Nutrition Research and Practice最新文献

{"title":"Associations between weight-control methods and depression among Korean adolescents: a study based on a national dataset.","authors":"Jaehyun Kong, Kyeongmin Lee, Sooji Lee, Soeun Kim, Jinyoung Jeong, Yejun Son, Hayeon Lee, Louis Jacob, Masoud Rahmati, Guillaume Fond, Laurent Boyer, Lee Smith, Elena Dragioti, Selin Woo, Jiyoung Hwang, Dong Keon Yon","doi":"10.4162/nrp.2024.18.6.818","DOIUrl":"10.4162/nrp.2024.18.6.818","url":null,"abstract":"<p><strong>Background/objectives: </strong>The increasing prevalence of overweight and obesity has become a significant global burden, with more than 40% of the global adult population attempting to lose weight. Previous studies on the impact of weight-control methods on mental health, especially among adolescents, are limited. Thus, this study aimed to investigate the association between various weight-control methods and depression among adolescents, with the goal of informing healthier weight management decisions and promoting effective methods.</p><p><strong>Subjects/methods: </strong>This nationwide study utilized data from the Korea Youth Risk Behavior Web-based Survey, including a sample of 418,254 adolescents collected over 12 yrs (2007-2019). We conducted a weighted complex sample analysis to compare depression rates associated with specific weight-control methods, including exercise, fasting (≥ 24 h), eating less, taking prescription/non-prescription weight-loss medication, taking laxatives or diuretics, vomiting, one-food diet, taking oriental medicine, and diet foods.</p><p><strong>Results: </strong>Of the 418,254 participants, 45.96% (192,246) were male. Among male participants, fasting (≥ 24 h; weighted odds ratio [wOR], 1.43; 95% confidence interval [CI], 1.36-1.51) and vomiting (wOR, 1.49; 95% CI, 1.35-1.66) were associated with an increased risk of depression. Among female participants, prescribed (wOR, 0.82; 95% CI, 0.74-0.90) and non-prescribed (wOR, 0.89; 95% CI, 0.82-0.97) weight-loss medication reduced the risk of depression. However, fasting (≥ 24 h; wOR, 1.47; 95% CI, 1.41-1.52) and vomiting (wOR, 1.45; 95% CI, 1.36-1.55) significantly increased the risk of depression.</p><p><strong>Conclusion: </strong>The risk of depression varies depending on the weight-control method, with a consistent trend observed across both sexes. Methods such as vomiting, fasting, taking oriental medicine for weight loss, and consuming diet foods increased the risk of depression, while weight-loss medications were associated with reduced depression symptoms in females. These findings highlight the need for further research on weight-control medications and policies that support effective weight management while reducing depressive effects.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 6","pages":"818-828"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"α-Tocopherol and γ-tocopherol decrease inflammatory response and insulin resistance during the interaction of adipocytes and macrophages.","authors":"Sella Lee, Hye-Kyeong Kim","doi":"10.4162/nrp.2024.18.6.761","DOIUrl":"10.4162/nrp.2024.18.6.761","url":null,"abstract":"<p><strong>Background/objectives: </strong>The infiltration of macrophages into adipose tissue mediates chronic inflammation that is associated with insulin resistance in obesity. Although vitamin E is beneficial against insulin resistance, its impact on adipose tissue inflammation has not been elucidated. This study aims to investigate the effects of α-tocopherol and γ-tocopherol, major vitamin E isoforms, on the interaction between macrophages and adipocytes with regard to obesity-induced inflammation and insulin resistance.</p><p><strong>Materials/methods: </strong>Hypertrophied 3T3-L1 adipocytes were cocultured with RAW 264.7 macrophages and treated with α-tocopherol or γ-tocopherol at 12.5, 25, and 50 µM. The inflammatory cytokines (monocyte chemoattractant protein-1, tumor necrosis factor-α, and interleukin-6) and free fatty acid (FFA) release were measured by assay kits, and nuclear factor-kappaB (NF-κB) and c-Jun NH₂ terminal kinase (JNK) signals were evaluated by immunoblotting. Glucose uptake was measured with a fluorescent glucose derivative.</p><p><strong>Results: </strong>Treatment with α-tocopherol and γ-tocopherol restrained the coculture-induced increase in cytokines and FFA release. γ-Tocopherol exhibited greater suppression of inflammatory cytokines at 12.5 and 25 µM (<i>P</i> < 0.001). Both tocopherols inhibited NF-κB activation by limiting translocation of NF-κB (p65) to the nucleus, with γ-tocopherol showing a stronger effect compared to α-tocopherol. α-Tocopherol inhibited JNK phosphorylation at 50 μM, whereas γ-tocopherol did not. Furthermore, coculture with macrophages impaired glucose uptake in response to insulin, but both tocopherols restored insulin responsiveness (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>α-Tocopherol and γ-tocopherol effectively mitigate inflammation induced by adipocyte-macrophage interaction, thereby ameliorating coculture-induced insulin resistance. These findings suggest the therapeutic potential of tocopherols in managing obesity-related metabolic dysfunction.