Nutrition Research and Practice最新文献

{"title":"Raw <i>Inonotus obliquus</i> polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system.","authors":"Shumin Wang, Kaiye Dong, Ji Zhang, Chaochao Chen, Hongyan Shuai, Xin Yu","doi":"10.4162/nrp.2023.17.6.1128","DOIUrl":"10.4162/nrp.2023.17.6.1128","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>Inonotus obliquus</i> has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer's disease (AD), which is widely considered to be type III diabetes. To investigate whether <i>I. obliquus</i> can also ameliorate AD, it would be interesting to identify new clues for AD treatment. We tested the anti-AD effects of raw <i>Inonotus obliquus</i> polysaccharide (IOP) in a mouse model of AD (3×Tg-AD transgenic mice).</p><p><strong>Materials/methods: </strong>SPF-grade 3×Tg-AD mice were randomly divided into three groups (Control, Metformin, and raw IOP groups, n = 5 per group). β-Amyloid deposition in the brain was analyzed using immunohistochemistry for AD characterization. Gene and protein expression of pertinent factors of the ubiquitin-proteasome system (UPS) was determined using real-time quantitative polymerase chain reaction and Western blotting.</p><p><strong>Results: </strong>Raw IOP significantly reduced the accumulation of amyloid aggregates and facilitated UPS activity, resulting in a significant reduction in AD-related symptoms in an AD mouse model. The presence of raw IOP significantly enhanced the expression of ubiquitin, E1, and Parkin (E3) at both the mRNA and protein levels in the mouse hippocampus. The mRNA level of ubiquitin carboxyl-terminal hydrolase isozyme L1, a key factor involved in UPS activation, also increased by approximately 50%.</p><p><strong>Conclusions: </strong>Raw IOP could contribute to AD amelioration via the UPS pathway, which could be considered as a new potential strategy for AD treatment, although we could not exclude other mechanisms involved in counteracting AD processing.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracts of <i>Grifola frondosa</i> inhibit the MAPK signaling pathways involved in keratinocyte inflammation and ameliorate atopic dermatitis.","authors":"Eun-Ju Choi, Jin Kyeong Choi","doi":"10.4162/nrp.2023.17.6.1056","DOIUrl":"10.4162/nrp.2023.17.6.1056","url":null,"abstract":"<p><strong>Background/objectives: </strong><i>Grifola frondosa</i>, commonly referred to as the maitake mushroom, has been studied extensively to explore its potential health benefits. However, its anti-inflammatory effects in skin disorders have not been sufficiently elucidated. This study aimed to elucidate the anti-inflammatory role of the ethanol extract of <i>G. frondosa</i> in atopic dermatitis (AD) using in vivo and in vitro models.</p><p><strong>Materials/methods: </strong>We investigated its impact on skin and spleen inflammatory responses in <i>Dermatophagoides farinae</i> extract (DFE)/1-chloro-2,4 dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in a mouse model. Additionally, we determined the immunosuppressive response and mechanism of <i>G. frondosa</i> by inducing atopic-like immune reactions in keratinocytes through tumor necrosis factor (TNF)-α/interferon (IFN)-γ stimulation.</p><p><strong>Results: </strong>Our study revealed that <i>G. frondosa</i> ameliorates clinical symptoms in an AD-like mouse model. These effects contributed to the suppression of Th1, Th2, Th17, and Th22 immune responses in the skin and spleen, leading to protection against cutaneous inflammation. Furthermore, <i>G. frondosa</i> inhibited the production of antibodies immunoglobulin (Ig)E and IgG2a in the serum of AD mice. Importantly, the inhibitory effect of <i>G. frondosa</i> on inflammatory cytokines in TNF-α/IFN-γ-stimulated AD-like keratinocytes was associated with the suppression of MAPK (Mitogen Activated Protein Kinase) pathway activation.</p><p><strong>Conclusions: </strong>Collectively, these findings highlight the potential of <i>G. frondosa</i> as a novel therapeutic agent for AD treatment and prevention.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beliefs, self-efficacy, subjective norms, and eating behaviors according to the breakfast frequency among female university students in South Korea.","authors":"Hye Jin Kim, Kyung Won Kim","doi":"10.4162/nrp.2023.17.6.1170","DOIUrl":"10.4162/nrp.2023.17.6.1170","url":null,"abstract":"<p><strong>Background/objectives: </strong>Skipping breakfast is prevalent in young adult women. This study examined the psychosocial factors and eating behaviors according to the breakfast frequency among female university students.