Dermatopathology最新文献

Treatment Resistant Acneiform Eruption in a Young Female: A Diagnostic Pitfall. 治疗抵抗痤疮疱在年轻女性：一个诊断陷阱。

IF 1.7

Dermatopathology Pub Date : 2025-09-17 DOI: 10.3390/dermatopathology12030032

Ioannis-Alexios Koumprentziotis, Evdoxia Panou, Antonis Tsimpidakis, Maria Gerochristou, Theodoros Iliakis, Leonidas Marinos, Alexander Stratigos, Vasiliki Nikolaou

引用次数: 0

Molecular and Genetic Markers for Malignant Melanoma: Implications for Prognosis and Therapy. 恶性黑色素瘤的分子和遗传标记：对预后和治疗的影响。

IF 1.7

Dermatopathology Pub Date : 2025-09-12 DOI: 10.3390/dermatopathology12030031

Lauren Fleshner, Alyssa Sayegh, Mehmet Fatih Atak, Rahim Hirani, Banu Farabi, Bijan Safai, Shoshana Marmon

{"title":"Molecular and Genetic Markers for Malignant Melanoma: Implications for Prognosis and Therapy.","authors":"Lauren Fleshner, Alyssa Sayegh, Mehmet Fatih Atak, Rahim Hirani, Banu Farabi, Bijan Safai, Shoshana Marmon","doi":"10.3390/dermatopathology12030031","DOIUrl":"10.3390/dermatopathology12030031","url":null,"abstract":"Despite therapeutic advancements, malignant melanoma remains a leading cause of skin cancer-related mortality, with incidence continuing to rise globally. Traditional prognostic tools offer important clinical guidance but fail to capture the biological heterogeneity of melanoma or reliably predict responses to emerging therapies. In this review, we summarize recent advances in prognostic and predictive molecular biomarkers reported over the past five years. We discuss immunohistochemical and tissue-based markers, circulating biomarkers, microRNAs, and gene expression profiles that enhance risk stratification and inform surveillance strategies. We also review immune-related markers that may predict response to immune-checkpoint inhibitor therapy. Lastly, we highlight investigational biomarkers-including gene signatures, epigenomic alterations, and microbiome influences-that are shaping the future landscape. Together, these advances reflect a shift toward precision oncology in melanoma, with the integration of biomarker-driven strategies offering the potential to personalize treatment and improve patient outcomes.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking the LOX-Related Autosomal Recessive Congenital Ichthyosis Skin Disease Using a CRISPR-Cas9 System and Unravelling 12S-LOX Function in the Skin. 使用CRISPR-Cas9系统模拟与lox相关的常染色体隐性先天性鱼鳞病皮肤病并揭示皮肤中的12S-LOX功能

IF 1.7

Dermatopathology Pub Date : 2025-09-11 DOI: 10.3390/dermatopathology12030030

Carolyne Simard-Bisson, Sébastien Larochelle, Véronique J Moulin, Bernard Fruteau de Laclos

{"title":"Mimicking the LOX-Related Autosomal Recessive Congenital Ichthyosis Skin Disease Using a CRISPR-Cas9 System and Unravelling 12S-LOX Function in the Skin.","authors":"Carolyne Simard-Bisson, Sébastien Larochelle, Véronique J Moulin, Bernard Fruteau de Laclos","doi":"10.3390/dermatopathology12030030","DOIUrl":"10.3390/dermatopathology12030030","url":null,"abstract":"Stratum Corneum (SC) formation in the human epidermis requires lipid processing. Lipoxygenases (LOXs) such as 12R-Lipoxygenase (12R-LOX) and Epidermis-type lipoxygenase 3 (eLOX-3) contribute to this process. Mutations in their genes cause Autosomal Recessive Congenital Ichthyosis (ARCI) in patients. On the other hand, 12S-lipoxygenase (12S-LOX) is expressed in the human epidermis, but its role still remains to be clarified. The involvement of eLOX-3, 12R, and 12S-LOX in conditions or processes such as skin photodamage, wound healing, psoriasis, and atopic dermatitis is suggested but still remains unclear. In order to eventually gain a better understanding of the role of these LOXs in such processes, models of Tissue-Engineered Skins (TESs) with an impaired expression for the native form of either eLOX-3, 12R-LOX, or 12S-LOX were produced using CRISPR-Cas9(D10A) technology. All three models showed impaired keratinocyte differentiation and changes in the prevalence or the size of lipid droplets within the most superficial layers, thus reproducing features observed in ARCI and supporting a role for 12S-LOX in SC formation. Since eLOX-3 and 12R-LOX depleted TES's reproduced features observed in ARCI, such models can be considered as reliable tools for the functional studies of these LOXs in the human epidermis.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Value of Immunohistochemical T-Cell Marker Loss in Early-Stage Mycosis Fungoides: A Single-Center Cohort Study. 免疫组织化学t细胞标志物缺失对早期蕈样真菌病的预后价值：一项单中心队列研究

