Dermatopathology最新文献_第7页

An Unusual Presentation of Dermatofibroma with Ulcer: A Case Report. 罕见的皮肤纤维瘤合并溃疡1例报告。

IF 1.7

Dermatopathology Pub Date : 2025-09-04 DOI: 10.3390/dermatopathology12030028

Lamia Alakrash, Renad AlKanaan, Rema Aldihan, Alanoud Alsuhibani, Salman Almalki

{"title":"An Unusual Presentation of Dermatofibroma with Ulcer: A Case Report.","authors":"Lamia Alakrash, Renad AlKanaan, Rema Aldihan, Alanoud Alsuhibani, Salman Almalki","doi":"10.3390/dermatopathology12030028","DOIUrl":"10.3390/dermatopathology12030028","url":null,"abstract":"Dermatofibroma is a common mesenchymal skin lesion that typically presents as a firm, slow-growing nodule. Generally, such lesions are asymptomatic; however, they can also cause discomfort in some cases. Ulceration is an uncommon feature of dermatofibroma, and diagnosis in such cases is often difficult. We report a case of a 67-year-old female with multiple comorbidities, including pancreatic cancer undergoing neoadjuvant chemotherapy, who was admitted for acute pulmonary embolism. The patient presented with an incidental medial thigh lesion. The lesion was asymptomatic, ulcerated, and oozing pus one month before presentation. Clinical examination revealed a 3 × 2 cm deep ulcer with a punched-out edge, a dry yellow-white base, and a firm violaceous border. Histopathology confirmed dermatofibroma with epidermal hyperplasia, dermal spindle cell proliferation, histiocytes, and collagen trapping. Immunohistochemistry was positive for CD68, CD10, and Factor XIII. Due to the deteriorating condition of the patient, no intervention was provided to her, and she succumbed to her primary illness. This case is unique due to its atypical ulcerative presentation in a patient with complex systemic illness and emphasizes distinguishing between benign lesions and malignant mimics, especially in cases which have ambiguous clinical presentation.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Demiral et al. Comment on "Mahmood, M.N. Direct Immunofluorescence of Skin and Oral Mucosa: Guidelines for Selecting the Optimum Biopsy Site. Dermatopathology 2024, 11, 52-61". 回复Demiral等人对Mahmood， M.N.《皮肤和口腔黏膜的直接免疫荧光：选择最佳活检部位的指南》的评论。皮肤病理学杂志，2024,11,52-61”。

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Dermatopathology Pub Date : 2025-09-04 DOI: 10.3390/dermatopathology12030027

Muhammad N Mahmood

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Comment on Mahmood, M.N. Direct Immunofluorescence of Skin and Oral Mucosa: Guidelines for Selecting the Optimum Biopsy Site. Dermatopathology 2024, 11, 52-61. 评论Mahmood， M.N.皮肤和口腔黏膜的直接免疫荧光：选择最佳活检部位的指南。皮肤病理学杂志，2014,11,52-61。

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Dermatopathology Pub Date : 2025-08-26 DOI: 10.3390/dermatopathology12030026

Şebnem Demiral, Yunus Özcan, Mehmet Gamsızkan

引用次数: 0

Immunohistochemical Characterisation of the Interstitial Inflammatory Environment: T-Cell- and B-Cell-Dominant Subtypes of Hidradenitis Suppurativa. 间质性炎症环境的免疫组织化学特征：化脓性汗腺炎的t细胞和b细胞显性亚型。

IF 1.7

Dermatopathology Pub Date : 2025-08-25 DOI: 10.3390/dermatopathology12030025

Nessr Abu Rached, Stefanie Bruckmüller, Martin Doerler, Hanna Telkemeyer, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Markus Stücker, Eggert Stockfleth, Falk G Bechara