</p><p><strong>Subjects/methods: </strong>The subjects were female university students in Seoul, South Korea. A survey was done, and the data from 291 students were analyzed. The subjects were categorized into a high breakfast group (HBG) and low breakfast group (LBG). Analysis of covariance and multiple linear regression were mainly used in data analysis.</p><p><strong>Results: </strong>The subjects had breakfast 3.6 days/week on average. The HBG (47.4%) and the LBG (52.6%) differed significantly in breakfast status, including place, people eating together, breakfast menu, and breakfast preparers (<i>P</i> < 0.001). The HBG agreed more strongly with the advantages of breakfast than the LBG (<i>P</i> < 0.001). The disadvantages/barriers of breakfast were stronger in the LBG (<i>P</i> < 0.001). The HBG felt more confidence in having breakfast (<i>P</i> < 0.001) and confidence in general eating behaviors (<i>P</i> < 0.05). The two groups also differed in the subjective norms from parents/professionals (<i>P</i> < 0.001) and siblings/friends (<i>P</i> < 0.01). The HBG showed desirable eating behaviors more frequently (<i>P</i> < 0.001) and undesirable eating behaviors less frequently (<i>P</i> < 0.001). Multiple regression showed that the following were significantly related to the breakfast frequency, explaining 57.3% of the variance: self-efficacy regarding having breakfast (<i>P</i> < 0.001), perceived barriers of breakfast (no appetite/habit/indigestion, <i>P</i> < 0.001), desirable and undesirable eating behaviors (<i>P</i> < 0.01), subjective norms from parents/professionals (<i>P</i> < 0.05), and perceived barriers due to lack of time/preparation difficulties (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Psychosocial factors and eating behaviors were significantly related to the breakfast frequency. Nutrition education might include strategies to increase self-efficacy for breakfast, modify the beliefs, particularly the disadvantages/barriers of breakfast, adopt desirable eating behaviors, and elicit support from significant others.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food sources of zinc and nutritional status with usual dietary zinc intake in Korean toddlers and preschool children.","authors":"SuJin Song, Jae Eun Shim","doi":"10.4162/nrp.2023.17.6.1211","DOIUrl":"10.4162/nrp.2023.17.6.1211","url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aimed to evaluate the food sources of zinc and the usual intake of dietary zinc among Korean toddlers and preschool children.</p><p><strong>Subjects/methods: </strong>A total of 2,679 children aged 1-5 years was selected from the 2009-2013 Korea National Health and Nutrition Examination Survey (KNHANES) data. Dietary data collected from a single 24-h recall were used to evaluate the food sources of zinc. To estimate usual zinc intake, the distribution obtained from single 24-h recall data in the total sample was adjusted using the ratio of within-to-between-person variance in zinc intake obtained from 2-day 24-h recall sub-sample data of the 2009 KNHANES. The proportion of children with usual zinc intake below the estimated average requirement (EAR) and above the tolerable upper intake level (UL) was assessed.</p><p><strong>Results: </strong>The main sources of zinc in Korean children were grains, dairy products, and meat. The mean usual intakes of zinc among all individuals, those aged 1-2 yrs, and those aged 3-5 yrs were 5.50, 5.01, and 5.83 mg/d, respectively. In all participants, 1.1% of the children consumed zinc below the EAR, whereas 10.7% exceeded the UL. The proportion of children with excessive zinc intake was 25.6% in the 1-2 yrs age group and 0.6% in the 3-5 yrs age group.</p><p><strong>Conclusions: </strong>According to the current UL, the risk of excessive zinc intake appears to be high among Korean toddlers. Future studies that monitor the health effects of excessive zinc intake are needed to appropriately guide zinc intake in children.