Nutrition Research and Practice最新文献

{"title":"Causal effect of coffee consumption on metabolic syndrome in Korean adults: a 2-sample Mendelian randomization study.","authors":"Subin Kim, Dayeon Shin","doi":"10.4162/nrp.2025.19.6.943","DOIUrl":"10.4162/nrp.2025.19.6.943","url":null,"abstract":"<p><strong>Background/objectives: </strong>Coffee consumption is associated with metabolic syndrome (MetS), but the findings have been inconsistent because of residual confounding. This study investigated the relationship between coffee consumption and MetS and its components using Mendelian randomization (MR) with genetic instrumental variables (IVs).</p><p><strong>Subjects/methods: </strong>Coffee consumption was calculated from a food-frequency questionnaire using the 12-mon frequency and portion size, with cups converted to grams (2.7 g/cup) in the Korean Genome and Epidemiology Study-Health Examinees cohort (n = 58,144) for genetic instrument selection. MetS was defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines in the Ansan and Ansung cohort (n = 5,351) for the outcome estimation. Genome-wide association analysis (GWAS) for coffee consumption (g/day) was conducted using linear regression, and logistic regression was used for MetS and its components. IVs were single-nucleotide polymorphisms associated with coffee consumption at genome-wide significance (<i>P</i> < 5 × 10^-6) from GWAS after linkage disequilibrium clumping (r² < 0.05 within ± 500 kb). MR analyses of the association between coffee consumption and MetS and its components were conducted using 5 approaches (inverse variance weighted [IVW], MR-Egger, weighted median, weighted mode, and simple mode). Sensitivity analyses were conducted using Cochran's Q and the horizontal pleiotropy test.</p><p><strong>Results: </strong>IVW indicated a negative association with MetS in males (odds ratio, 0.702; 95% confidence interval, 0.613-0.805). In females, MetS and its components had no association (<i>P</i> < 0.05). Cochran's Q detected heterogeneity in females for elevated waist circumference, and MR-pleiotropy residual sum and outlier analysis identified outliers, but the results remained unchanged.</p><p><strong>Conclusion: </strong>This MR study revealed sex-specific causal relationships between coffee consumption and MetS in Korean adults, suggesting protection against MetS and its components in males.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"943-966"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of collagen tripeptide supplementation on oxidative stress and mitochondrial function in aging.","authors":"Chae-Eun Kim, Joong Su Lee, Yun-Ho Kim, Yong Chul Shin, Su-Kyung Shin, Eun-Young Kwon","doi":"10.4162/nrp.2025.19.6.867","DOIUrl":"10.4162/nrp.2025.19.6.867","url":null,"abstract":"<p><strong>Background/objectives: </strong>Aging is often accompanied by chronic oxidative stress, contributing to the progression of metabolic disorders. A previous study reported that supplementation with collagen tripeptide (CTP) inhibits fatty liver and lipid hypertrophy, but the mechanism is unclear.</p><p><strong>Materials/methods: </strong>This study examined the effects of 12-week CTP supplementation on oxidative stress, insulin resistance, and adenosine monophosphate-activated protein kinase (AMPK) α activation, key factors in metabolic disorders in aged mice. Thirty-eight male C57BL/6J mice (58 weeks old) were assigned to 4 groups: aging control, 0.03% Gly-Pro-Hyp, 0.9% CTP, and 0.9% granulated collagen tripeptide (gCTP) supplementation. A group of young mice (YC, n = 8) served as the positive control.</p><p><strong>Results: </strong>The results showed that CTP and gCTP enhance antioxidant capacity by reducing thiobarbituric acid reactive substances and H₂O₂ and improving the antioxidant enzyme activities, including superoxide dismutase and glutathione peroxidase. CTP also improved insulin sensitivity by increasing the expression of insulin receptors and glucose transporters in the liver and white adipose tissue. Furthermore, CTP and gCTP improved energy metabolism and mitochondrial function via AMPKα activation.</p><p><strong>Conclusion: </strong>CTP supplementation is a promising intervention to mitigate comorbidities in older adults, such as obesity and fatty liver disease. CTP and gCTP supplementation may serve as functional ingredients to improve energy metabolism and mitochondrial function. Their potential to reduce oxidative stress, improve insulin resistance, and enhance AMPKα expression supports their use in managing obesity and fatty liver disease, particularly in older adults.