Dermatopathology最新文献_第9页

Conceptual Evolution and Current Approach to Spitz Tumors Spitz肿瘤的概念演变和目前的研究方法

IF 1.9

Dermatopathology Pub Date : 2022-04-26 DOI: 10.3390/dermatopathology9020017

C. Urso, V. de Giorgi, D. Massi

引用次数: 1

“Lichenoid Granulomatous Pattern” in a Case of Lupus Vulgaris 一例寻常型狼疮的“地衣样肉芽肿型”

IF 1.9

Dermatopathology Pub Date : 2022-04-20 DOI: 10.3390/dermatopathology9020016

C. Desai, Ismail Shaikh

引用次数: 0

Aggressive Cutaneous Squamous Cell Carcinomas Following Treatment for Graft-versus-Host Disease: A Case Report and Review of Risk Factors 移植物抗宿主病治疗后侵袭性皮肤鳞状细胞癌一例报告及危险因素回顾

IF 1.9

Dermatopathology Pub Date : 2022-03-31 DOI: 10.3390/dermatopathology9020015

Gehan A Pendlebury, M. Bongiorno, Jeffrey N. Lackey

{"title":"Aggressive Cutaneous Squamous Cell Carcinomas Following Treatment for Graft-versus-Host Disease: A Case Report and Review of Risk Factors","authors":"Gehan A Pendlebury, M. Bongiorno, Jeffrey N. Lackey","doi":"10.3390/dermatopathology9020015","DOIUrl":"https://doi.org/10.3390/dermatopathology9020015","url":null,"abstract":"A 19-year-old female with a history of pre-B cell acute lymphocytic leukemia (ALL) presented with two aggressive cutaneous squamous cell carcinomas (C-SCC) in the right hand. The patient was diagnosed with pre-B cell ALL at four years of age. She underwent chemotherapy with initial remission. However, recurrence of the pre-B cell ALL required an unrelated allogeneic cord hematopoietic stem cell transplant (alloHSCT). Post-transplant, the patient developed Graft-Versus-Host Disease (GVHD), which was treated with immunosuppressant therapy for six years until resolution. Fourteen years following the transplant, the patient developed a morbilliform drug eruption secondary to clindamycin. She consequently received prednisone treatment. During the treatment period, the patient developed a new ulcerated and tender nodule on the dorsal aspect of her right hand. Further histopathological biopsy confirmed the diagnosis of C-SCC, which required excision. Ten months following the excision, the patient developed an additional C-SCC nodule on the same right hand, separated by 2.6 cm from the prior C-SCC. She was referred for a ray resection procedure. This case illustrates a patient with multiple risk factors that may have contributed to the continued development of C-SCC. Such risk factors include: a prolonged course of immunosuppressant medications and voriconazole treatment. Additional research is needed to investigate the etiologies and risks of C-SCC development in patients who require a transplant and long-duration immunosuppressive therapy.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"0 - 0"},"PeriodicalIF":1.9,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49354860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Histopathologic Features of Maculopapular Drug Eruption 黄斑丘疹药疹的组织病理学特征

IF 1.9

Dermatopathology Pub Date : 2022-03-30 DOI: 10.3390/dermatopathology9020014

Madison Ernst, A. Giubellino

{"title":"Histopathologic Features of Maculopapular Drug Eruption","authors":"Madison Ernst, A. Giubellino","doi":"10.3390/dermatopathology9020014","DOIUrl":"https://doi.org/10.3390/dermatopathology9020014","url":null,"abstract":"Background: Cutaneous adverse drug reaction (CADR) is common in both inpatient and outpatient clinical settings and has been associated with a large variety of medications. Drug reactions represent a significant burden to the healthcare system due to increased hospital stay durations and associated costs. Moreover, some of these reactions may be life-threatening. The most common clinical manifestation of a CADR is a maculopapular drug eruption (MDE). Due to its many clinical mimics and associations with a variety of histopathologic patterns, maculopapular drug eruption is difficult to definitively diagnose from both a clinical and histopathological perspective. Summary: We reviewed the clinical and histopathologic features of 327 cases of MDE from several studies in the literature and summarized characteristic histopathologic findings and their frequencies of occurrence. We found that the most common and suggestive histopathologic features of MDE were epidermal spongiosis, lymphocytic infiltrate, and occasional necrotic keratinocytes; interface change at the DEJ; superficial perivascular and interstitial lymphocytic infiltrate with or without eosinophils and neutrophils in the mid-to-deep dermis and mild papillary dermal edema; and dilation of superficial vessels. The presence of multiple histopathologic patterns within the same tissue specimen is also suggestive of MDE. This review and analysis suggest that a biopsy may improve the diagnostic accuracy by both establishing common and uncommon features associated with MDE and reviewing features that help to exclude other causes of maculopapular eruption. Key Message: Histopathologic criteria for the diagnosis of MDE, while not entirely specific, may aid in establishing a differential that includes a drug eruption. Thus, a biopsy can be a helpful diagnostic tool when MDE is suspected by demonstrating findings suggestive of MDE or by ruling out clinical mimics. However, biopsy results cannot be used in isolation as clinical-pathologic correlation is paramount in MDE.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"111 - 121"},"PeriodicalIF":1.9,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43281679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature 气球细胞黑色素瘤4例报告并文献综述

