Dermatopathology最新文献

A Scoping Review on Melasma Treatments and Their Histopathologic Correlates. 黄褐斑治疗及其组织病理学相关性的综述。

IF 1.6

Dermatopathology Pub Date : 2025-04-11 DOI: 10.3390/dermatopathology12020013

Aurore D Zhang, Michelle Lazar, Emiliya Akhundova, Candice E Brem, Eric J Beltrami, Neelam A Vashi

引用次数: 0

Congenital Melanocytic Nevus with Neurocristic Cutaneous Hamartoma: A Case Report. 先天性黑素细胞痣合并神经性皮肤错构瘤1例。

IF 1.6

Dermatopathology Pub Date : 2025-04-10 DOI: 10.3390/dermatopathology12020012

Dina El-Rayes, Katlin Wilson, Sheilagh Maguiness, Daniel Miller, Gerardo Cazzato, Alessio Giubellino

{"title":"Congenital Melanocytic Nevus with Neurocristic Cutaneous Hamartoma: A Case Report.","authors":"Dina El-Rayes, Katlin Wilson, Sheilagh Maguiness, Daniel Miller, Gerardo Cazzato, Alessio Giubellino","doi":"10.3390/dermatopathology12020012","DOIUrl":"https://doi.org/10.3390/dermatopathology12020012","url":null,"abstract":"Congenital melanocytic nevi (CMN) are benign tumors present at birth or arising in the first few months of life. A small subset of these nevi present with mild atypical features and heterogeneous differentiation, including Schwannian differentiation. We present a case of a 3-week-old with a 7 cm red/purple scalp nodule consistent with CMN with mild atypical heterogeneous areas. On histology, there were dermal nests of spindle cells in a fibrillar matrix, with increased vessels and clusters of small round melanocytes interspersed between collagen bundles and around adnexal structures. The lesion also exhibited rare pagetoid ascent of melanocytes as single cells and nests. Overall, these features were consistent with a CMN with nodular proliferative neurocristic cutaneous hamartoma (NCH) with a component of a compound mild atypical melanocytic proliferation. Next generation sequencing (NGS) identified a novel SH2B1::BRAF fusion. This case highlights the diagnostic challenges of heterogeneous differentiation within CMN in young children.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatomyositis-like Eruptions, Hydroxyurea-Associated Squamous Dysplasia, and Nonmelanoma Skin Cancer: A Case Report and Systematic Review. 皮肌炎样疹、羟基脲相关鳞状发育不良和非黑色素瘤皮肤癌：一例报告和系统回顾。

IF 1.6

Dermatopathology Pub Date : 2025-03-30 DOI: 10.3390/dermatopathology12020011

Giorgia Di Marco, Gianmarco Diego Bigotto, Eleonora Cossar, Nathalie Rizzo, Stefania Guida, Franco Rongioletti

{"title":"Dermatomyositis-like Eruptions, Hydroxyurea-Associated Squamous Dysplasia, and Nonmelanoma Skin Cancer: A Case Report and Systematic Review.","authors":"Giorgia Di Marco, Gianmarco Diego Bigotto, Eleonora Cossar, Nathalie Rizzo, Stefania Guida, Franco Rongioletti","doi":"10.3390/dermatopathology12020011","DOIUrl":"https://doi.org/10.3390/dermatopathology12020011","url":null,"abstract":"Hydroxyurea (HU), a cornerstone treatment for myeloproliferative disorders, is associated with a wide range of cutaneous side effects, from xerosis and hyperpigmentation to more severe conditions like dermatomyositis-like eruptions (DM-LE) and nonmelanoma skin cancers (NMSC), particularly squamous cell carcinoma (SCC). In this review, we present a unique case of HU-induced DM-LE with histological evidence of keratinocyte dysplasia and p53 overexpression, followed by a systematic analysis of similar cases. Our findings reveal that the clinical presentation of DM-LE, while typically considered benign, shares clinical and histological features with hydroxyurea-associated squamous dysplasia (HUSD), a precancerous condition that may progress to SCC in chronically exposed patients. Key insights include the characteristic histopathological findings of DM-LE, the role of chronic HU therapy and UV-induced damage in promoting p53 overexpression, and the overlap between DM-LE and HUSD. Regular dermatologic monitoring, patient education on photoprotection, and the careful assessment of skin lesions in long-term HU users are essential for the early detection and prevention of malignancies. This review underscores the importance of distinguishing between DM-LE, HUSD, and SCC to optimize management and minimize risks associated with HU therapy.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncommon Collision Tumors: Dermoscopic and Histopathological Features of Basal Cell Carcinoma Overlying Dermatofibroma. 罕见碰撞肿瘤：皮肤纤维瘤上覆基底细胞癌的皮肤镜及组织病理学特征。