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"867-879"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of nutritional status between adults with and without disabilities: a population-based cross-sectional study in South Korea.","authors":"Jong Eun Park, Tae Hui Jang, So Young Kim, Jong Hyock Park","doi":"10.4162/nrp.2025.19.6.967","DOIUrl":"10.4162/nrp.2025.19.6.967","url":null,"abstract":"<p><strong>Background/objectives: </strong>There has been a notable lack of effort to evaluate the nutritional status of persons with disabilities objectively and identify their nutritional challenges. This study aimed to assess whether nutritional inadequacies and imbalances are more pronounced in persons with disabilities compared to those without, using data from the 6th Korea National Health and Nutrition Examination Survey (2013).</p><p><strong>Subjects/methods: </strong>The participants were classified into 387 persons with disabilities and 4,909 without disabilities. The 15 types of disabilities were categorized into 5 groups, and disability severity was classified as severe or mild. Nutrient intake and nutritional status were assessed using 24-h dietary recall data.</p><p><strong>Results: </strong>Compared to persons without disabilities, those with disabilities had significantly lower nutrient adequacy ratios for 8 of 10 nutrients, the exceptions being vitamins B1 and C (all <i>P</i> < 0.05). The likelihood of low overall nutrient adequacy based on the mean adequacy ratio was significantly higher among persons with disabilities (odds ratio [OR], 1.50; 95% confidence interval [CI], 1.11-2.04), with particularly elevated odds for those with severe, visual, and internal organ disabilities. Persons with severe disabilities had higher odds of consuming a diet with low nutrient density (OR, 1.59; 95% CI, 1.05-2.40) and of experiencing nutritional deficiency (OR, 2.21; 95% CI, 1.02-4.75) than those without disabilities. Additionally, the odds of consuming a high-carbohydrate diet, with > 70% of daily energy intake from carbohydrates, was 3.63-fold higher (95% CI, 1.40-9.42) among persons with mental disabilities.</p><p><strong>Conclusion: </strong>Persons with disabilities faced significant nutritional inadequacies and imbalances compared to those without disabilities. Targeted nutrition interventions and disability-inclusive nutrition policies and practices are urgently needed to reduce these disparities.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"967-984"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-3 highly unsaturated fatty acids combined with pro-biotics or post-biotics synergistically alleviate dyslipidemia in rats exposed to chronic mild stress.","authors":"Jeongmin Lee, Youri Jin, Yongsoon Park","doi":"10.4162/nrp.2025.19.6.853","DOIUrl":"10.4162/nrp.2025.19.6.853","url":null,"abstract":"<p><strong>Background/objectives: </strong>This research is objective to examine the synergistic hypocholesterolemic effects of n-3 highly unsaturated fatty acids (HUFA) combined with pro- or post-biotics on dyslipidemia caused by chronic mild stress (CMS) through modulating biosynthesis and clearance of cholesterol.</p><p><strong>Materials/methods: </strong>Rats were assigned into 7 random groups, each containing 8 rats: n-3 HUFA deficient diet without CMS, CMS with n-3 HUFA deficient diet, pro-biotics, post-biotics, n-3 HUFA, n-3 HUFA with pro-biotics, and n-3 HUFA with post-biotics. The induction of CMS occurred over 5 weeks during the 12-week dietary supplementation period.</p><p><strong>Results: </strong>The n-3 HUFA, pro-biotics, and post-biotics ameliorated dyslipidemia caused by CMS and downregulated cholesterol biosynthesis through decreasing sterol regulatory element-binding protein-2 (biotics, <i>P</i> < 0.001; N3, <i>P</i> < 0.001; synergistic, <i>P</i> = 0.014) and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (biotics, <i>P</i> < 0.001; N3, <i>P</i> < 0.001; synergistic, <i>P</i> < 0.001). Moreover, they upregulated cholesterol clearance by increasing low-density lipoprotein-cholesterol reuptake through proprotein convertase subtilisin/kexin type 9 (biotics, <i>P</i> < 0.001; N3, <i>P</i> < 0.001; synergistic, <i>P</i> = 0.036) and bile acids biosynthesis through cytochrome p450 family 7 subfamily A member 1 (biotics, <i>P</i> < 0.001; N3, <i>P</i> < 0.001; synergistic, <i>P</i> < 0.001) and cytochrome p450 family 27 subfamily A member 1 (biotics, <i>P</i> < 0.001; N3, <i>P</i> < 0.001; synergistic, <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Therefore, n-3 HUFA with pro-biotics or post-biotics exert synergistic hypocholesterolemic effects on dyslipidemia induced by CMS through regulating biosynthesis and cholesterol clearance.