Nutrition Research and Practice最新文献

{"title":"Associations of higher protein intake with diet quality and diabetes-related metabolic health indicators in Korean adults without diabetes: analysis of Korean National Health and Nutrition Examination Survey (KNHANES) 2019-2021.","authors":"Ye-Jin Kim, Soo-Kyung Lee","doi":"10.4162/nrp.2026.20.3.521","DOIUrl":"10.4162/nrp.2026.20.3.521","url":null,"abstract":"<p><strong>Background/objectives: </strong>Rising pre-diabetes in Korean adults is an emerging concern, with notable increases observed even among younger adults. The interest in high-protein diets is also increasing in Korea, while concerns about excess intake remain. This study examined the associations of protein intake, diet quality, and diabetes-related metabolic indicators in Korean adults.</p><p><strong>Subjects/methods: </strong>This study analyzed 8,254 adults aged 19-64 yrs without diabetes from the Korean National Health and Nutrition Examination Survey 2019-2021, stratified by sex and pre-diabetic status. The protein intake was assessed using a 24-h recall, expressed as a percentage of the total energy intake, and divided into quintiles. The diet quality was examined using the Korean Healthy Eating Index. The diabetes-related metabolic indicators were waist circumference, triglyceride, high-density lipoprotein cholesterol (HDL-C), blood pressure, homeostasis model assessment of insulin resistance, and triglyceride-glucose index. The associations were analyzed using complex sample general linear models and logistic regression, adjusting for sociodemographic factors, lifestyle, and total energy intake.</p><p><strong>Results: </strong>The protein intake was positively associated with the diet quality, peaking at Q4, then declining. Pre-diabetic men showed a decreasing trend in the elevated triglyceride risk with higher protein intake (Q4: odds ratio [OR], 0.697 [0.489-0.995]; <i>P</i> for trend = 0.041). In women, higher protein intake was significantly associated with an increased risk of low HDL-C in the non-diabetic group (Q5: OR, 1.544 [1.141-2.088]; <i>P</i> for trend = 0.020) and with the pre-diabetic group showing a lower risk of elevated blood pressure (Q5: OR, 0.657 [0.458-0.944]; <i>P</i> for trend = 0.012).</p><p><strong>Conclusion: </strong>These findings suggest that in Korean adults without diabetes, maintaining an appropriate, balanced protein intake rather than simply increasing consumption may help manage the metabolic alterations associated with diabetes.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 3","pages":"521-538"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency modifies the association between ambient PM_2.5 exposure and possible sarcopenia in Korean adults: evidence from the HEXA study.","authors":"Jimi Kim","doi":"10.4162/nrp.2026.20.3.504","DOIUrl":"10.4162/nrp.2026.20.3.504","url":null,"abstract":"<p><strong>Background/objectives: </strong>Maintaining muscular power is essential for preventing sarcopenia and ensuring optimal physical performance. Although inadequate vitamin D levels and environmental pollutants are increasingly recognized as threats to musculoskeletal integrity, their synergistic impact has not been fully established. This study examined how the vitamin D status and atmospheric contaminants independently and collectively influence the prevalence of suspected sarcopenia, defined strictly as low handgrip strength.</p><p><strong>Subjects/methods: </strong>This cross-sectional analysis included 20,304 individuals from the Health Examinees cohort using baseline data. Vitamin D insufficiency was categorized as circulating 25-hydroxyvitamin D [25(OH)D] concentrations below 20 ng/mL. Residential address-linked data were used to estimate the annual mean exposure to nitrogen dioxide (NO₂) and particulate matter (PM_2.5 and PM₁₀). Possible sarcopenia was distinguished from clinically diagnosed sarcopenia by relying solely on gender-specific low grip strength cut-offs, according to the Asian Working Group for Sarcopenia guidelines. Multivariable linear and logistic regression models were used to assess the associations, and the interaction terms were included to evaluate the effect modification according to the vitamin D status.