Nutrition Research and Practice最新文献

{"title":"Amelioration of chronic inflammation, insulin resistance, and gut microbiota homeostasis by a combination of <i>Bifidobacterium</i>, <i>Lactobacillus</i>, <i>Enterococcus</i>, and <i>Bacillus</i> in obese type 2 diabetic mice.","authors":"Sisi Fu, Fei Zhou, Liya Gong, Aili Ye","doi":"10.4162/nrp.2026.20.5.800","DOIUrl":"10.4162/nrp.2026.20.5.800","url":null,"abstract":"<p><strong>Background/objectives: </strong>To examine the effects of a combination of live <i>Bifidobacterium</i>, <i>Lactobacillus</i>, <i>Enterococcus</i>, and <i>Bacillus</i> (CBLEB) on glucose/lipid metabolism, inflammation, gut microbiota, and related mechanisms in obese type 2 diabetes mellitus (T2DM) mice.</p><p><strong>Materials/methods: </strong>Obese T2DM mice were established by feeding mice a high-fat diet for four weeks, followed by a single intraperitoneal injection of streptozotocin (100 mg/kg). The mice were then divided randomly into 5 groups (n = 8/group): normal control (NC), T2DM model, CBLEB (585 mg/kg/d, by gavage), dimethylbiguanide (DMBG, 200 mg/kg/d, by gavage), and CBLEB+DMBG combination. All treatments were administered daily for four weeks. The body weight and fasting blood glucose were monitored weekly. An oral glucose tolerance test was performed to assess the glucose tolerance. The serum levels of lipids (triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), insulin, and inflammatory factors (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-10, and lipopolysaccharide) were measured by enzyme-linked immunosorbent assay. Pancreatic IL-6 and TNF-α expression was detected by immunohistochemistry. The histopathological changes in the pancreas, colon, and adipose tissues were evaluated by hematoxylin and eosin staining. The protein expression of insulin receptor substrate 1 (IRS-1)/p-IRS-1 (Ser307), Toll-like receptor 4 (TLR4)/MyD88, tight junction proteins (zonula occludens protein 1 [ZO-1]/claudin 1 [CLDN1]/occludin), and B-cell lymphoma/leukemia-2 (Bcl-2)-associated X protein A (BAX)/Bcl-2 was analyzed by Western blot. The gut microbiota composition was profiled by 16S rRNA gene sequencing.</p><p><strong>Results: </strong>CBLEB significantly improved the weight gain, hyperglycemia, insulin resistance (IR), dyslipidemia, reduced adipocyte size, suppressed systemic inflammation, and alleviated pancreatic and colonic damage in T2DM mice. The combination of CBLEB and DMBG showed the most pronounced improvements in metabolic and inflammatory parameters. Western blot showed that CBLEB inhibited TLR4/MyD88 signaling, enhanced insulin signaling (IRS-1/p-IRS-1), repaired the intestinal barrier (ZO-1/CLDN1/occludin), and regulated the apoptotic balance (BAX/Bcl-2). Gut microbiota analysis suggested that CBLEB remodeled the gut microbiota, with a functional prediction suggesting shifts in the metabolic pathways and a decrease in the abundance of <i>Escherichia</i> spp.</p><p><strong>Conclusion: </strong>CBLEB ameliorated systemic inflammation and IR in obese T2DM mice through gut microbiota modulation, intestinal barrier restoration, and suppression of inflammatory pathways.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"800-819"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a sustainable dietary pattern for Korean adults using quadratic programming.","authors":"So-Yoon Yun, Sewoon Ka, Youngmin Nam, Soojin Park, Youngmi Lee, Jihyun Yoon","doi":"10.4162/nrp.2026.20.5.848","DOIUrl":"10.4162/nrp.2026.20.5.848","url":null,"abstract":"<p><strong>Background/objectives: </strong>Dietary patterns play a critical role in mitigating environmental impacts while ensuring nutritional adequacy. Although several global models of sustainable diets have been proposed, evidence-based research reflecting Korea's unique dietary culture remains limited. This study aimed to develop a sustainable dietary pattern for Korean adults that balances cultural acceptability, nutritional adequacy, and environmental sustainability.