Dermatopathology最新文献_第3页

Scar Endometriosis: A Rare Cause of Abdominal Pain 瘢痕性子宫内膜异位症:一种罕见的腹痛原因

IF 1.9

Dermatopathology Pub Date : 2022-05-05 DOI: 10.3390/dermatopathology9020020

R. Nepali, S. Upadhyaya Kafle, T. Pradhan, Jibanath Dhamala

引用次数: 2

PRAME Expression as Helpful Immunohistochemical Marker in Rhabdoid Melanoma PRAME的表达作为有帮助的免疫组织化学标记物在横纹肌样黑色素瘤中的表达

IF 1.9

Dermatopathology Pub Date : 2022-05-02 DOI: 10.3390/dermatopathology9020019

V. Glutsch, M. Wobser, B. Schilling, A. Gesierich, M. Goebeler, H. Kneitz

{"title":"PRAME Expression as Helpful Immunohistochemical Marker in Rhabdoid Melanoma","authors":"V. Glutsch, M. Wobser, B. Schilling, A. Gesierich, M. Goebeler, H. Kneitz","doi":"10.3390/dermatopathology9020019","DOIUrl":"https://doi.org/10.3390/dermatopathology9020019","url":null,"abstract":"Background: Rhabdoid melanoma is a rare variant of malignant melanoma with characteristic cytomorphologic features. Due to the potential loss of conventional melanocytic markers, histopathologic diagnosis is often challenging. We hypothesize that immunostaining for PReferentially expressed Antigen in MElanoma (PRAME) might have the potential to uncover the melanocytic origin of these dedifferentiated tumors. Methods: Four cases of rhabdoid primary melanomas were assessed by immunohistochemistry for expression of PRAME and conventional melanocytic markers. Immunohistochemical expression patterns were analyzed in the rhabdoid primaries and, if available, associated metastases. Results: All four cases of rhabdoid primary melanomas showed a strong nuclear positivity for PRAME, while the expression of conventional melanocytic markers S100, MART-1, SOX-10 and HMB-45 was variable between the analyzed cases. Conclusions: In summary, we report four cases of rhabdoid primary melanoma with high to intermediate expression of PRAME despite the partial and variable loss of other melanocytic markers. Hence, PRAME might facilitate the recognition of this highly aggressive entity to avoid misdiagnosis due to histopathologic pitfalls.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"148 - 157"},"PeriodicalIF":1.9,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42188972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Primary Cutaneous Gamma-Delta T-Cell Lymphoma Initially Diagnosed as Subcutaneous Panniculitis-like T-Cell Lymphoma with Dermatomyositis 原发性皮肤γ - δ t细胞淋巴瘤最初诊断为皮下泛膜炎样t细胞淋巴瘤伴皮肌炎

IF 1.9

Dermatopathology Pub Date : 2022-04-29 DOI: 10.3390/dermatopathology9020018

Chika Hirata, K. Nakai, Yusuke Kurasawa, N. Maekawa, S. Kuniyuki, K. Yamagami, M. Ohsawa, D. Tsuruta

{"title":"Primary Cutaneous Gamma-Delta T-Cell Lymphoma Initially Diagnosed as Subcutaneous Panniculitis-like T-Cell Lymphoma with Dermatomyositis","authors":"Chika Hirata, K. Nakai, Yusuke Kurasawa, N. Maekawa, S. Kuniyuki, K. Yamagami, M. Ohsawa, D. Tsuruta","doi":"10.3390/dermatopathology9020018","DOIUrl":"https://doi.org/10.3390/dermatopathology9020018","url":null,"abstract":"Primary cutaneous gamma-delta T-cell lymphoma (CGD-TCL) is a rare cutaneous lymphoma. Panniculitis-like T-cell lymphoma (SPTCL) has a better prognosis than CGD-TCL. SPTCL is sometimes associated with autoimmune disease. A 64-year-old Japanese female with a history of dermatomyositis presented with subcutaneous nodules on the upper extremities and exacerbated dermatomyositis. A skin biopsy showed lobular panniculitis, a vacuolar interface change, and a dermal mucin deposit. Fat cells rimmed by neoplastic cells, fat necrosis, and karyorrhexis were observed. The atypical lymphoid cells showed CD3+, CD4−, CD8+, granzyme B+, CD20−, and CD56−. Polymerase chain reaction analysis demonstrated a T-cell receptor rearrangement. The patient was initially diagnosed with SPTCL, so the dose of prednisone was raised from 7.5 to 50 mg daily (1 mg/kg). After one month, erythematous nodules regressed, and muscle symptoms improved. Subsequently, prednisone was tapered, and cyclosporin A was added. After one year, the patient remained symptom-free and continued taking 7.5 mg prednisone and 100 mg cyclosporin A daily. Afterward, we immunostained skin samples with antibodies against TCR-ß and δ and found positive TCR-δ and negative TCR-ß. Therefore, we corrected the diagnosis to CGD-TCL, although the clinical course and the presence of dermatomyositis were reminiscent of SPTCL.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"143 - 147"},"PeriodicalIF":1.9,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47733979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conceptual Evolution and Current Approach to Spitz Tumors Spitz肿瘤的概念演变和目前的研究方法

