Dermatopathology最新文献_第5页

Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders 角质溶解症和自身免疫性红斑狼疮中 Claudin-4 的上调

IF 1.9

Dermatopathology Pub Date : 2023-12-21 DOI: 10.3390/dermatopathology11010001

Chau M. Bui, H. Vuong, Minh-Khang Le, Kristin J Rybski, Hatice B Zengin, Haiming Tang, Bruce R. Smoller

{"title":"Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders","authors":"Chau M. Bui, H. Vuong, Minh-Khang Le, Kristin J Rybski, Hatice B Zengin, Haiming Tang, Bruce R. Smoller","doi":"10.3390/dermatopathology11010001","DOIUrl":"https://doi.org/10.3390/dermatopathology11010001","url":null,"abstract":"Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The aim of this study is to illustrate claudin-4 immunohistochemical staining patterns of different blistering disorders. We collected 35 cases, including two Hailey–Hailey disease, one Darier disease, three Grover disease, one acantholytic acanthoma, two warty dyskeratoma, 11 pemphigus vulgaris (PV) including six mucosal PV, and two pemphigus foliaceus. For comparison, we included five cases of normal skin, five eczema, and three bullous pemphigoid cases. Claudin-4 demonstrated weak-to-moderate expression in keratinocytes located in the stratum granulosum, keratinocytes surrounding hair follicles, and adnexal glands. Further, claudin-4 exhibited moderate-to-strong membranous staining in disrupted keratinocytes surrounding and within the acantholytic and bullous areas in 16/22 of the acantholytic cases (not seen in the six cases of mucosal PV) and all three bullous pemphigoids. This finding suggests that claudin-4 is upregulated in these conditions, which may be a compensatory response to the disrupted barrier function. This finding could shed light on the molecular mechanisms underlying disrupted barrier function in blistering disorders, independent of the specific underlying disease mechanism.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"136 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatomyositis with Eosinophils. 伴有嗜酸性粒细胞的皮肌炎

IF 1.9

Dermatopathology Pub Date : 2023-11-21 DOI: 10.3390/dermatopathology10040039

Isabella I Sanchez, Henry O Herrera, Ashley Elsensohn, Bonnie A Lee, Christina N Kraus

引用次数: 0

Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides. 与经典型蕈样肉芽肿相比，毛囊萎缩型蕈状肉芽肿与PD1染色减少有关。

IF 1.9

Dermatopathology Pub Date : 2023-10-23 DOI: 10.3390/dermatopathology10040038

Haiming Tang, Kristin J Rybski, Yi Luan, Bruce R Smoller

{"title":"Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides.","authors":"Haiming Tang, Kristin J Rybski, Yi Luan, Bruce R Smoller","doi":"10.3390/dermatopathology10040038","DOIUrl":"10.3390/dermatopathology10040038","url":null,"abstract":"Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and little attention has been given to PD-1 staining in different MF variants. To address this, we conducted a retrospective study, employing immunohistochemistry to examine PD-1 expression in cases of folliculotropic MF and non-folliculotropic MF. We analyzed 24 cases of folliculotropic MF and 18 cases of non-folliculotropic MF, and recorded both the percentage of PD-1-labeled tumor cells and the intensity score (negative, weak, medium, or strong). Our results revealed significant disparity in PD-1 labeling between patch/plaque MF and folliculotropic MF (p = 0.028). Non-folliculotropic MF exhibited higher PD-1 labeling in tumor cells (58.3%) compared to folliculotropic MF (40.2%). Notably, there was no significant difference in PD-1 staining between folliculotropic MF and non-folliculotropic MF when both were in the early stage/indolent disease category. However, when considering the tumor stage, folliculotropic MF exhibited PD-1 staining in tumor cells at a rate of 21.1%, while non-folliculotropic MF showed PD-1 staining in tumor cells at a rate of 46.6% (p = 0.005). Additionally, among folliculotropic MF cases, 13 out of 24 cases displayed differing PD-1 expression patterns between epidermal and dermal components, with preserved PD-1 staining in the epidermal component and loss of staining in the dermal component. Furthermore, consistent with the prior literature, tumor cells with large cell transformations exhibited significantly lower PD-1 labeling (p = 0.017). Our findings showcase the unique PD-1 staining patterns in MF.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"10 4","pages":"303-309"},"PeriodicalIF":1.9,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging. 凝结芽孢杆菌诱导肠道细菌、代谢产物和炎症分子之间的相互作用在改善自然皮肤衰老中的作用。

IF 1.9

Dermatopathology Pub Date : 2023-09-28 DOI: 10.3390/dermatopathology10040037

Keiichi Hiramoto, Sayaka Kubo, Keiko Tsuji, Daijiro Sugiyama, Yasutaka Iizuka, Hideo Hamano

{"title":"The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging.","authors":"Keiichi Hiramoto, Sayaka Kubo, Keiko Tsuji, Daijiro Sugiyama, Yasutaka Iizuka, Hideo Hamano","doi":"10.3390/dermatopathology10040037","DOIUrl":"10.3390/dermatopathology10040037","url":null,"abstract":"Background: Lactic acid bacteria consumption serves several health benefits to humans. However, their effect on natural skin aging is still unclear.Methods: This study examined the effects of skin naturalization (particularly skin drying) by administering a spore-bearing lactic acid bacteria (Bacillus coagulans) in mice for 2 years.Results: B. coagulans administration improved the natural skin of mice and significantly increased proportions of the genera Bacteroides and Muribaculum, among other intestinal bacteria. As metabolites, increases in nicotinic acid, putrescin, and pantothenic acid levels and a decrease in choline levels were observed. Increased hyaluronic acid, interleukin-10, and M2 macrophage levels indicate aging-related molecules in the skin. Intestinal permeability was also suppressed. Thus, these changes together improved natural skin aging.Conclusions: This study revealed that B. coagulans administration improved the natural skin aging in mice. This enhancement might be induced by the interaction of alterations in intestinal flora, metabolites, or inflammatory substances.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"10 4","pages":"287-302"},"PeriodicalIF":1.9,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear Cell Acanthoma with Malignant Cytologic Features: A Case Report and Review of the Literature. 具有恶性细胞学特征的透明细胞棘瘤1例报告及文献复习。