IF 1.6

Dermatopathology Pub Date : 2025-03-25 DOI: 10.3390/dermatopathology12020010

Amal Makansi, Charlotta Enerbäck, Maria Madentzoglou, Georgios Kravvas, Sandra Jerkovic Gulin

{"title":"Uncommon Collision Tumors: Dermoscopic and Histopathological Features of Basal Cell Carcinoma Overlying Dermatofibroma.","authors":"Amal Makansi, Charlotta Enerbäck, Maria Madentzoglou, Georgios Kravvas, Sandra Jerkovic Gulin","doi":"10.3390/dermatopathology12020010","DOIUrl":"https://doi.org/10.3390/dermatopathology12020010","url":null,"abstract":"Dermatofibromas (DFs) represent prevalent benign fibrohistiocytic tumors, typically manifesting as solitary lesions. In the majority of cases, the clinical presentation and dermoscopic and histopathological features of DFs adhere to a characteristic profile. However, DFs may exhibit atypical clinical presentations and, more commonly, histologic attributes, posing challenges in differential diagnosis. Both DFs and basal cell carcinomas (BCCs) are frequently encountered cutaneous lesions, each characterized by distinct clinical and dermoscopic features and microscopic morphology. The simultaneous occurrence of these two entities within the same lesion is rare. DFs have been documented to form collision tumors in conjunction with a spectrum of benign and malignant lesions, encompassing not only BCC but also balloon cell nevus, squamous cell carcinoma (SCC), and melanoma. Alterations in the epidermis overlaying a DF range from simple hyperplasia to the proliferation of basaloid cells. Accurate diagnosis, leading to the complete excision of the lesion, is contingent upon the recognition of dermoscopic criteria, precluding misinterpretation as a benign lesion. We present two cases of collision tumors comprising DF and BCC. This case report underscores the paramount importance of dermoscopy and adherence to dermoscopic criteria in the assessment of collision lesions and the diagnostic process related to cutaneous malignancies.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postherpetic Pseudolymphomatous Angiosarcoma Concealed Within Milia en Plaque: Expanding the Spectrum of Wolf Isotopic Response with a Literature Review. 隐匿于粟粒斑块内的疱疹后假淋巴瘤血管肉瘤：扩大Wolf同位素反应谱的文献综述。

IF 1.6

Dermatopathology Pub Date : 2025-03-22 DOI: 10.3390/dermatopathology12020009

Marina Corral-Forteza, Noelia Pérez-Muñoz, Maria-Teresa Fernández-Figueras

{"title":"Postherpetic Pseudolymphomatous Angiosarcoma Concealed Within Milia en Plaque: Expanding the Spectrum of Wolf Isotopic Response with a Literature Review.","authors":"Marina Corral-Forteza, Noelia Pérez-Muñoz, Maria-Teresa Fernández-Figueras","doi":"10.3390/dermatopathology12020009","DOIUrl":"10.3390/dermatopathology12020009","url":null,"abstract":"The Wolf isotopic response (WIR) refers to the development of cutaneous lesions in areas of previously healed but unrelated skin disease. While most are observed in healed herpes zoster, WIR has been reported in various other contexts. Affected areas are believed to exhibit immune dysregulation, lymphatic dysfunction, and altered neuromediator activity, increasing susceptibility to inflammatory, neoplastic, and infectious conditions. This phenomenon aligns with the broader concept of the \"immunocompromised district\", which also encompasses the Koebner phenomenon and its reverse. Herein, we present the case of a 96-year-old woman who developed multiple cysts and comedones at the site of a resolved herpes zoster. Due to persistent and refractory inflammation, curettage was performed, and histopathological examination revealed angiosarcoma with a pseudolymphomatous reaction interspersed among the cysts. The coexistence of multiple types of WIR is rare but not unprecedented, highlighting the importance of recognizing the diverse pathologic conditions that can arise in such settings. In this review, we explore the historical evolution of terminology used to describe lesions in vulnerable skin areas and related phenomena. We also provide an updated overview of current pathogenic theories and present a comprehensive compilation of postherpetic reactions reported to date.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrophic Lichen Planus and Hypertrophic Skin Lesions Associated with Histological Lichenoid Infiltrate: A Case Report and Literature Review. 增生性扁平苔藓和增生性皮肤病变与组织学类地衣浸润：1例报告并文献复习。