IF 1.7

Dermatopathology Pub Date : 2025-09-10 DOI: 10.3390/dermatopathology12030029

Sandra Jerkovic Gulin, Ivana Ilic, Dario Gulin, Georgios Kravvas, Romana Ceovic

{"title":"Prognostic Value of Immunohistochemical T-Cell Marker Loss in Early-Stage Mycosis Fungoides: A Single-Center Cohort Study.","authors":"Sandra Jerkovic Gulin, Ivana Ilic, Dario Gulin, Georgios Kravvas, Romana Ceovic","doi":"10.3390/dermatopathology12030029","DOIUrl":"10.3390/dermatopathology12030029","url":null,"abstract":"Introduction: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma, often exhibiting loss of pan-T-cell markers such as CD2, CD3, CD5, and CD7. While these immunophenotypic alterations assist in diagnosis, their prognostic relevance in early-stage MF remains uncertain. This study aimed to determine whether immunohistochemical loss of T-cell markers CD2, CD3, CD5, and CD7 in patients with early-stage mycosis fungoides is associated with overall survival and progression-free survival.Methods: This retrospective included 83 patients with stage IA-IIA MF diagnosed between 2003 and 2012 at a single institution. Immunohistochemical staining of archived biopsy specimens was performed for CD2, CD3, CD5, and CD7. Loss of marker expression was defined as absence in ≥30% of lymphocytes. Clinical and histopathological data were correlated with survival and progression outcomes using Kaplan-Meier curves and log-rank tests.Results: Loss of at least one T-cell marker was identified in 66% of patients, most commonly CD7 (72%), followed by CD5 (11%) and CD2 (11%). No cases showed loss of CD3 expression. CD7 loss was significantly associated with shorter progression-free survival (p < 0.05), but not with overall survival. No significant associations were found between CD2 or CD5 loss and either survival or disease progression.Conclusions: CD7 loss was the only immunohistochemical abnormality significantly associated with earlier disease progression in early-stage MF, suggesting a potential prognostic role. In contrast, loss of CD2 and CD5 did not affect survival or progression, and CD3 was preserved in all cases. These findings highlight the value of incorporating CD7 status into prognostic assessment, although larger studies are needed to confirm its utility.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Presentation of Dermatofibroma with Ulcer: A Case Report. 罕见的皮肤纤维瘤合并溃疡1例报告。

IF 1.7

Dermatopathology Pub Date : 2025-09-04 DOI: 10.3390/dermatopathology12030028

Lamia Alakrash, Renad AlKanaan, Rema Aldihan, Alanoud Alsuhibani, Salman Almalki

{"title":"An Unusual Presentation of Dermatofibroma with Ulcer: A Case Report.","authors":"Lamia Alakrash, Renad AlKanaan, Rema Aldihan, Alanoud Alsuhibani, Salman Almalki","doi":"10.3390/dermatopathology12030028","DOIUrl":"10.3390/dermatopathology12030028","url":null,"abstract":"Dermatofibroma is a common mesenchymal skin lesion that typically presents as a firm, slow-growing nodule. Generally, such lesions are asymptomatic; however, they can also cause discomfort in some cases. Ulceration is an uncommon feature of dermatofibroma, and diagnosis in such cases is often difficult. We report a case of a 67-year-old female with multiple comorbidities, including pancreatic cancer undergoing neoadjuvant chemotherapy, who was admitted for acute pulmonary embolism. The patient presented with an incidental medial thigh lesion. The lesion was asymptomatic, ulcerated, and oozing pus one month before presentation. Clinical examination revealed a 3 × 2 cm deep ulcer with a punched-out edge, a dry yellow-white base, and a firm violaceous border. Histopathology confirmed dermatofibroma with epidermal hyperplasia, dermal spindle cell proliferation, histiocytes, and collagen trapping. Immunohistochemistry was positive for CD68, CD10, and Factor XIII. Due to the deteriorating condition of the patient, no intervention was provided to her, and she succumbed to her primary illness. This case is unique due to its atypical ulcerative presentation in a patient with complex systemic illness and emphasizes distinguishing between benign lesions and malignant mimics, especially in cases which have ambiguous clinical presentation.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Demiral et al. Comment on "Mahmood, M.N. Direct Immunofluorescence of Skin and Oral Mucosa: Guidelines for Selecting the Optimum Biopsy Site. Dermatopathology 2024, 11, 52-61". 回复Demiral等人对Mahmood， M.N.《皮肤和口腔黏膜的直接免疫荧光：选择最佳活检部位的指南》的评论。皮肤病理学杂志，2024,11,52-61”。

