Nutrition & Metabolism最新文献

{"title":"Muscle-building interventions improve glucose metabolism in elderly type 2 diabetic patients with sarcopenic obesity.","authors":"Tingting Han, Xinyue Liang, Hongxia Liu, Mingyu Zhu, Sisi Shen, Jia Song, Hongwei Chen, Ningxin Chen, Yue Liu, Ziyi Wei, Yurong Weng, Xian Jin, Yaomin Hu","doi":"10.1186/s12986-025-00993-2","DOIUrl":"10.1186/s12986-025-00993-2","url":null,"abstract":"<p><strong>Background: </strong>Among all the elderly patients with type 2 diabetes mellitus (T2DM) of different body compositions, patients with sarcopenic obesity exhibited the most severe degree of insulin resistance despite possessing a normal body weight. It is well-established that interventions encompassing resistance training alone or in combination with whey protein supplementation, referred to hereafter as muscle-building interventions, are effective for increasing muscle mass and function in the elderly population. However, the impact of these muscle-building interventions on glucose metabolism in elderly T2DM patients with sarcopenic obesity remains unclear. The objective of this study was to elucidate the effect of muscle-building interventions on blood glucose and insulin resistance in elderly T2DM patients with sarcopenic obesity.</p><p><strong>Methods: </strong>The muscle-building interventions in this study included resistance training alone and resistance training combined with whey protein supplementation. In this randomized controlled trial, elderly T2DM patients with sarcopenic obesity were divided into three distinct groups: the control group, the resistance training group, and the resistance training combined with whey protein supplement group. The muscle-building interventions were conducted for 12 weeks.</p><p><strong>Results: </strong>Implementing muscle-building interventions showed significant improvements in glycemic indices (HbA1c, OGTT 2-hour plasma glucose) and insulin resistance levels (HOMA-IR, Gutt index) for elderly T2DM patients with sarcopenic obesity. These muscle-building interventions enhanced muscle functional indices (handgrip strength, 5-time chair stand test). The combination of resistance training with whey protein supplementation did not significantly enhance the favorable effects on glucose metabolism compared to resistance exercise alone. Correlation analyses revealed that improvements in muscle strength were significantly associated with enhancements in glucose metabolism.</p><p><strong>Conclusions: </strong>In elderly T2DM patients with sarcopenic obesity, muscle-building interventions (particularly resistance exercise) have been shown to significantly improve blood glucose control and insulin resistance.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"98"},"PeriodicalIF":4.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of inulin supplementation on eating behaviours in children and adolescents with obesity: a randomized double-blinded placebo-controlled study.","authors":"Ekkarit Panichsillaphakit, Chonnikant Visuthranukul, Yuda Chongpison, Natthaya Chuaypen, Tanisa Kwanbunbumpen, Jaraspong Uaariyapanichkul, Sirinuch Chomtho","doi":"10.1186/s12986-025-00995-0","DOIUrl":"10.1186/s12986-025-00995-0","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"97"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype-specific associations of meal timing patterns with cardiometabolic health in women: a cross-sectional study.","authors":"Azadeh Lesani, Neda Soveid, Cain C T Clark, Bahar Barkhidarian, Fatemeh Gholami, Mansooreh Sadat Mojani-Qomi","doi":"10.1186/s12986-025-00985-2","DOIUrl":"10.1186/s12986-025-00985-2","url":null,"abstract":"<p><strong>Background: </strong>Although prior studies have examined meal timing and health, few have considered the impact of individual chronotypes and diurnal preference. This study explored how meal distribution and chronotype-morning (M-type) versus evening (E-type)- are associated with cardiometabolic health.