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"853-866"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes-specific oral nutritional supplement for prediabetes improves postprandial glycemic responses: an open-label, crossover clinical trial.","authors":"Yeongtaek Hwang, Minkyung Bok, Suk Chon, Hyunjung Lim","doi":"10.4162/nrp.2025.19.6.904","DOIUrl":"10.4162/nrp.2025.19.6.904","url":null,"abstract":"<p><strong>Background/objectives: </strong>Regulating the postprandial glucose levels is crucial for preventing the progression of prediabetes to diabetes. This study examined the effects of a diabetes-specific nutrition formula (DSNF) on the postprandial plasma glucose, serum insulin, and serum c-peptide levels in individuals with prediabetes.</p><p><strong>Subjects/methods: </strong>An open-label, crossover clinical trial was conducted to compare the effects of the DSNF versus standard oral nutritional supplement (ONS) on glycemic control. Fifteen subjects with prediabetes were enrolled and received the DSNF on the first visit and standard ONS on the second. The postprandial plasma glucose, serum insulin, and serum c-peptide incremental area under the curve (iAUC), as well as the incremental maximal concentration (iC_max) and the maximum concentration (C_max), were measured after each intervention. Statistical comparisons between DSNF and standard ONS were conducted using a Wilcoxon's signed-rank test.</p><p><strong>Results: </strong>After consuming the DSNF, the iAUC of the postprandial glucose level was significantly low compared to the standard ONS (1,683.49 ± 911.65 vs. 4,455.92 ± 1,658.77, <i>P</i> < 0.0001). Similarly, the serum insulin iAUC (2,017.33 ± 987.64 vs. 2,570.59 ± 1,201.09, <i>P</i> = 0.0181) and c-peptide iAUC (274.17 ± 116.12 vs. 491.18 ± 123.90, <i>P</i> < 0.0001) decreased significantly after DSNF administration compared to the standard ONS.</p><p><strong>Conclusions: </strong>The consumption of DSNF significantly improved the postprandial glucose, insulin, and c-peptide responses compared to the standard ONS.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0008904.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"904-916"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an illustrated questionnaire on healthy eating practices among Korean preschool children.","authors":"Dawon Park, Bo-Jeong Gong, Dahyeon Kim, Young-Hee Han, Saerom Shin, Eun Yeol Woo, Hye-Kyung Park, Taisun Hyun","doi":"10.4162/nrp.2025.19.6.985","DOIUrl":"10.4162/nrp.2025.19.6.985","url":null,"abstract":"<p><strong>Background/objectives: </strong>An illustrated questionnaire, the Healthy Eating Practice Questionnaire (HEPQ), was developed and validated to assess healthy eating practices among Korean preschool children.</p><p><strong>Subjects/methods: </strong>The development process consisted of 4 phases: (1) item generation based on a literature review and focus group interviews, (2) item refinement through expert consultation, (3) illustration design, and (4) validation. One hundred and eighty-seven child-parent pairs and 24 teachers participated in the validation study. The reliability was examined using test-retest analysis, and the validity was assessed by comparing the children's self-reports with those of their parents and teachers. The level of agreement was determined using the percentage agreement, kappa statistics, and intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The final 30-item questionnaire consisted of 4 domains: food preferences, eating behaviors, hand/oral hygiene practices, and nutrition knowledge. Most items showed a percentage agreement above 60% and kappa coefficients exceeding 0.5 in test-retest analysis, indicating acceptable consistency. The child-caregiver agreement was moderate to substantial, with kappa values generally above 0.4. The domain-level ICCs indicated good reliability (ICC = 0.49-0.83) and validity (ICC = 0.33-0.77) across all domains and subgroups. The comparisons by age showed that 4-yr-olds provided valid and reliable responses comparable to 5-yr-olds. The parents and teachers confirmed that the illustrated format was easy for the children to understand and complete independently.</p><p><strong>Conclusion: </strong>The HEPQ showed satisfactory reliability and validity for assessing healthy eating practices among preschool children. The illustrated format enhances comprehension and engagement, supporting its applicability for research and nutrition education in daycare settings.