Nutrition Research and Practice最新文献

{"title":"Association of stress-related genetic risk and lifestyle factors with BMI in Korean adults.","authors":"Ga Young Lee, Junghak Lee, Jeong-Han Kim, Kyong-Mee Chung, Sung Nim Han","doi":"10.4162/nrp.2026.20.5.820","DOIUrl":"10.4162/nrp.2026.20.5.820","url":null,"abstract":"<p><strong>Background/objectives: </strong>Genetic susceptibility to stress may influence behavioral and metabolic responses involved in dietary choices and body weight regulation. While previous studies have focused on individual genetic variants related to dietary intake and obesity risk, a polygenic approach integrating multiple stress-related single nucleotide polymorphisms may better capture overall genetic susceptibility to stress. This study examined the relationship among stress-related polygenic risk, dietary intake, serum metabolite profiles, and body weight, and determined whether this relationship could be influenced by sleep duration and physical activity (PA).</p><p><strong>Subjects/methods: </strong>This study included 100 disease-free participants with a body mass index (BMI) of 18.5 to 25.0 kg/m². The genetic scores for stress (GS_stress) were determined using 4 genes: <i>DRD2</i> rs1800497, <i>COMT</i> rs4680, <i>BDNF</i> rs6265, and <i>HTR2C</i> rs3813929. Participants were classified into 4 categories: Low GS_stress (n = 29), Normal GS_stress (n = 16), Alert GS_stress (n = 36), and Risk GS_stress (n = 19). Anthropometric measurements, dietary intake, PA, sleep duration, serum cortisol, and serum metabolite levels were evaluated.</p><p><strong>Results: </strong>Serum cortisol concentration was significantly higher in the Risk GS_stress group than in the Low GS_stress and Alert GS_stress groups. Participants with higher risk for stress consumed significantly higher sugar-sweetened beverages (SSB) than those at low risk. Additionally, there was a significant interaction effect between GS_stress and sleep duration in relation to BMI (<i>P</i> = 0.041), with a positive association found only in individuals with short sleep duration (< 6 h/day).</p><p><strong>Conclusion: </strong>This study demonstrated that individuals with a higher genetic risk for stress exhibited elevated cortisol levels and were associated with greater SSB intake and higher BMI. This relationship was more pronounced in those with insufficient sleep, emphasizing the importance of lifestyle factors in mitigating the effect of genetic stress risk on body weight.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0004650.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"820-833"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparability of food frequency questionnaires between Korean Children's Environmental Health Study (Ko-CHENS) and Korean Genome and Epidemiology Study (KoGES) in pregnant women.","authors":"Minsu Cho, Bom Kim, Hyesook Kim, Sunghun Na, Se Jin Lee, Tae Gyu Ahn, Kyung Ho Son, Woo Jin Kim, Jung Eun Lee","doi":"10.4162/nrp.2026.20.5.866","DOIUrl":"10.4162/nrp.2026.20.5.866","url":null,"abstract":"<p><strong>Background/objectives: </strong>The Korean Children's Environmental Health Study (Ko-CHENS) developed a food frequency questionnaire (FFQ) to assess maternal dietary intake during pregnancy. This FFQ shares high structural similarity with the validated FFQ of the Korean Genome and Epidemiology Study (KoGES), a representative dietary assessment tool for the Korean adult population, which includes 97 of the 112 items in the Ko-CHENS FFQ. The comparability of the Ko-CHENS and KoGES FFQs among pregnant women was evaluated.</p><p><strong>Subjects/methods: </strong>Ninety-four women recruited from Kangwon National University Hospital between December 2024 and February 2025 were included. The participants consecutively completed the Ko-CHENS and KoGES FFQs. The nutrient intakes were adjusted for the total energy intake using the residual method. Log-transformed intakes of energy, nutrients, and food groups were compared using the correlation coefficients, cross-classification percent agreement, weighted kappa statistics, and Bland-Altman plots.