Nutrition Research and Practice最新文献

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Strategies for preventing bone loss in populations with insufficient calcium and vitamin D intake. 预防钙和维生素D摄入不足人群骨质流失的策略。
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2025-03-13 DOI: 10.4162/nrp.2025.19.2.155
Kyung-Jin Yeum, Seyoung Ju, Uyory Choe
{"title":"Strategies for preventing bone loss in populations with insufficient calcium and vitamin D intake.","authors":"Kyung-Jin Yeum, Seyoung Ju, Uyory Choe","doi":"10.4162/nrp.2025.19.2.155","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.155","url":null,"abstract":"<p><p>Calcium and vitamin D are essential nutrients for maintaining skeletal health, yet deficiencies in these nutrients are particularly widespread in regions such as Asia and Africa. Inadequate intake of these nutrients in these areas has been associated with diminished bone integrity and a rising incidence of osteoporosis. This review examines the underlying mechanisms of bone loss driven by calcium and vitamin D deficiencies, emphasizing their crucial roles in bone metabolism. It also presents strategies to improve nutrient intake, such as fortification of staple foods and supplementation, along with lifestyle modifications including increased physical activity, sun exposure, and dietary education, to prevent bone loss effectively. Special consideration is given to vulnerable populations, including older adults, individuals with limited sun exposure, and those with dietary restrictions, who are at higher risk of deficiency. The review further evaluates public health strategies, including government-initiated fortification and educational programs, as essential measures for tackling widespread nutrient deficiencies. Lastly, it explores future avenues for addressing calcium and vitamin D deficiencies, including the potential role of digital health tools, personalized nutrition, and innovative public health policies to alleviate the global burden of bone-related diseases.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"155-169"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative bioavailability of β-carotene from raw carrots and fresh carrot juice in humans: a crossover study. 生胡萝卜和新鲜胡萝卜汁中β-胡萝卜素在人体中的比较生物利用度:一项交叉研究。
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2024-11-27 DOI: 10.4162/nrp.2025.19.2.215
Mijoo Choi, Juha Baek, Eunju Park
{"title":"Comparative bioavailability of β-carotene from raw carrots and fresh carrot juice in humans: a crossover study.","authors":"Mijoo Choi, Juha Baek, Eunju Park","doi":"10.4162/nrp.2025.19.2.215","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.215","url":null,"abstract":"<p><strong>Background/objectives: </strong>Carrots are a major source of beta-carotene, but comparative studies on different consumption methods are limited. This study compared the rates of β-carotene absorption from fresh carrots versus fresh carrot juice.</p><p><strong>Subjects/methods: </strong>For β-carotene absorption, a separate randomized controlled crossover trial was conducted with 16 healthy adults. The participants consumed 25 mg of β-carotene from raw carrots or fresh carrot juice. Blood samples were collected at the baseline (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 h post-consumption.</p><p><strong>Results: </strong>The carrot juice group exhibited 2.33 times higher peak plasma concentrations 1.5 h post-consumption than those in the raw carrot group. The area under the curve for β-carotene absorption was 2.09 times greater in the carrot juice group than in the raw carrot group. The plasma α-carotene levels increased in both groups, but no significant differences were found. Similarly, no significant changes in the plasma levels of other fat-soluble vitamins were observed. In addition, no significant differences in antioxidant capacity (oxygen radical absorbance capacity and total radical-trapping antioxidant potential) were found between the 2 groups.</p><p><strong>Conclusion: </strong>Consuming fresh carrot juice, without added sugars, may enhance the bioavailability of β-carotene compared to raw produce.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"215-224"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart. 白藜芦醇减轻衰老诱导的大鼠心脏线粒体功能障碍和线粒体介导的细胞凋亡。
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2024-10-29 DOI: 10.4162/nrp.2025.19.2.186
Youngju Choi, Mi-Hyun No, Jun-Won Heo, Eun-Jeong Cho, Dong-Ho Park, Ju-Hee Kang, Chang-Ju Kim, Dae Yun Seo, Jin Han, Hyo-Bum Kwak
