Journal of Feline Medicine and Surgery Open Reports最新文献

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Ventral fixation and dorsal decompression of a complex occipitoatlantoaxial malformation using a custom-made plate in a cat. 使用特制钢板对猫复杂枕寰枢畸形进行腹侧固定和背侧减压。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251328579
Carmen Aires Serrano, Alba Farré Mariné, Alejandro Luján Feliu-Pascual
{"title":"Ventral fixation and dorsal decompression of a complex occipitoatlantoaxial malformation using a custom-made plate in a cat.","authors":"Carmen Aires Serrano, Alba Farré Mariné, Alejandro Luján Feliu-Pascual","doi":"10.1177/20551169251328579","DOIUrl":"https://doi.org/10.1177/20551169251328579","url":null,"abstract":"<p><strong>Case summary: </strong>The cat described in this case report presented with progressive non-ambulatory tetraparesis. It was diagnosed with an occipitoatlantoaxial malformation (OAAM), which resulted in severe compressive myelopathy. This condition was caused by a flattening of the occipital condyles and shortening of the vertebral body of the axis. In addition, there was dysplasia in the atlantoaxial joint, which was observed on CT. The cat was treated surgically using a plate, which was custom-made with the help of a three-dimensional model of the malformation. Three weeks after surgery, the cat was able to walk without assistance; 5 years after surgery, the cat showed a normal neurological examination.</p><p><strong>Relevance and novel information: </strong>Surgical planning using three-dimensional technology was useful in a complex case of OAAM. This is the first documented feline case that uses this type of technology for this condition.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251328579"},"PeriodicalIF":0.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute non-traumatic abdominal pseudoherniation in a geriatric cat. 老年猫急性非创伤性腹部假性疝。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251332826
Lauren Stack, QiCai Jason Hoon
{"title":"Acute non-traumatic abdominal pseudoherniation in a geriatric cat.","authors":"Lauren Stack, QiCai Jason Hoon","doi":"10.1177/20551169251332826","DOIUrl":"https://doi.org/10.1177/20551169251332826","url":null,"abstract":"<p><strong>Case summary: </strong>A 16-year-old female spayed domestic shorthair cat presented with an acute mass-like outpouching of abdominal viscera unilaterally in the right caudal abdominal ventrum without history of trauma. This abnormality was not identified on prior diagnostic investigations for hyporexia up to 3 weeks prior. A CT examination revealed a protrusion of the viscus through an area of anomalous abdominal wall thinning associated with the discontinuation of the transverse abdominis muscle in this region, rather than a true hernia. Exploratory celiotomy confirmed these findings, with the external rectus sheath and parietal peritoneum remaining intact without an overt hernia ring identified. Abdominal wall augmentation and reconstruction using internal abdominal oblique advancement and fold-over external rectus sheath imbrication resulted in complete resolution without recurrence on subsequent follow-ups. Despite gastrointestinal and muscle biopsies showing no evidence of neoplasia on histopathology, the patient developed an abdominal effusion and was diagnosed with granular lymphocyte lymphoma 4 weeks postoperatively, leading to euthanasia.</p><p><strong>Relevance and novel information: </strong>This case describes a non-traumatic abdominal wall pseudohernia in a geriatric cat, a condition which has not previously been reported. A novel reconstruction technique was used to correct the body wall anomaly, with a good short-term outcome without recurrence.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251332826"},"PeriodicalIF":0.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glomus tumour of the abdominal wall in a cat. 猫腹壁球囊瘤。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251332395
Lisa Castellano, Debra Fews
{"title":"Glomus tumour of the abdominal wall in a cat.","authors":"Lisa Castellano, Debra Fews","doi":"10.1177/20551169251332395","DOIUrl":"https://doi.org/10.1177/20551169251332395","url":null,"abstract":"<p><p>Case summaryA 4-year-old male castrated domestic shorthair cat presented with a 2 cm painful cutaneous mass on its right lateral abdominal wall. The cat inflicted self-trauma to the lesion site causing secondary ulceration and mild haemorrhage. Fine-needle aspiration or incisional biopsy was advised, along with diagnostic imaging; however, excisional biopsy was preferred by the owners. The mass was surgically removed with 1 cm lateral margins and a deep fascial plane. The histopathological features were most consistent with a diagnosis of a glomus tumour; the diagnosis was supported by subsequent immunohistochemistry. The tumour was completely removed and there were no signs of recurrence at the 6-month follow-up. In this case, surgery is expected to be curative. <i>Relevance and novel information</i> To the authors' knowledge, this is the first report of a glomus tumour of the body wall in a cat and its association with pain and self-trauma. This report aims to add more data to the diagnosis and presentation of glomus tumours in animals.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251332395"},"PeriodicalIF":0.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of splenic perforation during percutaneous endoscopic gastrostomy tube placement in a cat via laparoscopic partial splenectomy. 经皮内镜胃造口管置入猫经腹腔镜部分脾切除术过程中脾脏穿孔的成功处理。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-26 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251328957