</p><p><strong>Results: </strong>The Ko-CHENS FFQ yielded higher absolute intake estimates for energy and the majority of nutrients and food groups than the KoGES FFQ. The Pearson or Spearman correlation coefficients ranged from 0.34 (vitamin E) to 0.68 (β-carotene) for energy and nutrients and from 0.15 (sugars and jams) to 0.77 (salted vegetables) for food groups, with median values of 0.55 and 0.61, respectively. The median proportions of the participants classified into the same or adjacent quartiles were 96.39% for energy and nutrients and 96.52% for food groups. The weighted kappa statistics ranged from 0.23 to 0.52 for energy and nutrients and from 0.06 to 0.59 for food groups, with median values of 0.38 and 0.45, respectively. The Bland-Altman plots for energy and macronutrients showed that the data points were primarily within the limits of agreement.</p><p><strong>Conclusion: </strong>The Ko-CHENS and KoGES FFQs showed fair-to-moderate comparability, suggesting that the Ko-CHENS FFQ can be used for ranking Korean pregnant women based on their dietary intake levels.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"866-878"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ready-to-prepare meal set consumption patterns and nutritional status evaluation using the Nutrition Quotient among Korean adults in their 20s and 30s.","authors":"Jiwon Ma, Ji-An Shim, Hyun-Joo Bae","doi":"10.4162/nrp.2026.20.5.911","DOIUrl":"https://doi.org/10.4162/nrp.2026.20.5.911","url":null,"abstract":"<p><strong>Background/objectives: </strong>As the ready-to-prepare (RTP) meal set market expands rapidly in South Korea, understanding the preferences of young adult consumers and dietary quality is essential. This study examined RTP consumption patterns, selection attributes using Importance-Satisfaction Analysis (ISA), and dietary quality using the Nutrition Quotient (NQ) for adults.</p><p><strong>Subjects/methods: </strong>An online survey was conducted on 304 adults aged 20-39 yrs who had purchased RTP meal sets within the past year. The data were analyzed using SPSS 28.0 for descriptive statistics, χ² tests, gap analysis, paired-samples <i>t</i>-tests, and ISA. The NQ assessed four domains: balance, diversity, moderation, and dietary behavior.</p><p><strong>Results: </strong>Most participants purchased RTP meal sets offline (64.5%) and consumed them with others (71.4%). Korean soups/stews were the most frequently purchased items (71.4%). In the overall ISA and gap analysis, \"price\" was identified as the primary attribute requiring urgent improvement (\"Focus here\"). For workers and multi-person households, the \"expiration date\" was also categorized under \"Focus here,\" while \"quality certification\" fell into this quadrant for students and multi-person households. Regarding NQ, 81.9% of participants were classified in the low category for the moderation domain. Single-person households showed a significantly higher proportion of participants in the low-grade category for the total NQ, balance, and diversity compared to multi-person households (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>RTP manufacturers should expand quick-frozen meal sets to improve price competitiveness and extend shelf life. Differentiated strategies are needed, such as developing affordable single-serving options for single-person households and enhancing nutritional balance and food quality certifications to promote healthy dietary habits among young adults.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"911-929"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sugar profile, phenolic compounds, and antioxidant capacity of the most preferred commercial fruit juices in a sample of school-age children: a combined laboratory and survey-based study.","authors":"Damla Unlu, Merve Ozdemir","doi":"10.4162/nrp.2026.20.5.879","DOIUrl":"10.4162/nrp.2026.20.5.879","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study evaluated the commercial fruit juice consumption habits and laboratory-analyzed nutritional quality (sugar profile, phenolics, antioxidant capacity) in school-age children (6-12 yrs) relative to the body mass index (BMI) z-score and dietary Oxygen Radical Absorbance Capacity (ORAC) density.</p><p><strong>Subjects/methods: </strong>This cross-sectional study with 183 parents evaluated the dietary intake and dietary ORAC density using the Food Frequency Questionnaire and BEBIS 9.0. Juice sugar profiles (HPLC), total phenolics, and antioxidant capacity (ABTS assay) were measured spectrophotometrically.