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 574 women in Tehran, Iran. Dietary intake was assessed through three 24-hour recalls and chronotype was determined via the Morningness-Eveningness Questionnaire. Cardiometabolic markers-including blood pressure (BP), glucose, lipids, insulin, and high-sensitivity C-reactive protein (hs-CRP)-were measured.</p><p><strong>Results: </strong>In E-type individuals, higher breakfast energy intake was linearly associated with lower systolic [β 95% CI, -0.03 (-0.05 _to -0.01)] and diastolic BP [-0.01 (-0.04 _to -0.003)]. Afternoon energy intake was associated with lower BMI [-0.02 (-0.04 _to -0.001)] and hs-CRP [-0.001 (-0.002 _to -0.0006)] in E-type women. Additionally, U-shaped associations were found between breakfast intake and systolic BP (turning point: 23% of total energy intake (TEI)), and between afternoon intake and BMI (13% TEI) and hs-CRP (12% TEI). In contrast, higher dinner energy intake was linearly associated with greater BMI in the intermediate [-0.01 (-0.02 _to -0.002)] and E-type group [0.05 (0.003 _to 0.09)], respectively. Eating window was associated with higher fasting blood glucose [0.001 (0.002 _to 0.003)] in E-type vs. M-type individuals.</p><p><strong>Conclusion: </strong>Aligning energy intake with wake-up time-rather than delaying meals-may benefit evening chronotypes prone to circadian misalignment. Moderate breakfast and afternoon intake, with lower dinner intake, was related to better cardiometabolic health. Accordingly, longitudinal studies are advocated.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"96"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 12 nutritional interventions on type 2 diabetes: a systematic review with network meta-analysis of randomized trials.","authors":"Yi Liu, Haiyue Li, Qian Zhao, Wenxiang Cui","doi":"10.1186/s12986-025-00968-3","DOIUrl":"10.1186/s12986-025-00968-3","url":null,"abstract":"<p><strong>Background: </strong>Numerous trials confirm dietary interventions benefit type 2 diabetes mellitus (T2DM) management, but the optimal model is unclear. We evaluated 12 interventions through a Network Meta-Analysis (NMA) on their effects on Fasting Plasma Glucose (FPG), 2-h Postprandial Glucose (2hPG), HbA1c, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), Total Cholesterol (TC), Triglycerides (TG), and BMI, providing evidence to guide clinical nursing.</p><p><strong>Methods: </strong>We conducted an NMA of randomized controlled trials (RCTs) (PROSPERO registration: CRD42023429616), searching eight databases for studies published between January 1, 2010, and August 31, 2024. Two reviewers independently screened studies, extracted data, and assessed bias using the Cochrane Risk of Bias tool. Key and important outcomes were analyzed using Stata 17.0, with evidence quality assessed via the Grading of Recommendations Assessment, Development and Evaluation (GRADE) and Confidence in Network Meta-Analysis (CINeMA) scores.</p><p><strong>Results: </strong>Eighteen RCTs comprising 1,687 patients were included. Among 12 evaluated dietary interventions, MNT ranked highest in reducing FPG (SUCRA = 77.6%; SMD = -0.75; 95% CI: -0.88 to -0.61). Digital dietary models were most effective for reducing HbA1c (SUCRA = 84.6%; SMD = -1.06; 95% CI: -2.11 to -0.01), while LGI diets were superior for both 2hPG (SUCRA = 62.1%; SMD = -0.62; 95% CI: -0.76 to -0.47) and HOMA-IR (SUCRA = 96.9%; SMD = -10.13; 95% CI: -15.96 to -4.30). The LGI + LGL intervention was most effective in reducing TC (SUCRA = 88.3%), TG (SUCRA = 80.6%), and BMI (SUCRA = 99.8%), with statistically significant differences observed in pairwise comparisons (P < 0.05). The quality of evidence was rated as high for FPG, 2hPG, HbA1c, and BMI, and moderate for HOMA-IR, TC, and TG.</p><p><strong>Conclusions: </strong>These findings highlight the potential of MNT, LGI, digital dietary models, and LGI + LGL interventions to improve glycemic control and metabolic outcomes in patients with T2DM. However, further large-scale, multicenter RCTs are warranted to validate their long-term efficacy and safety.</p><p><strong>Trial registration: </strong>CRD42023429616.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"94"},"PeriodicalIF":4.