Dermatopathology最新文献

Expression of TRPS1 in Metastatic Tumors of the Skin: An Immunohistochemical Study of 72 Cases. 皮肤转移性肿瘤中 TRPS1 的表达：72 个病例的免疫组化研究。

IF 1.6

Dermatopathology Pub Date : 2024-10-23 DOI: 10.3390/dermatopathology11040031

Kassiani Boulogeorgou, Christos Topalidis, Triantafyllia Koletsa, Georgia Karayannopoulou, Jean Kanitakis

{"title":"Expression of TRPS1 in Metastatic Tumors of the Skin: An Immunohistochemical Study of 72 Cases.","authors":"Kassiani Boulogeorgou, Christos Topalidis, Triantafyllia Koletsa, Georgia Karayannopoulou, Jean Kanitakis","doi":"10.3390/dermatopathology11040031","DOIUrl":"https://doi.org/10.3390/dermatopathology11040031","url":null,"abstract":"TRPS1 (Tricho-rhino-phalangeal syndrome 1) is a GATA transcriptional activator gene encoding for a protein used as a sensitive immunohistochemical marker of breast carcinomas. In dermatopathology, TRPS1 is used as a marker of mammary and extramammary Paget's disease and is also expressed by a variety of primary cutaneous tumors, mostly of adnexal origin. So far, very limited data exist on the expression of TRPS1 in metastatic skin tumors. We studied the immunohistochemical expression of TRPS1 in 72 cutaneous metastatic tumors from the breast (n: 19) and other origins (n: 53) in order to assess its diagnostic usefulness. The intensity of TRPS1 immunostaining was expressed as a histoscore: the product of the percentage of positive cells (scored semi-quantitatively 0-4) and the staining intensity (scored 0-3). In normal skin, nuclear TRPS1 expression was predominantly observed in cells of adnexal structures (pilosebaceous follicles and sweat glands). Eighteen (18/19, 94.7%) metastatic breast carcinomas showed diffuse and strong TRPS1 positivity (histoscore 12). Lower reactivity was found in some other metastases, including from the lung (11/22), the female genital tract (3/4), and the kidney (2/4), whereas most (20/22) metastases from the digestive system and peritoneum, along with a case of metastatic prostate carcinoma, were negative. These results suggest that a high histoscore for TRPS1 is in favor of the mammary origin of metastatic cutaneous carcinoma. Although TRPS1 is not absolutely specific or sensitive to a particular primary, we consider that it can be added to a panel of other markers when investigating the origin of a cutaneous metastasis, namely when this is the first manifestation of the neoplastic disease.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 4","pages":"293-302"},"PeriodicalIF":1.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report. 未分化多形性肉瘤伴有反应性蜕膜鞘膜纤维腺瘤：一份病例报告。

IF 1.6

Dermatopathology Pub Date : 2024-10-20 DOI: 10.3390/dermatopathology11040030

Navinda Donsakul, Suthep Jerasutus, Ittipon Tubtieng, Ravion Assavanatenapa, Voraphol Vejjabhinanta