</p><p><strong>Results: </strong>Energy intake was negatively correlated with the dietary ORAC density (<i>r</i> = -0.284, <i>P</i> < 0.001). Unadjusted bivariate analysis showed that every 1 mL increase in daily fruit juice intake was associated with a 0.389 g increase in total sugar intake (<i>B</i> = 0.389, <i>P</i> < 0.001). This association lost its statistical significance after adjusting for the daily total energy intake, age, sex, and maternal education level (<i>B</i> = 0.055, β = 0.081, <i>P</i> = 0.093, ΔR² = 0.004). The mean daily intake was 53.3 mL/day (99.5% adherence to AAP guidelines), showing no correlation with the BMI z-scores (<i>r</i> = -0.030, <i>P</i> = 0.683) or a significant difference across BMI categories (<i>P</i> = 0.335). Laboratory analyses of the children's most consumed commercial juices revealed total sugar concentrations of 20.2-21.4 g/100 mL.</p><p><strong>Conclusion: </strong>Despite commercial fruit juices having a high sugar concentration, consuming them in small amounts may limit the total sugar intake. Provided portion control is maintained, 100% fruit juice should be evaluated as a nutrient-dense, polyphenol-rich matrix rather than as mere free sugar. Public health strategies should prioritize portion management, food literacy, and clear front-of-pack labeling (such as Traffic Light and Nutri-Score) to help consumers distinguish 100% juices from added-sugar nectars rather than eliminating fruit juices from pediatric diets.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"879-891"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting vascular endothelial growth factor (VEGF)-induced angiogenesis with <i>Rosa hybrida</i> leaf extract via VEGF receptor-2 signaling and matrix metalloproteinase-2 inhibition.","authors":"Byungdoo Hwang, Soyeon Kim, Jun-Hui Song, Hoon Kim, Sanghyun Lee, Sung-Kwon Moon","doi":"10.4162/nrp.2026.20.5.735","DOIUrl":"10.4162/nrp.2026.20.5.735","url":null,"abstract":"<p><strong>Background/objectives: </strong>Angiogenesis is essential for tumor growth, tissue repair, and cell development. <i>Rosa hybrida</i> is a widely cultivated ornamental plant, and research on its petals has been conducted. However, despite the presence of flavonoids and terpenoids in the leaves, the biological activity of rose leaves remains unclear. This study investigated the anti-angiogenic potential of <i>R. hybrida</i> leaf extract (RLE) using a vascular endothelial growth factor (VEGF)-stimulated angiogenic model.</p><p><strong>Materials/methods: </strong>RLE was prepared, chemically profiled by high-performance liquid chromatography, and used in both <i>in vitro</i> and <i>ex vivo</i> assays. Human umbilical vein endothelial cells (HUVECs) were treated with RLE in the presence of VEGF. Assays for endothelial cell proliferation, tube formation, migration, invasion, and angiogenic signaling protein (VEGFR-2, protein kinase B [AKT], extracellular signal-regulated kinase [ERK], and endothelial nitric oxide synthase [eNOS]) phosphorylation were conducted. Molecular docking was performed to predict interactions between major RLE compounds and VEGFR-2. Matrix metalloproteinase-2 (MMP-2) level was also evaluated by immunoblot and gelatin zymography. The mouse aortic ring assay was used to assess microvessel sprouting.</p><p><strong>Results: </strong>RLE inhibited VEGF-induced proliferation, tube formation, migration, and invasion in HUVECs. RLE treatment also reduced the phosphorylation of VEGFR-2 and downstream signaling molecules, including AKT, ERK, and eNOS. Molecular docking supported the potential interaction between major RLE compounds and VEGFR-2. Additionally, RLE inhibited MMP-2-mediated extracellular matrix remodeling and attenuated VEGF-stimulated microvessel sprouting in the aortic ring assay.</p><p><strong>Conclusion: </strong>RLE exerts potent anti-angiogenic effects by modulating the VEGF/VEGFR-2 signaling cascade and inhibiting MMP-2 activity. As a previously underutilized botanical resource, RLE may serve as a promising complementary therapeutic agent for diseases related to angiogenesis.