</p><p><strong>Subjects/methods: </strong>Quadratic programming was applied to derive an optimized dietary pattern minimizing the deviations from the observed dietary intakes while satisfying cultural acceptability, nutritional adequacy, and environmental sustainability constraints. The model parameters were derived from nationally representative 24-h dietary recall data from 3,983 Korean adults aged 19-64 yrs in the 2023 Korea National Health and Nutrition Examination Survey. The cultural acceptability constraints were defined within the intake-distribution bounds at the food group and food subgroup levels. The nutritional adequacy constraints were based on the 2025 Korean Dietary Reference Intakes. The environmental sustainability constraints were implemented by progressively tightening the allowable level of diet-related greenhouse gas (GHG) emissions. Elasticity analysis identified the final optimized pattern, hereafter termed the sustainable dietary pattern.</p><p><strong>Results: </strong>A sustainable dietary pattern was identified at a diet-related GHG emissions level of 2.19 kg CO₂eq/day, representing a 49% reduction from the current level (4.29 kg CO₂eq/day). Plant-based foods accounted for 68.5% of total intake by weight, animal-based foods for 18.3%, and sugars, seasonings, and fats for 13.2%. Vegetables (26.9%) and grains (23.5%) together comprised approximately half of the total food intake by weight, followed by fruits (12.9%) and animal-based protein foods (12.0%). Red meat intake decreased from 81.1 to 49.1 g/day, whereas combined fruit and vegetable intake increased from 395.9 to 500.0 g/day.</p><p><strong>Conclusion: </strong>A sustainable dietary pattern satisfying the cultural acceptability, nutritional adequacy, and environmental sustainability constraints was identified. This pattern provides a scientific basis for developing Korean-style sustainable dietary guidelines and may inform future nutrition policies and food service practices.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 5","pages":"848-865"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year trends in sugar-sweetened beverages consumption among Koreans, 2014-2023.","authors":"HyunJi Son, Khongorzul Ganbat, SuJin Song","doi":"10.4162/nrp.2026.20.4.683","DOIUrl":"10.4162/nrp.2026.20.4.683","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study investigated the 10-yr trends in sugar-sweetened beverages (SSBs) consumption among Koreans.</p><p><strong>Subjects/methods: </strong>Data from the 2014-2023 Korea National Health and Nutrition Examination Surveys, including 62,887 participants, were analyzed. SSBs consumption was assessed as the number of servings per day using a 24-h dietary recall. The proportions (%) of individuals consuming SSBs ≥ 1 and ≥ 2 servings/day were reported. The energy and sugar intakes from SSBs were evaluated. These analyses were also conducted separately among SSBs consumers only (n = 33,396). The trends in SSBs consumption over time were assessed using multivariable linear regression.</p><p><strong>Results: </strong>Over 2014-2023, SSBs consumption showed decreasing trends among individuals aged 19-29 yrs, from 1.30 servings/day (SE = 0.10) to 0.92 servings/day (SE = 0.08), and those aged 30-49 yrs, from 1.20 servings/day (SE = 0.05) to 0.90 servings/day (SE = 0.05) (<i>P</i>-trends < 0.001). Among SSBs consumers only, a significant decline was observed among children aged 6-8 yrs, from 1.57 servings/day (SE = 0.17) to 1.54 servings/day (SE = 0.15), but no significant changes were observed in other age groups. From 2014 to 2023, the percentage of individuals consuming SSBs ≥ 1 serving/day decreased from 41.4% to 36.3% among the study subjects aged 19-29 yrs, and from 43.6% to 35.2% among those aged 30-49 yrs, but SSBs consumers aged 30-49 yrs showed an increasing trend (from 65.3% to 68.3%) (<i>P</i>-trends < 0.05). In the total subjects, the energy and sugar intakes from SSBs showed decreasing trends among adults (<i>P</i>-trends < 0.05), while no significant changes were observed in children and adolescents.</p><p><strong>Conclusion: </strong>These findings highlight the age-specific consumption trends of SSBs among Koreans and underscore the importance of continued monitoring of SSBs consumption.