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Both subcutaneous semaglutide and calorie restriction improves pancreatic cell hyperplasia and gut microbiota in high-fat diet-induced obese mice.","authors":"Yunfei Luo, Shiqi Yang, Haixia Zeng, Shuang Liu, Yuying Zhang, Jin-E Li, Jianping Liu","doi":"10.1186/s12986-025-00987-0","DOIUrl":"10.1186/s12986-025-00987-0","url":null,"abstract":"<p><strong>Background: </strong>Obesity has emerged as a global health crisis, with its prevalence having increased alarmingly over recent decades. There is significant damage to pancreatic islets due to obesity, as well as metabolic syndrome. Improving the function of β-cells in obese patients is meaningful for treatment. Thus, GLP-1 receptor agonists like semaglutide may be beneficial for islet structural remodeling and their endocrine function in diet-induced obese mice and associated with food intake. However, whether the specific impact of semaglutide on obesity is the same as calorie restriction(CR) has not been investigated.</p><p><strong>Methods: </strong>In this study, Five-week-old male C57BL/6 mice were divided into two dietary groups and fed for 12 weeks a control diet or a high-fat diet (HFD). Then, for an additional four weeks, the main groups were resampled to include treatment (Semaglutide, SME, 40 µg/kg), or CR, totaling four groups: Control, Model, Model + SME, Model + CR. Immunofluorescence, Western blot, and RT-qPCR were used in the study.</p><p><strong>Results: </strong>Semaglutide or CR was capable of ameliorating hyperglycemia and insulin sensitivity, and reduces the lesion on the islet, increases islet cell proliferation, and recovers islet size and alpha- and beta-cell masses. Moreover, the changes include improvement of METTL3/14, pancreatic duodenal homeobox 1 (PDX-1), and insulin signaling. Meanwhile, Semaglutide or CR significantly decreases the abundance of Firmicutes, Proteobacteria, and Verrucomicrobia, but increases the Bacteroides content.</p><p><strong>Conclusions: </strong>Semaglutide plays a positive role in alleviating β-cell dysfunction by regulating gut microbiota, and METTL3/14, PDX-1, insulin signal pathway-related genes may be associated with CR.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"95"},"PeriodicalIF":4.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cornelian cherry, cardiometabolic health, and dietary intake: a GRADE-assessed systematic review and meta-analysis.","authors":"Morteza Omrani, Mostafa Norouzzadeh, Hamid Ahmadirad, Mehrnaz Abbasi, Mitra Kazemi Jahromi, Farshad Teymoori, Minoo Hasan Rashedi, Seyedeh Tayebeh Rahideh, Hossein Farhadnejad, Parvin Mirmiran, Mohsen Khaleghian","doi":"10.1186/s12986-025-00991-4","DOIUrl":"10.1186/s12986-025-00991-4","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"92"},"PeriodicalIF":4.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic index of some protein-free food products for individuals with non-dialysis-dependent chronic kidney disease.","authors":"Alessandro Leone, Francesca Menichetti, Franca Criscuoli, Giovanni Fiorillo, Stefano Ravasenghi, Maria Cristina Casiraghi, Simona Bertoli","doi":"10.1186/s12986-025-00990-5","DOIUrl":"10.1186/s12986-025-00990-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a major public health issue and the third leading cause of death globally. In the conservative phase of CKD, a low-protein diet is recommended to slow disease progression, and protein-free products are commonly used in clinical nutrition for CKD. Since diabetes is highly prevalent in this population, it is crucial that such foods also have a low glycemic index (GI) to support glycemic control and reduce associated complications. This study aimed to assess the GI of selected commercial protein-free products.</p><p><strong>Methods: </strong>Twelve healthy volunteers (six males, six females; mean age 20.7 ± 0.8 years; BMI 22.6 ± 3.6 kg/m²) consumed four commonly available protein-free foods: sliced white bread, pasta, crackers, and cookies filled with vanilla cream (with sweeteners). The GI of each product was calculated according to ISO 2010 standards, using glucose as a reference. Each test meal provided 50 g of available carbohydrates.