Jaehan Jun, Eunjung Park, Dongmin Sihn, Joohyun Jung
{"title":"Successful management of splenic perforation during percutaneous endoscopic gastrostomy tube placement in a cat via laparoscopic partial splenectomy.","authors":"Jaehan Jun, Eunjung Park, Dongmin Sihn, Joohyun Jung","doi":"10.1177/20551169251328957","DOIUrl":"https://doi.org/10.1177/20551169251328957","url":null,"abstract":"<p><strong>Case summary: </strong>A 12-year-old spayed female domestic shorthair cat with a weight of 4.5 kg and a body condition score of 3/9 presented with anorexia and vomiting. Feline hepatic lipidosis was diagnosed based on blood tests and ultrasound examination. Naso-oesophageal tube feeding was initiated, but hypersalivation persisted despite supportive care. As a result of poor feeding tolerance, a percutaneous endoscopic gastrostomy (PEG) tube was placed for long-term enteral nutrition, with endoscopic confirmation of gastric placement. Two hours after the procedure, blood staining on the PEG tube bandage suggested bleeding at the insertion site. Abdominal ultrasonography and CT revealed splenic perforation. A laparoscopic partial splenectomy was performed successfully and the cat recovered without complications. Follow-up laboratory tests demonstrated a gradual improvement in haematological parameters, including haematocrit and total bilirubin. The cat remained clinically stable without further complications.</p><p><strong>Relevance and novel information: </strong>This report details the first documented case of splenic perforation during PEG tube placement in a cat, successfully managed through laparoscopic partial splenectomy. Minimally invasive laparoscopy has demonstrated efficacy in addressing rare complications, including splenic perforation associated with PEG tube placement in cats.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251328957"},"PeriodicalIF":0.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenteric lymphatic malformation with chylothorax in a cat. 猫肠系膜淋巴畸形伴乳糜胸。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-19 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251327400
Claudia Wy Leung, Krysten Lee, Erin Mooney, Jia Wen Siow, Shannon L Donahoe
{"title":"Mesenteric lymphatic malformation with chylothorax in a cat.","authors":"Claudia Wy Leung, Krysten Lee, Erin Mooney, Jia Wen Siow, Shannon L Donahoe","doi":"10.1177/20551169251327400","DOIUrl":"https://doi.org/10.1177/20551169251327400","url":null,"abstract":"<p><strong>Case summary: </strong>An 8-year-old female spayed Russian Blue cat presented for acute progressive dyspnoea. The patient had pleural effusion and was diagnosed with chylothorax. A multiphase contrast-enhanced CT scan of thoracic and abdominal cavities was performed to facilitate diagnosis and surgical planning. Incidentally, a large lobulated, elongated, cystic and encapsulated peritoneal mass was found. Contrast pooled within the peritoneal mass during lymphography, suggesting lymphatic origin. The patient was eventually euthanased as a result of recurrence of chylothorax. Necropsy revealed multiple irregular, thin-walled pockets of chylous fluid pooling within the mesentery. Histopathology of the affected mesentery was compatible with a diagnosis of lymphatic malformation.</p><p><strong>Relevance and novel information: </strong>To the authors' knowledge, this is the first case describing a feline presentation of mesenteric lymphatic malformation. This is also the first case reporting the presentation of chylothorax for a veterinary patient with mesenteric lymphatic malformation.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251327400"},"PeriodicalIF":0.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic features and clinical outcome in a cat with nodal T-zone lymphoma. 猫淋巴结t区淋巴瘤的临床病理特征和临床转归。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251329189
Amanda K Midkiff, Matthew R Cook, William Vernau, Brian D Husbands