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 6","pages":"761-773"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Korean Healthy Eating Index and sleep duration with prediabetes in middle-aged adults.","authors":"Ji-Myung Kim, Yun-Jung Bae","doi":"10.4162/nrp.2024.18.6.857","DOIUrl":"10.4162/nrp.2024.18.6.857","url":null,"abstract":"<p><strong>Background/objectives: </strong>Sleep duration and diet quality are reportedly associated with the risk of diabetes. This study aimed to examine the risk of diabetes according to sleep duration and diet quality in middle-aged Koreans.</p><p><strong>Subjects/methods: </strong>Using the Korea National Health and Nutrition Examination Survey 2019-2020, raw data from 2,934 participants aged 40-64 yrs (1,090 men and 1,844 women) who were not diagnosed with type 2 diabetes were analyzed. With a sleep duration of 7-7.9 h per night as the referent category, diet quality was assessed using the Korean Healthy Eating Index (KHEI), which comprises adequacy, moderation, and energy balance.</p><p><strong>Results: </strong>The study results showed that individuals with a short sleep duration had significantly higher blood glucose (<i>P</i> = 0.034) and HbA1c levels (<i>P</i> < 0.001) than those had by individuals with a sleep duration of 7-7.9 h. Within the group with a sleep duration of 7-7.9 h, the lowest quintile of the KHEI score had a significantly higher risk of prediabetes than that had by the highest quintile of the KHEI score (Model 1: odds ratio [OR], 1.775; 95% confidence interval [CI], 1.072-2.939; <i>P</i> < 0.05 and Model 2: OR, 1.731; 95% CI, 1.040-2.882; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Our findings suggest that achieving the sleep duration of 7-7.9 h and eating good diet are associated with the lowest risk of prediabetes. We recommend that the results of this study be used to educate adults aged 40-64 yrs on diet and lifestyle habits to prevent diabetes.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 6","pages":"857-871"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary ellagic acid blocks inflammation-associated atherosclerotic plaque formation in cholesterol-fed apoE-deficient mice.","authors":"Sin-Hye Park, Min-Kyung Kang, Dong Yeon Kim, Soon Sung Lim, Young-Hee Kang","doi":"10.4162/nrp.2024.18.5.617","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.617","url":null,"abstract":"<p><strong>Background/objectives: </strong>Atherosclerosis particularly due to high circulating level of low-density lipoprotein is a major cause of cardiovascular diseases. Ellagic acid is a natural polyphenolic compound rich in pomegranates and berries. Our previous study showed that ellagic acid improved functionality of reverse cholesterol transport in murine model of atherosclerosis. The aim of this study is to investigate whether ellagic acid inhibited inflammation-associated atherosclerotic plaque formation in cholesterol-fed apolipoprotein E (apoE)-knockout (KO) mice.</p><p><strong>Materials/methods: </strong>Wild type mice and apoE-KO mice were fed a cholesterol-rich Paigen diet for 10 weeks to induce severe atherosclerosis. Concurrently, 10 mg/kg ellagic acid was orally administered to the apoE-KO mice. Plaque lesion formation and lipid deposition were examined by staining with hematoxylin and eosin, Sudan IV and oil red O.</p><p><strong>Results: </strong>The plasma leukocyte profile of cholesterol-fed mice was not altered by apoE deficiency. Oral administration of ellagic acid attenuated plaque lesion formation and lipid deposition in the aorta tree of apoE-KO mice. Ellagic acid substantially reduced plasma levels of soluble vascular cell adhesion molecule and interferon-γ in Paigen diet-fed apoE-KO mice. When 10 mg/kg ellagic acid was administered to cholesterol-fed apoE-KO mice, the levels of CD68 and MCP-1 were strongly reduced in aorta vessels. The protein expression level of nitric oxide synthase-2 (NOS2) in the aorta was highly enhanced by supplementation of ellagic acid to apoE-KO mice, but the expression level of heme oxygenase-1 (HO-1) in the aorta was reduced. Furthermore, ellagic acid diminished the increased aorta expression of the inflammatory adhesion molecules in cholesterol-fed apoE-KO mice. The treatment of ellagic acid inhibited the scavenger receptor-B1 expression in the aorta of apoE-KO mice, while the cholesterol efflux-related transporters were not significantly changed.</p><p><strong>Conclusion: </strong>These results suggest that ellagic acid may be an atheroprotective compound by attenuating apoE deficiency-induced vascular inflammation and reducing atherosclerotic plaque lesion formation.