{"title":"Undifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report.","authors":"Navinda Donsakul, Suthep Jerasutus, Ittipon Tubtieng, Ravion Assavanatenapa, Voraphol Vejjabhinanta","doi":"10.3390/dermatopathology11040030","DOIUrl":"https://doi.org/10.3390/dermatopathology11040030","url":null,"abstract":"Undifferentiated pleomorphic sarcoma (UPS) is an aggressive soft tissue sarcoma with a poor prognosis. The patients are usually found to have metastasis when the primary tumor is diagnosed. Eccrine syringofibroadenoma (ESFA) is a rare cutaneous adnexal lesion of eccrine duct origin. There are five subtypes, one of which is reactive ESFA, known to occur in reaction to an inflammatory or neoplastic process. In this article, we report a case of the co-existence of both UPS and ESFA in a 70-year-old male patient, presenting with a painless, erythematous, irregular surface nodule with a peripherally extended brownish hyperkeratotic plaque on the right palm. The histologic findings revealed an ill-defined dermal tumor of atypical epithelioid and spindle-shaped cells with large pleomorphic hyperchromatic nuclei and abundant eosinophilic cytoplasm. Some of those cells were multinucleated giant cells in the stroma with vascular proliferation and mixed inflammatory cell infiltrate. The tumor cells, which were only positive for vimentin, supported the diagnosis of undifferentiated pleomorphic sarcoma (UPS). Meanwhile, the overlying epidermis demonstrated hyperkeratosis, papillated epidermal hyperplasia, and proliferation of anastomosing slender cords and strands of cuboid cells within loose fibrovascular stroma. These findings are the characteristics of eccrine syringofibroadenoma (ESFA). We describe here a patient in whom reactive ESFA occurred on and surrounded the UPS tumor.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 4","pages":"286-292"},"PeriodicalIF":1.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratoacanthoma versus Squamous-Cell Carcinoma: Histopathological Features and Molecular Markers. 角化棘皮瘤与鳞状细胞癌：组织病理学特征与分子标记。

IF 1.6

Dermatopathology Pub Date : 2024-10-08 DOI: 10.3390/dermatopathology11040029

Hisham F Bahmad, Kalin Stoyanov, Teresita Mendez, Sally Trinh, Kristy Terp, Linda Qian, John Alexis

{"title":"Keratoacanthoma versus Squamous-Cell Carcinoma: Histopathological Features and Molecular Markers.","authors":"Hisham F Bahmad, Kalin Stoyanov, Teresita Mendez, Sally Trinh, Kristy Terp, Linda Qian, John Alexis","doi":"10.3390/dermatopathology11040029","DOIUrl":"https://doi.org/10.3390/dermatopathology11040029","url":null,"abstract":"Considerable controversy exists within the field of dermatopathology in differentiating keratoacanthoma (KA) from squamous-cell carcinoma (SCC). KAs are rapidly growing, benign squamous tumors that are typically well differentiated. This controversy stems from the diverging perspectives on the management, classification, and diagnosis of each entity. Many believe that KAs are benign neoplasms in which intervention may be unnecessary since they are self-limiting and resolve on their own. On the other hand, SCC needs to be treated, as it carries significant morbidity and mortality risks. Early diagnosis and treatment are vital to prevent serious consequences of SCC. Nevertheless, KAs may resemble SCC grossly and microscopically. Various ancillary tests, including immunohistochemical (IHC) staining, have been proposed to differentiate between these entities, though mixed patterns of expression can limit the diagnostic utility of these techniques. Research into this topic is ongoing, with newer genetic and molecular findings illuminating the previously difficult-to-understand aspects of KA and increasing our understanding of this entity. In this review, KA and SCC will be compared along the lines of histological features, genetic, immune, and molecular markers, differential diagnosis, and management to clarify the similarities, differences, and misconceptions about both entities.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 4","pages":"272-285"},"PeriodicalIF":1.6,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Issues Regarding Dermatopathology Care for Service-Members: A Review. 军人皮肤病理学护理的伦理问题：综述。

IF 1.6

Dermatopathology Pub Date : 2024-09-24 DOI: 10.3390/dermatopathology11040027

Samir Kamat, Ross O'Hagan, Catherine Brahe, Curtis L Hardy, Vikas Shrivastava, Jane M Grant-Kels, Angela M Crotty

引用次数: 0

Enhancing Melanoma Diagnosis with Advanced Deep Learning Models Focusing on Vision Transformer, Swin Transformer, and ConvNeXt. 以 Vision Transformer、Swin Transformer 和 ConvNeXt 为重点，利用先进的深度学习模型加强黑色素瘤诊断。