</p><p><strong>Results: </strong>GI values ranged from 48 for cookies filled with vanilla cream to 69 for crackers. Sliced white bread (GI 49.4) and cookies (GI 47.8) were classified as low-GI foods, while pasta (GI 68.2) and crackers (GI 69.2) fell within the medium-GI range.</p><p><strong>Conclusion: </strong>Several commercially available protein-free products exhibit low to moderate GI values, supporting their use in dietary management of patients with non-dialysis-dependent CKD and or at risk of diabetes. However, given the growing market of such products, further studies-including those on patients with CKD-are needed to expand the current evidence base.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"93"},"PeriodicalIF":4.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary intakes of nitrate with nitrite from animal and plant food sources and the incidence of pre-diabetes and type 2 diabetes: a prospective study.","authors":"Milad Davarpanah, Zahra Bahadoran, Maryam Javadi, Amir Javadi, Davood Khalili, Parvin Mirmiran, Fereidoun Azizi","doi":"10.1186/s12986-025-00988-z","DOIUrl":"10.1186/s12986-025-00988-z","url":null,"abstract":"<p><strong>Aim: </strong>We investigated the potential effect of dietary nitrate (NO₃)/nitrite (NO₂) on the incidence of pre-diabetes (Pre-DM) and type 2 diabetes (T2D).</p><p><strong>Methods: </strong>This longitudinal study was conducted on 2417 T2D- and Pre-DM free adults, aged 21-70 years (mean age of 39.6 ± 13.3 and 45.8% men) who participated in the third (2006-2008) examinations of the Tehran Lipid and Glucose Study (TLGS) and followed up to 2018-2022. The participants' habitual dietary intakes of NO₃ and NO₂ were estimated using a semi-quantitative food frequency questionnaire (FFQ) at baseline. Multivariable-adjusted Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of incidence of Pre-DM and T2D across quartile categories of NO₃ and NO₂ intakes.</p><p><strong>Results: </strong>Mean (SD) daily intake of NO₃ and NO₂ were 489 (206) mg/d and 9.6 (3.8) mg/d; NO₃ intakes mainly were derived from plant sources (95.7%). The highest compared to the lowest quartile of total and plant-based dietary NO3 intakes was accompanied by a significantly decreased risk of Pre-DM (HR = 0.65, 95% CI = 0.50-0.85, HR = 0.68, 95% CI = 0.52-0.88). A reduced risk of T2D was observed in medium intakes of NO₃ (HR = 0.68, 95% CI = 0.47-0.97, HR = 0.70, 95% CI = 0.49-1.00, in the total and plant-based sources, respectively). The lowest compared to the highest quartile of dietary NO₂ was accompanied by a reduced incidence of T2D (HR = 0.71, 95% CI = 0.51-0.98, HR = 0.61, 95% CI = 0.44-0.84 in the total and plant-based sources, respectively).</p><p><strong>Conclusion: </strong>Higher and medium intakes of NO₃ are associated with a reduced incidence of Pre-DM and T2D, respectively.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"91"},"PeriodicalIF":4.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dried blood spot technique for dietary fat assessment in a human nutritional intervention focused on oily fish intake.","authors":"Laura Garcia-Urtiaga, Ainara Cano, Mercedes Caro, Jaione Pagaldai, Javier Amezaga, Itziar Tueros, Sara Arranz","doi":"10.1186/s12986-025-00983-4","DOIUrl":"10.1186/s12986-025-00983-4","url":null,"abstract":"<p><strong>Background: </strong>Several studies have employed dried blood spot (DBS) analysis to measure omega-3 levels in whole blood and investigate their associations with cardiovascular risk. Our study evaluated the effectiveness of using DBS as a marker for dietary intake, specifically focusing on omega-3 fatty acids, over both short- and long-term periods. As a novel approach, this study aims to determine whether the fatty acid (FA) profile of DBS can be useful to accurately reflect nutritional habits and monitor changes in fish intake over different consumption periods.