Nutrition & Metabolism最新文献

{"title":"Relationships between the Planetary Health Diet Index, its food groups, and polygenic risk of obesity in the CARTaGENE cohort.","authors":"Guiomar Masip, Daiva E Nielsen","doi":"10.1186/s12986-024-00890-0","DOIUrl":"10.1186/s12986-024-00890-0","url":null,"abstract":"<p><strong>Background: </strong>The Planetary Health Diet, proposed by the EAT-Lancet Commission, seeks to promote a sustainable and healthy diet for both humans and the environment. However, few studies have investigated relationships between the Planetary Health Diet and the genetic pathway of obesity. The aim of this study was to assess whether adherence to a Planetary Health Diet Index (PHDI) mediated or moderated the genetic susceptibility to obesity.</p><p><strong>Methods: </strong>Participants were 7,037 adults (57% females, aged 55.6 ± 7.7) from the Quebec CARTaGENE Biobank. We constructed a primary polygenic risk score (PRS-Khera) for body mass index (BMI) comprised of ~ 2 million SNPs and utilized a secondary 97 SNPs polygenic risk score (PRS-Locke) for sensitivity analyses. The PHDI was based on 16 food groups. General linear models were conducted to assess main effect associations between the PRSs, the Planetary Health Diet Index (PHDI), and the individual food groups that comprise the PHDI on obesity outcomes. Causal mediation analyses (CMA) were used to evaluate mediation and interaction effects. All models were adjusted for age, sex, genetic ancestry, socio-demographic, and lifestyle variables, including those associated with dietary habits.</p><p><strong>Results: </strong>The overall PHDI was inversely associated with BMI (β = - 0.11, 95% confidence interval (CI): - 0.13, - 0.09), waist circumference (WC) (β = - 0.12, 95% CI: - 0.14, - 0.10), and body fat % (β = - 0.10, 95% CI: - 0.12, - 0.08) for all participants, but did not mediate or moderate obesity polygenic risk. Associations between the PRS-Khera and obesity outcomes in all participants were partly mediated by the intake of red meat (mediation effect BMI: 1.72%, p = 0.01; WC: 2.22%, p = 0.01; body fat %: 2.14%, p = 0.01). Moreover, among males, whole grains intake partly mediated the association between the PRS-Khera and outcomes cross-sectionally (BMI: 1.28%, p = 0.03; WC: 1.71%, p = 0.02; body fat %: 2.19%, p = 0.02) and longitudinally (BMI: 3.80%, p = 0.02; WC: 7.38%, p = 0.04), but some observations were attenuated upon correction for multiple comparisons.</p><p><strong>Conclusions: </strong>PHDI adherence was associated with a lower BMI, WC, and body fat % and genetic susceptibility to obesity was partly mediated by the intake of red meat and whole grains. Some components of a plant-based diet could be implicated in mechanisms underlying genetic susceptibility to obesity.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"116"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11689624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway.","authors":"Liangzhi Zhang, Xiaojie Liu, Jing Hu, Helong Quan, Sang Ki Lee, Mallikarjuna Korivi, Lifeng Wang, Ting Li, Wei Li","doi":"10.1186/s12986-024-00888-8","DOIUrl":"10.1186/s12986-024-00888-8","url":null,"abstract":"<p><strong>Objective: </strong>Impaired skeletal muscle glycogen synthesis contributes to insulin resistance (IR). Aerobic exercise reported to ameliorate IR by augmenting insulin signaling, however the detailed mechanism behind this improvement remains unclear. This study investigated whether aerobic exercise enhances glycogen anabolism and insulin sensitivity via EGR-1/PTP1B signaling pathway in skeletal muscle of rats.</p><p><strong>Methods: </strong>Sprague-Dawley rats fed a high-fat diet (HFD), and performed treadmill exercise training for 6-week. Oral glucose tolerance test was conducted to confirm the IR. Periodic Acid-Schiff (PAS) staining and anthrone colorimetry were used to assess the skeletal muscle glycogen. RT-qPCR, western blot, and immunofluorescence were used to detect the EGR-1/PTP1B pathway and associated signaling molecules.</p><p><strong>Results: </strong>We found that exercise training significantly decreased blood glucose, insulin, and homeostasis model assessment for IR (HOMA-IR) against HFD-induced elevation. Decreased muscle glycogen content due to HFD was significantly restored after exercise training. Exercise training promoted mRNA expressions of Irs1, Akt, and Glut4, while inhibited Gsk-3β expression against HFD. Next, the decreased IRS1 (phosphorylated/total), AKT (phosphorylated/total), and GLUT4, and increased GSK-3β proteins with HFD were significantly reversed by exercise. Furthermore, HFD-induced overexpression of EGR-1 and PTP1B evidenced by mRNA, protein, and immunofluorescence intensity, were substantially inhibited by exercise, which may contribute to promote insulin sensitivity and glycogen anabolism.