IF 1.6

Dermatopathology Pub Date : 2024-08-15 DOI: 10.3390/dermatopathology11030026

Serra Aksoy, Pinar Demircioglu, Ismail Bogrekci

{"title":"Enhancing Melanoma Diagnosis with Advanced Deep Learning Models Focusing on Vision Transformer, Swin Transformer, and ConvNeXt.","authors":"Serra Aksoy, Pinar Demircioglu, Ismail Bogrekci","doi":"10.3390/dermatopathology11030026","DOIUrl":"10.3390/dermatopathology11030026","url":null,"abstract":"Skin tumors, especially melanoma, which is highly aggressive and progresses quickly to other sites, are an issue in various parts of the world. Nevertheless, the one and only way to save lives is to detect it at its initial stages. This study explores the application of advanced deep learning models for classifying benign and malignant melanoma using dermoscopic images. The aim of the study is to enhance the accuracy and efficiency of melanoma diagnosis with the ConvNeXt, Vision Transformer (ViT) Base-16, and Swin Transformer V2 Small (Swin V2 S) deep learning models. The ConvNeXt model, which integrates principles of both convolutional neural networks and transformers, demonstrated superior performance, with balanced precision and recall metrics. The dataset, sourced from Kaggle, comprises 13,900 uniformly sized images, preprocessed to standardize the inputs for the models. Experimental results revealed that ConvNeXt achieved the highest diagnostic accuracy among the tested models. Experimental results revealed that ConvNeXt achieved an accuracy of 91.5%, with balanced precision and recall rates of 90.45% and 92.8% for benign cases, and 92.61% and 90.2% for malignant cases, respectively. The F1-scores for ConvNeXt were 91.61% for benign cases and 91.39% for malignant cases. This research points out the potential of hybrid deep learning architectures in medical image analysis, particularly for early melanoma detection.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 3","pages":"239-252"},"PeriodicalIF":1.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Challenge: A New Article Type in Dermatopathology. 临床病理挑战：皮肤病理学的新文章类型。

IF 1.6

Dermatopathology Pub Date : 2024-08-14 DOI: 10.3390/dermatopathology11030025

Gürkan Kaya

引用次数: 0

Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome. 两名奈瑟顿综合征患者的皮肤活检组织中白细胞介素-36高度表达

IF 1.6

Dermatopathology Pub Date : 2024-08-12 DOI: 10.3390/dermatopathology11030024

Johannes Pawlowski, Tatsiana Pukhalskaya, Kelly Cordoro, Marina Kristy Ibraheim, Jeffrey P North

{"title":"Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome.","authors":"Johannes Pawlowski, Tatsiana Pukhalskaya, Kelly Cordoro, Marina Kristy Ibraheim, Jeffrey P North","doi":"10.3390/dermatopathology11030024","DOIUrl":"10.3390/dermatopathology11030024","url":null,"abstract":"Netherton syndrome (NS) is a rare autosomal recessive disorder that occurs due to a loss-of-function mutation in SPINK5; this loss results in significant inflammation, as well as perturbations of the skin barrier's integrity and functionality. While it is unclear which inflammatory pathways contribute to the development of NS, recent studies have demonstrated the expression of interleukin (IL)-17/IL-36, as well as several Th2 cytokines. Consequently, immunohistochemistry (IHC) with IL-36 may serve as a potential tool for aiding the histopathological diagnosis of this condition. In this case series, we present two cases of NS and capture their immunostaining pattern with IL-36. Both cases demonstrated robust expression of IL-36. This finding bolsters the hypothesis that NS is partially driven by Th17 activation and suggests the potential utility of IL-36 IHC as part of the workup for this rare and diagnostically elusive entity. LEKTI IHC was negative in one biopsy, revealing a limitation of this stain in diagnosing NS.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 3","pages":"230-237"},"PeriodicalIF":1.6,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases. 数字乳头状腺癌：在部分病例中检测到低风险人类乳头状瘤病毒和 BRAF p.V600E 突变。

