Nutrition Research and Practice最新文献

{"title":"Factors associated with behavioral and weight changes across adult to elderly age groups during the COVID-19 pandemic.","authors":"Tomoya Itatani, Hisao Nakai, Yutaro Takahashi, Chika Togami","doi":"10.4162/nrp.2024.18.4.544","DOIUrl":"10.4162/nrp.2024.18.4.544","url":null,"abstract":"<p><strong>Background/objectives: </strong>There are concerns about the adverse health effects of behavioral changes linked to coronavirus disease 2019 (COVID-19). We conducted a survey to investigate changes in lifestyle habits, including exercise and eating, during the COVID-19 pandemic and their association with changes in weight.</p><p><strong>Subjects/methods: </strong>We conducted a survey of 5,000 people in Hakui City, Japan, to assess their lifestyles and diets during the COVID-19 pandemic. A total of 3,992 complete responses were received. We also obtained pre- and post-pandemic health check-up data for 704 of the respondents. These health data were combined with the results of the questionnaire survey to identify factors associated with weight changes. Data were analyzed for 704 individuals.</p><p><strong>Results: </strong>The mean body mass index was 22.5 ± 3.1 kg/m² for respondents whose weight did not change and 25.1 ± 2.7 kg/m² for respondents whose weight increased. The pre-pandemic mean values for abdominal circumference in females and for gamma-glutamyl transferase in males tended to be higher in those whose weight increased. Those with decreased weight tended to be older. Respondents who were already overweight were more likely to gain weight because of COVID-19-related changes in their lifestyle. In males, alcohol consumption was directly associated with weight, and in females, abdominal circumference was more important.</p><p><strong>Conclusion: </strong>The study found pre-pandemic overweight individuals likely gained more weight during it, with alcohol consumption being a significant factor for males. Weight loss was more crucial for those over 70, rather than weight gain.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"544-553"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Opuntia humifusa</i> stems rich in quercetin and isorhamnetin alleviate insulin resistance in high-fat diet-fed rats.","authors":"Young-Min Lee, Yeonjeong Choi, Eunseo Kim, In-Guk Hwang, Yoona Kim","doi":"10.4162/nrp.2024.18.4.498","DOIUrl":"10.4162/nrp.2024.18.4.498","url":null,"abstract":"<p><strong>Background/objectives: </strong>Obesity, characterized by abnormal fat accumulation and metabolic disturbances, presents a significant health challenge. <i>Opuntia humifusa</i> Raf., commonly known as Korean Cheonnyuncho, is rich in various beneficial compounds and has demonstrated antioxidant and anti-inflammatory effects. However, its potential impact on glucose and lipid metabolism, particularly in obese rats, remains unexplored. We aimed to investigate whether <i>O. humifusa</i> stems and fruits could beneficially alter glucose metabolism and lipid profiles in a rat model of high-fat diet (HFD)-induced obesity.</p><p><strong>Materials/methods: </strong>Thirty-two rats were allocated into 4 groups: normal diet (NF), HFD control (HF), HFD treated with 2% <i>O. humifusa</i> stems (HF-OS), and HFD treated with 2% <i>O. humifusa</i> fruits (HF-OF). Experimental diets were administered for 6 weeks. At the end of the treatment, liver and fat tissues were isolated, and serum was collected for biochemical analysis. The major flavonoid from <i>O. humifusa</i> stems and fruits was identified and quantified.</p><p><strong>Results: </strong>After 6 weeks of treatment, the serum fasting glucose concentration in the HF-OS group was significantly lower than that in the HF group. Serum fasting insulin concentrations in both HF-OS and HF-OF groups tended to be lower than those in the HF group, indicating a significant improvement in insulin sensitivity in the HF-OS group. Additionally, the HF-OS group exhibited a tendency towards the restoration of adiponectin levels to that of the NF group.</p><p><strong>Conclusion: </strong>The 2% <i>O. humifusa</i> stems contain abundant quercetin and isorhamnetin, which alter fasting blood glucose levels in rats fed a HFD, leading to a favorable improvement in insulin resistance.