

Dermatopathology Pub Date : 2025-02-11 DOI: 10.3390/dermatopathology12010005

Zachary K Ford, Adam J Kirry, Steve Davidson

{"title":"Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming.","authors":"Zachary K Ford, Adam J Kirry, Steve Davidson","doi":"10.3390/dermatopathology12010005","DOIUrl":"10.3390/dermatopathology12010005","url":null,"abstract":"Hyperalgesic priming is a model of the transition from acute to chronic pain. Whether a similar mechanism exists for \"pruritic priming\" of itch is unknown. Here, we tested the hypothesis that itchy skin in a commonly used mouse model of dry skin pruritus develops latent sensitization after resolution. Acetone-ether-water (AEW) treatment induced a dry and itchy skin condition in the mouse cheek that elicited site-directed scratching behavior. After cessation of treatment and the complete resolution of AEW-induced scratching, histaminergic and non-histaminergic pruritogens were administered to the cheek to test for altered site-directed scratching and wiping behavior. Each pruritogen was also tested following the resolution of carrageenan-induced nociceptor hypersensitivity to test for cross-modality priming. Peak AEW-induced scratching occurred 24 h after the final day of treatment, and 5 days were required for scratching levels to return to baseline. Likewise, epidermal thickening was the greatest on the final treatment day and completely returned to baseline after 5 days. After the resolution of itchy cheek skin, acute histamine- and non-histamine-evoked scratching and wiping behaviors were unchanged, nor were scratching and wiping behaviors to acute pruritogens altered after the resolution of carrageenan-induced hypersensitivity. The results indicate that persistent itch due to dry skin likely resolves completely, without producing a latent primed response to subsequent pruritic stimuli. We conclude that the mechanisms regulating hyperalgesic priming are likely distinct from pruritic signaling in the dry and itchy skin model.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asteroid Shower: Cutaneous Silica Granuloma with Asteroid Bodies. 小行星雨：小行星体的皮肤二氧化硅肉芽肿。

IF 1.6

Dermatopathology Pub Date : 2025-01-31 DOI: 10.3390/dermatopathology12010004

Fadwa Ahmed, Christopher DiMarco

引用次数: 0

Dysplastic Nevi and Superficial Borderline Atypical Melanocytic Lesions: Description of an Algorithmic Clinico-Pathological Classification. 发育不良痣和浅交界性非典型黑素细胞病变：一种算法临床病理分类的描述。

IF 1.6

Dermatopathology Pub Date : 2025-01-21 DOI: 10.3390/dermatopathology12010003

Sébastien Menzinger, Rastine Merat, Gürkan Kaya

引用次数: 0

Violaceous Nodules on the Left Forearm of an Immunosuppressed Patient Following Heart Transplantation for Cardiac Amyloidosis. 心脏淀粉样变性心脏移植后免疫抑制患者左前臂紫色结节。

IF 1.6

Dermatopathology Pub Date : 2025-01-16 DOI: 10.3390/dermatopathology12010002

Zachary Corey, Lydia A Luu, Sabrina Newman, Shyam S Raghavan

{"title":"Violaceous Nodules on the Left Forearm of an Immunosuppressed Patient Following Heart Transplantation for Cardiac Amyloidosis.","authors":"Zachary Corey, Lydia A Luu, Sabrina Newman, Shyam S Raghavan","doi":"10.3390/dermatopathology12010002","DOIUrl":"10.3390/dermatopathology12010002","url":null,"abstract":"We present the case of a 60-year-old immunocompromised man who presented with two pruritic pink-red indurated nodules with overlying scale and focal areas of ulceration on his left dorsal and left medial forearm, which evolved over a 2-month period. The pathology showed numerous fungal hyphae present that were pauci-septate with various branched angles and variable hyphal thickness. Fungal cultures grew Rhizopus species and a universal fungal PCR detected the Rhizopus oryzae complex. Based on the clinicopathologic correlation, the diagnosis of cutaneous mucormycosis was made. Cutaneous mucormycosis is an aggressive fungal infection of the Mucorales family occurring after the inoculation of fungal spores in disrupted skin. It usually presents as a necrotic eschar but can also present as cellulitis that evolves into a necrotic ulcer. A prompt diagnosis is critical for the effective management of cutaneous mucormycosis. The treatment includes an immediate systemic treatment with amphotericin B and a surgical debridement of the necrotic regions. Given the wide range of presenting symptoms, clinical suspicion for this emergent condition must remain high in immunocompromised and diabetic patients.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review. 鳞状黑色素细胞肿瘤，一个仍然笼罩在神秘的实体：病例报告和文献复习。