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"617-632"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-related media use and eating behavior in different food-related lifestyle groups of Korean adolescents in metropolitan areas.","authors":"SooBin Lee, Seoyoung Choi, Se Eun Ahn, Yoon Jung Park, Ji-Yun Hwang, Gaeun Yeo, Jieun Oh","doi":"10.4162/nrp.2024.18.5.687","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.687","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study investigated the relationship between adolescent food-related lifestyles and food-related media use and eating behavior in Korea.</p><p><strong>Subjects/methods: </strong>Participants were 392 Korean adolescents, ranging in age from 12 to 18, recruited via convenience sampling. They completed a self-report questionnaire survey consisting of questions about food-related lifestyle, food-related media use, food consumption behavior, food literacy, and nutrition quotient. Data analysis was conducted using SPSS 29.0. (IBM Co., Armonk, NY, USA).</p><p><strong>Results: </strong>The factor analysis of food-related lifestyles identified four factors. Based on the cluster analysis results, participants were classified into three clusters reflecting different levels of interest: high interest in food, moderate interest in food, and low interest in food. The analysis revealed significant differences between groups in food-related liestyle factors (<i>P</i> < 0.05). Notably, the high-interest group demonstrated proactive engagement with food-related content, a willingness to explore diverse culinary experiences, and a conscientious consideration of nutritional labeling during food purchases. In contrast, the low-interest group reported tendencies toward overeating or succumbing to stimulating food consumption post-exposure to food-related content, coupled with a disregard for nutritional labeling when making food choices. A stronger inclination toward a food-related lifestyle was positively correlated with higher levels of food literacy and nutrition quotient.</p><p><strong>Conclusion: </strong>This study proposes that the implementation of a nutrition education program using media could effectively promote a healthy diet among adolescents with a high level of interest in their dietary habits. For adolescents with low interest in their dietary habits, it suggests that introducing an education program with a primary focus on enhancing food literacy could be beneficial in fostering a healthy diet. Our research findings provide insight for the development of tailored nutritional education programs and establishment of effective nutrition policies.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"687-700"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults.","authors":"Suyeon Lee, Dayeon Shin","doi":"10.4162/nrp.2024.18.5.721","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.721","url":null,"abstract":"<p><strong>Background/objectives: </strong>The high consumption of purine-rich meat is associated with hyperuricemia. However, there is limited evidence linking the consumption of red and processed meat to the genetic risk of hyperuricemia. We investigated the relationship between various combinations of red and processed meat consumption and the polygenic risk scores (PRSs) and the incidence of hyperuricemia in middle-aged Koreans.</p><p><strong>Subjects/methods: </strong>We analyzed the data from 44,053 participants aged ≥40 years sourced from the Health Examinees (HEXA) cohort of the Korean Genome and Epidemiology Study (KoGES). Information regarding red and processed meat intake was obtained using a semiquantitative food frequency questionnaire (SQ-FFQ). We identified 69 independent single-nucleotide polymorphisms (SNPs) at uric acid-related loci using genome-wide association studies (GWASs) and clumping analyses. The individual PRS, which is the weighted sum of the effect size of each allele at the SNP, was calculated. We used multivariable Cox proportional hazards models adjusted for covariates to determine the relationship between red and processed meat intake and the PRS in the incidence of hyperuricemia.</p><p><strong>Results: </strong>During an average follow-up period of 5 years, 2,556 patients with hyperuricemia were identified. For both men and women, the group with the highest red and processed meat intake and the highest PRS was positively associated with the development of hyperuricemia when compared with the group with the lowest red and processed meat intake and the lowest PRS (hazard ratio [HR], 2.72; 95% confidence interval [CI], 2.10-3.53; <i>P</i> < 0.0001; HR, 3.28; 95% CI, 2.45-4.40; <i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>Individuals at a high genetic risk for uric acid levels should moderate their consumption of red and processed meat to prevent hyperuricemia.