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition and health challenges among low-income families of young children in the post COVID-19 era: a qualitative study.","authors":"Hyunjung Lee, Wilna Oldewage-Theron, Conrad Lyford, Stephanie Shine","doi":"10.4162/nrp.2023.17.6.1185","DOIUrl":"10.4162/nrp.2023.17.6.1185","url":null,"abstract":"<p><strong>Background/objectives: </strong>In the United States, one in every 5 children is obese with greater likelihood in low-income households. The coronavirus disease 2019 (COVID-19) pandemic may have accelerated disparities in child obesity risk factors, such as poor dietary intake and increased sedentary behaviors, among low-income families because of financial difficulties, social isolation and other struggles. This study reveals insights into nutrition and health challenges among low-income families of young children in West Texas to better understand needs and develop interventions.</p><p><strong>Subjects/methods: </strong>In-depth individual interviews were performed via Zoom among 11 families of children under the age of 3. A semi-structured interview guide was developed to explore 3 areas: changes in (1) dietary intake and (2) sedentary behaviors and (3) families' preferences regarding a parent nutrition education program. Each interview was audio-recorded, transcribed, and coded using MaxQDA software.</p><p><strong>Results: </strong>Eating together as a family become challenging because of irregular work schedules during the COVID-19 pandemic. Most parents stated that their children's dietary habits shifted with an increased consumption of processed foods. Many parents are unable to afford healthful foods and have utilized food and nutrition assistance programs to help feed their families. All families reported that their children's screen time substantially increased compared to the pre-pandemic times. Moreover, the majority of parents did not associate child screen time with an obesity risk, so this area could be of particular interest for future interventions. Meal preparation ideas, remote modality, and early timing were identified as key intervention strategies.</p><p><strong>Conclusions: </strong>Online nutrition interventions that emphasize the guidelines for child screen time and regular meal routines will be effective and promising tools to reach low-income parents for early childhood health promotion and obesity prevention.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who has a high level of food literacy, and who does not?: a qualitative study of college students in South Korea.","authors":"Hyelim Yoo, Eunbin Jo, Hyeongyeong Lee, Eunji Ko, Eunjin Jang, Jiwon Sim, Sohyun Park","doi":"10.4162/nrp.2023.17.6.1155","DOIUrl":"10.4162/nrp.2023.17.6.1155","url":null,"abstract":"<p><strong>Background/objectives: </strong>Unhealthy food choices among young adults are common globally, and the incidence of chronic diseases, such as obesity, is rising. Food literacy (FL) is important for improving and maintaining individual health in a rapidly changing food environment and can form the basis for following a sustainable diet. Therefore, it is essential to improve FL among young adults, particularly college students, who are in the formative years of their lifelong food habits. This study examined the facilitators and barriers of FL and related dietary behavior among college students in South Korea.</p><p><strong>Subjects/methods: </strong>This study recruited 25 college students with different residence types using convenience and snowball sampling. In-person, telephone, and video interviews were conducted from March to November 2021. The interview data were analyzed using framework analysis based on the socio-ecological model.</p><p><strong>Results: </strong>At the individual level, prior good experiences with food were the most frequently mentioned facilitator. In contrast, the major barriers were a lack of knowledge, financial hardship, irregular schedules, and academic stress. At the interpersonal level, the influences of family and peers, such as early exposure to healthy eating habits and opportunities to have easy accessibility to farms and farming, are major facilitators, but the lack of a sense of community was the major barrier. At the environmental level, the major barriers were unfavorable food environments at home and in neighborhoods, such as the absence of kitchens in housing and large packaging of produce at markets.