{"title":"Immunohistochemical Characterisation of the Interstitial Inflammatory Environment: T-Cell- and B-Cell-Dominant Subtypes of Hidradenitis Suppurativa.","authors":"Nessr Abu Rached, Stefanie Bruckmüller, Martin Doerler, Hanna Telkemeyer, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Markus Stücker, Eggert Stockfleth, Falk G Bechara","doi":"10.3390/dermatopathology12030025","DOIUrl":"10.3390/dermatopathology12030025","url":null,"abstract":"Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a complex immune response. Given the considerable heterogeneity of the clinical phenotype of HS, this study aimed to analyse the immunohistochemical pattern of interstitial inflammation.Methods: Immunohistochemical analysis was performed on skin samples from 49 patients with HS. The immunohistochemical markers CD3, CD4 and CD8 for T-cells, CD20 for B-cells, CD138 for plasma cells and CD30, CD56, Bcl-2 and Bcl-6 were stained on lesional skin.Results: The analysis of immune cell dominance in patients with HS revealed that 33.3% of the cohort exhibited B-cell dominance, defined as a ratio of the sum of CD20+ and CD138+ cells to CD3+ cells greater than 1, while the majority (66.7%) demonstrated T-cell dominance, defined as a ratio of CD3+ cells to the sum of CD20+ and CD138+ cells greater than 1. B-cell-dominant HS is associated with a significantly elevated probability of mammary involvement (13.3% vs. 0%; p = 0.041). T-cell-dominant HS patients tended to demonstrate a higher mean tobacco consumption, but not significantly (20 vs. 5 tobacco pack-years; p = 0.06). CD4-dominant HS patients exhibited a significantly greater involvement of the mons pubis (62.5% vs. 28.6%, p = 0.023) compared to CD8-dominant patients, who demonstrated a significantly higher number of abscesses (p = 0.027).Conclusions: For the first time, we describe the clinical and immunohistochemical characteristics of T-cell- and B-cell-dominant HS. Although HS seems to be more dominated by T-cells, a B-cell dominance was found in 33% of cases.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilomatricoma in Syndromic Contexts: A Literature Review and a Report of a Case in Apert Syndrome. 综合征背景下的毛囊基质瘤：文献回顾和Apert综合征1例报告。

IF 1.7

Dermatopathology Pub Date : 2025-08-01 DOI: 10.3390/dermatopathology12030024

Gianmarco Saponaro, Elisa De Paolis, Mattia Todaro, Francesca Azzuni, Giulio Gasparini, Antonio Bosso, Giuliano Ascani, Angelo Minucci, Alessandro Moro

{"title":"Pilomatricoma in Syndromic Contexts: A Literature Review and a Report of a Case in Apert Syndrome.","authors":"Gianmarco Saponaro, Elisa De Paolis, Mattia Todaro, Francesca Azzuni, Giulio Gasparini, Antonio Bosso, Giuliano Ascani, Angelo Minucci, Alessandro Moro","doi":"10.3390/dermatopathology12030024","DOIUrl":"10.3390/dermatopathology12030024","url":null,"abstract":"Pilomatricomas are benign tumors originating from hair follicle matrix cells and represent the most common skin tumors in pediatric patients. Pilomatricomas may be associated with genetic syndromes such as myotonic dystrophy, familial adenomatous polyposis (FAP), Turner syndrome, Rubinstein-Taybi syndrome, Kabuki syndrome, and Sotos syndrome. This study reviews the literature on pilomatricomas occurring in syndromic contexts and presents a novel case linked to Apert syndrome. A systematic review was conducted using PubMed and Cochrane databases, focusing on case reports, case series, and reviews describing pilomatricomas associated with syndromes. A total of 1272 articles were initially screened; after removing duplicates and excluding articles without syndromic diagnoses or lacking sufficient data, 81 full-text articles were reviewed. Overall, 96 cases of pilomatricomas associated with genetic syndromes were identified. Reports of patients with Apert syndrome who do not develop pilomatricomas are absent in the literature. Pilomatricomas predominantly affect pediatric patients, with a slight female predominance, and are often the first manifestation of underlying genetic syndromes. Our study highlights previously unreported associations of pilomatricoma with Apert syndrome, providing molecular insights. This study contributes to understanding the clinical and molecular features of pilomatricomas in syndromic contexts and underscores the importance of genetic analysis for accurate diagnosis and management.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistopathological Analysis of Spongiosis Formation in Atopic Dermatitis Compared with Other Skin Diseases. 特应性皮炎与其他皮肤病海绵状病变的免疫组织病理学分析。