IF 1.6

Dermatopathology Pub Date : 2025-01-13 DOI: 10.3390/dermatopathology12010001

Joana Sorino, Mario Della Mura, Anna Colagrande, Cecilia Salzillo, Giuseppe Ingravallo, Gerardo Cazzato

{"title":"Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review.","authors":"Joana Sorino, Mario Della Mura, Anna Colagrande, Cecilia Salzillo, Giuseppe Ingravallo, Gerardo Cazzato","doi":"10.3390/dermatopathology12010001","DOIUrl":"10.3390/dermatopathology12010001","url":null,"abstract":"Cutaneous squamomelanocytic tumor (SMT) is a very rare cutaneous malignancy, composed of a dual phenotypic population of both malignant melanocytes and keratinocytes, intimately intermingled together. Herein, we report a new case of a SMT occurring in an 82-year-old man, located on the scalp. Histopathology revealed a mixed population consisting of squamous cell carcinoma and melanoma within the same lesion, also confirmed using immunohistochemical staining for high molecular-weight cytokeratins (HMWCKs) and Melan-A. Moreover, to the best of our knowledge, for the first time, we tested SMT for the preferentially expressed antigen in melanoma (PRAME), which revealed a strong and diffuse positivity in the melanocytic component. These tumors need to be distinguished by more frequent collision tumors and colonization. Furthermore, we provide a comprehensive review of the literature, focusing on clinical and histopathological aspects, biological behavior and still-debated, but fascinating histogenesis of this elusive entity.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Pitfalls of IgG4 Immunohistochemical Staining on Lesional Tissue in Cutaneous Acantholytic Disorders. IgG4免疫组化染色在皮肤棘突溶解性疾病病变组织中的潜在缺陷。

IF 1.6

Dermatopathology Pub Date : 2024-12-19 DOI: 10.3390/dermatopathology11040041

Carla Stephan, Linglei Ma

{"title":"Potential Pitfalls of IgG4 Immunohistochemical Staining on Lesional Tissue in Cutaneous Acantholytic Disorders.","authors":"Carla Stephan, Linglei Ma","doi":"10.3390/dermatopathology11040041","DOIUrl":"10.3390/dermatopathology11040041","url":null,"abstract":"The diagnostic utility of immunohistochemistry on paraffin-embedded sections in bullous disorders is useful when frozen tissue is not available. In pemphigus vulgaris and pemphigus foliaceus, an intercellular lace-like staining pattern of IgG4 on lesional tissue by immunohistochemistry has been described, with a comparable sensitivity and specificity to direct immunofluorescence on perilesional tissue. This study aimed to evaluate the staining pattern of IgG4 in non-immunobullous disorders to highlight the potential pitfalls when using this stain. In this study, we conducted a retrospective review of our institution's database of non-immunobullous disorders where immunohistochemistry of IgG4 was performed to rule out pemphigus. We identified 27 cases where IgG4 immunohistochemistry was performed and observed intercellular IgG4 staining in some cases of Grover disease, bullous impetigo, irritated dermal hypersensitivity reaction, acantholytic actinic keratosis, and graft versus host disease. Our results indicate that the interpretation of IgG4 staining by immunohistochemistry in cutaneous acantholytic disorders should be approached with caution. Confirmation on cryosections with direct immunofluorescence study results is important in these settings.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 4","pages":"377-382"},"PeriodicalIF":1.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Insights in Paediatric Dermatopathology-2nd Edition. 儿科皮肤病理学新见解-第二版。

IF 1.6

Dermatopathology Pub Date : 2024-12-17 DOI: 10.3390/dermatopathology11040040

Sylvie Fraitag

引用次数: 0