Dermatopathology最新文献_第2页

Diagnosing Cutaneous Melanocytic Tumors in the Molecular Era: Updates and Review of Literature. 分子时代的皮肤黑色素细胞肿瘤诊断：最新进展和文献综述。

IF 1.6

Dermatopathology Pub Date : 2024-01-18 DOI: 10.3390/dermatopathology11010005

Chelsea Huang, Tiffany Wing-See Lau, Bruce R Smoller

引用次数: 0

Giant Folliculosebaceous Cystic Hamartoma of the Face 面部巨型毛囊囊性脂肪瘤

IF 1.9

Dermatopathology Pub Date : 2023-12-31 DOI: 10.3390/dermatopathology11010004

Ramona Tasar, Melanie Peckruhn, Jörg Tittelbach

{"title":"Giant Folliculosebaceous Cystic Hamartoma of the Face","authors":"Ramona Tasar, Melanie Peckruhn, Jörg Tittelbach","doi":"10.3390/dermatopathology11010004","DOIUrl":"https://doi.org/10.3390/dermatopathology11010004","url":null,"abstract":"Folliculosebaceous cystic hamartoma (FSCH) is a rare and benign form of cutaneous hamartomas. These skin lesions often lead to clinical and histopathological misdiagnosis due to their similarities to cutaneous lesions with overproduction of clustered sebaceous glands. Clinically, the lesions often present as solitary, skin-colored, pedunculated warts to cauliflower-like, exophytic papules and nodules, usually with a diameter ranging 0.5–1.5 cm that rarely exceed 2 cm in size. Only a small number of giant variants are reported in the literature with a diameter in the range of 5–23 cm. The vast majority of the lesions appear in the central face and show a striking predilection for the nose, ears, and scalp, but also emerge on the nipples, extremities, and genitals. Histologically, the epithelial components of folliculosebaceous cystic hamartoma comprise dilated infundibular cystic proliferation with surrounding mesenchymal components, which commonly include fibroplasia and vascular and adipose tissue proliferation. These histological characteristics were coined by Kimura and colleagues (1991). To the best of our knowledge, our case represents the biggest variant of giant folliculosebaceous cystic hamartoma.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"6 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139135862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus 一例多形性真皮肉瘤：内侧鱼尾纹巨型外生瘤

IF 1.9

Dermatopathology Pub Date : 2023-12-29 DOI: 10.3390/dermatopathology11010003

Rylee Moody, Kavita Darji, Tricia A Missall, Peter Chow, R. Behshad

{"title":"A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus","authors":"Rylee Moody, Kavita Darji, Tricia A Missall, Peter Chow, R. Behshad","doi":"10.3390/dermatopathology11010003","DOIUrl":"https://doi.org/10.3390/dermatopathology11010003","url":null,"abstract":"We present the case of a 99-year-old Caucasian female who was referred for treatment of a painless, 8.0 cm × 7.8 cm exophytic, pedunculated, ulcerated tumor of the left medial canthus. Pathology showed spindled, oval, and polygonal cells with pleomorphic nuclei. Many multinuclear giant cells and mitotic figures were also noted. The tumor was highlighted with CD10, showed focal positivity with actin, desmin, and CD68, and had increased Ki67 immunohistochemical staining. The tumor was negative for pancytokeratin, CK5/6, p63, MART-1/MelanA, S100, Sox10, p40, CD34, and CD23. Based on clinicopathologic correlation, the diagnosis of pleomorphic dermal sarcoma (PDS) was made. Pleomorphic dermal sarcoma (PDS) refers to a deep, histologically high-grade tumor that often resembles other tumors clinically and histologically. As PDS is frequently aggressive and related to adverse outcomes, it is important to recognize its distinguishing features in comparison to other similar entities, including atypical fibroxanthoma (AFX) and pleomorphic leiomyosarcoma (PLMS). To our knowledge, there is only one other reported case in the literature of PDS occurring on the eye. By reviewing and understanding characteristic etiologies, locations of presentation, histopathological features, and management techniques, pathologists can make a more accurate diagnosis and dermatologists can provide more effective patient care in a timely manner.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":" 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139142604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perforating Fibrous Histiocytoma Mimicking Keratoacanthoma: A Case Report 模仿角化棘皮瘤的穿孔性纤维组织细胞瘤：病例报告

IF 1.9

Dermatopathology Pub Date : 2023-12-25 DOI: 10.3390/dermatopathology11010002

Alina Lungu, Aurélie Hsieh, Gürkan Kaya, S. Menzinger

引用次数: 0

Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders 角质溶解症和自身免疫性红斑狼疮中 Claudin-4 的上调

IF 1.9

Dermatopathology Pub Date : 2023-12-21 DOI: 10.3390/dermatopathology11010001

Chau M. Bui, H. Vuong, Minh-Khang Le, Kristin J Rybski, Hatice B Zengin, Haiming Tang, Bruce R. Smoller