IF 1.9

Dermatopathology Pub Date : 2022-03-28 DOI: 10.3390/dermatopathology9020013

Gerardo Cazzato, E. Cascardi, A. Colagrande, A. Cimmino, G. Ingravallo, L. Lospalluti, P. Romita, A. Demarco, F. Arezzo, V. Loizzi, M. Dellino, Irma Trilli, E. Bellitti, P. Parente, T. Lettini, C. Foti, G. Cormio, E. Maiorano, L. Resta

引用次数: 3

A Case of Adult-Onset Eccrine Angiomatous Hamartoma—The Comparison with Epithelioid Hemangioma 成人发病的胰腺血管瘤错构瘤1例与上皮样血管瘤的比较

IF 1.9

Dermatopathology Pub Date : 2022-03-25 DOI: 10.3390/dermatopathology9020012

Mai Nishimura, Y. Matsushima, Y. Nakai, K. Habe, A. Hayashi, K. Yamanaka

{"title":"A Case of Adult-Onset Eccrine Angiomatous Hamartoma—The Comparison with Epithelioid Hemangioma","authors":"Mai Nishimura, Y. Matsushima, Y. Nakai, K. Habe, A. Hayashi, K. Yamanaka","doi":"10.3390/dermatopathology9020012","DOIUrl":"https://doi.org/10.3390/dermatopathology9020012","url":null,"abstract":"Eccrine angiomatous hamartoma (EAH) is a relatively rare benign skin disease characterized by the proliferation of eccrine sweat glands associated with capillary hemangioma and the proliferation of other skin elements such as adipose tissue, hair, and epidermis. The onset of the disease is usually at birth or in childhood and tends to occur in the extremities of females, but it occurred in an adult male in this case. The patient was a 72-year-old man with a 12 × 12 mm light brown, elastic, slightly firm skin nodule on the flexor aspect of his right forearm. A biopsy revealed enlargement of blood vessels, sweat glands, sweat ducts, and erector spongiosum with both lumen dilation and narrowing, leading to the diagnosis of EAH. The histopathological features of EAH include a marked proliferation of microvessels, epithelial-like changes in vascular endothelial cells (such as enlarged nuclei), and infiltration of inflammatory cells, mainly lymphocytes and plasma cells. In adult-onset cases, EAH can be clinically difficult to distinguish from epithelioid hemangioma (EH), which differs in the predominance of microvascular proliferation and the presence of eosinophils in the infiltrating inflammatory cells. It can also be distinguished from EAH by the negative results of S100 and anti-EMA in immunohistological staining. In the current cases, we were able to differentiate the two cases from characteristic findings on HE staining.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"94 - 99"},"PeriodicalIF":1.9,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42811942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of Immunohistochemically Stained Cells in Skin Biopsies 皮肤活检中免疫组织化学染色细胞的定量

IF 1.9

Dermatopathology Pub Date : 2022-03-24 DOI: 10.3390/dermatopathology9020011

T. Emmanuel, M. Brent, L. Iversen, C. Johansen

{"title":"Quantification of Immunohistochemically Stained Cells in Skin Biopsies","authors":"T. Emmanuel, M. Brent, L. Iversen, C. Johansen","doi":"10.3390/dermatopathology9020011","DOIUrl":"https://doi.org/10.3390/dermatopathology9020011","url":null,"abstract":"Immunohistochemical quantification of inflammatory cells in skin biopsies is a valuable tool for diagnosing skin diseases and assessing treatment response. The quantification of individual cells in biopsies is time-consuming, tedious, and difficult. In this study, we presented and compared two methods for the quantification of CD8+ T cells in skin biopsies from patients with psoriasis using both commercial software (Adobe Photoshop) and open-source software (Qupath). In addition, we provided a detailed, step-by-step description of both methods. The methods are scalable by replacing the CD8 antibody with other antibodies to target different cells. Moreover, we investigated the correlation between quantifying CD8+ cells normalized to area or epidermal length and cell classifications, compared cell classifications in QuPath with threshold classifications in Photoshop, and analyzed the impact of data normalization to epidermal length or area on inflammatory cell densities in skin biopsies from patients with psoriasis. We found a satisfactory correlation between normalizing data to epidermal length and area for psoriasis skin. However, when non-lesional and lesional skin samples were compared, a significant underestimation of inflammatory cell density was found when data were normalized to area instead of epidermal length. Finally, Bland–Altman plots comparing Qupath and Photoshop to quantify inflammatory cell density demonstrated a good agreement between the two methods.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"82 - 93"},"PeriodicalIF":1.9,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41798437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polarization of Macrophages in Granulomatous Cutaneous T Cell Lymphoma Granulomatous Mycosis Fungoides Microenvironment. 肉芽肿性皮肤T细胞淋巴瘤中巨噬细胞的极化。