IF 1.9

Dermatopathology Pub Date : 2022-10-20 DOI: 10.3390/dermatopathology9040041

Gabriella Melson, Elie Saliba, Shreya Patel, Richard Eisen, Candice E Brem

引用次数: 1

Reactive Epidermal Hyperplasia and Angiogenesis of the Rear (REAR): A Proposed Unifying Name for Senile Gluteal Dermatosis and Prurigiform Angiomatosis. 后侧反应性表皮增生和血管生成:老年性臀皮肤病和瘙痒样血管瘤病的统一名称。

IF 1.9

Dermatopathology Pub Date : 2022-10-13 DOI: 10.3390/dermatopathology9040040

Michelle Weiting Liang, Joel H L Lim, Hui Yi Chia, Shang-Ian Tee, Joyce S S Lee

引用次数: 1

Dermatopathology 皮肤病理学

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Dermatopathology Pub Date : 2022-10-01 DOI: 10.1007/978-3-030-82820-2

Werner Kempf, Markus Hantschke, H. Kutzner

引用次数: 0

A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis. 一例罕见的模仿淋巴瘤/白血病皮肤的儿童成母浆细胞样树突状细胞肿瘤。

IF 1.9

Dermatopathology Pub Date : 2022-09-30 DOI: 10.3390/dermatopathology9040038

Phanitchanat Phusuphitchayanan, Voraphol Vejjabhinanta, Chayamon Takpradit, Poonnawis Sudtikoonaseth, Manasmon Chairatchaneeboon, Thamonpan Kiatvichukul, Sanya Sukpanichnant

{"title":"A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis.","authors":"Phanitchanat Phusuphitchayanan, Voraphol Vejjabhinanta, Chayamon Takpradit, Poonnawis Sudtikoonaseth, Manasmon Chairatchaneeboon, Thamonpan Kiatvichukul, Sanya Sukpanichnant","doi":"10.3390/dermatopathology9040038","DOIUrl":"https://doi.org/10.3390/dermatopathology9040038","url":null,"abstract":"Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient's excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":" ","pages":"321-326"},"PeriodicalIF":1.9,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40568287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cutaneous Involvement of Extranodal NK/T Cell Lymphoma, Nasal Type, a Clinical and Histopathological Mimicker of Various Skin Diseases. 结外NK/T细胞淋巴瘤的皮肤侵犯，鼻型，各种皮肤病的临床和组织病理学模拟者。

IF 1.9

Dermatopathology Pub Date : 2022-09-09 DOI: 10.3390/dermatopathology9030037

Preeyawat Ngamdamrongkiat, Sanya Sukpanichnant, Manasmon Chairatchaneeboon, Archrob Khuhapinant, Panitta Sitthinamsuwan

{"title":"Cutaneous Involvement of Extranodal NK/T Cell Lymphoma, Nasal Type, a Clinical and Histopathological Mimicker of Various Skin Diseases.","authors":"Preeyawat Ngamdamrongkiat, Sanya Sukpanichnant, Manasmon Chairatchaneeboon, Archrob Khuhapinant, Panitta Sitthinamsuwan","doi":"10.3390/dermatopathology9030037","DOIUrl":"https://doi.org/10.3390/dermatopathology9030037","url":null,"abstract":"Background: Extranodal NK/T cell lymphoma, nasal type (ENK/T) with cutaneous involvement has various histopathological findings and diverse clinical manifestations.Methods: A retrospective study of cutaneous involvement of ENK/T lymphoma between 2006 and 2018 was conducted.Results: Twenty-two cases were eligible for this study. Twelve cases could be proven as secondary cutaneous involvement by ENK/T lymphoma, while the remaining could not be confirmed as primary cutaneous ENK/T lymphoma. The histopathological patterns included dermal and subcutaneous nodular infiltration pattern in 11/22 cases (50%), lobular panniculitis pattern in 6/22 cases (27.3%), interface dermatitis pattern in 4/22 cases (18.2%), and granulomatous dermatitis pattern in 1/22 case (4.5%). The median follow-up was 18.3 months. Overall, the one-year and five-year survival rates were 31.3% and 13.3%, respectively.Conclusions: A variety of histopathological patterns of cutaneous involvement by ENK/T lymphoma should be differentiated from other cutaneous lymphomas, dermatitis, and infection. When atypical medium or large-sized lymphoid cells are encountered within skin lesions, pathologists should realize these lesions can be ENK/T lymphoma, especially in cases with coexisting tumor necrosis or angioinvasion. A complete evaluation of the upper aerodigestive tract is mandatory to identify the occult primary site of ENK/T lymphoma before establishing primary cutaneous ENK/T lymphoma.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":" ","pages":"307-320"},"PeriodicalIF":1.9,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33469847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In Memoriam-Martin C. Mihm, Jr. 纪念马丁·c·米姆

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Dermatopathology Pub Date : 2022-09-08 DOI: 10.3390/dermatopathology9030036

Thomas Kupper, Adriano Piris, Daniela Kroshinsky, Gürkan Kaya

引用次数: 0