{"title":"Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart.","authors":"Youngju Choi, Mi-Hyun No, Jun-Won Heo, Eun-Jeong Cho, Dong-Ho Park, Ju-Hee Kang, Chang-Ju Kim, Dae Yun Seo, Jin Han, Hyo-Bum Kwak","doi":"10.4162/nrp.2025.19.2.186","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.186","url":null,"abstract":"<p><strong>Backgroud/objectives: </strong>Resveratrol, a natural polyphenolic compound, has potent antioxidant and anti-inflammatory properties, leading to beneficial effects against cardiovascular diseases. The purpose of this study was to determine whether resveratrol induces protective effects against aging-induced cardiac remodeling, mitochondrial dysfunction, and mitochondria-mediated apoptosis in the heart.</p><p><strong>Materials/methods: </strong>Thirty-two male Fischer 344 rats were divided into 4 groups: 2 groups that were orally treated with resveratrol (50 mg/kg/day) for 6 weeks (young and old resveratrol groups), and 2 control groups (young and old control groups). Mitochondrial function and mitochondria-mediated apoptotic pathway were analyzed in cardiac muscle fibers from the left ventricle.</p><p><strong>Results: </strong>Resveratrol significantly reduced cardiac hypertrophy and remodeling in aging hearts. In addition, resveratrol significantly ameliorated aging-induced mitochondrial dysfunction (e.g., decreased oxygen respiration and increased hydrogen peroxide emission) and mitochondria-dependent apoptotic signaling (the Bax/Bcl-2 ratio, mitochondrial permeability transition pore opening sensitivity, and cleaved caspase-3 protein levels). Resveratrol also significantly attenuated aging-induced apoptosis (determined via cleaved caspase-3 staining and TUNEL-positive myonuclei) in cardiac muscles.</p><p><strong>Conclusion: </strong>This study demonstrates that resveratrol treatment has a beneficial effect on aging-induced cardiac remodeling by ameliorating mitochondrial dysfunction and inhibiting mitochondria-mediated apoptosis in the heart.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"186-199"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient intake and food consumption of Korean preschool children: a comparison between a daycare meal group and non-daycare meal group using the data from the 2016-2019 Korea National Health and Nutrition Examination Survey. 韩国学龄前儿童的营养摄入和食物消费:使用2016-2019年韩国国家健康与营养检查调查数据的日托餐组和非日托餐组的比较
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.4162/nrp.2025.19.2.225
Young-Hee Han, Taisun Hyun
{"title":"Nutrient intake and food consumption of Korean preschool children: a comparison between a daycare meal group and non-daycare meal group using the data from the 2016-2019 Korea National Health and Nutrition Examination Survey.","authors":"Young-Hee Han, Taisun Hyun","doi":"10.4162/nrp.2025.19.2.225","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.225","url":null,"abstract":"<p><strong>Background/objectives: </strong>In Korea, childcare facilities providing food service for 100 or more children are required to employ dietitians, while those serving fewer than 100 children must register with the Center for Children's Foodservice Management to receive dietary guidance from its dietitians. This study compared the dietary intake of children who had daycare meals and those who did not to evaluate the impact of dietitian-managed nutritional services.</p><p><strong>Subjects/methods: </strong>This study analyzed the 24-h recalls from 706 children aged 3-5 yrs using the data from the 2016-2019 Korea National Health and Nutrition Examination Survey. Among them, 578 children had daycare meals, while 128 did not. The differences in energy contributions from meals and snacks, nutrient intake, and the amount and number of servings of various food groups consumed by these two groups were investigated.</p><p><strong>Results: </strong>The daycare meal group (DMG) showed a significantly higher intake of protein, thiamin, niacin, sodium, potassium, and iron during lunch and higher protein and sodium consumption during snack times after adjusting for the energy intake compared to the non-daycare meal group (NDMG). On the other hand, the DMG consumed less sugar and fat during lunch and snack times and less vitamin C during snack times. The DMG also showed higher consumption of legumes and vegetables but lower consumption of sweets during lunch and in the total daily consumption. The overall dietary quality assessed by the mean adequacy ratio was significantly higher among the DMG than in the NDMG.</p><p><strong>Conclusion: </strong>Children were provided with higher-quality meals in daycare settings than in other environments. These results underscore the importance of nutrition management by dietitians. These findings also highlight the need for nutrition education for caregivers, particularly increasing vegetable intake and reducing sugar-sweetened beverage consumption.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"225-240"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma metabolite based clustering of breast cancer survivors and identification of dietary and health related characteristics: an application of unsupervised machine learning. 基于血浆代谢物的乳腺癌幸存者聚类和饮食和健康相关特征的识别:无监督机器学习的应用