IF 1.7

Dermatopathology Pub Date : 2025-09-04 DOI: 10.3390/dermatopathology12030027

Muhammad N Mahmood

引用次数: 0

Comment on Mahmood, M.N. Direct Immunofluorescence of Skin and Oral Mucosa: Guidelines for Selecting the Optimum Biopsy Site. Dermatopathology 2024, 11, 52-61. 评论Mahmood， M.N.皮肤和口腔黏膜的直接免疫荧光：选择最佳活检部位的指南。皮肤病理学杂志，2014,11,52-61。

IF 1.7

Dermatopathology Pub Date : 2025-08-26 DOI: 10.3390/dermatopathology12030026

Şebnem Demiral, Yunus Özcan, Mehmet Gamsızkan

引用次数: 0

Immunohistochemical Characterisation of the Interstitial Inflammatory Environment: T-Cell- and B-Cell-Dominant Subtypes of Hidradenitis Suppurativa. 间质性炎症环境的免疫组织化学特征：化脓性汗腺炎的t细胞和b细胞显性亚型。

IF 1.7

Dermatopathology Pub Date : 2025-08-25 DOI: 10.3390/dermatopathology12030025

Nessr Abu Rached, Stefanie Bruckmüller, Martin Doerler, Hanna Telkemeyer, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Markus Stücker, Eggert Stockfleth, Falk G Bechara

{"title":"Immunohistochemical Characterisation of the Interstitial Inflammatory Environment: T-Cell- and B-Cell-Dominant Subtypes of Hidradenitis Suppurativa.","authors":"Nessr Abu Rached, Stefanie Bruckmüller, Martin Doerler, Hanna Telkemeyer, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Markus Stücker, Eggert Stockfleth, Falk G Bechara","doi":"10.3390/dermatopathology12030025","DOIUrl":"10.3390/dermatopathology12030025","url":null,"abstract":"Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a complex immune response. Given the considerable heterogeneity of the clinical phenotype of HS, this study aimed to analyse the immunohistochemical pattern of interstitial inflammation.Methods: Immunohistochemical analysis was performed on skin samples from 49 patients with HS. The immunohistochemical markers CD3, CD4 and CD8 for T-cells, CD20 for B-cells, CD138 for plasma cells and CD30, CD56, Bcl-2 and Bcl-6 were stained on lesional skin.Results: The analysis of immune cell dominance in patients with HS revealed that 33.3% of the cohort exhibited B-cell dominance, defined as a ratio of the sum of CD20+ and CD138+ cells to CD3+ cells greater than 1, while the majority (66.7%) demonstrated T-cell dominance, defined as a ratio of CD3+ cells to the sum of CD20+ and CD138+ cells greater than 1. B-cell-dominant HS is associated with a significantly elevated probability of mammary involvement (13.3% vs. 0%; p = 0.041). T-cell-dominant HS patients tended to demonstrate a higher mean tobacco consumption, but not significantly (20 vs. 5 tobacco pack-years; p = 0.06). CD4-dominant HS patients exhibited a significantly greater involvement of the mons pubis (62.5% vs. 28.6%, p = 0.023) compared to CD8-dominant patients, who demonstrated a significantly higher number of abscesses (p = 0.027).Conclusions: For the first time, we describe the clinical and immunohistochemical characteristics of T-cell- and B-cell-dominant HS. Although HS seems to be more dominated by T-cells, a B-cell dominance was found in 33% of cases.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilomatricoma in Syndromic Contexts: A Literature Review and a Report of a Case in Apert Syndrome. 综合征背景下的毛囊基质瘤：文献回顾和Apert综合征1例报告。