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"683-696"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with saponins from <i>Panax japonicus</i> decreases jejunal inflammation in mice fed a high-fat diet.","authors":"Yaoyan Dun, Jiao'e Dong, Hanyu Xiang, Zhaoqi Chen, Huiwen Wang, Zhengguo Xiong, Min Liu","doi":"10.4162/nrp.2026.20.4.590","DOIUrl":"10.4162/nrp.2026.20.4.590","url":null,"abstract":"<p><strong>Background/objectives: </strong>Chronic high-fat diet (HFD) consumption induces low-grade intestinal inflammation. Although saponins from <i>Panax japonicus</i> (SPJs) have anti-inflammatory properties, the mechanisms by which they mitigate HFD-induced jejunal inflammation remain unclear. This study examined whether SPJs alleviate inflammation by modulating lipid metabolism and endoplasmic reticulum stress (ERS) in the jejunum.</p><p><strong>Materials/methods: </strong>HFD-fed mice were administered high-dose SPJs extract. The jejunal triglyceride (TG) levels, gene expression related to TG synthesis (glycerol-3-phosphate acyltransferase 3 [Gpat3] and diacylglycerol O-acyltransferase 2 [Dgat2]) and lipolysis (adipose triglyceride lipase [Atgl]), cytosolic lipid droplets (CLDs) deposition, ERS markers, and inflammatory responses were assessed.</p><p><strong>Results: </strong>HFD feeding induced TG accumulation, upregulated Gpat3 and Dgat2, downregulated Atgl, and promoted CLDs deposition in jejunal epithelial cells. High-dose SPJs attenuated these changes. Furthermore, SPJs suppressed HFD-induced ERS and inflammation in the jejunum. In particular, short-term HFD exposure initially enhanced the antioxidant responses without significant ERS activation.</p><p><strong>Conclusion: </strong>SPJs ameliorate HFD-induced jejunal inflammation by modulating lipid metabolic genes, reducing intracellular lipid accumulation, and alleviating ERS. These findings highlight the role of lipid-driven ERS in gut inflammation and the potential of SPJs as a therapeutic intervention.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"590-608"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of B-vitamin-derived dietary pattern with depressive symptoms: evidence from the NHANES.","authors":"Peng Zhao, Mengyuan Zheng, Mengyao Wu, Yiquan Xiong, Fangyao Chen","doi":"10.4162/nrp.2026.20.4.639","DOIUrl":"10.4162/nrp.2026.20.4.639","url":null,"abstract":"<p><strong>Background/objectives: </strong>Depressive symptoms are a multifactorial global mental health issue. B-vitamin intake is associated with mental and neurological health, but the association between B-vitamin-related dietary patterns and depressive symptoms remains unclear. This study examined the association between B-vitamin-related dietary patterns and depressive symptoms.</p><p><strong>Subjects/methods: </strong>Data were obtained from the National Health and Nutrition Examination Survey 2005-2018. Reduced rank regression (RRR) was used to derive the dietary patterns, with 6 energy-adjusted B-vitamin intakes (B1, B2, B3, B6, B9, and B12) as response variables. Both predictor food groups and B-vitamin response variables were energy-adjusted before RRR using the residual method. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Survey-weighted multivariable logistic regression models were used to estimate the adjusted odds ratios (aORs) and 95% confidence intervals (CIs), adjusting for the sociodemographic, lifestyle, and health-related confounders.</p><p><strong>Results: </strong>A total of 31,037 participants were included in the analytic sample for dietary pattern derivation and association analyses. The identified dietary pattern was characterized by the higher consumption of milk, soy products, whole grains, dark green vegetables, red and orange vegetables, and fruit, and lower consumption of added sugar, solid fat, and alcoholic drinks. In the fully adjusted model, each 1 SD increase in the dietary pattern score was associated with lower odds of depressive symptoms (aOR, 0.856; 95% CI, 0.802-0.913). Compared with the lowest quartile (Q1), participants in the highest quartile (Q4) had significantly lower odds (aOR, 0.668; 95% CI, 0.571-0.781; <i>P</i> for trend < 0.001).