</p><p><strong>Conclusions: </strong>Aerobic exercise training promotes insulin sensitivity and skeletal muscle glycogen synthesis in HFD-fed rats. The beneficial effects of exercise might be mediated by EGR-1/PTP1B signaling pathway in skeletal muscle, however further studies are necessary to confirm this mechanism.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"113"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Impact of fish oil supplementation on plasma levels of highly unsaturated fatty acid-containing lipid classes and molecular species in American football athletes.","authors":"Veronica Anne Mullins, Justin M Snider, Bryce Michael, Lydia Rose Porter, Roberta Diaz Brinton, Floyd H Chilton","doi":"10.1186/s12986-024-00878-w","DOIUrl":"10.1186/s12986-024-00878-w","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"115"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The association between age of menopause and type 2 diabetes: a systematic review and meta-analysis.","authors":"Mansoureh Yazdkhasti, Kyana Jafarabady, Arman Shafiee, Samira Parvizi Omran, Zohre Mahmoodi, Sara Esmaeilzadeh, Touran Bahrami Babaheidari, Kourosh Kabir, Maral Peisepar, Mahmood Bakhtiyari","doi":"10.1186/s12986-024-00891-z","DOIUrl":"10.1186/s12986-024-00891-z","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"114"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food intake in relation to metabolic health status in Iranian adolescents with overweight and obesity.","authors":"Sana Farzam, Donya Poursalehi, Saeideh Mirzaei, Ali Asadi, Masoumeh Akhlaghi, Parvane Saneei","doi":"10.1186/s12986-024-00886-w","DOIUrl":"10.1186/s12986-024-00886-w","url":null,"abstract":"<p><strong>Background: </strong>Many studies have explored the association between food intake and metabolic health. However, research on the association of consuming ultra-processed foods (UPFs) and metabolic health in children and adolescents remains unclear. The objective of our study was to investigate the relation between UPFs consumption and metabolic health status in Iranian adolescents with overweight/obesity.</p><p><strong>Methods: </strong>For this cross-sectional study, we selected a sample of 203 adolescents (101 boys and 102 girls) with a mean age of 13.98 ± 1.61 who were chosen using a multistage cluster random sampling method. We collected data on their dietary patterns using a validated 147-item semi-quantitative food frequency questionnaire. Additionally, we measured anthropometric indices, blood pressure, fasting glucose, insulin, and lipid profiles. Participants were categorized to either metabolically healthy or unhealthy overweight/obesity (MHO and MUO) based on the International Diabetes Federation (IDF) and IDF/ Homeostasis Model Assessment Insulin Resistance (HOMA-IR) criteria.</p><p><strong>Results: </strong>Our findings revealed that every 10 g/d increase in UPFs consumption was related to an elevated odds of MUO as defined by the IDF (OR = 1.14; 95%CI: 1.08-1.19) and IDF/HOMA-IR (OR = 1.14; 95%CI; 1.08-1.19) criteria, after controlling all confounders. The severity of this association varied among girls and boys and also among those with overweight and obesity according to the applied definitions. Moreover, each 10 g/d increase in daily UPFs intake was associated with increased odds of metabolic factors including hyperglycemia, hypertriglyceridemia, hypo-HDL-cholesterolemia, hypertension, and high insulin resistance levels.</p><p><strong>Conclusion: </strong>These findings highlighted a direct association between higher UPFs consumption and MUO status among adolescents.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"111"},"PeriodicalIF":3.