</p><p><strong>Conclusions: </strong>Many factors affected the students' FL and related healthy eating practices. These findings suggest that a campus-based FL program should be developed by reflecting on these facilitators and barriers.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of dietary self-monitoring intervention on anthropometric and metabolic changes via a mobile application or paper-based diary: a randomized trial.","authors":"Taiyue Jin, Gyumin Kang, Sihan Song, Heejin Lee, Yang Chen, Sung-Eun Kim, Mal-Soon Shin, Youngja H Park, Jung Eun Lee","doi":"10.4162/nrp.2023.17.6.1238","DOIUrl":"10.4162/nrp.2023.17.6.1238","url":null,"abstract":"<p><strong>Background/objectives: </strong>Weight loss via a mobile application (App) or a paper-based diary (Paper) may confer favorable metabolic and anthropometric changes.</p><p><strong>Subjects/methods: </strong>A randomized parallel trial was conducted among 57 adults whose body mass indices (BMIs) were 25 kg/m² or greater. Participants randomly assigned to either the App group (n = 30) or the Paper group (n = 27) were advised to record their foods and supplements through App or Paper during the 12-week intervention period. Relative changes of anthropometries and biomarker levels were compared between the 2 intervention groups. Untargeted metabolic profiling was identified to discriminate metabolic profiles.</p><p><strong>Results: </strong>Out of the 57 participants, 54 participants completed the trial. Changes in body weight and BMI were not significantly different between the 2 groups (<i>P</i> = 0.11). However, body fat and low-density lipoprotein (LDL)-cholesterol levels increased in the App group but decreased in the Paper group, and the difference was statistically significant (<i>P</i> = 0.03 for body fat and 0.02 for LDL-cholesterol). In the metabolomics analysis, decreases in methylglyoxal and (S)-malate in pyruvate metabolism and phosphatidylcholine (lecithin) in linoleic acid metabolism from pre- to post-intervention were observed in the Paper group.</p><p><strong>Conclusions: </strong>In the 12-week randomized parallel trial of weight loss through a App or a Paper, we found no significant difference in change in BMI or weight between the App and Paper groups, but improvement in body fatness and LDL-cholesterol levels only in the Paper group under the circumstances with minimal contact by dietitians or health care providers.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0004226.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food contributing to fermentable oligosaccharide, disaccharide, monosaccharide, and polyols intake in Korean adults.","authors":"Woori Na, Cheongmin Sohn","doi":"10.4162/nrp.2023.17.6.1201","DOIUrl":"10.4162/nrp.2023.17.6.1201","url":null,"abstract":"<p><strong>Background/objectives: </strong>The dietary intake of foods with fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is known to adversely affect patients with irritable bowel syndrome (IBS). However, the effects of FODMAP have been studied predominantly among Western populations. This study aimed to identify foods high in FODMAP content which form a part of the Korean adult diet and obtain basic data for the preparation of IBS guidelines.</p><p><strong>Subjects/methods: </strong>An online survey of 1,000 adults from the general population in the age group of 20 to 40 years was performed. Data from 787 participants (men, 386; women, 401) were analyzed. The general characteristics of the participants, health status, IBS diagnosis using the Rome III diagnostic criteria, semi-quantitative food frequency questionnaire findings, and food items causing symptoms were analyzed.</p><p><strong>Results: </strong>Overall, 169 participants (21.5%) had IBS. The contribution of the FODMAP nutrients in both IBS and healthy groups was as follows: fructan > lactose > excess fructose > sorbitol > mannitol > galacto-oligosaccharides (GOS). The fructan intake was 4.6 ± 2.2 g/day and 4.3 ± 2.5 g/day in the IBS and healthy groups (<i>P</i> = 0.014), respectively. In the IBS group, the ratio of the intake of fructan to the total FODMAP intake was 39.5%, 29.8%, and 5.8% through onions, garlic, and bananas, respectively.</p><p><strong>Conclusions: </strong>Fructan was the FODMAP nutrient most consumed by Korean adults. Therefore, given the difference in the dietary habits of each country's population, the dietary guidelines for IBS should be country specific.