</p><p><strong>Results: </strong>Suboptimal vitamin D levels were widespread in the cohort (65.0%) and strongly correlated with increased pollutant exposure. After accounting for all potential confounders, elevated PM_2.5, PM₁₀, and NO₂ levels were associated with reduced serum 25(OH)D levels and a greater likelihood of suspected sarcopenia. Significant interplay was detected between PM_2.5 exposure and the vitamin D status, suggesting a combined effect on muscle health (<i>P</i> for interaction = 0.005).</p><p><strong>Conclusion: </strong>Vitamin D deficiency and air pollution exposure are independently associated with possible sarcopenia. In particular, PM_2.5 and a vitamin D deficiency exhibit a synergistic adverse association. These findings suggest that adequate vitamin D levels may be protective against pollution-associated declines in muscle strength, highlighting the need for longitudinal studies to explore integrated nutritional and environmental prevention strategies.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 3","pages":"504-520"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic reviews and meta-analyses.","authors":"Jinyoung Jeong, Jaehyeong Cho, Yeona Jo, Dongjin Yeo, Jiyoung Hwang, Yejun Son, Seohyun Hong, Selin Woo, Masoud Rahmati, Lee Smith, André Hajek, Dong Keon Yon","doi":"10.4162/nrp.2026.20.3.382","DOIUrl":"10.4162/nrp.2026.20.3.382","url":null,"abstract":"<p><strong>Background: </strong>Long-term health effects of low- and no-calorie sweeteners (LNCSs) have not been established.</p><p><strong>Objective: </strong>This review aimed to evaluate the associations between different types of LNCSs and a wide range of health outcomes from observational studies and randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>We systematically searched PubMed/MEDLINE, Embase, CINAHL, and Google Scholar from inception to December 2024 for meta-analyses. LNCSs were categorized into artificial sweeteners and other non-sugar sweeteners (NSSs), including non-nutritive sweeteners and sugar alcohols, along with their corresponding beverages. The A Measurement Tool Assessment Systematic Reviews 2 (AMSTAR 2) tool was used in this study. The credibility of observational evidence was evaluated using a classification system. The certainty of evidence from RCTs was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Eligible meta-analyses were reanalyzed using random-effects models and presented as estimated odds ratios (eOR) or standard mean differences (SMDs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 29 meta-analyses (AMSTAR 2: high, 22; moderate, 2; low, 3; and critically low, 2) with 24 observational studies and 6 RCTs, covering 50,034,327 participants, were included. Among the 135 associations, observational studies indicated that higher intake of NSSs was associated with increased risk of being overweight (eOR, 1.84; 95% CI, 1.30 to 2.61; credibility of evidence [CE], IV), having metabolic syndrome (eOR, 1.31; 95% CI, 1.21 to 1.42; CE, I), type 2 diabetes (eOR, 1.14; 95% CI, 1.02 to 1.29; CE, IV), and hypertension (eOR, 1.13; 95% CI, 1.07 to 1.19; CE, II). In contrast, RCTs showed that NSS consumption significantly decreased body weight in populations with overweight or obesity (SMD, -0.50; 95% CI, -0.70 to -0.30; GRADE, high).</p><p><strong>Conclusions: </strong>Our findings indicate that the use of LNCSs and their corresponding beverages is associated with potential health risks and modest benefits.</p><p><strong>Trial registration: </strong>International Prospective Registration of Systematic Reviews (PROSPERO) Identifier: CRD420251006761.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 3","pages":"382-397"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial sweeteners and risk of cardiometabolic outcomes and mortality: a systematic review and meta-analysis.","authors":"Minseo Kim, Sunny Kumar, Gerald Chi, Jane J Lee","doi":"10.4162/nrp.2026.20.3.359","DOIUrl":"10.4162/nrp.2026.20.3.359","url":null,"abstract":"<p><strong>Background: </strong>Artificial sweeteners are widely used as sugar substitutes to reduce sugar intake and mitigate health risks. However, their potential long-term health effects remain uncertain as existing studies have reported inconsistent findings.