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"498-510"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary fiber intake and kidney stones: results from the National Health and Nutrition Examination Survey (2011-2018).","authors":"Weinan Chen, Yang Hong, Sailimai Man, Tao Xu","doi":"10.4162/nrp.2024.18.4.534","DOIUrl":"10.4162/nrp.2024.18.4.534","url":null,"abstract":"<p><strong>Background/objectives: </strong>Studies on the impact of dietary fiber intake on kidney stones are few, and their results were controversial. This study aimed to explore the association between dietary fiber intake and kidney stones in the nationally representative population of the USA.</p><p><strong>Subjects/methods: </strong>This cross-sectional research included 8,588 participants from the National Health and Nutrition Examination Survey, 2011 to 2018. Information regarding dietary fiber intake was obtained from a 24-h recall survey. Participants were categorized into different dietary fiber intake tertiles according to the average of 2 days of dietary recall data. The outcome was self-reported kidney stones. After adjusting for the traditional risk factors, a multivariate logistic regression model was used to examine the association between dietary fiber intake and kidney stones.</p><p><strong>Results: </strong>Eight hundred seventy-two participants had kidney stones. The weighted prevalence (SE) of kidney stones in the lowest tertile, medium tertile, and highest tertile of dietary fiber intake was 11.8% (0.8%), 10.3% (0.8%), and 9.1% (0.8%), respectively. After adjusting for age, sex, race and ethnicity, education level, smoking status, alcohol consumption, physical activity, body mass index, hypertension, diabetes, dyslipidemia, daily water intake, chronic kidney disease stage 3-5, and total energy intake, participants with the highest tertile of fiber intake had a significantly lower risk of kidney stones (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.48-0.95) compared to those in the lowest tertile. Every 5 g/day increment in dietary fiber intake was associated with a significant decrease in risk of kidney stones (OR, 0.90; 95% CI, 0.83-0.98).</p><p><strong>Conclusion: </strong>An increase in dietary fiber intake was associated with a lower risk of kidney stones, suggesting adults should be encouraged to maintain an adequate dietary fiber intake to prevent the development of kidney stones. Our results provide evidence to formulate nutrition management strategies for the prevention of kidney stones.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"534-543"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the consumer behavior and attitude toward low-sodium convenience store foods.","authors":"Suah Moon, Jimin Lim, Gaeun Yeo, Yuri Kim, Jieun Oh","doi":"10.4162/nrp.2024.18.4.567","DOIUrl":"10.4162/nrp.2024.18.4.567","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aims to explore the potential of convenience stores as platforms for healthy food consumption, including low-sodium options, in response to the increasing trend of meal behaviors at convenience stores and the growing demand for healthy eating.</p><p><strong>Subjects/methods: </strong>In the study, 627 Korean participants aged 10 to 39 were involved. A self-reported questionnaire survey was used and questions were regarding purchase patterns, consumption behaviors, perceptions and selection attributes of convenience store foods, and consumer perception factors for low-sodium options. Data analysis was conducted using SPSS 26.0 (SPSS, Version 26.0 for Windows, SPSS Inc., Chicago, IL, USA).</p><p><strong>Results: </strong>The study uncovered significant disparities in the consumption behavior and perception of convenience store foods, as well as variations in the importance and satisfaction levels with convenience store food attributes, including consumer perception factors for low-sodium options, based on sex and age. Furthermore, it was observed that awareness of the need for low-sodium options significantly influenced purchase intentions.</p><p><strong>Conclusion: </strong>This study analyzed consumer attitude toward low-sodium convenience store foods to assess the potentiality for promoting healthy eating in convenience stores. These findings indicate the important role that convenience stores can play as platforms for healthy food sales.