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverting hepatic lipid fluxes with lifestyles revision and pharmacological interventions as a strategy to tackle steatotic liver disease (SLD) and hepatocellular carcinoma (HCC).","authors":"Davide Misceo, Gabriele Mocciaro, Simona D'Amore, Michele Vacca","doi":"10.1186/s12986-024-00871-3","DOIUrl":"10.1186/s12986-024-00871-3","url":null,"abstract":"<p><p>Steatotic liver disease (SLD) and Hepatocellular Carcinoma (HCC) are characterised by a substantial rewiring of lipid fluxes caused by systemic metabolic unbalances and/or disrupted intracellular metabolic pathways. SLD is a direct consequence of the interaction between genetic predisposition and a chronic positive energy balance affecting whole-body energy homeostasis and the function of metabolically-competent organs. In this review, we discuss how the impairment of the cross-talk between peripheral organs and the liver stalls glucose and lipid metabolism, leading to unbalances in hepatic lipid fluxes that promote hepatic fat accumulation. We also describe how prolonged metabolic stress builds up toxic lipid species in the liver, and how lipotoxicity and metabolic disturbances drive disease progression by promoting a chronic activation of wound healing, leading to fibrosis and HCC. Last, we provide a critical overview of current state of the art (pre-clinical and clinical evidence) regarding mechanisms of action and therapeutic efficacy of candidate SLD treatment options, and their potential to interfere with SLD/HCC pathophysiology by diverting lipids away from the liver therefore improving metabolic health.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"112"},"PeriodicalIF":3.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study.","authors":"Takahiro Ichikawa, Yoshitaka Hashimoto, Yusuke Igarashi, Sayaka Kawai, Ayumi Kaji, Ryosuke Sakai, Takafumi Osaka, Ryo Inoue, Saori Kashiwagi, Katsura Mizushima, Kazuhiko Uchiyama, Tomohisa Takagi, Yuji Naito, Masahide Hamaguchi, Michiaki Fukui","doi":"10.1186/s12986-024-00884-y","DOIUrl":"10.1186/s12986-024-00884-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-administered diet history questionnaire, quantified as the density of UPFs intake (g/1000 kcal). Gut microbial composition was evaluated via 16S rRNA gene sequencing. We investigated the association between gut microbiota, previously identified as relevant to T2D, and the density of UPFs intake using Spearman rank correlation coefficients. Multiple regression analysis, adjusting for age, sex, BMI, smoking status, exercise, and medication use, was conducted to further investigate these associations.</p><p><strong>Results: </strong>The mean age of participants was 68 (63-74) years. The density of UPFs intake showed significant associations with Bifidobacterium (r = 0.11, p = 0.031), Lactobacillus (r = 0.11, p = 0.046), Ruminococcus (r = -0.12, p = 0.019), Roseburia (r = 0.11, p = 0.045). After adjusting for covariates in multiple regression analysis, Ruminococcus and Roseburia showed modest negative (β = -0.11, p = 0.038) and positive (β = 0.12, p = 0.033) correlations, with the density of UPFs intake among participants with T2D, respectively.</p><p><strong>Conclusions: </strong>The density of UPFs intake was modestly inversely associated with Ruminococcus among patients with T2D and modestly positively associated with Roseburia.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"110"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary diversity and patterns in Chinese university students with abnormal uterine bleeding: a cross-sectional study.","authors":"Sha Yu, Lei Lai, Xiang Li, Lifeng Lei, Xuan Zhang, Leyi Liu, Peize Song, Xinyue Zhang, Yuxin Ma, Qianqian Lan, Yufang Liu, Yuanqun Chen, Yuping Tang, Zhiying Yu","doi":"10.1186/s12986-024-00873-1","DOIUrl":"10.1186/s12986-024-00873-1","url":null,"abstract":"<p><strong>Background: </strong>Abnormal uterine bleeding (AUB) is a common gynecological issue during reproductive years. Researches on how dietary diversity and patterns influence AUB in Chinese university students are limited, with some studies not clearly defining irregular menstruation. This research investigated the incidence of AUB according to the International Federation of Gynecology and Obstetrics criteria and sought to identify preventative factors via online questionnaires.</p><p><strong>Methods: </strong>Food intake was assessed via factor analysis. This study analyzed the relationships among the dietary diversity score (DDS), dietary patterns, and AUB via univariate and multivariate binary logistic regression models and generalized additive models.