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aimed to examine the association between artificial sweetener intake and the risk of cardiometabolic outcomes and mortality.</p><p><strong>Methods: </strong>Studies were identified through comprehensive searches of PubMed and Embase up to October 8, 2025. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) comparing the highest and lowest artificial sweetener consumption categories were calculated using a random-effects model. Heterogeneity was assessed using the I² statistic. The methodological quality of the included studies was evaluated using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>In total, 3,625,613 participants from 37 studies were included. Higher artificial sweetener intake was associated with an increased risk of type 2 diabetes (HR, 1.26; 95% CI, 1.14-1.40), hypertension (HR, 1.13; 95% CI, 1.09-1.18), heart failure (HR, 1.26; 95% CI, 1.14-1.39), stroke (HR, 1.12; 95% CI, 1.05-1.19), coronary artery disease (HR, 1.11; 95% CI, 1.00-1.23), cardiovascular mortality (HR, 1.18; 95% CI, 1.03-1.35), and all-cause mortality (HR, 1.09; 95% CI, 1.01-1.17). The association with atrial fibrillation was not significant (HR, 1.13; 95% CI, 0.94-1.37). Significant heterogeneity was observed for all endpoints except for stroke and heart failure.</p><p><strong>Conclusions: </strong>This meta-analysis demonstrates that a higher intake of artificial sweeteners is associated with an increased risk of several cardiometabolic outcomes and mortality. These findings underscore the need for cautious consumption and further research into their cardiometabolic effects.</p><p><strong>Trial registration: </strong>International Prospective Registration of Systematic Reviews (PROSPERO) Identifier: CRD420251020488.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 3","pages":"359-381"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A low-protein diet supplemented with an α-ketoacid-diet modulates intestinal flora and urinary metabolism in diabetic nephropathy mice.","authors":"Zhonghan Chen, Xiaoqian Jin, Xiaoyan Qiu","doi":"10.4162/nrp.2026.20.3.398","DOIUrl":"10.4162/nrp.2026.20.3.398","url":null,"abstract":"<p><strong>Background/objectives: </strong>Diabetic nephropathy (DN) is one of the most frequent and serious complications of diabetes mellitus. A low-protein diet supplemented with an α-ketoacid diet (LPD-KA) is a crucial intervention for individuals with chronic kidney disease. Nevertheless, the effects and mechanism of LPD-KA in DN remain unclear.</p><p><strong>Materials/methods: </strong>Db/db mice were randomly assigned into three groups: normal protein diet (NPD), low-protein diet (LPD), and LPD-KA groups, with db/m mice fed with NPD as the Control (Cont) group. PAS and Masson staining were performed after detecting the weight, blood glucose, and renal biochemical indicators. 16S rRNA sequencing and Urine metabolomics were conducted.</p><p><strong>Results: </strong>LPD-KA for DN mice improved the renal tissue damage and fibrosis, with lower body and kidney weights, blood glucose, urinary glucose, serum creatinine, blood urea nitrogen, urinary albumin/creatinine ratio, 24-h urine microalbumin, and glycosylated hemoglobin A1c levels. Compared to the NPD group, LPD-KA increased relative abundance of <i>Firmicutes</i>/<i>Bacteroides</i>, <i>f_Lachnospiraceae</i>, <i>g_Akkermansia, g_Clostridium</i>, <i>g_Staphylococcus</i>, <i>g_Enterococcus</i>, and <i>f_Enterococcaceae</i>. Moreover, LPD-KA altered urinary metabolomics, including up-regulation of nephroprotective differentially expressed metabolites (DEMs) L-histidinol and gluconolactone, and down-regulation of nephrotoxic DEMs 2-ketobutyric acid, dihydrocortisol, citramalic acid, and L-erythrulose, which were enriched in the protein digestion and absorption and tyrosine metabolism pathway. Spearman's correlation analysis revealed strong correlation between the crucial genus flora (<i>Lactobacillus</i>, <i>Akkermansia, Bacteroides</i>, <i>Adlercreutzia</i>, <i>Rikenella</i>, and <i>Clostridium</i>) and the above metabolites.