白藜芦醇减轻衰老诱导的大鼠心脏线粒体功能障碍和线粒体介导的细胞凋亡。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2024-10-29 DOI:10.4162/nrp.2025.19.2.186
Youngju Choi, Mi-Hyun No, Jun-Won Heo, Eun-Jeong Cho, Dong-Ho Park, Ju-Hee Kang, Chang-Ju Kim, Dae Yun Seo, Jin Han, Hyo-Bum Kwak
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引用次数: 0

摘要

背景/目的:白藜芦醇是一种天然多酚类化合物,具有有效的抗氧化和抗炎特性,对心血管疾病有有益作用。本研究的目的是确定白藜芦醇是否对衰老诱导的心脏重塑、线粒体功能障碍和线粒体介导的心脏细胞凋亡具有保护作用。材料/方法:将32只雄性Fischer 344大鼠分为4组:2组口服白藜芦醇(50 mg/kg/d) 6周(年轻和老年白藜芦醇组),2组对照组(年轻和老年对照组)。分析左心室心肌纤维线粒体功能及线粒体介导的凋亡通路。结果:白藜芦醇能显著降低衰老心脏的肥厚和重构。此外,白藜芦醇显著改善衰老诱导的线粒体功能障碍(例如,氧呼吸减少和过氧化氢释放增加)和线粒体依赖的凋亡信号(Bax/Bcl-2比率,线粒体通透性过渡孔开放敏感性和裂解caspase-3蛋白水平)。白藜芦醇还能显著减弱衰老诱导的心肌细胞凋亡(通过裂解caspase-3染色和tunel阳性肌核测定)。结论:本研究表明白藜芦醇通过改善线粒体功能障碍和抑制线粒体介导的心脏细胞凋亡,对衰老诱导的心脏重塑具有有益作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart.

Backgroud/objectives: Resveratrol, a natural polyphenolic compound, has potent antioxidant and anti-inflammatory properties, leading to beneficial effects against cardiovascular diseases. The purpose of this study was to determine whether resveratrol induces protective effects against aging-induced cardiac remodeling, mitochondrial dysfunction, and mitochondria-mediated apoptosis in the heart.

Materials/methods: Thirty-two male Fischer 344 rats were divided into 4 groups: 2 groups that were orally treated with resveratrol (50 mg/kg/day) for 6 weeks (young and old resveratrol groups), and 2 control groups (young and old control groups). Mitochondrial function and mitochondria-mediated apoptotic pathway were analyzed in cardiac muscle fibers from the left ventricle.

Results: Resveratrol significantly reduced cardiac hypertrophy and remodeling in aging hearts. In addition, resveratrol significantly ameliorated aging-induced mitochondrial dysfunction (e.g., decreased oxygen respiration and increased hydrogen peroxide emission) and mitochondria-dependent apoptotic signaling (the Bax/Bcl-2 ratio, mitochondrial permeability transition pore opening sensitivity, and cleaved caspase-3 protein levels). Resveratrol also significantly attenuated aging-induced apoptosis (determined via cleaved caspase-3 staining and TUNEL-positive myonuclei) in cardiac muscles.

Conclusion: This study demonstrates that resveratrol treatment has a beneficial effect on aging-induced cardiac remodeling by ameliorating mitochondrial dysfunction and inhibiting mitochondria-mediated apoptosis in the heart.

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来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
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