Dermatopathology最新文献_第8页

Polarization of Macrophages in Granulomatous Cutaneous T Cell Lymphoma Granulomatous Mycosis Fungoides Microenvironment. 肉芽肿性皮肤T细胞淋巴瘤中巨噬细胞的极化。

IF 1.9

Dermatopathology Pub Date : 2022-02-25 DOI: 10.3390/dermatopathology9010009

Lopez Dominguez Johanny, Olayemi Sokumbi, Misty M Hobbs, Liuyan Jiang

{"title":"Polarization of Macrophages in Granulomatous Cutaneous T Cell Lymphoma Granulomatous Mycosis Fungoides Microenvironment.","authors":"Lopez Dominguez Johanny, Olayemi Sokumbi, Misty M Hobbs, Liuyan Jiang","doi":"10.3390/dermatopathology9010009","DOIUrl":"https://doi.org/10.3390/dermatopathology9010009","url":null,"abstract":"Polarization of tumor associated macrophages (TAMs) has been shown to have prognostic significance in different cancer types. This study evaluates the macrophage subtypes that predominates in GMF. Cases of GCTCL from 2007-2020 were identified (n = 6), clinical data was extracted from the electronic medical record, and all pathology slides were reviewed to confirm the diagnosis. Immunohistochemistry (IHC) studies were performed to characterize M1 and M2 macrophage polarization. CD68 (PGM1), pSTAT1, and CD163 were used as pan macrophage, M1, and M2 markers, respectively. The macrophages with positive staining at hot spot per high power field were counted and recorded for data analysis. The average age of patients was 60.5 years [range, 21-78], five patients (83%) were women and 1 (17%) was a man. Five patients were Caucasian (83%), and 1 was Black/African American (17%). Two patients had late stage GMF with M2 (CD163) predominance and the other three had early stage GMF with M1 (pSTAT1) predominance. Our study suggests that macrophage polarization present in GMF tends to be M1 in early stages and M2 in advanced stages. Additional studies are needed to further elucidate the microenvironment of macrophages present in GMF. Such findings may lead to prognostic and therapeutic advances in GMF.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":" ","pages":"54-59"},"PeriodicalIF":1.9,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40316126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study 皮肤混合肿瘤谱中TFE3免疫表达缺失:一项回顾性初步研究

IF 1.9

Dermatopathology Pub Date : 2022-01-29 DOI: 10.3390/dermatopathology9010008

Hatice Zengin, Bahadır Yıldız, T. Pukhalskaya, B. Smoller

{"title":"Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study","authors":"Hatice Zengin, Bahadır Yıldız, T. Pukhalskaya, B. Smoller","doi":"10.3390/dermatopathology9010008","DOIUrl":"https://doi.org/10.3390/dermatopathology9010008","url":null,"abstract":"Background: Cutaneous mixed tumors (CMTs) include benign, atypical, and malignant chondroid syringomas. This spectrum of entities is known to be a part of myoepithelial neoplasms, which display considerable genetic heterogeneity. In a previous report, a malignant chondroid syringoma (MCS) demonstrated PHF1-TFE3 gene fusion and strong TFE3 immunohistochemical (IHC) staining. The authors suggested that the MCS is genetically related to tumors with TFE3 rearrangements such as renal cell carcinoma and might have genetic heterogeneity. In this study, we aim to investigate potential TFE3 gene fusions with TFE3 IHC stain in a spectrum of CMTs. Materials: Eleven benign chondroid syringoma (BCS), one atypical chondroid syringoma (ACS), and one malignant chondroid syringoma cases were identified, stained with TFE3 IHC stain, and interpreted based on preset criteria. Results: ACS and MCS cases did not show any staining. In 7 of 11 BCS cases, weak (1+) staining was observed in less than 20% of the tumor cells and were considered negative. Additionally, in one BCS case, weak (1+) and (2+) staining was shown in approximately 15% and less than 1% of the tumor cells, respectively. Based on our positivity criteria, this case was also interpreted as negative. Conclusions: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"48 - 53"},"PeriodicalIF":1.9,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47883458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dermal Duct Tumor: A Diagnostic Dilemma 真皮导管肿瘤:诊断困境

IF 1.9

Dermatopathology Pub Date : 2022-01-28 DOI: 10.3390/dermatopathology9010007

Austin Miller, Susuana Adjei, L. Temiz, Pavandeep Gill, Alfredo Siller, S. Tyring

引用次数: 3

Acknowledgment to Reviewers of Dermatopathology in 2021 向2021年《皮肤病理学》审稿人致谢

IF 1.9

Dermatopathology Pub Date : 2022-01-26 DOI: 10.3390/dermatopathology9010006

引用次数: 0

Fibroblastic Connective Tissue Nevus Mimicking Lipoma on Ultrasound: Case Report and Brief Review. 纤维母细胞结缔组织痣的超声模拟脂肪瘤:1例报告及简要回顾。

IF 1.9

Dermatopathology Pub Date : 2022-01-17 DOI: 10.3390/dermatopathology9010005

Paola Lara-Valencia, Anna Ybo, Anna Coter

引用次数: 0

Annular Lichenoid Dermatitis (of Youth). 环状苔藓样皮炎(青年)。

IF 1.9

Dermatopathology Pub Date : 2022-01-16 DOI: 10.3390/dermatopathology9010004

Giorgio Annessi, Emanuele Annessi

{"title":"Annular Lichenoid Dermatitis (of Youth).","authors":"Giorgio Annessi, Emanuele Annessi","doi":"10.3390/dermatopathology9010004","DOIUrl":"https://doi.org/10.3390/dermatopathology9010004","url":null,"abstract":"About 20 years after its first description, Annular Lichenoid Dermatitis of Youth (ALDY) is recognized as a distinctive lichenoid dermatosis with specific clinical and histological features. The disease occurs mostly in young persons all over the world, runs a chronic course, and has an obscure etiopathogenesis. Clinically, lesions consist of persistent, asymptomatic erythematous macules and round-oval annular patches with a red-violaceous non-scaling border and central hypopigmentation, mostly localized on the groin and flanks. Histology shows a peculiar lichenoid dermatitis characterized by irregular epidermal hyperplasia with an alternation of thinned and quadrangular rete ridges and a dense band-like lichenoid infiltrate of lymphocytes in the papillary dermis. Typically, there is infiltration of lymphocytes into the lower epidermal layers with massive necrosis/apoptosis of keratinocytes, which is limited to the tips of rete ridges. Dermal lymphocytes are usually CD3+, CD4+, while most of the intraepidermal T cells are CD8+. Analysis of TCR-γ-chain gene rearrangement displayed polyclonality in all cases examined. Differential diagnosis mainly includes morphea, mycosis fungoides, annular erythemas and inflammatory lesions of vitiligo. Topical corticosteroids and topical tacrolimus represent the most effective drugs for ALDY treatment.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"23-31"},"PeriodicalIF":1.9,"publicationDate":"2022-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39858486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphea Profunda with Tertiary Lymphoid Follicles: Description of Two Cases and Review of the Literature. 深睡眠伴三级淋巴滤泡:两例报告及文献复习。

IF 1.9

Dermatopathology Pub Date : 2022-01-10 DOI: 10.3390/dermatopathology9010003

Angelo Cassisa, Margherita Vannucchi

引用次数: 0

Drug Reactions 药物反应

IF 1.9

Dermatopathology Pub Date : 2022-01-01 DOI: 10.1007/978-3-030-82820-2_16

W. Kempf, M. Hantschke, H. Kutzner

引用次数: 0

Principles of Diagnosis 诊断原则