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"735-747"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Chrysanthemum morifolium</i> extract prevents oxidative stress and ferroptosis in cerebral ischemia-reperfusion injury by modulating the miR-144/Nrf2 pathway.","authors":"Yin Jiang, Bo Li, Zheng Zhang, Jie Yang, JianE Chen, Yan Li","doi":"10.4162/nrp.2026.20.5.748","DOIUrl":"10.4162/nrp.2026.20.5.748","url":null,"abstract":"<p><strong>Background/objectives: </strong>Cerebral ischemia-reperfusion injury (CIRI) is characterized by oxidative stress (OS) and ferroptosis. <i>Chrysanthemum morifolium</i> extract (CME) has been reported to have antioxidant activity. This study evaluated its protective effects and underlying mechanisms against CIRI.</p><p><strong>Materials/methods: </strong><i>In vitro</i>, H19-7 cells were pretreated with CME before oxygen-glucose deprivation/reoxygenation (OGD/R). Cell viability, apoptosis, OS markers (reactive oxygen species [ROS], malondialdehyde [MDA], glutathione [GSH], and superoxide dismutase [SOD]), ferroptosis markers, and the related proteins of the miR-144/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway were assessed. The targeting relationship between miR-144 and Nrf2 was confirmed by dual-luciferase reporter assay. Rescue experiments were performed using Nrf2 overexpression. An <i>in vivo</i> rat middle cerebral artery occlusion (MCAO) model was established, and the effects of CME, agomir-144 (miR-144 agonist), and bardoxolone (BARD; Nrf2 agonist) on the cerebral infarct volume, histopathology, apoptosis, and the aforementioned molecular pathways were evaluated.</p><p><strong>Results: </strong>A CME pretreatment significantly restored the cell viability, reduced apoptosis, and suppressed OS and ferroptosis in OGD/R-induced H19-7 cells, as evidenced by decreased ROS, MDA, apoptosis, lipid peroxidation, and Fe²⁺ levels, and increased GSH, SOD, and the expression of nuclear Nrf2 and its downstream proteins (heme oxygenase-1, glutamate-cysteine ligase modifier subunit, solute carrier family 7 member 11, and glutathione peroxidase 4). These protective effects were reversed by miR-144 mimic but rescued by Nrf2 overexpression. Consistently, the <i>in vivo</i> results showed that CME reduced cerebral infarction, ameliorated neuronal damage and apoptosis in MCAO rats, and modulated the miR-144/Nrf2 pathway and related OS/ferroptosis markers. Agomir-144 attenuated these benefits, while a BARD co-treatment restored them.</p><p><strong>Conclusion: </strong>CME alleviates CIRI by inhibiting OS and ferroptosis via the miR-144/Nrf2 pathway, providing novel insights into CIRI treatment strategies.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"748-768"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of <i>Lactobacillus acidophilus</i> LM1060 on LPS/H₂O₂-induced cytotoxicity in SK-N-SH cells and scopolamine-induced memory impairment in mice.","authors":"Yunjung Lee, Jiyoung Hwang, Tae-Rahk Kim, Minn Sohn, Eunju Park","doi":"10.4162/nrp.2026.20.5.769","DOIUrl":"10.4162/nrp.2026.20.5.769","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study examined the neuroprotective effects of <i>Lactobacillus acidophilus</i> LM1060 against scopolamine-induced memory impairment to elucidate its underlying mechanisms.</p><p><strong>Materials/methods: </strong>LM1060 (1 × 10⁹ CFU/day) or donepezil (DO, 2 mg/kg) was administered to Institute of Cancer Research mice by oral gavage for 14 days (days 1-14). Memory impairment was induced by scopolamine (1 mg/kg, intraperitoneal injection) for 6 days (days 9-14). Behavioral tests, including the Y-maze and novel object recognition tests, were performed to evaluate the cognitive function. The effects of LM1060 on the acetylcholine (ACh), acetylcholinesterase (AChE), and choline acetyltransferase (ChAT) levels in the hippocampus were examined. The β-secretase activity, β-amyloid levels, and DNA damage in brain tissue were also assessed. <i>In vitro</i> studies were conducted using SK-N-SH neuroblastoma cells to evaluate the cell viability, antioxidant capacity, lactate dehydrogenase (LDH) release, AChE activity, and inflammatory cytokine gene expression.