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"985-1001"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of calcium, fucoidan and chitooligosaccharide supplementation on bone mineral density and calcium balance in ovariectomized rats.","authors":"Sunju Yun, Mi-Kyeong Choi, Mi-Hyun Kim","doi":"10.4162/nrp.2025.19.6.880","DOIUrl":"10.4162/nrp.2025.19.6.880","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study examined the effect of calcium (Ca), fucoidan, and chitooligosaccharide supplementation alone and in combination on bone mineral density (BMD), bone metabolism, and Ca balance in ovariectomized (OVX) rats.</p><p><strong>Materials/methods: </strong>Forty-eight female Wistar rats (6 weeks) were used in this study; among them, 40 rats were OVX, and the rest of the rats were sham-operated (sham). The sham group and one OVX group were fed a standard diet (AIN-96, Ca 0.5%), and the remaining OVX groups received either a fucoidan-supplemented diet (fucoidan 0.05%; OVX-Fu), a chitooligosaccharide-supplemented diet (chitooligosaccharide 0.5%; OVX-Chito), a seaweed Ca-supplemented diet (Ca 1.5%; OVX-Ca), or a fucoidan, chitooligosaccharide and seaweed Ca-supplemented diet (fucoidan 0.05%, chitooligosaccharide 0.5%, Ca 1.5%; OVX-CaFuChito) for 12 weeks.</p><p><strong>Results: </strong>The OVX-CaFuChito group had the highest feed intake, but had a significantly lower final body weight than the other groups in OVX rats. The Ca retention was significantly higher in the OVX-Ca and OVX-CaFuChito groups than in all the other groups (<i>P</i> < 0.001). There was no effect of the treatments on bone mineral content and BMD at any site. When analyzing BMD divided by final body weight, the combined supplementation group had significantly higher BMDs at the lumbar spine, femur, and tibia compared to the OVX group; in contrast, individual supplementation did not show significant improvement in the BMD at any site in OVX rats.</p><p><strong>Conclusion: </strong>These results suggest that only the combined supplementation of Ca, fucoidan, and chitooligosaccharides may have a beneficial effect on preserving BMD along with suppressing postmenopausal weight gain.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 6","pages":"880-890"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of dietary and supplemental vitamin C intake according to the level of fruit and vegetable consumption.","authors":"Seulgi Lee, Ji-Yun Hwang, Kirang Kim","doi":"10.4162/nrp.2025.19.5.786","DOIUrl":"10.4162/nrp.2025.19.5.786","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study examined whether the intake pattern of dietary and supplementary vitamin C differs according to the sufficiency of fruit and vegetable (FV) intake and assessed the risk of vitamin C insufficiency according to FV sufficiency and vitamin C supplement use.</p><p><strong>Subjects/methods: </strong>Data from 10,464 adults aged ≥ 19 yrs from the 2019-2021 Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed. The participants were categorized into an FV-sufficiency (FVS; ≥ 500 g/day) and FV-insufficiency (FVINS; < 500 g/day) groups. The vitamin C intake from diet, supplements, and major food sources was examined.</p><p><strong>Results: </strong>Approximately 19.6% of young adults, 41.5% of middle-aged adults, and 39.6% of older adults met the recommended intake of FV. Most participants in the FVS group consumed more than 90 mg of dietary vitamin C (90% of the recommended nutrient intake [RNI]), whereas most in the FVINS group consumed less than 50 mg (50% of the RNI). Even among the FVS group, the proportion meeting the RNI ranged from 27% to 37%. In the FVINS group with adequate vitamin C intake, vitamin C was derived predominantly from sugar-sweetened beverages, fruit juice products, and meat. The participants who took vitamin C supplements had a lower risk of vitamin C insufficiency than non-users, regardless of the FV intake status.</p><p><strong>Conclusion: </strong>Although the prevalence of vitamin C insufficiency was high, regardless of FV sufficiency, supplementation allowed the FVS and FVINS groups to meet the recommended levels. Nevertheless, the quality of dietary sources remains a concern, with a reliance on less healthy options such as sugar-sweetened beverages and fruit juice products, particularly among young adults. These findings highlight the importance of promoting natural food sources like FV for better diet quality.