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2025-03-19 DOI: 10.4162/nrp.2025.19.2.273
Ga-Eun Yie, Woojin Kyeong, Sihan Song, Zisun Kim, Hyun Jo Youn, Jihyoung Cho, Jun Won Min, Yoo Seok Kim, Jung Eun Lee
{"title":"Plasma metabolite based clustering of breast cancer survivors and identification of dietary and health related characteristics: an application of unsupervised machine learning.","authors":"Ga-Eun Yie, Woojin Kyeong, Sihan Song, Zisun Kim, Hyun Jo Youn, Jihyoung Cho, Jun Won Min, Yoo Seok Kim, Jung Eun Lee","doi":"10.4162/nrp.2025.19.2.273","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.273","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aimed to use plasma metabolites to identify clusters of breast cancer survivors and to compare their dietary characteristics and health-related factors across the clusters using unsupervised machine learning.</p><p><strong>Subjects/methods: </strong>A total of 419 breast cancer survivors were included in this cross-sectional study. We considered 30 plasma metabolites, quantified by high-throughput nuclear magnetic resonance metabolomics. Clusters were obtained based on metabolites using 4 different unsupervised clustering methods: k-means (KM), partitioning around medoids (PAM), self-organizing maps (SOM), and hierarchical agglomerative clustering (HAC). The <i>t</i>-test, χ<sup>2</sup> test, and Fisher's exact test were used to compare sociodemographic, lifestyle, clinical, and dietary characteristics across the clusters. <i>P</i>-values were adjusted through a false discovery rate (FDR).</p><p><strong>Results: </strong>Two clusters were identified using the 4 methods. Participants in cluster 2 had lower concentrations of apolipoprotein A1 and large high-density lipoprotein (HDL) particles and smaller HDL particle sizes, but higher concentrations of chylomicrons and extremely large very-low-density-lipoprotein (VLDL) particles and glycoprotein acetyls, a higher ratio of monounsaturated fatty acids to total fatty acids, and larger VLDL particle sizes compared with cluster 1. Body mass index was significantly higher in cluster 2 compared with cluster 1 (FDR adjusted-<i>P</i> <sub>KM</sub> < 0.001; <i>P</i> <sub>PAM</sub> = 0.001; <i>P</i> <sub>SOM</sub> < 0.001; and <i>P</i> <sub>HAC</sub> = 0.043).</p><p><strong>Conclusion: </strong>The breast cancer survivors clustered on the basis of plasma metabolites had distinct characteristics. Further prospective studies are needed to investigate the associations between metabolites, obesity, dietary factors, and breast cancer prognosis.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"273-291"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary status and the relationship between dietary competencies, cooking skills, and nutrition quotient of middle-aged adults living alone in Korea. 韩国独居中年人的饮食状况及饮食能力、烹饪技能和营养商数之间的关系
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.4162/nrp.2025.19.2.257
Sooyoun Kwon, Youngmi Lee, Yun-Jung Bae
{"title":"Dietary status and the relationship between dietary competencies, cooking skills, and nutrition quotient of middle-aged adults living alone in Korea.","authors":"Sooyoun Kwon, Youngmi Lee, Yun-Jung Bae","doi":"10.4162/nrp.2025.19.2.257","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.257","url":null,"abstract":"<p><strong>Background/objectives: </strong>Living alone has a bearing on unhealthy lifestyle choices, such as skipping meals, unbalanced diets, smoking, and drinking, raising concerns about health problems. This study aimed to examine the dietary habits, competencies, and cooking skills of adults living alone and their relationship with the nutritional quotient (NQ).</p><p><strong>Subjects/methods: </strong>We conducted an online survey spanning April 20-26, 2023 that was administered to 500 adults aged 35-64 yrs who were living alone in Korea. The questionnaire included questions regarding general information, eating habits, cooking environment, dietary competencies, cooking skills, and NQ. The results were stratified according to sex and age.</p><p><strong>Results: </strong>Middle-aged adults who were living alone responded that the main reason they skipped meals when eating alone was \"because meal preparation is a hassle.