</p><p><strong>Conclusion: </strong>Higher scores for the B-vitamin-related dietary pattern were associated with lower odds of depressive symptoms among United States adults. These findings suggest that B-vitamin-related food patterns may be relevant to depressive symptoms, but causality cannot be inferred from this cross-sectional study. Prospective studies are needed to confirm these associations.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"639-655"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oyster hydrolysate attenuates osteoarthritis progression by modulating inflammatory signaling and extracellular matrix homeostasis.","authors":"Seon Yeong Ji, Hyun Hwangbo, Min Yeong Kim, Da Hye Kim, Su Hyun Hong, Jung-Hyun Shim, Sung-Kwon Moon, Gi-Young Kim, Suengmok Cho, Yung Hyun Choi","doi":"10.4162/nrp.2026.20.4.571","DOIUrl":"10.4162/nrp.2026.20.4.571","url":null,"abstract":"<p><strong>Background/objectives: </strong>Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage destruction and persistent low-grade inflammation, in which extracellular matrix (ECM) homeostasis plays a pivotal role. Although oyster hydrolysate (OH), derived from <i>Crassostrea gigas</i> (<i>Magallana gigas</i>), is rich in bioactive peptides and has antioxidant and anti-inflammatory properties, its effects on the pathogenesis of OA have not yet been studied. This study aimed to investigate the anti-inflammatory and chondroprotective effects of OH using <i>in vitro</i> and <i>in vivo</i> OA models.</p><p><strong>Materials/methods: </strong>To evaluate the protective effects of OH against OA-associated inflammation and ECM degradation, an <i>in vitro</i> inflammatory model was established by stimulating human chondrosarcoma SW1353 cells with interleukin (IL)-1β, followed by assessment of inflammatory and ECM-related proteins. <i>In vivo</i>, OA was induced by intra-articular injection of monosodium iodoacetate (MIA) into the knee joints of Sprague-Dawley rats, and arthritis-related histological, molecular, and biochemical biomarkers were analyzed in joint tissues and serum.</p><p><strong>Results: </strong><i>In vitro</i>, OH reduced IL-1β-induced pro-inflammatory cytokine production and downregulated ECM-degrading enzymes, including a disintegrin and metalloproteinase with thrombospondin motifs-5, matrix metalloproteinase (MMP)-3, and MMP-13, but preserved the expression levels of anabolic proteins, such as aggrecan and collagen II. These effects were associated with the suppression of phosphoinositide 3-kinase/protein kinase B, c-Jun N-terminal kinase, p38, and nuclear factor κB cells signaling pathways. Consistently, oral administration of OH for 14 days alleviated joint swelling, preserved proteoglycan content, and improved the histological Osteoarthritis Research Society International scores in MIA-induced OA rats. OH treatment also reduced the cartilage expression levels of inflammatory cytokines and MMPs and serum levels of IL-1β, IL-6, leukotriene B4, MMP-9, C-reactive protein, and cartilage oligomeric matrix protein.</p><p><strong>Conclusion: </strong>Overall, our results suggest that OH attenuates OA progression by modulating inflammatory signaling and restoring ECM homeostasis, highlighting its potential as a marine-derived candidate for OA prevention and therapy.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"571-589"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barley sprouts as a modulator of the gut microbiota, influencing glucose and lipid metabolism in ovariectomized female rats fed a high-fat diet.","authors":"Yeonjeong Choi, Yoona Kim, Young-Min Lee","doi":"10.4162/nrp.2026.20.4.609","DOIUrl":"10.4162/nrp.2026.20.4.609","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study examined the effects of barley sprout supplementation on glucose and lipid metabolism, and on the changes in the gut microbiota in high-fat-fed ovariectomized (OVX) rats.