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 5","pages":"786-798"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of mobile application-based dietary recommendations on patients aged 50 and older with type 2 diabetes, obesity, and hypertension in Gwangju, South Korea: a pilot trial.","authors":"Kyoung Yun Kim, Ha-Rin Moon, Seung-Hui Choi, Daeun Hong, Ha-Yun Jeong, Young-Rok Yu, Young-Shick Hong, Jung-Mi Yun","doi":"10.4162/nrp.2025.19.5.742","DOIUrl":"10.4162/nrp.2025.19.5.742","url":null,"abstract":"<p><strong>Background/objectives: </strong>Interest in health improvement through mobile application (app)-based dietary interventions is increasing, and related research is on the rise. Mobile app usage as a means of dietary intervention is currently underwhelming. Therefore, this study aimed to provide dietary recommendations to patients through a mobile app and analyze the impact of their consumption on the improvement of health indicators.</p><p><strong>Subjects/methods: </strong>This pilot intervention study evaluated the changes in disease-related indicator levels following a 2-week dietary intervention in patients (n = 15; mean age = 71 years) with type 2 diabetes, hypertension, and obesity from January to February 2024 at Chonnam National University in Korea. We calculated participants' daily caloric requirements based on the information they had entered into the mobile application and also provided disease-specific dietary recommendations. Moreover, we measured their body characteristics and collected blood samples before and after the intervention to analyze changes in disease-related biomarkers and metabolites.</p><p><strong>Results: </strong>The body mass index (<i>P</i> = 0.028), systolic blood pressure (<i>P</i> = 0.038), and grip strength (left) (<i>P</i> = 0.009) values of 14 participants significantly improved following the dietary intervention. Additionally, their fasting blood glucose, high-sensitivity C-reactive protein, malondialdehyde, adiponectin, and leptin levels also improved. In the serum metabolite analysis, participants with hypertension exhibited a significant decrease in circulating lactate (<i>P</i> = 0.03) and trimethylamine <i>N</i>-oxide (<i>P</i> = 0.06) levels after following the mobile app-based dietary recommendations.</p><p><strong>Conclusion: </strong>Although a pilot, this mobile app-based dietary intervention yielded marked improvements across several disease indicators, suggesting that its advancement may help prevent and manage chronic diseases.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 5","pages":"742-757"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steamed ginger extract ameliorates the symptoms of osteoarthritis in monosodium iodoacetate-induced osteoarthritis rats.","authors":"Hyun Sook Lee, Jae In Jung, Seungtae Lim, Dae Won Park, Seong Ho Lee, Jaewoo Bae, Jae Kyoung Lee, Eun Ji Kim","doi":"10.4162/nrp.2025.19.5.682","DOIUrl":"10.4162/nrp.2025.19.5.682","url":null,"abstract":"<p><strong>Background/objectives: </strong>Steamed ginger extract (GGE03) has been proposed as a complementary treatment for osteoarthritis (OA). On the other hand, the efficacy and mechanism are incompletely understood. This study examined the anti-osteoarthritic effects of GGE03 in monosodium iodoacetate (MIA)-induced OA Sprague-Dawley (SD) rats.</p><p><strong>Materials/methods: </strong>The rats were divided into the following groups: normal control group (NC); OA control group (OC); OA+30, 50, or 100 mg/kg body weight (BW)/day GGE03 group (O+G30, O+G50, or O+G100); OA+150 mg/kg BW/day methyl sulfonyl methane (MSM, positive control group (O+M). The SD rats were given GGE03 or MSM orally for 5 weeks. MIA was injected intra-articularly into the knee joints on day 15 to induce OA. The exercise performance test, pain behavior test, micro-computed tomography, histological examination, and immunofluorescence staining were performed on the knee joint. The inflammatory mediators, cytokines, and matrix metalloproteinase (MMP) mRNA expression were measured in the knee joint synovial fluid.</p><p><strong>Results: </strong>The OC group had significantly shorter exercise times to exhaustion and withdrawal threshold according to the von Frey test, more severe knee joint swelling and subchondral bone erosion than the NC group, and reduced type II collagen and aggrecan expression in the articular cartilage. The OC group showed a significantly higher mRNA expression of inflammatory mediators, cytokines, and MMPs than the NC group. In OA rats, GGE03 administration reduced knee swelling and cartilage degradation and increased type II collagen and aggrecan expression in the articular cartilage. GGE03 administration reduced the expression of inducible nitric oxide synthase, cyclooxygenase-2, 5-lipoxygenase, interleukin (IL)-1β, IL-6, tumor necrosis factor-α, MMP-2, MMP-3, MMP-9, and MMP-13 in the synovia of the knee joints.</p><p><strong>Conclusion: </strong>GGE03 administration is a useful supplementary agent for anti-OA treatment.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"19 5","pages":"682-697"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}