IF 1.6

Dermatopathology Pub Date : 2025-02-25 DOI: 10.3390/dermatopathology12010008

Biagio Scotti, Cosimo Misciali, Federico Bardazzi, Bianca Maria Piraccini, Michelangelo La Placa

{"title":"Hypertrophic Lichen Planus and Hypertrophic Skin Lesions Associated with Histological Lichenoid Infiltrate: A Case Report and Literature Review.","authors":"Biagio Scotti, Cosimo Misciali, Federico Bardazzi, Bianca Maria Piraccini, Michelangelo La Placa","doi":"10.3390/dermatopathology12010008","DOIUrl":"10.3390/dermatopathology12010008","url":null,"abstract":"Hypertrophic lichen planus (HLP) is a chronic inflammatory skin condition defined by verrucous, pruritic, papules and plaques usually affecting the lower limbs. The diagnosis of HLP is primarily clinical. However, due to its feasible generalized presentation and similarities with other hypertrophic cutaneous disorders, histological evaluation is often necessary. Many dermatological conditions that present with a hypertrophic clinical appearance can arise from a histological lichenoid infiltrate (HCLI). Hence, we provide an overview of the clinical, histopathological, and prognostic features of selected HCLI, including HLP, hypertrophic lichenoid dermatitis, hypertrophic lichen sclerosus (HLS), lichen simplex chronicus (LSC), squamous cell carcinoma (SCC), keratoacanthoma (KA), pseudoepitheliomatous hyperplasia (PEH), viral warts, and lupus erythematosus/lichen planus (LE/LP) overlap. Choosing the appropriate procedure and the anatomical site for an incisional biopsy requires thoughtful consideration to ensure sufficient depth and improve diagnostic accuracy by identifying the histological features specific to each hypertrophic condition.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Kikuchi-Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood. 儿童菊池-藤本病：儿童皮肤和组织病理学特征的病例报告和回顾。

IF 1.6

Dermatopathology Pub Date : 2025-02-13 DOI: 10.3390/dermatopathology12010007

Alberto Soto-Moreno, Francisco Vílchez-Márquez, María Narváez-Simón, Julia Castro-Martín, Francisco Manuel Ramos-Pleguezuelos, Agustín Soto-Díaz, Jesús Tercedor-Sánchez, Salvador Arias-Santiago

{"title":"Pediatric Kikuchi-Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood.","authors":"Alberto Soto-Moreno, Francisco Vílchez-Márquez, María Narváez-Simón, Julia Castro-Martín, Francisco Manuel Ramos-Pleguezuelos, Agustín Soto-Díaz, Jesús Tercedor-Sánchez, Salvador Arias-Santiago","doi":"10.3390/dermatopathology12010007","DOIUrl":"10.3390/dermatopathology12010007","url":null,"abstract":"Kikuchi-Fujimoto disease (KFD) is a rare condition characterized by necrotizing lymphadenitis and fever, often associated with immune dysregulation. Histologically, it features necrotic foci with abundant histiocytes and plasmacytoid dendritic cells but notably lacks neutrophils and eosinophils. Recent evidence reveals a notable prevalence among pediatric patients, who may exhibit distinct features compared to adults. We reported the case of an 11-year-old girl presenting with persistent fever, cervical adenopathy, and a malar rash, leading to a diagnosis of KFD following lymph node biopsy, which revealed non-suppurative necrosis and histiocytic infiltration. Empirical treatment with antivirals and antibiotics was ineffective, but corticosteroid therapy achieved symptom remission. A literature review identified 48 relevant studies involving 386 pediatric cases, with histopathological findings consistent with classical descriptions of KFD. Cutaneous involvement was reported in 11.14% of cases, ranging from maculopapular rashes to lupus-like eruptions. Notable complications included the development of systemic lupus erythematous, Sjögren syndrome, and rare instances of hemophagocytic syndrome or central nervous system involvement. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of pediatric patients presenting with fever and lymphadenopathy, taking into account a higher frequency of cutaneous manifestations in pediatric cases. A skin biopsy may be helpful in diagnosing KFD and provide valuable information regarding the potential risk of developing systemic lupus erythematosus in the future.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11860556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histologic and Immunohistochemical Patterns in Lymphomatoid Papulosis: A Systematic Review of Published Cases. 淋巴瘤样丘疹病的组织学和免疫组织化学模式：对已发表病例的系统回顾。