</p><p><strong>Materials/methods: </strong>Female Sprague-Dawley rats aged 8 weeks (14 with an ovariectomy and 12 without) were assigned to one of 4 experimental groups: Sham-operated control group fed a high-fat diet (Sham-C; n = 6), Sham-operated group fed a high-fat diet with 2% barley sprout supplementation (Sham-B; n = 6), OVX control group fed a high-fat diet (OVX-C; n = 7), and OVX group fed a high-fat diet with 2% barley sprout supplementation (OVX-B; n = 7).</p><p><strong>Results: </strong>After diet administration for 7 weeks, the OVX-B group showed lower serum fasting glucose and total cholesterol levels than the OVX-C group. Taxonomy analysis revealed significantly lower abundance of the gut microbial families <i>Clostiridiaceae</i> and species <i>Enterococcus hirae</i> and higher abundance levels of gut microbial species <i>Clostridium saudiense</i> in the OVX-B group than in the OVX-C group. The Principal Coordinates Analysis plot for the β-diversity assessment showed that the OVX-C group had a different gut microbiota structure than the Sham-C group. The OVX-B group formed a different microbiota structure from that of the OVX-C group, while the distribution of the OVX-B group overlapped with the regions of the Sham-C and Sham-B groups; its centroid shifted toward the Sham-B group.</p><p><strong>Conclusion: </strong>Barley sprout supplementation might improve glucose and lipid metabolism by modulating the gut microbiota in OVX female rats fed a high-fat diet.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"609-626"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cancer effect of estradiol and β-carotene in human colon cancer cells.","authors":"Sejin Park, Yuri Kim","doi":"10.4162/nrp.2026.20.4.722","DOIUrl":"10.4162/nrp.2026.20.4.722","url":null,"abstract":"<p><strong>Background/objectives: </strong>Colorectal cancer (CRC) is a common malignancy worldwide and continues to account for significant cancer-associated morbidity and mortality. This study aimed to explore the anti-cancer effects of estradiol (E2), a female hormone, and β-carotene (BC), a dietary antioxidant, focusing on their roles in promoting apoptosis and regulating the expression of BC-related metabolic enzymes in human colon cancer cells.</p><p><strong>Materials/methods: </strong>E2, BC, and a combination of both were administered to 2 human colon cancer cell lines, HCT116 and HT29. Cell survival was analyzed using the MTT assay. Expression of estrogen receptor beta (ERβ), β,β-carotene-15',15'-monooxygenase 1 (BCMO1), β,β-carotene-9',10'-oxygenase 2 (BCO2), and apoptosis-related markers such as Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) was analyzed using polymerase chain reaction or Western blotting.</p><p><strong>Results: </strong>E2 treatment decreased cell viability in both cell lines, indicating that E2 promotes anti-cancer effects. BC treatment modestly increased E2 secretion, while the combined E2 and BC treatment enhanced this effect. Treatment with E2, BC, and their combination suppressed Bcl-2 expression and upregulated Bax. The combination treatment was more effective than each treatment administered individually. Furthermore, treatment with E2, BC, and their combination upregulated the expression of ERβ, BCMO1, and BCO2.</p><p><strong>Conclusion: </strong>The anti-cancer effects of E2, BC, and their combination are mediated through apoptosis induction. These findings highlight the potential for utilizing dietary antioxidants and hormonal regulation as complementary strategies in CRC treatment.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"722-733"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sustainable consumption tendency on lunchbox purchase behavioral intention among university students in Gyeongnam: the mediating role of ESG management perception.","authors":"Yoo Sun Kwon, Eun Sil Her","doi":"10.4162/nrp.2026.20.4.697","DOIUrl":"https://doi.org/10.4162/nrp.2026.20.4.697","url":null,"abstract":"<p><strong>Background/objectives: </strong>The importance of Environmental, Social, and Governance (ESG) management in the food service industry is increasing as value-based consumption emphasizing the climate crisis and social values expands. This study empirically investigated the structural relationship between university students' sustainable consumption tendencies and their lunchbox-purchase behavioral intentions through the mediation of the perceived importance of ESG management.