</p><p><strong>Results: </strong>LM1060 showed a protective effect against scopolamine-induced cognitive dysfunction, as confirmed by behavioral tests including the Y-maze and novel object recognition tests. Oral administration of LM1060 restored the ACh and ChAT activity reduced by scopolamine. The β-secretase activity and β-amyloid levels decreased after the LM1060 and DO treatment. The LM1060 administration group exhibited a higher protective effect against scopolamine-induced DNA damage in brain tissue than the scopolamine-treated group. In vitro studies showed that LM1060 significantly enhanced the cell viability and antioxidant capacity, reduced LDH release and AChE activity, and modulated inflammatory cytokine gene expression by downregulating interleukin (IL)-1β and IL-6 and upregulating IL-10.</p><p><strong>Conclusion: </strong><i>L. acidophilus</i> LM1060 exerts potent neuroprotective effects through anti-inflammatory, antioxidant, and cholinergic mechanisms, highlighting its potential as a functional ingredient for cognitive health.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"769-782"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with current non-nutritive sweetener use among adults in Chungcheong, Korea: focusing on the sociodemographic and dietary characteristics.","authors":"Dai Lee, Munkyong Pae","doi":"10.4162/nrp.2026.20.5.834","DOIUrl":"10.4162/nrp.2026.20.5.834","url":null,"abstract":"<p><strong>Background/objectives: </strong>Although the use of zero-sugar products containing non-nutritive sweeteners (NNSs) has increased, limited information is available on the current NNS use across product categories and its relationships with consumer perceptions and dietary quality. This study examined the consumption patterns and factors associated with current NNS use.</p><p><strong>Subjects/methods: </strong>Four hundred and sixteen adults residing in the Chungcheong region of Korea participated in an online survey between May and June 2024. The participants were classified as current or non-current NNS users based on their consumption of zero-sugar products containing NNSs. The questionnaire assessed the general characteristics, consumption patterns, awareness and perceptions, information needs, sugar intake behaviors, sugar reduction awareness, and the Nutrition Quotient (NQ). The group differences were examined using χ² tests, independent <i>t</i>-tests, and analysis of covariance. Multivariable logistic regression analysis was conducted to identify the factors associated with current NNS use.</p><p><strong>Results: </strong>Overall, 218 participants (52.4%) were current NNS users. Carbonated beverages were the most frequently consumed product category, followed by tabletop sweeteners, coffee products, and sports drinks. The current users had greater awareness and more favorable safety perceptions than non-current users. In the fully adjusted model, adults aged 30-39 yrs had higher odds of current NNS use than those aged 19-29 yrs (odds ratio [OR], 2.55; 95% confidence interval [CI], 1.44-4.49). Higher sugar reduction awareness was associated with higher odds of current use (OR, 1.64; 95% CI, 1.17-2.29), whereas each 10-point increase in the total NQ score was associated with lower odds of current use (OR, 0.79; 95% CI, 0.63-0.99).</p><p><strong>Conclusion: </strong>Current NNS use was associated with stronger sugar reduction awareness but not with better overall dietary quality, highlighting the need for practical guidance on NNS safety and balanced dietary practices.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"834-847"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oleanolic acid inhibits diet-induced adiposity through blocking neovascularization and macrophage accumulation involving Delta-like 4-Notch 1-nuclear factor-κB signaling.","authors":"Sin-Hye Park, Eunkyeong Kim, Young-Hee Kang","doi":"10.4162/nrp.2026.20.5.783","DOIUrl":"10.4162/nrp.2026.20.5.783","url":null,"abstract":"<p><strong>Background/objectives: </strong>Obesity is a major risk factor in the pathogenesis of cardiometabolic disorders. Most of these obesity-related disorders are closely associated with vascular dysfunctions. Due to the increase of fat mass in obesity, oxygen deficiency is induced, thus developing adipose tissue vascularization. Additionally, local hypoxia generates adipokine expression and proinflammatory macrophage recruitment. This study was conducted to test efficiency of oleanolic acid on angiogenesis and proinflammation in diet-induced obese mice model.