{"title":"Clinicopathologic features and clinical outcome in a cat with nodal T-zone lymphoma.","authors":"Amanda K Midkiff, Matthew R Cook, William Vernau, Brian D Husbands","doi":"10.1177/20551169251329189","DOIUrl":"https://doi.org/10.1177/20551169251329189","url":null,"abstract":"<p><strong>Case summary: </strong>An 11-year-old male castrated domestic shorthair cat presented with increased respiratory effort, pleural effusion, lymphadenopathy, lethargy and decreased appetite with weight loss. A diagnosis of T-zone lymphoma was made from histopathology of an extirpated popliteal lymph node that had a marked paracortical expansion of small lymphocytes and prominent high endothelial venule proliferation. T-cell receptor gamma (TRG) molecular clonality PCR yielded a clonal rearrangement and immunohistochemistry demonstrated that the neoplastic lymphocytes expressed CD3 and did not express CD20. The cat was initially treated with two doses of intravenous vincristine and oral prednisolone followed by oral chlorambucil. The pleural effusion, lymphadenopathy, lymphocytosis, abdominal organomegaly and lethargy resolved, and the cat's appetite and body weight returned to normal. At the time of manuscript submission, the cat continued to do well, more than 24 months after presentation.</p><p><strong>Relevance and novel information: </strong>T-zone lymphoma is a common indolent lymphoma in dogs, but it has only been histopathologically described in one cat before this report. This is the first report to describe the clinical presentation, clinicopathologic findings and outcome for a cat with T-zone lymphoma.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251329189"},"PeriodicalIF":0.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral haematomas as the major presenting sign of primary immune thrombocytopenia in a cat. 口腔血肿是猫原发性免疫性血小板减少症的主要表现。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251326784
Lidia Cammack, Annabel Sutch, Yan Ru Choi, Vanessa R Barrs, Julia A Beatty
{"title":"Oral haematomas as the major presenting sign of primary immune thrombocytopenia in a cat.","authors":"Lidia Cammack, Annabel Sutch, Yan Ru Choi, Vanessa R Barrs, Julia A Beatty","doi":"10.1177/20551169251326784","DOIUrl":"https://doi.org/10.1177/20551169251326784","url":null,"abstract":"<p><strong>Case summary: </strong>An unowned, entire male domestic shorthair cat was surrendered to a rescue centre. On physical examination, poor body condition (score 3/9) and pigmented mass lesions on the lateral aspects of the upper gingivae were noted. The oral lesions were identified as haematomas only after examination under sedation. A diagnosis of probable primary immune thrombocytopenia (pITP) was made based on profound thrombocytopenia, rapid response to glucocorticoid therapy and the absence of identified triggers for secondary immune thrombocytopenia. The patient was treated with glucocorticoids and remained in remission 18 months from diagnosis.</p><p><strong>Relevance and novel information: </strong>pITP is infrequently reported in cats and oral haematomas have not previously been documented as a presenting clinical sign. This case report serves to raise awareness of feline ITP and highlights the availability of evidence-based diagnostic and therapeutic guidelines that were published after the case was treated. While pITP can be refractory to treatment and can be associated with treatment-related morbidity, this case report demonstrates that an acceptable outcome can be achieved, albeit with a requirement for long-term treatment and regular monitoring.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251326784"},"PeriodicalIF":0.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyalinizing pancreatic adenocarcinoma in a cat. 猫的透明化胰腺腺癌。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251325333
Taylor C Chan, Elisa Heacock, Ashleigh Cournoyer, Koranda Walsh, Amy C Durham
{"title":"Hyalinizing pancreatic adenocarcinoma in a cat.","authors":"Taylor C Chan, Elisa Heacock, Ashleigh Cournoyer, Koranda Walsh, Amy C Durham","doi":"10.1177/20551169251325333","DOIUrl":"https://doi.org/10.1177/20551169251325333","url":null,"abstract":"<p><strong>Case summary: </strong>A 6-year-old female spayed domestic shorthair cat was presented for abdominal distension and weight loss. Abdominal radiographs and ultrasound revealed two cranial abdominal masses and another mass adjacent to the jejunum. Cytologic features of the cranial abdominal masses were consistent with exocrine pancreatic tissue. Four months later, a repeat abdominal ultrasound revealed progressive enlargement of the abdominal masses and medial iliac lymphadenopathy. On exploratory laparotomy, two abdominal masses were associated with the pancreas and incorporated large blood vessels supplying the liver, pancreas and spleen. The masses were non-resectable and incisional biopsies were obtained. The histologic features were diagnostic for a hyalinizing subtype of exocrine pancreatic adenocarcinoma. Chemotherapy was not pursued. Over 28 months after the initial detection of abdominal masses, the cat was still alive and reportedly doing well.</p><p><strong>Relevance and novel information: </strong>To the authors' knowledge, this is the first report of a hyalinizing subtype of pancreatic adenocarcinoma in a cat. This subtype is considered to behave less aggressively in dogs, and this case may support that a similar, more indolent behavior may be seen in cats.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251325333"},"PeriodicalIF":0.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a pleural access port in the staged management of idiopathic chylothorax in a cat. 胸膜通道在猫特发性乳糜胸分期治疗中的应用。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-12 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251326747