</p><p><strong>Subjects/methods: </strong>An online survey was conducted among 285 university students in the Gyeongsangnam-do region. The collected data were analyzed using structural equation modeling and bootstrapping techniques to verify the mediating effects.</p><p><strong>Results: </strong>Hypothesis testing showed that sustainable consumption tendency had a significant positive effect on the perceived importance of ESG management (β = 0.544, <i>P</i> < 0.001). The perceived importance of ESG management was a key determinant directly influencing purchase behavioral intentions (β = 0.482, <i>P</i> < 0.001). Furthermore, mediation analysis confirmed that a tendency toward sustainable consumption had a significant indirect effect on purchase behavioral intentions through the perceived importance of ESG management (β = 0.308).</p><p><strong>Conclusion: </strong>The perceived importance of ESG management may serve as a mechanism linking university students' sustainable consumption tendency to their lunchbox-purchase behavioral intentions. These findings suggest that lunchbox companies should communicate concrete ESG practices, such as environmental protection, healthy meal offerings, and transparent nutrition and product information, to support healthier and more sustainable food choices.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"697-708"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isothiocyanates inhibit the cisplatin-induced apoptosis and inflammation in human kidney HEK-293 cells.","authors":"Ha-Rin Moon, Jung-Mi Yun","doi":"10.4162/nrp.2026.20.4.709","DOIUrl":"10.4162/nrp.2026.20.4.709","url":null,"abstract":"<p><strong>Background/objectives: </strong>Cisplatin is a widely used drug clinically for the treatment of numerous solid malignant tumors. However, the use of cisplatin has resulted in serious side effects, of which renal toxicity and renal dysfunction are the most common. In this study, we explored the effect of isothiocyanates in cisplatin-treated human embryonic kidney (HEK)-293 cells. Allyl isothiocyanate (AITC) and benzyl isothiocyanate (BITC) are substances found in cruciferous vegetables such as watercress and broccoli. They possess various physiological activities including anti-inflammatory, anticancer and antioxidant. However, the protective effect of AITC and BITC against cisplatin-induced nephrotoxicity has not yet been elucidated.</p><p><strong>Materials/methods: </strong>HEK-293 cells were treated with cisplatin (50 µM) in AITC and BITC (0.3-1.25 µM) in the absence or presence for 24 h. MTT assays detected cell viability, and Hoechst 33342 staining allowed us to observe nuclear morphology changes such as chromatin condensation and apoptotic nuclei. Reactive oxygen species (ROS) detection assays measured intracellular ROS production and the griess reaction assays assessed nitric oxide (NO) production. Western blotting and quantitative polymerase chain reactions quantified corresponding proteins and mRNA.</p><p><strong>Results: </strong>Cisplatin treatment for 24 h increased the generation of intracellular ROS and NO production compared to untreated cells. In contrast, pretreatment with AITC and BITC significantly reduced intracellular ROS generation and NO production. AITC and BITC also significantly inhibited cisplatin-induced inflammation-related genes expression. AITC and BITC decreased cisplatin-induced mitogen-activated protein kinase (MAPK) protein expression. Pretreatment of cells with AITC and BITC in cisplatin-treated cells downregulated the Bax/Bcl-2 expression ratio, resulting in a dose-dependent inhibition of apoptosis.</p><p><strong>Conclusion: </strong>Our results suggest that the inhibition of inflammation and cell death via MAPK signaling in HEK-293 cells plays a protective role in kidney damage. Therefore, AITC and BITC may be potential candidates to attenuate and prevent the onset and progression of nephrotoxicity.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 4","pages":"709-721"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}