Nutrition Research and Practice最新文献

{"title":"Trends in cross-border shopping for dietary supplements in South Korea with a focus on major types of health functional foods.","authors":"Youngmin Nam, Linxi Huang, Jong-Youn Rha, Bongwon Suh, Jihyun Yoon","doi":"10.4162/nrp.2025.19.2.241","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.241","url":null,"abstract":"<p><strong>Background/objectives: </strong>Dietary supplements are popular among Korean consumers in the cross-border market. This study examined the cross-border shopping trends of dietary supplements in Korea, focusing on the major health functional foods.</p><p><strong>Materials/methods: </strong>This study analyzed the customs clearance data provided by the Korea Customs Service, spanning 2019-2021. The term 'health functional foods,' which are manufactured with functional ingredients specified by law, was distinguished from the broader concept of 'dietary supplements.' The trends in dietary supplements and the major types of health functional foods in cross-border shopping were analyzed. The top 10 most purchased health functional foods were identified and analyzed by consumer gender and age group.</p><p><strong>Results: </strong>Dietary supplements constituted 19.1% of all cross-border items, with the primary consumers being women aged 30 and 40 yrs. The most popular type of health functional foods was the 'multi-nutrient product,' comprising 14.5% of all health functional food items. 'Protein' was popular among men and younger age groups, while 'probiotics' was favored by women. In particular, 32.3% of health functional food items were related to blood health.</p><p><strong>Conclusion: </strong>The cross-border market for dietary supplements in Korea is experiencing growth, with consumer preferences varying by gender and age. These findings can assist in the development of regulatory policies that align with market trends and consumer needs in cross-border shopping for dietary supplements.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"241-256"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nutrition class with cooking lab on college students' eating behaviors and well-being in the United States: a mixed-methods study.","authors":"Borham Yoon, Kyungyul Jun","doi":"10.4162/nrp.2025.19.2.305","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.305","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aimed to investigate the effects of college-level nutrition and culinary education on cooking and eating behaviors, as well as psychosocial well-being among students in the United States.</p><p><strong>Subjects/methods: </strong>The study examined changes in cooking attitude, confidence, skills, cooking frequency, and the intake of fruits, vegetables, and whole grains among 73 college students at a university in the southeastern United States over 4 consecutive semesters, from Fall 2018 to Spring 2020. A mixed-methods research design was used to obtain both qualitative and quantitative data. Qualitative data analysis was conducted to explore additional life and psychosocial benefits beyond cooking.</p><p><strong>Results: </strong>Significant improvements were observed in participants' cooking attitudes, confidence, and skills following the education intervention (<i>P</i> < 0.001). Cooking attitude scores increased from 3.89 to 4.29, while cooking confidence rose from 2.89 to 3.99. Participants also reported higher cooking frequency, along with increased fruit and vegetable consumption (2.68 to 3.77 and 2.74 to 3.8, <i>P</i> < 0.001), though there was no significant change in whole grains intake. Qualitative analysis revealed 4 major themes-teamwork, time management, self-esteem, and financial literacy-highlighting the perceived life and psychological benefits of the course.</p><p><strong>Conclusion: </strong>Integrating cooking labs into college nutrition courses effectively enhances cooking skills, promotes healthful eating behaviors, and contributes to broader psychosocial well-being among students. These improvements were attributed to hands-on lab activities and collaborative learning environments, fostering self-efficacy and life skills.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"305-317"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary patterns and lower urinary tract symptoms (LUTS) in Korean adults.","authors":"Jung-Sun Lim, Wonkyung Hwang, Jung Kwon Kim, Minhyun Kim, Oran Kwon, Sujeong Han, Bumjo Oh, Jong Seung Kim","doi":"10.4162/nrp.2025.19.2.318","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.318","url":null,"abstract":"<p><strong>Background/objectives: </strong>Dietary factors act on lower urinary tract symptoms (LUTS). This study examined the relationship between the overall diet quality and LUTS.