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Cydonia oblonga</i> Miller fruit extract exerts an anti-obesity effect in 3T3-L1 adipocytes by activating the AMPK signaling pathway.","authors":"Hyun Sook Lee, Jae In Jung, Jung Soon Hwang, Myeong Oh Hwang, Eun Ji Kim","doi":"10.4162/nrp.2023.17.6.1043","DOIUrl":"10.4162/nrp.2023.17.6.1043","url":null,"abstract":"<p><strong>Background/objectives: </strong>The fruit of <i>Cydonia oblonga</i> Miller (COM) is used traditionally in Mediterranean region medicine to prevent or treat obesity, but its mechanism of action is still unclear. Beyond a demonstrated anti-obesity effect, the fruit was tested for the mechanism of adipogenesis in 3T3-L1 preadipocytes.</p><p><strong>Materials/methods: </strong>3T3-L1 preadipocytes were cultured for 8 days with COM fruit extract (COME) at different concentrations (0-600 µg/mL) with adipocyte differentiation medium. The cell viability was measured using an MTT assay; triglyceride (TG) was stained with Oil Red O. The expression levels of the adipogenesis-related genes and protein expression were analyzed by reverse transcription polymerase chain reaction and Western blotting, respectively.</p><p><strong>Results: </strong>COME inhibited intracellular TG accumulation during adipogenesis. A COME treatment in 3T3-L1 cells induced upregulation of the adenosine monophosphate-activated protein kinase (AMPK)α phosphorylation and downregulation of the adipogenic transcription factors, such as sterol regulatory element-binding protein 1c, peroxisome proliferator-activated receptor γ, and CCAAT/enhancer binding protein α. The COME treatment reduced the mRNA expression of fatty acyl synthetase, adenosine triphosphate-citrate lyase, adipocyte protein 2, and lipoprotein lipase. It increased the mRNA expression of hormone-sensitive lipase and carnitine palmitoyltransferase I in 3T3-L1 cells.</p><p><strong>Conclusions: </strong>COME inhibits adipogenesis via the AMPK signaling pathways. COME may be used to prevent and treat obesity.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of milk and dairy product consumption with the incidence of cardio-cerebrovascular disease incidence in middle-aged and older Korean adults: a 16-year follow-up of the Korean Genome and Epidemiology Study.","authors":"Yeseung Jeong, Kyung Won Lee, Hyekyeong Kim, Yuri Kim","doi":"10.4162/nrp.2023.17.6.1225","DOIUrl":"10.4162/nrp.2023.17.6.1225","url":null,"abstract":"<p><strong>Background/objectives: </strong>Unhealthy dietary behaviors constitute one of risk the factors for chronic and cardiovascular diseases, which are prevalent in middle-aged and older populations. Milk and dairy products are high-quality foods and important sources of calcium. Calcium protects against osteoporosis and cardiovascular disease. Therefore, this study investigated the association of milk and dairy product consumption with cardio-cerebrovascular disease incidence in middle-aged and older Korean adults.</p><p><strong>Subjects/methods: </strong>Data were derived from the Ansan-Anseong cohort study, and a total of 8,009 individuals aged 40-69 years were selected and followed up biennially. Cox proportional hazard models were used to examine the association of milk and dairy product consumption with cardio-cerebrovascular disease incidence.</p><p><strong>Results: </strong>During a mean follow-up period of 96.5 person-months, 552 new cases of cardio-cerebrovascular disease were documented. Milk consumers (< 1 serving/day) exhibited a 23% lower risk of cardio-cerebrovascular disease incidence than non-milk consumers (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.61-0.97; <i>P</i> for trend = 0.842). High yogurt consumption was associated with a 29% lower incidence risk (≥ 0.5 servings/day vs. none: HR, 0.71; 95% CI, 0.53-0.96; <i>P</i> for trend = 0.049), whereas high ice cream consumption was associated with a 70% higher risk of cardio-cerebrovascular disease incidence (≥ 0.5 servings/day vs. none: HR, 1.70; 95% CI, 1.01-2.88; <i>P</i> for trend = 0.070).</p><p><strong>Conclusions: </strong>This study indicates that less than one serving of milk and high yogurt consumption are associated with a lower cardio-cerebrovascular disease risk in the middle-aged and older populations.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}