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"567-585"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptotanshinone promotes brown fat activity by AMPK activation to inhibit obesity.","authors":"Jie Ni, Aili Ye, Liya Gong, Xiafei Zhao, Sisi Fu, Jieya Guo","doi":"10.4162/nrp.2024.18.4.479","DOIUrl":"10.4162/nrp.2024.18.4.479","url":null,"abstract":"<p><strong>Background/objectives: </strong>Activating brown adipose tissue (BAT) and browning of white adipose tissue (WAT) can protect against obesity and obesity-related metabolic conditions. Cryptotanshinone (CT) regulates lipid metabolism and significantly ameliorates insulin resistance. Adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK), a receptor for cellular energy metabolism, is believed to regulate brown fat activity in humans.</p><p><strong>Materials/methods: </strong>The <i>in vivo</i> study included high-fat-fed obese mice administered orally 200/400 mg/kg/d CT. They were evaluated through weight measurement, the intraperitoneal glucose tolerance test (IPGTT), intraperitoneal insulin tolerance test (IPITT), cold stimulation test, serum lipid (total cholesterol, triglycerides, and low-density lipoprotein) measurement, hematoxylin and eosin staining, and immunohistochemistry. Furthermore, the <i>in vitro</i> study investigated primary adipose mesenchymal stem cells (MSCs) with incubation of CT and AMPK agonists (acadesine)/inhibitor (Compound C). Cells were evaluated using Oil Red O staining, Alizarin red staining, flow cytometry, and immunofluorescence staining to identify and observe the osteogenic versus adipogenic differentiation. Quantitative real-time polymerase chain reaction and the Western blot were used to observe related gene expression.</p><p><strong>Results: </strong>In the diet-induced obesity mouse model mice CT suppressed body weight, food intake, glucose levels in the IPGTT and IPTT, serum lipids, the volume of adipose tissue, and increased thermogenesis, uncoupling protein 1, and the AMPK pathway expression. In the <i>in vitro</i> study, CT prevented the formation of lipid droplets from MSCs while activating brown genes and the AMPK pathway. AMPK activator enhanced CT's effects, while the AMPK inhibitor reversed the effects of CT.</p><p><strong>Conclusion: </strong>CT promotes adipose tissue browning to increase body thermogenesis and reduce obesity by activating the AMPK pathway. This study provides an experimental foundation for the use of CT in obesity treatment.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"479-497"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homocysteine levels are associated with diabetes mellitus in Chinese with H-type hypertension.","authors":"Dejian Fu, Wanbao Gong, Xiaomin Bao, Bo Yang, Feng Wang, Yubing Qiao, Yuanjiang Wu, Guangzhen Chen, Weixun Sun, Qiongzhi Xiao, Wenbo Zou, Ning Fang","doi":"10.4162/nrp.2024.18.4.511","DOIUrl":"10.4162/nrp.2024.18.4.511","url":null,"abstract":"<p><strong>Background/objectives: </strong>The study examined the association between homocysteine and diabetes mellitus in patients with H-type hypertension and assessed the possible effect modifiers.</p><p><strong>Subjects/methods: </strong>This cross-sectional study included 1,255 eligible participants in the 'H-type Hypertension Management and Stroke Prevention Strategic International Science and Technology Innovation Cooperation Project' among rural Chinese people with H-type hypertension. A multivariate logistic regression model was used to evaluate the relationship between homocysteine and diabetes mellitus.</p><p><strong>Results: </strong>The mean level of total homocysteine (tHcy) in the diabetes mellitus population was 19.37 μmol/L, which was significantly higher than the non-diabetic patients (18.18 μmol/L). When tHcy was analyzed as a continuous variable, the odds ratio (OR) of diabetes was 1.17 (95% confidence interval [CI], 1.01-1.35; per interquartile range). When tHcy was stratified according to the quintile, the ORs for diabetes were 2.86 (95% CI, 1.22-6.69) in the highest quintile (tHcy ≥ 20.60 μmol/L) compared to the reference group (tHcy < 12.04 μmol/L). When tHcy was grouped by 15 μmol/L and 20 μmol/L, patients with tHcy ≥ 20 μmol/L had a significantly (<i>P</i> = 0.037) higher risk of diabetes (OR, 2.03; 95% CI, 1.04-3.96) than in those with tHcy < 15 μmol/L. Subgroup analysis showed that the tHcy-diabetes association was unaffected by other variables.</p><p><strong>Conclusion: </strong>In this study of rural Chinese people with H-type hypertension, the tHcy levels showed a positive association with diabetes mellitus. This independent association is unaffected by other potential risk factors.