</p><p><strong>Subjects/methods: </strong>This study analyzed the data from examinees who visited a general hospital in Korea (October 13, 2014-March 12, 2020). The number of subjects in the study was 6,506 adult men. The recommended food score was used to evaluate the overall quality of the diet, and the International Prostate Symptom Score was used to quantify LUTS. Logistic regression analysis was used to derive the odds ratio (OR) and 95% confidence interval (CI) to evaluate the relationship between the dietary quality and LUTS. The influence of age, education, marital history, income, occupation, smoking, drinking, exercise, metabolic syndrome, body mass index (BMI), and prostate-specific antigen (PSA) level was analyzed to determine the net influence of the overall diet quality on LUTS.</p><p><strong>Results: </strong>The group with high overall dietary quality showed a lower incidence of LUTS than the group with relatively lower dietary quality (OR, 0.88; 95% CI, 0.79-0.99). These results were also observed after correcting for other risk factors and associated variables: age, education, smoking, metabolic syndrome, BMI, and PSA level.</p><p><strong>Conclusion: </strong>The overall diet quality and LUTS were correlated. Nevertheless, further research will be needed to find the relationship between diet quality and LUTS.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"318-327"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of <i>Zanthoxylum schinifolium</i> leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway.","authors":"Cheol Park, Eun Ok Choi, Hyun Hwangbo, Hyesook Lee, Jin-Woo Jeong, Min Ho Han, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Gi-Young Kim, Hye-Jin Hwang, Yung Hyun Choi","doi":"10.4162/nrp.2025.19.2.328","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.328","url":null,"abstract":"<p><p>[This corrects the article on p. 330 in vol. 16, PMID: 35663445.].</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"328-330"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effects of rutin in lipopolysaccharide-stimulated canine macrophage cells.","authors":"Hyunsoo Jang, Su-Cheol Han, Jisu Lee, Ha-Young Shin, Jeong Ho Hwang, Jung-Heun Ha","doi":"10.4162/nrp.2025.19.1.143","DOIUrl":"10.4162/nrp.2025.19.1.143","url":null,"abstract":"<p><strong>Background/objectives: </strong>Inflammatory responses are key pathological factors in various canine diseases, making the control of inflammatory responses vital for canine health. This study examined the anti-inflammatory effects of rutin on DH82 cells, a type of canine macrophage, against lipopolysaccharide (LPS)-induced inflammatory responses.</p><p><strong>Materials/methods: </strong>The inflammatory <i>in vitro</i> experimental model was established by stimulating canine macrophage DH82 cells with LPS. To evaluate the inflammation-preventative effects of rutin, analyses were conducted using enzyme-linked immunosorbent assay, western blot, and real-time quantitative reverse transcription polymerase chain reaction.</p><p><strong>Results: </strong>Rutin inhibited the LPS-induced increase in the protein and gene levels of pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor-α), while anti-inflammatory cytokines (IL-10, transforming growth factor-β1) levels remained unchanged. Furthermore, rutin suppressed the LPS-induced activation of phosphorylated extracellular signal-regulated kinase, Jun N-terminal kinase, inhibitor of nuclear factor kappa B, and nuclear factor kappa B (NF-κB) in DH82 cells.</p><p><strong>Conclusion: </strong>Rutin exerts anti-inflammatory effects by inhibiting the mitogen-activated protein kinase-NF-κB signaling pathway and reducing the production of pro-inflammatory cytokines in DH82 cells.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 1","pages":"143-153"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Orostachys japonicus</i> induce caspase-dependent apoptosis in HeLa human cervical cancer cells.","authors":"Seon-Hee Kim, Dong Seok Lee","doi":"10.4162/nrp.2025.19.1.131","DOIUrl":"10.4162/nrp.2025.19.1.131","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>Orostachys japonicus</i> A. Berger (<i>O. japonicus</i>) is a perennial herb belonging to the Crassulaceae family that has been traditionally used to treat inflammation, fever, and poisoning. Although studies on the anticancer activity of <i>O. japonicus</i> have been conducted, its effect on virus-induced cancers has yet to be elucidated.</p><p><strong>Materials/methods: </strong>In the present study, we investigated the effects and mechanisms of action of the ethyl acetate fraction of <i>O. japonicus</i> extract (E-OJ) on the viability and apoptosis of HeLa cervical cancer cells.</p><p><strong>Results: </strong>The effect of E-OJ on HeLa cells was compared to that of kaempferol, quercetin, and gallic acid, which are components of <i>O. japonicus</i>. Treatment with E-OJ induced a concentration-dependent decrease in cell viability, as confirmed by MTS assay. Pretreatment with a broad-spectrum caspase inhibitor resulted in the recovery of cell viability. Western blot analysis was conducted to determine whether the induction of apoptosis was caspase-dependent. E-OJ induced apoptosis by increasing Bax/Bcl-2 ratio. Furthermore, it modulated the levels of cleaved caspase-3, -8, and -9, indicative of an impact on both the intrinsic and extrinsic pathways of apoptosis. Pretreatment with caspase inhibitors reduced caspase activity.