IF 1.9

Dermatopathology Pub Date : 2022-02-25 DOI: 10.3390/dermatopathology9010009

Lopez Dominguez Johanny, Olayemi Sokumbi, Misty M Hobbs, Liuyan Jiang

{"title":"Polarization of Macrophages in Granulomatous Cutaneous T Cell Lymphoma Granulomatous Mycosis Fungoides Microenvironment.","authors":"Lopez Dominguez Johanny, Olayemi Sokumbi, Misty M Hobbs, Liuyan Jiang","doi":"10.3390/dermatopathology9010009","DOIUrl":"https://doi.org/10.3390/dermatopathology9010009","url":null,"abstract":"Polarization of tumor associated macrophages (TAMs) has been shown to have prognostic significance in different cancer types. This study evaluates the macrophage subtypes that predominates in GMF. Cases of GCTCL from 2007-2020 were identified (n = 6), clinical data was extracted from the electronic medical record, and all pathology slides were reviewed to confirm the diagnosis. Immunohistochemistry (IHC) studies were performed to characterize M1 and M2 macrophage polarization. CD68 (PGM1), pSTAT1, and CD163 were used as pan macrophage, M1, and M2 markers, respectively. The macrophages with positive staining at hot spot per high power field were counted and recorded for data analysis. The average age of patients was 60.5 years [range, 21-78], five patients (83%) were women and 1 (17%) was a man. Five patients were Caucasian (83%), and 1 was Black/African American (17%). Two patients had late stage GMF with M2 (CD163) predominance and the other three had early stage GMF with M1 (pSTAT1) predominance. Our study suggests that macrophage polarization present in GMF tends to be M1 in early stages and M2 in advanced stages. Additional studies are needed to further elucidate the microenvironment of macrophages present in GMF. Such findings may lead to prognostic and therapeutic advances in GMF.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":" ","pages":"54-59"},"PeriodicalIF":1.9,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40316126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study 皮肤混合肿瘤谱中TFE3免疫表达缺失:一项回顾性初步研究

IF 1.9

Dermatopathology Pub Date : 2022-01-29 DOI: 10.3390/dermatopathology9010008

Hatice Zengin, Bahadır Yıldız, T. Pukhalskaya, B. Smoller

{"title":"Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study","authors":"Hatice Zengin, Bahadır Yıldız, T. Pukhalskaya, B. Smoller","doi":"10.3390/dermatopathology9010008","DOIUrl":"https://doi.org/10.3390/dermatopathology9010008","url":null,"abstract":"Background: Cutaneous mixed tumors (CMTs) include benign, atypical, and malignant chondroid syringomas. This spectrum of entities is known to be a part of myoepithelial neoplasms, which display considerable genetic heterogeneity. In a previous report, a malignant chondroid syringoma (MCS) demonstrated PHF1-TFE3 gene fusion and strong TFE3 immunohistochemical (IHC) staining. The authors suggested that the MCS is genetically related to tumors with TFE3 rearrangements such as renal cell carcinoma and might have genetic heterogeneity. In this study, we aim to investigate potential TFE3 gene fusions with TFE3 IHC stain in a spectrum of CMTs. Materials: Eleven benign chondroid syringoma (BCS), one atypical chondroid syringoma (ACS), and one malignant chondroid syringoma cases were identified, stained with TFE3 IHC stain, and interpreted based on preset criteria. Results: ACS and MCS cases did not show any staining. In 7 of 11 BCS cases, weak (1+) staining was observed in less than 20% of the tumor cells and were considered negative. Additionally, in one BCS case, weak (1+) and (2+) staining was shown in approximately 15% and less than 1% of the tumor cells, respectively. Based on our positivity criteria, this case was also interpreted as negative. Conclusions: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"48 - 53"},"PeriodicalIF":1.9,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47883458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dermal Duct Tumor: A Diagnostic Dilemma 真皮导管肿瘤:诊断困境

IF 1.9

Dermatopathology Pub Date : 2022-01-28 DOI: 10.3390/dermatopathology9010007

Austin Miller, Susuana Adjei, L. Temiz, Pavandeep Gill, Alfredo Siller, S. Tyring

引用次数: 3