</p><p><strong>Conclusion: </strong>LPD-KA modulated the intestinal flora and urinary metabolism to attenuate DN progression, with <i>Lactobacillus</i>, <i>Akkermansia</i>, <i>Bacteroides</i>, L-histidinol, gluconolactone, 2-ketobutyric acid, and dihydrocortisol as potential biomarkers, providing new insights into the clinical application of LPD-KA for DN treatment.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 3","pages":"398-416"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-restricted feeding counters brown adipose tissue whitening and inflammation in obese mice under chronic light exposure.","authors":"Eunse Oh, Ji Yeon Nah, Narae Yun, Mi Nam Lee, Munkyong Pae","doi":"10.4162/nrp.2026.20.3.417","DOIUrl":"10.4162/nrp.2026.20.3.417","url":null,"abstract":"<p><strong>Background/objectives: </strong>Time-restricted feeding (TRF) is a promising dietary strategy to improve the metabolic parameters associated with obesity, but its potential benefits in obesity linked to nighttime light exposure remain largely unclear. This study examined whether chronic light exposure alone, or in combination with TRF, modulates brown adipose tissue (BAT) in lean and obese mice.</p><p><strong>Materials/methods: </strong>Six-week-old male C57BL/6J mice were fed a low-fat diet (LFD) or a high-fat diet (HFD) for six weeks, and were assigned to one of three experimental conditions for an additional 6 weeks: control light exposure, continuous 24-h light exposure, or 24-h light exposure combined with TRF. This yielded 6 experimental groups: LC, L24h, L24hT, HC, H24h, and H24hT.</p><p><strong>Results: </strong>Histological analyses showed that chronic light exposure alone induced BAT whitening, characterized by lipid droplet accumulation and structural disorganization, even in LFD-fed mice. This whitening occurred without a decrease in uncoupling protein 1 mRNA and protein levels, suggesting mechanisms independent of thermogenic suppression. Instead, lipid accumulation and elevated <i>Lep</i> mRNA expression were associated with increased expression of various inflammatory markers (<i>Adgre1</i>, <i>Itgax</i>, and <i>Pycard</i>) and F4/80-positive macrophage infiltration. Importantly, TRF intervention attenuated BAT whitening and markedly suppressed the inflammatory responses, restoring the tissue structure and reducing macrophage infiltration, particularly in HFD-fed mice.</p><p><strong>Conclusion: </strong>These findings suggest that TRF may have clinical implications for obese night workers by preventing BAT from shifting toward an inflammatory and metabolically dysfunctional phenotype associated with nighttime light exposure.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 3","pages":"417-434"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin/mineral and non-vitamin/non-mineral supplement use of breast cancer survivors in Korea.","authors":"Jioh Kang, Jiyoung Youn, Hyun Jeong Cho, Hyeong-Gon Moon, Dong-Young Noh, So-Youn Jung, Eun Sook Lee, Zisun Kim, Hyun Jo Youn, Jihyoung Cho, Young Bum Yoo, Se Kyung Lee, Jeong Eon Lee, Seok Jin Nam, Jun Won Min, Yoo Seok Kim, Jihyoun Lee, Seho Park, Joon Jeong, Jung Eun Lee","doi":"10.4162/nrp.2026.20.2.333","DOIUrl":"10.4162/nrp.2026.20.2.333","url":null,"abstract":"<p><strong>Background/objectives: </strong>Dietary supplement use is common among breast cancer survivors, but studies on Asian populations remain limited. This study investigated dietary supplement use among Korean breast cancer survivors, distinguishing between vitamin/mineral (VM) and non-vitamin/non-mineral (NVNM) supplements.</p><p><strong>Subjects/methods: </strong>This cross-sectional study included 1,136 stage I-III breast cancer survivors from 12 Korean hospitals, who survived more than 6 mon post-surgery. The participants completed a questionnaire on post-diagnostic dietary supplement use. Stepwise logistic regression was applied, calculating odds ratios (ORs) and 95% confidence intervals (CIs) to identify the demographic and clinical factors associated with VM and NVNM use.