</p><p><strong>Conclusion: </strong>These results suggest that the anticancer activity of <i>O. japonicus</i> is mediated by caspases, resulting in a decrease in the viability of HeLa cells.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 1","pages":"131-142"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of ferulic acid and exercise alleviates menopause symptoms and skin remodeling in ovariectomized rats.","authors":"Wonyoung Lee, Jinkyung Cho, Seung-Yeon Yoo, Eunmi Park","doi":"10.4162/nrp.2025.19.1.30","DOIUrl":"10.4162/nrp.2025.19.1.30","url":null,"abstract":"<p><strong>Background/objectives: </strong>Estrogen regulates certain biological functions, including bone health, maintenance of skin components, and cardiovascular and brain protection. Estrogen deficiency manifests as hot flashes, wrinkles, skin dryness, reduced bone mineral density (BMD), sleep disorders, and cardiovascular diseases. This study aimed to investigate the effects of aerobic exercise combined with ferulic acid (FA) in ovariectomized rats.</p><p><strong>Materials/methods: </strong>Female Sprague-Dawley rats were classified into control (N), ovariectomy (OV), ovariectomy and exercise (OV+EX), and ovariectomy and exercise with ferulic acid (OV+EX+F) groups. Following ovariectomy at 22 weeks of age, the rats were tower climbing exercise at gradually increase the load (3 days/week for 12 weeks) with or without FA (5 g/kg diet) administration.</p><p><strong>Results: </strong>Estrogen deficiency in female rats (OV group) resulted in increased body weight, increased blood triglyceride (TG) levels, and decreased BMD following ovariectomy. Interestingly, compared with the rats in the OV group, the rats in the OV+EX+F group exhibited reduced body weight and blood TG levels and maintained BMD following ovariectomy, similar to those in the N group. Histological analysis of the skin of estrogen-deficient rats (OV group) revealed significantly decreased skin thickness with fewer dermal cells and distorted subcutaneous fat layers, similar to the aging phenotype. Interestingly, the rats in the OV+EX+F group exhibited rescued skin phenotypes compared with those in the OV and OV+EX groups. The skin of rats from all groups was analyzed for the expression of DNA damage and repair proteins. The OV+EX+F and OV+EX groups exhibited enhanced protein levels of pCHK1 (S345), an initiator of DNA repair signaling, and p53, indicating increased cellular DNA damage because of ovariectomy and ultimately an underlying DNA repair process.</p><p><strong>Conclusion: </strong>Exercise with FA had beneficial effects on lipid profiles, BMD, and skin remodeling during menopause.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 1","pages":"30-40"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary habits of Koreans aged 95 years and older residing in rural and metropolitan areas.","authors":"Jieun Mun, Sein Kim, Suyoung Kim, Seunghee Kim, Sang Chul Park, Jae-Young Han, Kwangsung Park, Clara Yongjoo Park","doi":"10.4162/nrp.2025.19.1.66","DOIUrl":"10.4162/nrp.2025.19.1.66","url":null,"abstract":"<p><strong>Background/objectives: </strong>Cultural and environmental factors may affect dietary habits and intake, regardless of age. As recent assessments of dietary habits of adults 95 yrs and older are absent, we aimed to determine dietary habits, diet quality, and intake of adults 95 yrs and older and test if they vary by region.</p><p><strong>Subjects/methods: </strong>Adults 95 yrs and older residing in rural areas (Gurye-gun, Goksung-gun, and Sunchang-gun [GuGokSun]; n = 46), a near-city area (Hwasun-gun, and Damyang-gun [HwaDam]; n = 77), and a metropolitan city (Gwangju Metropolitan City [Gwangju]; n = 32) were surveyed. Dietary habits and quality were surveyed using the Nutrition Quotient for the Elderly (NQ-E). Participants (n = 20) recorded videos of their meals, which were subsequently analyzed for food and nutrient intake and compared with intakes of participants of the Korea National Health and Nutrition Examination Survey (KNHANES) aged ≥ 80 yrs (n = 1,769), which were assessed via 24-h recall.</p><p><strong>Results: </strong>Most participants (85.2%) consumed similar amounts of food at meals; however, only 65.1% ingested meals at regular times. The mean NQ-E score was 48.0 ± 11.9 and did not differ among regions. In Gwangju participants, subjective income was positively associated with diet quality. The mean energy and grain intakes per meal were lower, whereas the percent energy intake from protein and intakes of seaweed, meat and poultry, and iron were higher in GuGokSun and HwaDam participants with meal recordings than in KNHANES participants.