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"721-745"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of poly-γ-glutamate-vitamin B6 supplement and urinary microbiota profiles in Korean healthy adults: a randomized, double-blinded, placebo-controlled intervention study.","authors":"Jungmin Park, Inkyung Baik","doi":"10.4162/nrp.2024.18.5.663","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.663","url":null,"abstract":"<p><strong>Background/objectives: </strong>Poly-γ-glutamic acid (γ-PGA), a natural polymer found in fermented soybean products, has been reported to play a prebiotic role in the gut. This intervention study investigated the effects of γ-PGA-containing supplement consumption on urinary microbiota in healthy adults because of limited data on such investigation.</p><p><strong>Subjects/methods: </strong>A 4-week parallel trial including 39 male and female Korean adults, who were free of chronic diseases and infection, was designed as a randomized, double-blinded, placebo-controlled study. A total of 30 participants completed the study wherein the intervention group (n = 17) received a mixture supplement containing 600 mg/day of γ-PGA and 100 mg/day of vitamin B6, while the control group (n = 13) received a placebo. Paired datasets (baseline and endpoint data) of microbiota profiles, which were constructed via urinary assays of microbe-derived extracellular vesicles, were analyzed and compared between the two groups.</p><p><strong>Results: </strong>Only the intervention group yielded significant results for the Bray-Curtis and Jaccard dissimilarity indices between baseline and endpoint data (<i>P</i> < 0.05). In the phylum-level analysis of microbial composition, the <i>Firmicutes</i> to <i>Bacteroidetes</i> ratio (FB ratio) tended to decrease from baseline in the intervention group; however, it increased in the control group. Differences between the baseline and endpoint FB ratios were significant between the two groups (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>This study's findings suggest that γ-PGA-vitamin B6 supplementation potentially alters the microbial community composition of a host. Further investigation into the biological consequences of commensal microbiota alteration by γ-PGA-containing supplement consumption is warranted.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"663-673"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Cladophora glomerata</i> Kützing extract exhibits antioxidant, anti-inflammation, and anti-nitrosative stress against impairment of renal organic anion transport in an <i>in vivo</i> study.","authors":"Atcharaporn Ontawong, Chaliya J Aida, Pornpun Vivithanaporn, Doungporn Amornlerdpison, Chutima S Vaddhanaphuti","doi":"10.4162/nrp.2024.18.5.633","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.633","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>Cladophora glomerata</i> extract (CGE), rich in polyphenols, was reported to exhibit antidiabetic and renoprotective effects by modulating the functions of protein kinases-mediated organic anion transporter 1 (Oat1) and 3 (Oat3) in rats with type 2 diabetes mellitus (T2DM). Nevertheless, the antioxidant effects of CGE on such renoprotection have not been investigated. This study examined the mechanisms involved in the antioxidant effects of CGE on renal organic anion transport function in an <i>in vivo</i> study.</p><p><strong>Materials/methods: </strong>Diabetes was induced in the rats through a high-fat diet combined with a single dose of 40 mg/kg body weight (BW) streptozotocin. Subsequently, normal-diet rats were supplemented with a vehicle or 1,000 mg/kg BW of CGE, while T2DM rats were supplemented with a vehicle, CGE, or 200 mg/kg BW of vitamin C for 12 weeks. The study evaluated the general characteristics of T2DM and renal oxidative stress markers. The renal organic transport function was assessed by measuring the para-aminohippurate (PAH) uptake using renal cortical slices and renal inflammatory cytokine expression in the normal diet (ND) and ND + CGE treated groups.</p><p><strong>Results: </strong>CGE supplementation significantly reduced hyperglycemia, hypertriglyceridemia, insulin resistance, and renal lipid peroxidation in T2DM rats. This was accompanied by the normalization of high expressions of renal glutathione peroxidase and nuclear factor kappa B by CGE and vitamin C. The renal anti-inflammation of CGE was evidenced by the reduction of tumor necrosis factor-1α and interleukin-1β. CGE directly blunted sodium nitroprusside-induced renal oxidative/nitrosative stresses and mediated the PAH uptake in the normally treated CGE in rats was particularly noteworthy. These data also correlated with reduced nitric oxide production, highlighting the potential of CGE as a therapeutic agent for managing T2DM-related renal complications.</p><p><strong>Conclusion: </strong>These findings suggest that CGE has antidiabetic effects and directly prevents diabetic nephropathy through oxidative/nitrosative stress pathways.