</p><p><strong>Results: </strong>Seventy percent of survivors reported supplement use, with 25% using a single product. The most common VM supplements were multivitamins/minerals, vitamin D, and vitamin C, while the most common NVNM supplements included omega-3 fatty acids, probiotics, and ginseng. Survivors with higher education and greater physical activity were more likely to use VM supplements (ORs [95% CIs], 2.74 [1.76-4.25] for college graduates or above vs. middle school or below; 1.38 [1.02-1.88] for the most active group vs. the least active group). NVNM use was associated with higher education, greater physical activity levels, and a history of smoking (ORs [95% CIs], 2.29 [1.46-3.58] for college graduates or above vs. middle school or below; 1.52 [1.13-2.06] for the most active group vs. the least active group; 2.00 [1.23-3.25] for ever smokers vs. never smokers). Survivors who had undergone chemotherapy were also more likely to use NVNM supplements than those who had not (OR [95% CI], 1.37 [1.02-1.84]).</p><p><strong>Conclusion: </strong>Seventy percent of Korean breast cancer survivors used dietary supplements in this study. VM use was associated with higher education and physical activity, while higher NVNM use was associated with higher education, greater physical activity, a history of smoking, and chemotherapy.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 2","pages":"333-345"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of early administration of total enteral feeding with different regimens of nutritional preparations on the growth status of very low birth weight preterm infants.","authors":"Wei Liu, Wei Shen, Mingwu Chen","doi":"10.4162/nrp.2026.20.2.239","DOIUrl":"10.4162/nrp.2026.20.2.239","url":null,"abstract":"<p><strong>Background/objectives: </strong>Very low birth weight (VLBW) preterm infants face significant nutritional challenges, and the selection of an appropriate enteral nutrition protocol is critical for promoting growth and development while minimizing the risk of complications. This study aimed to analyze the impact of early administration of total enteral feeding with various nutritional preparations on the growth status of VLBW preterm infants.</p><p><strong>Subjects/methods: </strong>A retrospective study was conducted on 79 cases of VLBW preterm infants. The subjects were categorized into 3 groups based on the differences in nutritional intervention: the breastfeeding group (BF group, n = 28), the standard preterm formula group (SPF group, n = 25), and the extensively hydrolyzed protein formula group (EHF group, n = 26).</p><p><strong>Results: </strong>The discharge weight, weight gain, and growth rate of infants in the EHF group were significantly higher than those in the SPF and BF groups, and the growth rate in the SPF group was higher than that in the BF group. Upon discharge, the SPF group exhibited greater length and head circumference compared to the BF and EHF groups. The incidence of diarrhea in the SPF group was higher than that in the BF and EHF groups. Upon discharge, the uric acid level in the EHF group was higher than that in the SPF group. The hospital stay for infants in the SPF and EHF groups was shorter than that in the BF group. The EHF group had a significantly higher mean daily protein intake compared to the SPF and BF groups, while the SPF group exhibited a higher carbohydrate intake than the other 2 groups.</p><p><strong>Conclusion: </strong>While SPF feeding is effective in improving the head circumference and body length of VLBW preterm infants, it is associated with a higher incidence of diarrhea. In contrast, EHF feeding yields better weight gain outcomes and demonstrates superior safety.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 2","pages":"239-252"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhamnogalacturonan rich fractions isolated from <i>Saururus chinensis</i> alleviate ulcerative colitis via regulation of MAPK/NF-κB pathway and tight junction.","authors":"Tae Eun Kim, Seung-U Son, YangKook Rho, Kwang-Soon Shin","doi":"10.4162/nrp.2026.20.2.182","DOIUrl":"10.4162/nrp.2026.20.2.182","url":null,"abstract":"<p><strong>Backgrouond/objectives: </strong><i>Saururus chinensis</i> has been used as a traditional medicinal herb in many Asian countries such as Republic of Korea, Japan, and China. Previous studies on their pharmacological effects against anti-cancer, anti-oxidant, and anti-inflammation have mainly dealt with low-molecular-weight compounds, including flavonoids, saponins, and polyphenols. Nevertheless, the polysaccharide fraction of <i>S</i>. <i>chinensis</i> has received limited scholarly attention, and investigations regarding its effect on ulcerative colitis (UC) remain inconclusive. The present study was aimed to investigate effects of rhamnogalacturonan (RG) rich fraction (SCPE-II) isolated from <i>S. chinensis</i> on anti-UC.