{"title":"Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders","authors":"Chau M. Bui, H. Vuong, Minh-Khang Le, Kristin J Rybski, Hatice B Zengin, Haiming Tang, Bruce R. Smoller","doi":"10.3390/dermatopathology11010001","DOIUrl":"https://doi.org/10.3390/dermatopathology11010001","url":null,"abstract":"Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of this study is to illustrate claudin-4 immunohistochemical staining patterns of different blistering disorders. We collected 35 cases, including two Hailey–Hailey disease, one Darier disease, three Grover disease, one acantholytic acanthoma, two warty dyskeratoma, 11 pemphigus vulgaris (PV) including six mucosal PV, and two pemphigus foliaceus. For comparison, we included five cases of normal skin, five eczema, and three bullous pemphigoid cases. Claudin-4 demonstrated weak-to-moderate expression in keratinocytes located in the stratum granulosum, keratinocytes surrounding hair follicles, and adnexal glands. Further, claudin-4 exhibited moderate-to-strong membranous staining in disrupted keratinocytes surrounding and within the acantholytic and bullous areas in 16/22 of the acantholytic cases (not seen in the six cases of mucosal PV) and all three bullous pemphigoids. This finding suggests that claudin-4 is upregulated in these conditions, which may be a compensatory response to the disrupted barrier function. This finding could shed light on the molecular mechanisms underlying disrupted barrier function in blistering disorders, independent of the specific underlying disease mechanism.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"136 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatomyositis with Eosinophils. 伴有嗜酸性粒细胞的皮肌炎

IF 1.9

Dermatopathology Pub Date : 2023-11-21 DOI: 10.3390/dermatopathology10040039

Isabella I Sanchez, Henry O Herrera, Ashley Elsensohn, Bonnie A Lee, Christina N Kraus

引用次数: 0

Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides. 与经典型蕈样肉芽肿相比，毛囊萎缩型蕈状肉芽肿与PD1染色减少有关。

IF 1.9

Dermatopathology Pub Date : 2023-10-23 DOI: 10.3390/dermatopathology10040038

Haiming Tang, Kristin J Rybski, Yi Luan, Bruce R Smoller

{"title":"Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides.","authors":"Haiming Tang, Kristin J Rybski, Yi Luan, Bruce R Smoller","doi":"10.3390/dermatopathology10040038","DOIUrl":"10.3390/dermatopathology10040038","url":null,"abstract":"Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and little attention has been given to PD-1 staining in different MF variants. To address this, we conducted a retrospective study, employing immunohistochemistry to examine PD-1 expression in cases of folliculotropic MF and non-folliculotropic MF. We analyzed 24 cases of folliculotropic MF and 18 cases of non-folliculotropic MF, and recorded both the percentage of PD-1-labeled tumor cells and the intensity score (negative, weak, medium, or strong). Our results revealed significant disparity in PD-1 labeling between patch/plaque MF and folliculotropic MF (p = 0.028). Non-folliculotropic MF exhibited higher PD-1 labeling in tumor cells (58.3%) compared to folliculotropic MF (40.2%). Notably, there was no significant difference in PD-1 staining between folliculotropic MF and non-folliculotropic MF when both were in the early stage/indolent disease category. However, when considering the tumor stage, folliculotropic MF exhibited PD-1 staining in tumor cells at a rate of 21.1%, while non-folliculotropic MF showed PD-1 staining in tumor cells at a rate of 46.6% (p = 0.005). Additionally, among folliculotropic MF cases, 13 out of 24 cases displayed differing PD-1 expression patterns between epidermal and dermal components, with preserved PD-1 staining in the epidermal component and loss of staining in the dermal component. Furthermore, consistent with the prior literature, tumor cells with large cell transformations exhibited significantly lower PD-1 labeling (p = 0.017). Our findings showcase the unique PD-1 staining patterns in MF.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"10 4","pages":"303-309"},"PeriodicalIF":1.9,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging. 凝结芽孢杆菌诱导肠道细菌、代谢产物和炎症分子之间的相互作用在改善自然皮肤衰老中的作用。

IF 1.9

Dermatopathology Pub Date : 2023-09-28 DOI: 10.3390/dermatopathology10040037

Keiichi Hiramoto, Sayaka Kubo, Keiko Tsuji, Daijiro Sugiyama, Yasutaka Iizuka, Hideo Hamano

{"title":"The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging.","authors":"Keiichi Hiramoto, Sayaka Kubo, Keiko Tsuji, Daijiro Sugiyama, Yasutaka Iizuka, Hideo Hamano","doi":"10.3390/dermatopathology10040037","DOIUrl":"10.3390/dermatopathology10040037","url":null,"abstract":"Background: Lactic acid bacteria consumption serves several health benefits to humans. However, their effect on natural skin aging is still unclear.Methods: This study examined the effects of skin naturalization (particularly skin drying) by administering a spore-bearing lactic acid bacteria (Bacillus coagulans) in mice for 2 years.Results: B. coagulans administration improved the natural skin of mice and significantly increased proportions of the genera Bacteroides and Muribaculum, among other intestinal bacteria. As metabolites, increases in nicotinic acid, putrescin, and pantothenic acid levels and a decrease in choline levels were observed. Increased hyaluronic acid, interleukin-10, and M2 macrophage levels indicate aging-related molecules in the skin. Intestinal permeability was also suppressed. Thus, these changes together improved natural skin aging.Conclusions: This study revealed that B. coagulans administration improved the natural skin aging in mice. This enhancement might be induced by the interaction of alterations in intestinal flora, metabolites, or inflammatory substances.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"10 4","pages":"287-302"},"PeriodicalIF":1.9,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatopathology 皮肤病理学

IF 1.9

Dermatopathology Pub Date : 2022-10-01 DOI: 10.1007/978-3-030-82820-2

Werner Kempf, Markus Hantschke, H. Kutzner

引用次数: 0

Drug-Induced vs. Viral Maculopapular Exanthem—Resolving the Dilemma 药物致黄斑丘疹vs.病毒性黄斑丘疹:解决困境

IF 1.9

Dermatopathology Pub Date : 2022-05-07 DOI: 10.3390/dermatopathology9020021

S. Khandpur, R. Ahuja

引用次数: 2