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"633-646"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin protective effect of Indian gooseberry and barley sprout complex on skin dryness, wrinkles, and melanogenesis by cell models.","authors":"Minhee Lee, Dakyung Kim, Mi-Ryeong Park, Soyoung Kim, Jong-Lae Kim, Ok-Kyung Kim, Jeongmin Lee","doi":"10.4162/nrp.2024.18.5.587","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.587","url":null,"abstract":"<p><strong>Background/objectives: </strong>UV radiation is a major factor contributing to DNA damage in skin cells, including stem cells and mesenchymal stem cells, leading to the depletion of these crucial cells. This study examined whether a mixture of Indian gooseberry and barley sprout (IB) could inhibit UVB irradiation and 3-isobutyl-1-methylxanthine (IBMX)-induced photoaging and oxidative stress in the skin using HaCaT, Hs27, and B16F10 cells.</p><p><strong>Materials/methods: </strong>The moisturizing-related factors, the collagen synthesis-related c-Jun N-terminal kinase (JNK)/c-Fos/c-Jun/matrix metalloproteinases (MMPs) pathway, and the melanogenesis-related cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP-responsive binding protein (CREB)/melanocyte inducing transcription factor (MITF)/tyrosinase-related protein (TRP)/tyrosinase activation pathways were analyzed <i>in vitro</i> by an enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blot analysis.</p><p><strong>Results: </strong>The IB complex increased the hyaluronic acid and sphingomyelin levels and the collagenase inhibitory activity, enhanced hydration-related factors, including collagen, <i>hyaluronic acid synthase</i> (<i>HAS</i>), <i>elastin</i>, <i>long chain base subunit 1</i> (<i>LCB1</i>) (<i>serine palmitoyltransferase</i>; <i>SPT</i>), and <i>delta 4-desaturase sphingolipid 1</i> (<i>DEGS1</i>), modulated the inflammatory cytokines levels, antioxidant enzyme activities and the NF-κB/MMPs/cyclooxygenase-2 (COX-2) pathway in UVB-irradiated HaCaT cells, and inhibited wrinkle formation by down-regulation of the JNK/c-Fos/c-Jun/MMP pathway and up-regulation of the <i>transforming growth factor-β receptor I</i> (<i>TGFβR1</i>)/small mothers against decapentaplegic homolog (Smad3)/<i>procollagen type І</i> pathway in UVB-irradiated Hs27 cells. Moreover, the IB complex prevented melanin production by down-regulating the PKA/CREB/MITF/TRP-1/TRP-2 pathway in IBMX-induced B16F10 cells.</p><p><strong>Conclusion: </strong>These findings suggest that the IB complex has the potential to serve as a safeguard, shielding the skin from UVB radiation-induced photo-damage.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"587-601"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between food consumption and serum aryl hydrocarbon receptor ligand activity among middle-aged Korean adults.","authors":"Kyungho Ha, Hoonsung Choi, Youngmi Kim Pak, Hong Kyu Lee, Hyojee Joung","doi":"10.4162/nrp.2024.18.5.711","DOIUrl":"https://doi.org/10.4162/nrp.2024.18.5.711","url":null,"abstract":"<p><strong>Background/objectives: </strong>The diet is an important route of exposure to endocrine-disrupting chemicals (EDCs). However, few studies have investigated the association between dietary intake and EDC exposure levels among Koreans. In an earlier study, we showed that the bioactivity of serum aryl hydrocarbon receptor ligands (AhRLs) could be a surrogate biomarker to indicate exposure to EDCs and that they inhibit mitochondrial function. We also found that the mitochondria-inhibiting substances (MIS) in serum ascertained by intracellular adenosine triphosphate (MIS-ATP) and reactive oxygen species (MIS-ROS) levels could be biomarkers of exposure to EDCs, as they showed a strong correlation with AhRL and the levels of EDCs in the blood. Here, we investigated the association between the consumption of specific foods and surrogate serum biomarkers for EDCs, namely AhRL, MIS-ATP, and MIS-ROS, among middle-aged Korean adults.</p><p><strong>Subjects/methods: </strong>A total of 1,466 participants aged 45-76 yrs from the Ansung cohort of the Korean Genome and Epidemiology Study were included. Food consumption, including that of meat, fish, vegetables, and fruits, was measured using a semiquantitative food frequency questionnaire.</p><p><strong>Results: </strong>Fish intake was positively associated with AhRL (β = 0.0035, <i>P</i> = 0.0166), whereas cruciferous vegetable intake was negatively associated with AhRL (β = -0.0007, <i>P</i> = 0.0488). Cruciferous vegetable intake was positively associated with the MIS-ATP levels (β = 0.0051, <i>P</i> = 0.0420). A higher intake of fish was significantly associated with an increased risk of high AhRL (tertile: odds ratio [OR], 1.49; 95% confidence intervals (CIs), 1.08-2.06; <i>P</i> for trend = 0.0305). In addition, the second-highest tertile of cruciferous vegetable intake had lower odds of high AhRL than the lowest tertile (OR, 0.73; 95% CIs, 0.54-0.97), although no significant linear trend was observed.</p><p><strong>Conclusion: </strong>Consumption of different types of foods may be differentially associated with EDC exposure in middle-aged Korean adults.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 5","pages":"711-720"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}