</p><p><strong>Materials/methods: </strong>SCPE-II was isolated from <i>S. chinensis</i> using hot water extraction, ethanol precipitation, enzymatic hydrolysis, and gel filtration chromatography. SCPE-II was characterized by chemical properties, Fourier transform infrared spectroscopy, Congo red reaction, and methylation analysis. The anti-UC effects of the SCPE-II were preliminarily investigated <i>in vitro</i> using interleukin (IL)-1β-induced inflammatory Caco-2 cells. The preventive effects of polysaccharides on UC <i>in vivo</i> were evaluated in a dextran sulfate sodium (DSS)-induced UC mice model.</p><p><strong>Results: </strong>The SCPE-II was characterized as a typical RG type polysaccharide. In addition, tight junction (TJ) imbalance and inflammatory cytokines in IL-1β-induced inflammatory epithelial cells was inhibited by SCPE-II. Moreover, SCPE-II suppressed various clinical symptoms in DSS-induced UC mice. These preventive effects were strongly correlated with the regulation of inflammatory cytokine, immunoglobulin, mitogen-activated protein kinase, nuclear factor kappa B, TJ, short chain fatty acid.</p><p><strong>Conclusion: </strong>Consequently, the present finding strongly suggests that SCPE-II isolated from <i>S. chinensis</i> is an effective ingredient for preventing UC.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 2","pages":"182-200"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity.","authors":"So Young Kwon, Khuhee Na, Yerim Han, Seungmin Song, Yoon Jung Park","doi":"10.4162/nrp.2026.20.2.220","DOIUrl":"10.4162/nrp.2026.20.2.220","url":null,"abstract":"<p><strong>Background/objectives: </strong>Supplementation of nicotinamide adenine dinucleotide (NAD) precursors has been investigated for its potential to counteract age-related physiological decline. While decreased NAD⁺ level is associated with conditions such as obesity and dyslipidemia, few studies have explored its metabolic impact in relatively young animals. Here, we hypothesized that nicotinamide mononucleotide (NMN) could alleviate high-fat diet-induced metabolic stress in young mice and sought to elucidate the underlying mechanisms.</p><p><strong>Materials/methods: </strong>We first conducted a secondary analysis of hepatic transcriptome datasets from multiple NMN intervention studies to identify target pathways. Next, 11-week-old lean and obese C57BL/6N mice administrated NMN (500 mg/kg/day) for 1 mon were analyzed for metabolic parameters and gene expression for the target pathways. <i>In vitro</i> study using AML12 cell line was then conducted to confirm the effects of NMN. Additionally, transcriptomic data from liver-specific nicotinamide phosphoribosyltransferase (NAMPT)-deficient mice were analyzed to examine the relationship between NAD⁺ metabolism, endoplasmic reticulum (ER) stress, and circadian rhythm.</p><p><strong>Results: </strong>The secondary analysis of hepatic transcriptome datasets revealed potential target pathways related to circadian regulation and hepatic ER stress. In mouse study, short-term NMN administration significantly decreased body weight and fat mass. NMN also alleviated hepatic ER stress response <i>in vivo</i> and <i>in vitro</i>. Additional analysis revealed that the mice with diet-induced metabolic stress or NAMPT deficiency led to phase shifts of the hepatic circadian core clock oscillation by advancing the peak time, while time-restricted feeding shifted the opposite, indicating the metabolic regulation of the circadian phase.</p><p><strong>Conclusion: </strong>Short-term NMN administration effectively attenuated obese condition in young mice and mitigated hepatic ER stress. The altered ER stress was regulated by NAMPT, potentially through the phase shift of the hepatic circadian rhythm.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"20 2","pages":"220-238"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}