</p><p><strong>Methods: </strong>A within-subject nutritional intervention study was conducted with 18 healthy volunteers (both males and females aged 18-65 years). Their FA profiles were determined by GC-FID in DBS before the intervention began, and changes in their blood FA profiles were monitored at five different time-points across different periods of oily fish consumption. Dietary information was recorded daily through questionnaires. For statistical analysis, hierarchical clustering and principal component analysis were performed to detect patterns of FA profiles in DBS. Differences among groups were tested by Student´s t test or by Wilcoxon test, and changes across visits were analysed via linear mixed models.</p><p><strong>Results: </strong>The results revealed three main patterns of the DBS profile, which could be explained by the participants' dietary habits. Furthermore, the changes during the intervention indicated that eicosapentaenoic acid (20:5n-3) levels were highly affected by the diet of the previous day, whereas docosapentaenoic acid (22:5n-3) and docosahexaenoic acid (22:6n-3) required at least one or two weeks to show changes, with little difference depending on the FA levels of the participants before they started the intervention.</p><p><strong>Conclusion: </strong>The use of DBS to examine blood FA composition is a promising, reliable and convenient way to assess dietary habits and monitor responses to food intake, which could help advance personalised nutritional strategies.</p><p><strong>Trial registration: </strong>The study was registered at the ISRCTN (registration number ISRCTN47135203) the 22nd October 2024.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"89"},"PeriodicalIF":4.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient deficiency and physical inactivity in middle-aged adults with dynapenia and metabolic syndrome: results from a nationwide survey.","authors":"Mijin Kim, Toshiro Kobori","doi":"10.1186/s12986-025-00978-1","DOIUrl":"10.1186/s12986-025-00978-1","url":null,"abstract":"<p><strong>Background: </strong>This study examined the associations between dynapenia, metabolic syndrome (MetS), nutrient intake, and physical activity.</p><p><strong>Methods: </strong>We used data from a cross-sectional study that included middle-aged men and women (40-64 years old) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) between 2014 and 2017. Patients (n = 4700) were categorized into four groups based on diagnosis of dynapenia and MetS: dynapenic MetS (DM), dynapenia alone (D), MetS alone (M), and non-dynapenia and non-MetS (NDNM). Dynapenia was defined as the lowest tertile of the BMI-adjusted handgrip strength. MetS was defined as central obesity plus two or more of the following features: elevated fasting plasma glucose, blood pressure, or triglycerides, or reduced HDL cholesterol. Nutrient intake and physical activity were assessed via questionnaires.</p><p><strong>Results: </strong>In women, the DM group had a significantly lower intake of all nutrients except for total energy and carbohydrates compared to the NDNM group. In a model adjusted for age, osteoarthritis, and total energy intake, the DM group showed higher odds ratios (ORs) for not practicing resistance training (men: OR (95% confidence intervals (CI)) = 1.64 (1.22-2.20); women: OR (95% CI) = 2.26 (1.59-3.21)) and for engaging in physical activities below 600 metabolic equivalents of tasks per week (men: OR (95% CI) = 1.36 (1.05-1.78); women: OR (95% CI) = 1.29 (1.02-1.63)) than the NDNM group. The women in the DM group had significantly higher OR for leisure-related moderate (OR (95% CI) = 2.00 (1.49-2.68)) and vigorous (OR (95% CI) = 1.76 (1.10-2.82)) physical inactivity than in the NDNM group.</p><p><strong>Conclusions: </strong>This study showed that the combination of dynapenia and MetS was associated with poor nutrient intake in women and low physical activity in both sexes. These findings provide a foundation for developing intervention strategies to address dynapenia and MetS.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"88"},"PeriodicalIF":4.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}