Jason El Jalkh, Pia Maria Obeid, Dorra Guermazi, Aya Soubra, Elie Saliba
{"title":"Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge.","authors":"Jason El Jalkh, Pia Maria Obeid, Dorra Guermazi, Aya Soubra, Elie Saliba","doi":"10.3390/dermatopathology12020015","DOIUrl":null,"url":null,"abstract":"<p><p>A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and topical calcineurin inhibitor. Histopathologic examination showed a regular epidermis with increased melanophages in the papillary dermis, without vacuolar degeneration of the basement membrane. Verhoeff Van Gieson stain highlighted a band-like zone of attenuated elastic fibers in the papillary dermis, while Von Kossa stain was negative for calcified fibers. PAS staining was negative for fungal organisms and Alcian blue showed no increase in dermal mucin.</p>","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"12 2","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101269/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatopathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/dermatopathology12020015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and topical calcineurin inhibitor. Histopathologic examination showed a regular epidermis with increased melanophages in the papillary dermis, without vacuolar degeneration of the basement membrane. Verhoeff Van Gieson stain highlighted a band-like zone of attenuated elastic fibers in the papillary dermis, while Von Kossa stain was negative for calcified fibers. PAS staining was negative for fungal organisms and Alcian blue showed no increase in dermal mucin.
一位64岁的患者,在过去的两年里,因症状性皮肤色丘疹对称分布于颈部外侧,使用多种局部皮质类固醇、抗真菌药膏和局部钙调磷酸酶抑制剂均未能改善。组织病理学检查显示表皮规则,乳头状真皮中噬黑细胞增多,基底膜无空泡变性。Verhoeff Van Gieson染色显示乳突真皮内弹性纤维呈带状衰减,Von Kossa染色显示钙化纤维呈阴性。PAS染色未见真菌,阿利新蓝染色未见真皮粘蛋白增加。