IF 1.9

Dermatopathology Pub Date : 2022-04-26 DOI: 10.3390/dermatopathology9020017

C. Urso, V. de Giorgi, D. Massi

引用次数: 1

“Lichenoid Granulomatous Pattern” in a Case of Lupus Vulgaris 一例寻常型狼疮的“地衣样肉芽肿型”

IF 1.9

Dermatopathology Pub Date : 2022-04-20 DOI: 10.3390/dermatopathology9020016

C. Desai, Ismail Shaikh

引用次数: 0

Aggressive Cutaneous Squamous Cell Carcinomas Following Treatment for Graft-versus-Host Disease: A Case Report and Review of Risk Factors 移植物抗宿主病治疗后侵袭性皮肤鳞状细胞癌一例报告及危险因素回顾

IF 1.9

Dermatopathology Pub Date : 2022-03-31 DOI: 10.3390/dermatopathology9020015

Gehan A Pendlebury, M. Bongiorno, Jeffrey N. Lackey

{"title":"Aggressive Cutaneous Squamous Cell Carcinomas Following Treatment for Graft-versus-Host Disease: A Case Report and Review of Risk Factors","authors":"Gehan A Pendlebury, M. Bongiorno, Jeffrey N. Lackey","doi":"10.3390/dermatopathology9020015","DOIUrl":"https://doi.org/10.3390/dermatopathology9020015","url":null,"abstract":"A 19-year-old female with a history of pre-B cell acute lymphocytic leukemia (ALL) presented with two aggressive cutaneous squamous cell carcinomas (C-SCC) in the right hand. The patient was diagnosed with pre-B cell ALL at four years of age. She underwent chemotherapy with initial remission. However, recurrence of the pre-B cell ALL required an unrelated allogeneic cord hematopoietic stem cell transplant (alloHSCT). Post-transplant, the patient developed Graft-Versus-Host Disease (GVHD), which was treated with immunosuppressant therapy for six years until resolution. Fourteen years following the transplant, the patient developed a morbilliform drug eruption secondary to clindamycin. She consequently received prednisone treatment. During the treatment period, the patient developed a new ulcerated and tender nodule on the dorsal aspect of her right hand. Further histopathological biopsy confirmed the diagnosis of C-SCC, which required excision. Ten months following the excision, the patient developed an additional C-SCC nodule on the same right hand, separated by 2.6 cm from the prior C-SCC. She was referred for a ray resection procedure. This case illustrates a patient with multiple risk factors that may have contributed to the continued development of C-SCC. Such risk factors include: a prolonged course of immunosuppressant medications and voriconazole treatment. Additional research is needed to investigate the etiologies and risks of C-SCC development in patients who require a transplant and long-duration immunosuppressive therapy.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"0 - 0"},"PeriodicalIF":1.9,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49354860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Histopathologic Features of Maculopapular Drug Eruption 黄斑丘疹药疹的组织病理学特征

IF 1.9

Dermatopathology Pub Date : 2022-03-30 DOI: 10.3390/dermatopathology9020014

Madison Ernst, A. Giubellino

{"title":"Histopathologic Features of Maculopapular Drug Eruption","authors":"Madison Ernst, A. Giubellino","doi":"10.3390/dermatopathology9020014","DOIUrl":"https://doi.org/10.3390/dermatopathology9020014","url":null,"abstract":"Background: Cutaneous adverse drug reaction (CADR) is common in both inpatient and outpatient clinical settings and has been associated with a large variety of medications. Drug reactions represent a significant burden to the healthcare system due to increased hospital stay durations and associated costs. Moreover, some of these reactions may be life-threatening. The most common clinical manifestation of a CADR is a maculopapular drug eruption (MDE). Due to its many clinical mimics and associations with a variety of histopathologic patterns, maculopapular drug eruption is difficult to definitively diagnose from both a clinical and histopathological perspective. Summary: We reviewed the clinical and histopathologic features of 327 cases of MDE from several studies in the literature and summarized characteristic histopathologic findings and their frequencies of occurrence. We found that the most common and suggestive histopathologic features of MDE were epidermal spongiosis, lymphocytic infiltrate, and occasional necrotic keratinocytes; interface change at the DEJ; superficial perivascular and interstitial lymphocytic infiltrate with or without eosinophils and neutrophils in the mid-to-deep dermis and mild papillary dermal edema; and dilation of superficial vessels. The presence of multiple histopathologic patterns within the same tissue specimen is also suggestive of MDE. This review and analysis suggest that a biopsy may improve the diagnostic accuracy by both establishing common and uncommon features associated with MDE and reviewing features that help to exclude other causes of maculopapular eruption. Key Message: Histopathologic criteria for the diagnosis of MDE, while not entirely specific, may aid in establishing a differential that includes a drug eruption. Thus, a biopsy can be a helpful diagnostic tool when MDE is suspected by demonstrating findings suggestive of MDE or by ruling out clinical mimics. However, biopsy results cannot be used in isolation as clinical-pathologic correlation is paramount in MDE.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"111 - 121"},"PeriodicalIF":1.9,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43281679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature 气球细胞黑色素瘤4例报告并文献综述