IF 1.6

Dermatopathology Pub Date : 2024-06-28 DOI: 10.3390/dermatopathology11030018

Feifan Chen, Priyadharsini Nagarajan, Phyu P Aung

{"title":"Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases.","authors":"Feifan Chen, Priyadharsini Nagarajan, Phyu P Aung","doi":"10.3390/dermatopathology11030018","DOIUrl":"10.3390/dermatopathology11030018","url":null,"abstract":"Digital papillary adenocarcinoma (DPA) is a rare malignant neoplasm which arises from the sweat glands and has metastatic potential. DPA exhibits a wide range of architectural features and exhibits low-grade to high-grade features, so distinguishing DPA from benign skin neoplasms, including acral hidradenoma, poses significant diagnostic challenges. The recent literature suggests a strong association between DPA and human papillomavirus (HPV) 42, a low-risk HPV (LR-HPV) subtype, and a possible association between DPA and BRAF p.V600E. To explore these associations, we assessed the utility of in situ hybridization (ISH) for LR-HPV (types 6, 11, 40, 42, 43, 44) and immunohistochemistry (IHC) for BRAF p.V600E in diagnosing DPA and distinguishing DPA from acral hidradenoma. With institutional review board approval, we retrospectively identified 15 specimens of DPA (from 13 patients) and 3 cases of acral hidradenoma. Of the 13 DPA cases, 6 were negative for LR-HPV and BRAF p.V600E; 6 were positive for only LR-HPV; and 1 was positive for only BRAF p.V600E but negative for LR-HPV. All three cases of acral hidradenoma were negative for LR-HPV and BRAF p.V600E. As our sample size is limited, larger studies are needed to assess the value of detecting LR-HPV and BRAF p.V600E in the distinction of DPA and acral hidradenoma. However, our findings indicate a stronger association of DPA with LR-HPV than with BRAF p.V600E.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 3","pages":"177-183"},"PeriodicalIF":1.6,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Value of Histopathological Features in Early-Stage Mycosis Fungoides: Insights from a Retrospective-Prospective Cohort Study. 早期真菌病组织病理学特征的预后价值：一项回顾性-前瞻性队列研究的启示

IF 1.6

Dermatopathology Pub Date : 2024-06-14 DOI: 10.3390/dermatopathology11020017

Sandra Jerkovic Gulin, Ivana Ilic, Romana Ceovic

{"title":"The Prognostic Value of Histopathological Features in Early-Stage Mycosis Fungoides: Insights from a Retrospective-Prospective Cohort Study.","authors":"Sandra Jerkovic Gulin, Ivana Ilic, Romana Ceovic","doi":"10.3390/dermatopathology11020017","DOIUrl":"10.3390/dermatopathology11020017","url":null,"abstract":"Primary cutaneous lymphomas (PCLs), especially mycosis fungoides (MF), pose significant diagnostic and therapeutic challenges. This study aims to correlate initial histological features with the disease course and survival in MF patients. A retrospective-prospective cohort study was conducted on 83 patients diagnosed with early-stage MF at the Departments of Dermatovenerology and Pathology, UHC Zagreb, from January 2003 to December 2012. The analyzed histopathological parameters included lichenoid dermal lymphocyte infiltrate, Pautrier microabscesses, and lymphocyte atypia. Patients with more than 30 guardian lymphocytes per 100 keratinocytes exhibited worse overall and progression-free survival. Furthermore, those with over 50% atypical lymphocytes demonstrated a faster progression rate. A dense lichenoid dermal infiltrate and a high count of lymphocyte \"keepers\" significantly increased the mortality risk within five years of diagnosis. This study did not fully confirm the hypothesis regarding the prognostic value of large Pautrier microabscesses but highlighted the importance of dense lichenoid infiltrates. The study identified new potential histopathological prognostic factors in early-stage MF, suggesting the need for larger studies to confirm these findings. The identification of such predictors could enhance the prognostic stratification and guide more tailored therapeutic approaches for MF patients.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"11 2","pages":"161-176"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Histopathology of Leg Ulcers. 腿部溃疡的组织病理学。

IF 1.9

Dermatopathology Pub Date : 2024-01-29 DOI: 10.3390/dermatopathology11010007

Amun Georg Hofmann, Julia Deinsberger, André Oszwald, Benedikt Weber

引用次数: 0