</p><p><strong>Materials/methods: </strong>C57BL/6 mice were fed 10% fat or 45% fat and treated with 10 mg/kg oleanolic acid as gavage for 20 weeks. Body weight, adipose tissue weight, and adipocyte morphology were evaluated. Angiogenesis-related signaling pathways, oxidative stress, and inflammatory markers in adipose tissue were assessed using molecular and histological analyses.</p><p><strong>Results: </strong>Oleanolic acid decreased body weight and fat tissue weight of obese mice. Oleanolic acid inhibited diet-induced adipocyte expansion and adiposity. This natural compound reduced adipose tissue angiogenesis of obese mice through blockade of hypoxia-inducible factors 1α-vascular endothelial growth factor receptor-2 signaling and Ang-Tie2 axis. The reactive oxygen species production was reduced by oleanolic acid in fatty adipose tissues. Oleanolic acid inhibited macrophage infiltration into the adipose tissues of obese mice. Oral administration of oleanolic acid blocked Delta-like 4 (Dll4)-Notch 1-nuclear factor (NF)-κB signaling axis in adipose tissues of high fat-fed mice.</p><p><strong>Conclusion: </strong>These results indicate that oleanolic acid is a potential therapeutic strategy to alleviate diet-induced adiposity at least by blocking Dll4-Notch-NF-κB signaling-associated neovascularization and macrophage inflammation in adipose tissues.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"783-799"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of breakfast skipping with diet-quality-based low-carbohydrate and low-fat diet scores and metabolic syndrome components among Korean young adults: Korea National Health and Nutrition Examination Survey 2021-2023.","authors":"Junhyeok Jang, Eunjin Jang, Eunseo Lee, Sohyun Park","doi":"10.4162/nrp.2026.20.5.892","DOIUrl":"10.4162/nrp.2026.20.5.892","url":null,"abstract":"<p><strong>Background/objectives: </strong>The rate of breakfast skipping among Korean young adults has increased rapidly, but its association with the dietary macronutrient composition remains unclear. Using diet-quality-based low-carbohydrate diet (LCD) and low-fat diet (LFD) scoring systems, this study primarily examined the association between breakfast skipping and 6 diet-quality scores. As a secondary analysis, this study assessed how these scores, and breakfast skipping itself, were related to metabolic syndrome and its components, to gauge the metabolic relevance of the scores.</p><p><strong>Subjects/methods: </strong>This cross-sectional study analyzed 2,872 adults aged 19-39 yrs from the 2021-2023 Korea National Health and Nutrition Examination Survey, excluding those diagnosed or treated for chronic disease, implausible energy intake, or pregnancy/lactation. Breakfast skipping was defined as no intake reported as \"breakfast\" in the 24-h recall. The LCD and LFD scores were calculated using the method proposed by Shan <i>et al.</i>'s study. Multivariable complex-sample linear and logistic regression analyses were performed with sequential covariate adjustment.</p><p><strong>Results: </strong>Among the participants, 52.2% (n = 1,500) skipped breakfast. After adjustment, the skippers had significantly higher unhealthy LCD scores (β = 1.19) and lower overall LFD (β = -0.67) and healthy LFD (β = -1.55) scores than those who did not skip breakfast. A comparison of the extreme quartiles showed that the overall LCD score was inversely associated with abdominal obesity (odds ratio [OR], 0.56) and elevated triglycerides (OR, 0.60), a healthy LCD score with elevated triglycerides (OR, 0.70), and an unhealthy LCD score with abdominal obesity (OR, 0.59) and elevated blood pressure (OR, 0.50).</p><p><strong>Conclusion: </strong>Breakfast skipping was associated with a lower-quality composition of the same-day diet. Exploratory secondary analyses showed that most associations with metabolic syndrome components were not significant. Nevertheless, the findings should be interpreted with caution because this study was cross-sectional.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"892-910"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}