IF 1.7

Dermatopathology Pub Date : 2025-08-01 DOI: 10.3390/dermatopathology12030023

Ryoji Tanei, Yasuko Hasegawa

{"title":"Immunohistopathological Analysis of Spongiosis Formation in Atopic Dermatitis Compared with Other Skin Diseases.","authors":"Ryoji Tanei, Yasuko Hasegawa","doi":"10.3390/dermatopathology12030023","DOIUrl":"10.3390/dermatopathology12030023","url":null,"abstract":"Whether the spongiotic reaction caused by the interaction of keratinocytes, T-lymphocytes, inflammatory dendritic epidermal cells (IDECs), and Langerhans cells (LCs) observed in atopic dermatitis (AD) represents a common feature of spongiosis in various skin diseases remains unclear. We analyzed the characteristics of spongiosis in AD compared with those in other eczematous dermatitis and inflammatory skin diseases by using immunohistochemical methods. Infiltration of IDECs (CD11c+ cells and/or CD206+ cells) and T-lymphocytes, accompanied by degenerated keratinocytes and aggregated LCs (CD207+ cells), was frequently observed as a common feature of spongiosis in multiple conditions. However, IDECs expressing IgE were identified exclusively in IgE-mediated AD. Aggregation of IDECs was predominantly observed in the spongiosis of adaptive immune-mediated eczematous disorders, such as AD and allergic contact dermatitis. These IDEC aggregations constituted the major components of the epidermal dendritic cell clusters seen in AD and other eczematous or eczematoid dermatoses, and may serve as a useful distinguishing marker from Pautrier collections seen in cutaneous T-cell lymphoma. These findings suggest that IDECs, in cooperation with other immune cells, may play a pivotal role in spongiosis formation in AD and various skin diseases, although the underlying immunopathological mechanisms differ among these conditions.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatopathological Challenges in Objectively Characterizing Immunotherapy Response in Mycosis Fungoides. 客观表征真菌病免疫治疗反应的皮肤病理挑战。

IF 1.7

Dermatopathology Pub Date : 2025-07-29 DOI: 10.3390/dermatopathology12030022

Amy Xiao, Arivarasan Karunamurthy, Oleg Akilov

{"title":"Dermatopathological Challenges in Objectively Characterizing Immunotherapy Response in Mycosis Fungoides.","authors":"Amy Xiao, Arivarasan Karunamurthy, Oleg Akilov","doi":"10.3390/dermatopathology12030022","DOIUrl":"10.3390/dermatopathology12030022","url":null,"abstract":"In this review, we explore the complexities of objectively assessing the response to immunotherapy in mycosis fungoides (MF), a prevalent form of cutaneous T-cell lymphoma. The core challenge lies in distinguishing between reactive and malignant lymphocytes amidst treatment, particularly given the absence of uniform pathological biomarkers for MF. We highlight the vital role of emerging histological technologies, such as multispectral imaging and spatial transcriptomics, in offering a more profound insight into the tumor microenvironment (TME) and its dynamic response to immunomodulatory therapies. Drawing on parallels with melanoma-another immunogenic skin cancer-our review suggests that methodologies and insights from melanoma could be instrumental in refining the approach to MF. We specifically focus on the prognostic implications of various TME cell types, including CD8+ tumor-infiltrating lymphocytes, natural killer (NK) cells, and histiocytes, in predicting therapy responses. The review culminates in a discussion about adapting and evolving treatment response quantification strategies from melanoma research to the distinct context of MF, advocating for the implementation of novel techniques like high-throughput T-cell receptor gene rearrangement analysis. This exploration underscores the urgent need for continued innovation and standardization in evaluating responses to immunotherapies in MF, a field rapidly evolving with new therapeutic strategies.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Classic Signs Deceive: A Widespread Papulosquamous Eruption in Skin of Colour. 当经典的迹象欺骗：一个广泛的丘疹鳞状皮肤的颜色爆发。

IF 1.7

Dermatopathology Pub Date : 2025-07-21 DOI: 10.3390/dermatopathology12030021

Ji Fung Yong, Claudine Howard-James, Stephen Crowther, Anne-Marie Tobin, Caitriona Hackett