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"511-522"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mukbang and Cookbang watching and dietary behavior in Korean adolescents.","authors":"Jimin Sung, Jae-Young Hong, Jihong Kim, Jihye Jung, Seoeun Choi, Ji Yun Kang, Mi Ah Han","doi":"10.4162/nrp.2024.18.4.523","DOIUrl":"10.4162/nrp.2024.18.4.523","url":null,"abstract":"<p><strong>Background/objectives: </strong>Given that adolescents watch Mukbang (eating broadcast) more frequently than other age groups, interest in the potential health effects of watching Mukbang and Cookbang (cooking broadcast) is growing. This study aimed to determine the status of watching Mukbang and Cookbang among Korean adolescents and its relationship with their dietary behaviors.</p><p><strong>Subjects/methods: </strong>We used data from the 18th Korea Youth Risk Behavior Survey, conducted in 2022 (n = 51,850). The study included the frequency of watching Mukbang and Cookbang and the self-rated impact of watching them. Dietary behaviors included consumption of the following items: fruits (≥ once a day), vegetables (≥ 3 times a day), fast foods (≥ 3 times a week), late-night snacks (≥ 3 times a week), caffeinated drinks (≥ 3 times a week), and sweet-flavored drinks (≥ 3 times a week). Furthermore, obesity, weight loss attempts during the past 30 days, body image distortion, and inappropriate methods to control weight were also included.</p><p><strong>Results: </strong>Among adolescents, 70.6% watched Mukbang and Cookbang, and 13.2% watched them more than 5 times a week. Approximately 27.6% of the adolescents responded that they were influenced by watching Mukbang and Cookbang. Adolescents who frequently watched Mukbang and Cookbang consumed less vegetable and fruit; however, the likelihood of consuming fast food, late-night snacks, sugary drinks, and caffeinated drinks increased. In addition, they were more likely to attempt inappropriate weight-loss methods and become obese. Adolescents who responded that their eating habits were influenced by watching Mukbang and Cookbang were more likely to have unhealthy eating behavior compared to the group who responded that their habits were not influenced by these shows.</p><p><strong>Conclusion: </strong>Watching Mukbang and Cookbang is common among Korean adolescents and is associated with unhealthy dietary behaviors. Prospective studies, including broadcasting content, should evaluate the impact of Mukbang and Cookbang on health.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 4","pages":"523-533"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-osteoporotic effects of <i>Boswellia serrata</i> gum resin extract <i>in vitro</i> and <i>in vivo</i>.","authors":"Hyun Sook Lee, Jae In Jung, In-Kee Hong, YoungSun Jang, Hye-Bin Kim, Eun Ji Kim","doi":"10.4162/nrp.2024.18.3.309","DOIUrl":"10.4162/nrp.2024.18.3.309","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study evaluated the beneficial effects of an ethanol extract of <i>Boswellia serrata</i> gum resin (FJH-UBS) in osteoporosis.</p><p><strong>Materials/methods: </strong>MC3T3-E1 osteoblastic cells and RAW 264.7 osteoclastic cells were treated with FJH-UBS. The alkaline phosphatase (ALP) activity, mineralization, collagen synthesis, osteocalcin content, and Runt-related transcription factor 2 (RUNX2) and Osterix expression were measured in MC3T3-E1 cells. The actin ring structures, tartrate-resistant acid phosphatase (TRAP) activity, and the nuclear factor of activator T-cells, cytoplasm 1 (NFATc1) expression were evaluated in RAW 264.7 cells. Ovariectomized ICR mice were orally administered FJH-UBS for eight weeks. The bone mineral density (BMD) and the serum levels of osteocalcin, procollagen 1 N-terminal propeptide (P1NP), osteoprotegerin, and TRAP 5b were analyzed.</p><p><strong>Results: </strong>FJH-UBS increased the ALP activity, collagen, osteocalcin, mineralization, and RUNX2 and osterix expression in MC3T3-E1 osteoblastic cells, whereas it decreased the TRAP activity, actin ring structures, and NFATc1 expression in RAW 264.7 osteoclastic cells. In ovariectomy-induced osteoporosis mice, FJH-UBS positively restored all of the changes in the bone metabolism biomarkers (BMD, osteocalcin, P1NP, osteoprotegerin, and TRAP 5b) caused by the ovariectomy.</p><p><strong>Conclusion: </strong>FJH-UBS has anti-osteoporotic activity by promoting osteoblast activity and inhibiting osteoclast activity <i>in vitro</i> and <i>in vivo</i>, suggesting that FJH-UBS is a potential functional food ingredient for osteoporosis.