IF 1.7

Dermatopathology Pub Date : 2025-08-01 DOI: 10.3390/dermatopathology12030024

Gianmarco Saponaro, Elisa De Paolis, Mattia Todaro, Francesca Azzuni, Giulio Gasparini, Antonio Bosso, Giuliano Ascani, Angelo Minucci, Alessandro Moro

{"title":"Pilomatricoma in Syndromic Contexts: A Literature Review and a Report of a Case in Apert Syndrome.","authors":"Gianmarco Saponaro, Elisa De Paolis, Mattia Todaro, Francesca Azzuni, Giulio Gasparini, Antonio Bosso, Giuliano Ascani, Angelo Minucci, Alessandro Moro","doi":"10.3390/dermatopathology12030024","DOIUrl":"10.3390/dermatopathology12030024","url":null,"abstract":"Pilomatricomas are benign tumors originating from hair follicle matrix cells and represent the most common skin tumors in pediatric patients. Pilomatricomas may be associated with genetic syndromes such as myotonic dystrophy, familial adenomatous polyposis (FAP), Turner syndrome, Rubinstein-Taybi syndrome, Kabuki syndrome, and Sotos syndrome. This study reviews the literature on pilomatricomas occurring in syndromic contexts and presents a novel case linked to Apert syndrome. A systematic review was conducted using PubMed and Cochrane databases, focusing on case reports, case series, and reviews describing pilomatricomas associated with syndromes. A total of 1272 articles were initially screened; after removing duplicates and excluding articles without syndromic diagnoses or lacking sufficient data, 81 full-text articles were reviewed. Overall, 96 cases of pilomatricomas associated with genetic syndromes were identified. Reports of patients with Apert syndrome who do not develop pilomatricomas are absent in the literature. Pilomatricomas predominantly affect pediatric patients, with a slight female predominance, and are often the first manifestation of underlying genetic syndromes. Our study highlights previously unreported associations of pilomatricoma with Apert syndrome, providing molecular insights. This study contributes to understanding the clinical and molecular features of pilomatricomas in syndromic contexts and underscores the importance of genetic analysis for accurate diagnosis and management.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistopathological Analysis of Spongiosis Formation in Atopic Dermatitis Compared with Other Skin Diseases. 特应性皮炎与其他皮肤病海绵状病变的免疫组织病理学分析。

IF 1.7

Dermatopathology Pub Date : 2025-08-01 DOI: 10.3390/dermatopathology12030023

Ryoji Tanei, Yasuko Hasegawa

{"title":"Immunohistopathological Analysis of Spongiosis Formation in Atopic Dermatitis Compared with Other Skin Diseases.","authors":"Ryoji Tanei, Yasuko Hasegawa","doi":"10.3390/dermatopathology12030023","DOIUrl":"10.3390/dermatopathology12030023","url":null,"abstract":"Whether the spongiotic reaction caused by the interaction of keratinocytes, T-lymphocytes, inflammatory dendritic epidermal cells (IDECs), and Langerhans cells (LCs) observed in atopic dermatitis (AD) represents a common feature of spongiosis in various skin diseases remains unclear. We analyzed the characteristics of spongiosis in AD compared with those in other eczematous dermatitis and inflammatory skin diseases by using immunohistochemical methods. Infiltration of IDECs (CD11c+ cells and/or CD206+ cells) and T-lymphocytes, accompanied by degenerated keratinocytes and aggregated LCs (CD207+ cells), was frequently observed as a common feature of spongiosis in multiple conditions. However, IDECs expressing IgE were identified exclusively in IgE-mediated AD. Aggregation of IDECs was predominantly observed in the spongiosis of adaptive immune-mediated eczematous disorders, such as AD and allergic contact dermatitis. These IDEC aggregations constituted the major components of the epidermal dendritic cell clusters seen in AD and other eczematous or eczematoid dermatoses, and may serve as a useful distinguishing marker from Pautrier collections seen in cutaneous T-cell lymphoma. These findings suggest that IDECs, in cooperation with other immune cells, may play a pivotal role in spongiosis formation in AD and various skin diseases, although the underlying immunopathological mechanisms differ among these conditions.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0