IF 1.9

Dermatopathology Pub Date : 2022-03-28 DOI: 10.3390/dermatopathology9020013

Gerardo Cazzato, E. Cascardi, A. Colagrande, A. Cimmino, G. Ingravallo, L. Lospalluti, P. Romita, A. Demarco, F. Arezzo, V. Loizzi, M. Dellino, Irma Trilli, E. Bellitti, P. Parente, T. Lettini, C. Foti, G. Cormio, E. Maiorano, L. Resta

引用次数: 3

A Case of Adult-Onset Eccrine Angiomatous Hamartoma—The Comparison with Epithelioid Hemangioma 成人发病的胰腺血管瘤错构瘤1例与上皮样血管瘤的比较

IF 1.9

Dermatopathology Pub Date : 2022-03-25 DOI: 10.3390/dermatopathology9020012

Mai Nishimura, Y. Matsushima, Y. Nakai, K. Habe, A. Hayashi, K. Yamanaka

{"title":"A Case of Adult-Onset Eccrine Angiomatous Hamartoma—The Comparison with Epithelioid Hemangioma","authors":"Mai Nishimura, Y. Matsushima, Y. Nakai, K. Habe, A. Hayashi, K. Yamanaka","doi":"10.3390/dermatopathology9020012","DOIUrl":"https://doi.org/10.3390/dermatopathology9020012","url":null,"abstract":"Eccrine angiomatous hamartoma (EAH) is a relatively rare benign skin disease characterized by the proliferation of eccrine sweat glands associated with capillary hemangioma and the proliferation of other skin elements such as adipose tissue, hair, and epidermis. The onset of the disease is usually at birth or in childhood and tends to occur in the extremities of females, but it occurred in an adult male in this case. The patient was a 72-year-old man with a 12 × 12 mm light brown, elastic, slightly firm skin nodule on the flexor aspect of his right forearm. A biopsy revealed enlargement of blood vessels, sweat glands, sweat ducts, and erector spongiosum with both lumen dilation and narrowing, leading to the diagnosis of EAH. The histopathological features of EAH include a marked proliferation of microvessels, epithelial-like changes in vascular endothelial cells (such as enlarged nuclei), and infiltration of inflammatory cells, mainly lymphocytes and plasma cells. In adult-onset cases, EAH can be clinically difficult to distinguish from epithelioid hemangioma (EH), which differs in the predominance of microvascular proliferation and the presence of eosinophils in the infiltrating inflammatory cells. It can also be distinguished from EAH by the negative results of S100 and anti-EMA in immunohistological staining. In the current cases, we were able to differentiate the two cases from characteristic findings on HE staining.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"94 - 99"},"PeriodicalIF":1.9,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42811942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of Immunohistochemically Stained Cells in Skin Biopsies 皮肤活检中免疫组织化学染色细胞的定量

IF 1.9

Dermatopathology Pub Date : 2022-03-24 DOI: 10.3390/dermatopathology9020011

T. Emmanuel, M. Brent, L. Iversen, C. Johansen

{"title":"Quantification of Immunohistochemically Stained Cells in Skin Biopsies","authors":"T. Emmanuel, M. Brent, L. Iversen, C. Johansen","doi":"10.3390/dermatopathology9020011","DOIUrl":"https://doi.org/10.3390/dermatopathology9020011","url":null,"abstract":"Immunohistochemical quantification of inflammatory cells in skin biopsies is a valuable tool for diagnosing skin diseases and assessing treatment response. The quantification of individual cells in biopsies is time-consuming, tedious, and difficult. In this study, we presented and compared two methods for the quantification of CD8+ T cells in skin biopsies from patients with psoriasis using both commercial software (Adobe Photoshop) and open-source software (Qupath). In addition, we provided a detailed, step-by-step description of both methods. The methods are scalable by replacing the CD8 antibody with other antibodies to target different cells. Moreover, we investigated the correlation between quantifying CD8+ cells normalized to area or epidermal length and cell classifications, compared cell classifications in QuPath with threshold classifications in Photoshop, and analyzed the impact of data normalization to epidermal length or area on inflammatory cell densities in skin biopsies from patients with psoriasis. We found a satisfactory correlation between normalizing data to epidermal length and area for psoriasis skin. However, when non-lesional and lesional skin samples were compared, a significant underestimation of inflammatory cell density was found when data were normalized to area instead of epidermal length. Finally, Bland–Altman plots comparing Qupath and Photoshop to quantify inflammatory cell density demonstrated a good agreement between the two methods.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"82 - 93"},"PeriodicalIF":1.9,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41798437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0