</p><p><strong>Conclusion: </strong>Among Korean adults aged ≥ 95 yrs, few regional variations exist in dietary quality and habits, although associations with diet quality vary within regions. Adults 95 yrs and older exhibit lower energy intake but higher intakes of seaweed, meat and poultry, and iron than adults aged ≥ 80 yrs. Notwithstanding, further longitudinal studies on centenarians are warranted.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 1","pages":"66-79"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms, eating habits, and dietary quality among young adults in Chungcheong, Korea.","authors":"Seong-Hee Yoon, Mi-Kyeong Choi","doi":"10.4162/nrp.2025.19.1.55","DOIUrl":"10.4162/nrp.2025.19.1.55","url":null,"abstract":"<p><strong>Background/objectives: </strong>The prevalence of depression has increased globally, and depressive symptoms have been reported to lead to undesirable lifestyle choices, including poor eating behaviors. The aim of this study was to assess the severity of depressive symptoms in young adults and to investigate the differences in eating habits and dietary quality by the degree of these symptoms.</p><p><strong>Subjects/methods: </strong>This cross-sectional study included 497 young adults aged 19-39 yrs living in Chungcheong, Korea. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, and eating habits and dietary quality were surveyed using questionnaires and nutrition quotient (NQ) for Korean adults.</p><p><strong>Results: </strong>The prevalence of depression in the participants was approximately 31.4%, based on a depressive symptom score of 16 on the CES-D scale, and the proportion of women was significantly higher than men. The depressed group considered food combinations and consumed snacks more frequently than the nondepressed group. No statistically significant differences were found in the total NQ score between the depressed and nondepressed groups; however, the moderation score was significantly lower in the depressed group for all participants and female participants.</p><p><strong>Conclusion: </strong>We found that dietary quality, including snacking and moderation-related eating habits, varied with the degree of depressive symptoms in young adults. Further intervention studies are needed to clarify the association between dietary factors and depressive symptom.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 1","pages":"55-65"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The edible ethanol extract of <i>Rosa hybrida</i> suppresses colon cancer progression by inhibiting the proliferation-cell signaling-metastasis axis.","authors":"Hong-Man Kim, Daeun Lee, Jun-Hui Song, Hoon Kim, Sanghyun Lee, Sangah Shin, Sun-Dong Park, Young Woo Kim, Yung Hyun Choi, Wun-Jae Kim, Sung-Kwon Moon","doi":"10.4162/nrp.2025.19.1.14","DOIUrl":"10.4162/nrp.2025.19.1.14","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>Rosa hybrida</i> has been demonstrated to exert biological effects on several cell types. This study investigated the efficacy of the edible ethanol extract of <i>R. hybrida</i> (EERH) against human colorectal carcinoma cell line (HCT116) cells.</p><p><strong>Materials/methods: </strong>HCT116 cells were cultured with different concentrations of EERH (0, 400, 600, 800, and 1,000 µg/mL) in Dulbecco's modified Eagle medium. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide and viable cell counting assays. Cell cycle pattern was observed by flow cytometry analysis. The wound-healing migration assay, invasion assay, and zymography were used to determine the migratory and invasive level of HCT116 cells treated with EERH. The protein expression and binding ability level of HCT116 cells following EERH treatment were analyzed via immunoblotting and the electrophoretic mobility shift assay.</p><p><strong>Results: </strong>EERH suppressed HCT116 cell proliferation, thus arresting the G1-phase cell cycle. It also reduced cyclin-dependent kinases and cyclins, which are associated with p27KIP1 expression. Additionally, EERH differentially regulated the phosphorylation of extracellular signal-regulated kinase 1/2, c-Jun NH2-terminal kinase, p38, and protein kinase B. Moreover, EERH treatment inhibited the enzymatic activity of matrix metalloproteinase-9 (MMP-9) and MMP-2, resulting in HCT116 cell migration and invasion. The EERH-induced inhibition of MMP-9 and MMP-2 was attributed to the reduced transcriptional binding of activator protein-1, specificity protein-1, and nuclear factor-κB motifs in HCT116 cells. Kaempferol was identified as the main compound contributing to EERH's antitumor activity.</p><p><strong>Conclusion: </strong>EERH inhibits HCT116 cell proliferation and metastatic potential. Therefore, it is potentially useful as a preventive and curative nutraceutical agent against colorectal cancer.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 1","pages":"14-29"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}