Kaitlin N Bahlmann, Bryden J Stanley
{"title":"Use of a pleural access port in the staged management of idiopathic chylothorax in a cat.","authors":"Kaitlin N Bahlmann, Bryden J Stanley","doi":"10.1177/20551169251326747","DOIUrl":"https://doi.org/10.1177/20551169251326747","url":null,"abstract":"<p><strong>Case summary: </strong>A 4-year-old male castrated domestic shorthair cat presented with a 3-month history of coughing and progressive dyspnea. The cat was diagnosed with idiopathic chylothorax after serum biochemistry, thoracocentesis, cytology of pleural effusion, echocardiography and thoracic imaging were performed. After failure to respond to medical management with repeated thoracocenteses, the oral administration of rutin and a low-fat diet, the cat underwent staged interventions consisting of CT lymphangiogram, subtotal pericardiectomy and pleural access port (PAP) placement, followed by thoracic duct ligation (TDL) and cisterna chyli ablation (CCA) 2 months later. The cat made a clinical recovery based on resolution of chylous pleural effusion 1 month after TDL and CCA, and the PAP was removed 1 month later. The cat remained free of clinical signs 3 years postoperatively.</p><p><strong>Relevance and novel information: </strong>This is the first report documenting the use of a PAP for the management of feline chylothorax to disease resolution. Employing this device enabled frequent, low morbidity drainage of the pleural effusion as an alternative to repeated thoracocenteses and facilitated staging the interventions throughout management of idiopathic chylothorax in a cat. PAPs can be used successfully in the management of chylous pleural effusion in cats.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251326747"},"PeriodicalIF":0.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of pemphigus foliaceus with mycophenolate mofetil as a steroid-sparing agent in a cat with corticosteroid-associated congestive heart failure. 用霉酚酸酯作为类固醇保留剂成功治疗伴有皮质类固醇相关充血性心力衰竭的猫的叶状天疱疮。
IF 0.7
Journal of Feline Medicine and Surgery Open Reports Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.1177/20551169251321376
Giulia Striuli, Sophie Vandenabeele, Margot Gheeraert, Pascale Smets
{"title":"Successful management of pemphigus foliaceus with mycophenolate mofetil as a steroid-sparing agent in a cat with corticosteroid-associated congestive heart failure.","authors":"Giulia Striuli, Sophie Vandenabeele, Margot Gheeraert, Pascale Smets","doi":"10.1177/20551169251321376","DOIUrl":"10.1177/20551169251321376","url":null,"abstract":"<p><strong>Case summary: </strong>A 5-year-old British Shorthair cat was diagnosed with pemphigus foliaceus (PF) and was initially treated with methylprednisolone (0.7 mg/kg q12h), which possibly resulted in congestive heart failure (CHF). Treatment was switched to dexamethasone (0.09 mg/kg q24h) and mycophenolate mofetil (MMF) (10 mg/kg q12h) was added as a steroid-sparing agent. Although dexamethasone was slowly tapered off, MMF alone successfully maintained PF in remission. After 15 weeks of treatment, blood tests showed neutropenia and thrombocytopaenia. MMF dose reduction (10 mg/kg q24h) resulted in the normalisation of haematological parameters, although a mild flare of PF occurred. The reintroduction of dexamethasone (0.09 mg/kg twice weekly) rapidly restored disease control. MMF (10 mg/kg q24h) and dexamethasone (0.045 mg/kg twice weekly) were continued as maintenance therapy. After 36 weeks, the cat remained in clinical remission without further complications.</p><p><strong>Relevance and novel information: </strong>To the best of the authors' knowledge, this is the first case report to describe the use of MMF in a cat with PF. MMF was well tolerated and it was able to manage clinical signs even after the discontinuation of corticosteroids. Since mild and reversible haematological abnormalities were observed, careful monitoring during MMF administration is recommended. In this case, MMF dose reductions led to flares requiring a temporary reintroduction of corticosteroids to maintain disease control. MMF could be useful as an alternative treatment in cats affected by comorbidities where corticosteroid monotherapy would pose risks.</p>","PeriodicalId":36588,"journal":{"name":"Journal of Feline Medicine and Surgery Open Reports","volume":"11 1","pages":"20551169251321376"},"PeriodicalIF":0.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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