引用次数: 0

Basal Cell Carcinoma with Sarcomatoid Differentiation-A Rare Type and Its Possible Origin. 基底细胞癌伴肉瘤样分化——一种罕见类型及其可能的起源。

IF 1.7

Dermatopathology Pub Date : 2025-07-08 DOI: 10.3390/dermatopathology12030020

Nessr Abu Rached, Natalie Orlinski, Eggert Stockfleth, Markus Stücker, Martin Doerler

{"title":"Basal Cell Carcinoma with Sarcomatoid Differentiation-A Rare Type and Its Possible Origin.","authors":"Nessr Abu Rached, Natalie Orlinski, Eggert Stockfleth, Markus Stücker, Martin Doerler","doi":"10.3390/dermatopathology12030020","DOIUrl":"10.3390/dermatopathology12030020","url":null,"abstract":"Background: We present an interesting case involving a tumour comprising both basal cell tumour cells and sarcomatoid tumour cells. An 86-year-old woman presented with an erythematous lesion on her left cheek. Clinical and dermoscopic findings suggested BCC. Complete excision and histopathological examination revealed a BCC with a separate proliferation of atypical spindle and epithelioid cells. Immunohistochemical staining supported the diagnosis, with basaloid cells positive for CK5/6 and Ber-EP4 and sarcomatoid cells positive for CD10 and vimentin.Results: Histology and immunohistochemistry confirmed a basal cell carcinoma with sarcomatoid differentiation. The close proximity of sarcomatoid cells to the BCC component suggests a potential role of epithelial-mesenchymal interactions in tumour development. Further investigations into the exact origin of this tumour are required.Conclusion: Basal cell carcinoma with sarcomatoid differentiation is rare. This case highlights the importance of thorough histological and immunohistochemical evaluation. Further studies are necessary to better understand the pathogenesis of such collision tumours.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Invasive Diagnostic Techniques in Penile Intraepithelial Neoplasia (PeIN): Insights from Reflectance Confocal Microscopy (RCM), Line-Field Confocal Optical Coherence Tomography (LC-OCT), and Correlation with Histopathological Features. 阴茎上皮内瘤变（PeIN）的无创诊断技术：来自反射共聚焦显微镜（RCM）、线场共聚焦光学相干断层扫描（LC-OCT）的见解，以及与组织病理学特征的相关性。

IF 1.7

Dermatopathology Pub Date : 2025-07-07 DOI: 10.3390/dermatopathology12030019

Caterina Damiani, Cesare Ariasi, Giuseppe La Rosa, Francesca Di Lauro, Mariachiara Arisi, Vincenzo Maione, Marina Venturini, Simone Soglia

{"title":"Non-Invasive Diagnostic Techniques in Penile Intraepithelial Neoplasia (PeIN): Insights from Reflectance Confocal Microscopy (RCM), Line-Field Confocal Optical Coherence Tomography (LC-OCT), and Correlation with Histopathological Features.","authors":"Caterina Damiani, Cesare Ariasi, Giuseppe La Rosa, Francesca Di Lauro, Mariachiara Arisi, Vincenzo Maione, Marina Venturini, Simone Soglia","doi":"10.3390/dermatopathology12030019","DOIUrl":"10.3390/dermatopathology12030019","url":null,"abstract":"Penile intraepithelial neoplasia (PeIN) is a rare but clinically significant condition that can progress to invasive squamous carcinoma. Early diagnosis is crucial but often challenging due to its heterogeneous clinical and dermoscopic presentation, which can mimic other benign or malignant lesions. In this study, we report two cases of pigmented penile lesions evaluated using non-invasive imaging techniques: reflectance confocal microscopy (RCM) and line-field confocal optical coherence tomography (LC-OCT). Both methods revealed characteristic features such as hyperkeratosis, parakeratosis, acanthosis, nuclear pleomorphism of keratinocytes, and the presence of bright intraepithelial dendritic cells, correlating closely with histopathological findings of high-grade basaloid PeIN. Our findings highlight the valuable role of RCM and LC-OCT in improving the differential diagnosis of genital lesions, potentially reducing the need for invasive diagnostic procedures and ensuring early, appropriate management.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0