\" Middle-aged adults living alone consumed fewer vegetables, fruits, and milk than the recommended levels. The dietary competencies of the participants were 3.14 out of 5.0, and their cooking skills were 3.77 out of 5.0. Female had significantly higher scores for most items than male (<i>P</i> < 0.05). In addition, after adjusting for confounding factors, the odds of a high NQ score in the group with high dietary competencies was 3.75 (95% confidence interval [CI], 2.15-6.55; <i>P</i> for trend < 0.001), and the odds of a high NQ score for participants with higher cooking skills were 3.99 (95% CI, 2.27-7.02).</p><p><strong>Conclusion: </strong>These findings provide fundamental data for developing tailored nutrition education programs for adults aged 35-64 yrs living alone, considering age and sex differences.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"257-272"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sleep timing shifts and dietary quality in Korean high school girls during COVID-19: a cross-sectional study. COVID-19期间韩国高中女生睡眠时间变化与饮食质量之间的关系:一项横断面研究
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.4162/nrp.2025.19.2.292
Mi-Hyun Kim, Youbeen Jung, Eunju Kim
{"title":"Association between sleep timing shifts and dietary quality in Korean high school girls during COVID-19: a cross-sectional study.","authors":"Mi-Hyun Kim, Youbeen Jung, Eunju Kim","doi":"10.4162/nrp.2025.19.2.292","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.292","url":null,"abstract":"<p><strong>Background/objectives: </strong>Owing to coronavirus disease 2019 (COVID-19), the shift from offline to online classes has caused significant changes in high school students' daily habits, including sleep patterns and dietary intake. This study explored the association between sleep schedule fluctuations and dietary quality among high school girls during the COVID-19 pandemic. This study examined the association between bedtime, wake-up time, and adolescent dietary quality during the weekly online/offline school period among 517 high school girls in Incheon, South Korea.</p><p><strong>Subjects/methods: </strong>The participants were divided into 2 groups: normal sleepers (n = 244), who maintained normal sleep schedules defined as a midpoint between bedtime and wake-up time before 5:30 a.m., during in-person and online classes; and late sleepers (n = 273), who maintained a normal sleep schedule during in-person classes but exhibited late sleep patterns defined as a midpoint after 5:30 a.m., during online classes.</p><p><strong>Results: </strong>Shorter sleep duration was characteristic of late sleepers with circadian rhythm disruption, who also displayed poorer dietary quality, including higher consumption of caffeinated beverages and street food and never consuming breakfast. Among the 5 constituent factors, disrupted sleep timing was associated with lower Nutrition Quotient for Adolescents scores in total, moderation, and environment. This association persisted independent of the grade level, even after adjusting for school grade. These findings highlight the significant effect of sleep patterns on dietary habits.</p><p><strong>Conclusion: </strong>This study highlights the significant relationship between disrupted circadian rhythms and poor dietary quality among high-school girls. These findings reveal the need for interventions to promote healthy sleep patterns as a strategy to improve the dietary quality and overall health of adolescents.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"292-304"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tagetes erecta Linn flower extract inhibits particulate matter 2.5-promoted epithelial-mesenchymal transition by attenuating reactive oxygen species generation in human retinal pigment epithelial ARPE-19 cells. 万丽花提取物通过抑制人视网膜色素上皮ARPE-19细胞活性氧的产生,抑制颗粒物2.5促进的上皮-间质转化。
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.4162/nrp.2025.19.2.170
Beom Su Park, EunJin Bang, Hyesook Lee, Gi-Young Kim, Yung Hyun Choi