IF 1.6

Dermatopathology Pub Date : 2025-02-12 DOI: 10.3390/dermatopathology12010006

Torben Fricke, Werner Kempf, Michael P Schön, Christina Mitteldorf

{"title":"Histologic and Immunohistochemical Patterns in Lymphomatoid Papulosis: A Systematic Review of Published Cases.","authors":"Torben Fricke, Werner Kempf, Michael P Schön, Christina Mitteldorf","doi":"10.3390/dermatopathology12010006","DOIUrl":"10.3390/dermatopathology12010006","url":null,"abstract":"Based on histologic and genetic patterns, the current World Health Organization (WHO) classification distinguishes six subtypes of lymphomatoid papulosis (Lyp). The aim of our article was to analyze the frequency of histologic and immunohistochemical features of different Lyp subtypes reported in the literature. We used PubMed advanced search builder to systematically review and evaluate English and German literature of Lyp from 1968 to April 2022. We considered only papers in which histopathologic features were mentioned in detail. We identified 48 publications with a total of 518 cases. The diagnoses were based on the diagnostic criteria at the time of publication. In Lyp A and Lyp B a CD8+ phenotype was more often reported than expected (53% and 52%, respectively). A double positive phenotype (CD4+/CD8+) was found in 28% of Lyp E and a double negative (CD4-/CD8-) in 50% of Lyp with 6p25.3 rearrangement. High rates of folliculo- and syringotropism were reported in both Lyp A and B. Surprisingly, strong epidermotropism occurred in 20/38 (53%) cases reported as Lyp B and in 43/64 (67%) of Lyp D cases. The predominating phenotype in Lyp D was CD8+, while TIA-1/granzymeB/perforin expression was reported in 37/46 (80%), and CD56 was expressed in 13/47 (28%) of the investigated cases. The limitation of the data is due to the retrospective approach with diagnostic criteria changing over time and on a case selection in some publications. However, the data indicate that the Lyp subtypes overlap more than assumed. They also show that a prospective study is needed to obtain valid data on the frequency distribution of certain histopathologic criteria.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming. 丙酮-醚-水小鼠持续瘙痒模型完全解决，无潜伏性瘙痒或跨模态启动。

IF 1.6

Dermatopathology Pub Date : 2025-02-11 DOI: 10.3390/dermatopathology12010005

Zachary K Ford, Adam J Kirry, Steve Davidson

{"title":"Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming.","authors":"Zachary K Ford, Adam J Kirry, Steve Davidson","doi":"10.3390/dermatopathology12010005","DOIUrl":"10.3390/dermatopathology12010005","url":null,"abstract":"Hyperalgesic priming is a model of the transition from acute to chronic pain. Whether a similar mechanism exists for \"pruritic priming\" of itch is unknown. Here, we tested the hypothesis that itchy skin in a commonly used mouse model of dry skin pruritus develops latent sensitization after resolution. Acetone-ether-water (AEW) treatment induced a dry and itchy skin condition in the mouse cheek that elicited site-directed scratching behavior. After cessation of treatment and the complete resolution of AEW-induced scratching, histaminergic and non-histaminergic pruritogens were administered to the cheek to test for altered site-directed scratching and wiping behavior. Each pruritogen was also tested following the resolution of carrageenan-induced nociceptor hypersensitivity to test for cross-modality priming. Peak AEW-induced scratching occurred 24 h after the final day of treatment, and 5 days were required for scratching levels to return to baseline. Likewise, epidermal thickening was the greatest on the final treatment day and completely returned to baseline after 5 days. After the resolution of itchy cheek skin, acute histamine- and non-histamine-evoked scratching and wiping behaviors were unchanged, nor were scratching and wiping behaviors to acute pruritogens altered after the resolution of carrageenan-induced hypersensitivity. The results indicate that persistent itch due to dry skin likely resolves completely, without producing a latent primed response to subsequent pruritic stimuli. We conclude that the mechanisms regulating hyperalgesic priming are likely distinct from pruritic signaling in the dry and itchy skin model.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asteroid Shower: Cutaneous Silica Granuloma with Asteroid Bodies. 小行星雨：小行星体的皮肤二氧化硅肉芽肿。

IF 1.6

Dermatopathology Pub Date : 2025-01-31 DOI: 10.3390/dermatopathology12010004

Fadwa Ahmed, Christopher DiMarco

引用次数: 0