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 3","pages":"309-324"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine intake from brown seaweed and the related nutritional risk assessment in Koreans.","authors":"Sung Ok Kwon, Kwang-Il Kwon, Mi-Young Lee, Hye Young Lee, Cho-Il Kim","doi":"10.4162/nrp.2024.18.3.412","DOIUrl":"10.4162/nrp.2024.18.3.412","url":null,"abstract":"<p><strong>Background/objectives: </strong>Although iodine is essential for thyroid hormone production and controls many metabolic processes, there are few reports on the iodine intake of the population because of the scarcity of information on the iodine content in food. This study estimated the iodine intake of Koreans from brown seaweed, the major source of iodine in nature.</p><p><strong>Subjects/methods: </strong>The dietary intake data from the recent Korea National Health and Nutrition Examination Survey (2016-2021) and the iodine content in brown seaweed were used for the estimation. Nationwide brown seaweed samples were collected and prepared using the representative preparation/cooking methods in the Koreans' diet before iodine analysis by alkaline digestion followed by inductively coupled plasma mass spectrometry.</p><p><strong>Results: </strong>The mean (± SE) iodine intake from sea mustard was 96.01 ± 2.36 µg/day in the Korean population. Although the iodine content in kelp was approximately seven times higher than that in sea mustard, the mean iodine intake from kelp (except broth) was similar to that of sea mustard, 115.58 ± 7.71 µg/day, whereas that from kelp broth was 347.57 ± 10.03 µg/day. The overall mean iodine intake from brown seaweed was 559.16 ± 13.15 µg/day, well over the Recommended Nutrient Intake of iodine for Koreans. Nevertheless, the median intake was zero because only 37.6% of the population consumed brown seaweed on the survey date, suggesting that Koreans do not consume brown seaweed daily.</p><p><strong>Conclusion: </strong>The distribution of the usual intake of iodine from brown seaweed in Koreans would be much tighter, resulting in a lower proportion of people exceeding the tolerable upper intake levels and possibly a lower mean intake than this study presented. Further study evaluating the iodine nutriture of Koreans based on the usual intake is warranted. Nevertheless, this study adds to the few reports on the iodine nutriture of Koreans.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 3","pages":"412-424"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combination of myokines and genistein suppresses cancer stemness in MCF-7 human breast cancer cells.","authors":"Hyeji Kwon, Yuri Kim, Jung Hyun Kim","doi":"10.4162/nrp.2024.18.3.436","DOIUrl":"10.4162/nrp.2024.18.3.436","url":null,"abstract":"<p><strong>Background/objectives: </strong>Breast cancer is considered a serious health issue worldwide and is influenced by risk factors, including physical inactivity and unhealthy diet. Myokines secreted by muscles during physical activity play a crucial role in cancer development and the immune system. Genistein (Gen), an isoflavone primarily in legumes, induces anti-cancer activity by regulating cancer stem cells (CSCs). Therefore, this study investigated the potential anti-cancer effect of a combination of myokine and Gen on the human breast cancer MCF-7 cells.</p><p><strong>Materials/methods: </strong>MCF-7, a human breast cancer cell line, was used for <i>in vitro</i> study. The cell viability of MCF-7 cells was evaluated in response to treatment with myokines, irisin (Iri), oncostatin M (OSM), and Gen using the MTT assay. Clonogenic and sphere formation assays were used to evaluate the self-renewal capacity of breast CSCs. The mRNA expression levels of stem cell markers were analyzed in MCF-7 breast cancer cells.</p><p><strong>Results: </strong>Administering Iri or OSM with Gen significantly inhibited the self-renewal capacity of MCF-7 cells. In addition, mRNA expression of breast CSC markers <i>SOX2</i> and <i>OCT4</i>, which are characteristic of CSCs, was suppressed by both myokine and Gen. However, combining Iri or OSM with Gen was the most effective treatment.</p><p><strong>Conclusion: </strong>These results suggested that combining Iri or OSM with Gen has an additive effect on breast CSCs by regulating self-renewal capacity and expression of CSCs markers. Therefore, the combination of myokines and Gen may have the therapeutic potential for treating breast cancer and improving the quality of life of cancer patients.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 3","pages":"436-445"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}