{"title":"<i>Tagetes erecta</i> Linn flower extract inhibits particulate matter 2.5-promoted epithelial-mesenchymal transition by attenuating reactive oxygen species generation in human retinal pigment epithelial ARPE-19 cells.","authors":"Beom Su Park, EunJin Bang, Hyesook Lee, Gi-Young Kim, Yung Hyun Choi","doi":"10.4162/nrp.2025.19.2.170","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.170","url":null,"abstract":"<p><strong>Background/objectives: </strong>Particulate matter 2.5 (PM2.5) exposure can promote epithelial-mesenchymal transition (EMT) in human retinal pigment epithelial (RPE) cells. The flowers of <i>Tagetes erecta</i> Linn, commonly known as marigold, are rich in diverse flavonoids and carotenoids and play a significant role in preventing cellular damage induced by oxidative stress, but the role of their extracts in RPE cells has not been reported. This study aimed to evaluate the influence of an ethanol extract of <i>T. erecta</i> Linn flower (TE) on PM2.5-induced EMT processes in RPE ARPE-19 cells.</p><p><strong>Materials/methods: </strong>To investigate the protective effect of TE against ARPE-19 cell damage following PM2.5 treatment, cells were exposed to TE for 1 h before exposure to PM2.5 for 24 h. We investigated whether the efficacy of TE on suppressing PM2.5-induced EMT was related to antioxidant activity and the effect on the expression changes of factors involved in EMT regulation. Additionally, we further explored the role of intracellular signaling pathways associated with EMT inhibition.</p><p><strong>Results: </strong>TE significantly blocked PM2.5-induced cytotoxicity while effectively preventing mitochondrial dysfunction, increased reactive oxygen species (ROS) generation, and mitochondrial membrane potential disruption. TE inhibited PM2.5-induced EMT and inflammatory response by suppressing the ROS-mediated transforming growth factor-β/suppressor of mothers against decapentaplegic/mitogen-activated protein kinases signaling pathway.</p><p><strong>Conclusion: </strong>Our results suggest that marigold extract is a highly effective in protection against PM2.5-induced eye damage.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"170-185"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p-Coumaric acid alleviates metabolic dysregulation in high-fructose diet-fed hamsters. 对香豆酸减轻高果糖饮食喂养仓鼠的代谢失调。
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2024-11-27 DOI: 10.4162/nrp.2025.19.2.200
Hye Jin Yoon, Un Ju Jung
{"title":"<i>p</i>-Coumaric acid alleviates metabolic dysregulation in high-fructose diet-fed hamsters.","authors":"Hye Jin Yoon, Un Ju Jung","doi":"10.4162/nrp.2025.19.2.200","DOIUrl":"https://doi.org/10.4162/nrp.2025.19.2.200","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>p</i>-Coumaric acid (CA), a 4-hydroxycinnamic acid derivative, is widely distributed in nature and exerts various beneficial biological effects. However, the effects of CA on metabolic abnormalities triggered by excessive fructose intake, such as dyslipidemia, hyperglycemia, non-alcoholic fatty liver disease (NAFLD), and insulin resistance, have not been sufficiently investigated. Our objective was to investigate whether CA ameliorates high-fructose diet (HFrD)-induced metabolic dysregulation.</p><p><strong>Materials/methods: </strong>Golden Syrian hamsters were randomly assigned to 3 groups and were fed diets containing 60% cornstarch (CON group), 60% fructose (HFrD group), or 60% fructose with CA (0.02%) (HFrD+CA group) for 5 weeks.</p><p><strong>Results: </strong>HFrD feeding significantly increased the levels of plasma triglyceride, apolipoprotein (apo)-CIII, fasting blood glucose, and homeostatic model assessment insulin resistance, and tended to increase plasma total cholesterol (TC) and low-density lipoprotein/very low-density lipoprotein cholesterol (LDL/VLDL-C) compared with the CON group. In HFrD-fed hamsters, CA supplementation significantly decreased plasma TC, LDL/VLDL-C, apo-CIII, and fasting blood glucose levels. Moreover, CA significantly decreased the hepatic lipid levels and fibrosis induced by HFrD. The plasma and hepatic lipid-lowering effects of CA were associated with decreased enzyme activity and mRNA expression of genes involved in fatty acid, triglyceride, and cholesterol synthesis as well as increased activity of carnitine palmitoyltransferase, a rate-limiting enzyme in fatty acid oxidation, in the liver. CA-treated hamsters also exhibited decreased hepatic gluconeogenic enzyme activity and increased hepatic glycolytic enzyme activity, with mRNA expression changes similar to these activity patterns.</p><p><strong>Conclusion: </strong>Our findings indicate that CA potentially improves metabolic abnormalities associated with excessive fructose intake, such as hyperglycemia, dyslipidemia, and NAFLD.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 2","pages":"200-214"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in cross-border shopping for dietary supplements in South Korea with a focus on major types of health functional foods. 韩国膳食补充剂跨境购物趋势,重点关注主要类型的保健功能食品。
IF 2 4区 医学
Nutrition Research and Practice Pub Date : 2025-04-01 Epub Date: 2025-03-28 DOI: 10.4162/nrp.2025.19.2.241
Youngmin Nam, Linxi Huang, Jong-Youn Rha, Bongwon Suh, Jihyun Yoon
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