</p><p><strong>Results: </strong>The sample consisted of 698 students, with 434 (62.2%) having experienced AUB. Among them, 87 (20.05%) reported abnormal frequency, 250 (57.60%) reported irregular menstrual cycle, 41 (9.45%) reported prolonged duration, and 268 (61.75%) reported abnormal flow volume. A 1-unit increase in the DDS was linked to a 22% lower risk of AUB (odds ratio 0.78, 95% CI: 0.67, 0.90). A high DDS (≥ 6) was consistently associated with a lower risk of AUB across all the models. Using a two-piecewise linear regression model and recursive algorithm, a nonlinear, reverse L-shaped relationship was identified between the \"low fat plant-based\" dietary pattern factor score (FAC4) and AUB, with an inflection point of 1.45. Before this point, FAC4 had a protective effect on AUB (odds ratio 0.42, 95% CI: 0.21, 0.84).</p><p><strong>Conclusions: </strong>Our study underscores the importance of a varied diet as a preventive measure for AUB, utilizing a DDS to quantify the relationship between dietary diversity and AUB. According to our findings, higher dietary diversity and moderate adherence to a \"low fat plant-based\" dietary pattern may be significant protective factors against AUB in university students.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"108"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing nutritional adequacy ratios in women with and without binge eating disorder: a comprehensive evaluation.","authors":"Neda Lotfi Yagin, Soghra Aliasgharzadeh, Majid Mobasseri, Helda Tutunchi, Samaneh Hajarzadeh, Farzad Najafipour","doi":"10.1186/s12986-024-00887-9","DOIUrl":"10.1186/s12986-024-00887-9","url":null,"abstract":"<p><strong>Backgrounds: </strong>Bing eating disorder (BED) has been associated with a number of health problems. Remarkably little research has been done to measure dietary intake in people who suffer from binge eating disorder. This study aimed to compare the dietary intake and nutrient adequacy ratio (NAR) between BED individuals and those without BED and also to investigate the association between BED and NAR.</p><p><strong>Methods: </strong>In this cross- sectional study, 180 overweight and obese females who aged between 19 and 50 years old and with BMI between 25 and 40 kg/m² were interviewed. The women were categorized into BED and non- BED groups based on their earned score in Binge Eating Scale (BES) questionnaire. Nutritional adequacy ratio was assessed as Micronutrient adequacy ratio, Macronutrient adequacy ratio and total adequacy ratio (the sum of the previous two) based on last year's dietary intakes collected using a semi-quantitative food frequency questionnaire (FFQ). The odds of binge eating disorder across the nutritional adequacy scores were assessed using multiple logistic regression models. Data were analyzed using SPSS software.</p><p><strong>Results: </strong>About 41.6% (n = 75) of the subjects were diagnosed with BED. Carbohydrate, saturated fats, sugar levels were significantly higher in women with BED compared to non-BED women (P < 0.05). All vitamins, with the exception of Retinol, and all minerals' levels were significantly lower in BED participants (P < 0.05). Micronutrient adequacy score and total adequacy score differed significantly between individuals with and without BED (P < 0.001) and non- BED group were significantly more nutritional adequate. The odds of having BED were lower in micronutrient, macronutrient adequate individuals (OR = 0.87, 95% CI = 0.78-0.98, P = 0.02), (OR = 0.81, 95% CI = 0.66-0.99, P = 0.049) respectively.</p><p><strong>Conclusion: </strong>Overall, the results demonstrate low intake of key micronutrients and high intake of saturated fatty acids and carbohydrates among binge sufferers. Also, the findings indicate that individuals with BED experience a notably lower nutrient adequacy ratio compared to their peers without the disorder, suggesting that the eating behaviors associated with BED such as high consumption of processed foods and diet with low quality may lead to inadequate intake of vital nutrients.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"109"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interpretable machine learning model for precise prediction of biomarkers for intermittent fasting pattern.","authors":"Xiaoli Hu, Qingjun Xu, Xuan Ma, Lin Li, Yongning Wu, Feifei Sun","doi":"10.1186/s12986-024-00876-y","DOIUrl":"10.1186/s12986-024-00876-y","url":null,"abstract":"<p><p>Intermittent fasting is currently a highly sought-after dietary pattern. To explore the potential biomarkers of intermittent fasting, untargeted metabolomics analysis of fecal metabolites in two groups of mice, intermittent fasting and normal feeding, was conducted using UPLC-HRMS. The data was further analyzed through interpretable machine learning (ML) to data mine the biomarkers for two dietary patterns. We developed five machine learning models and results showed that under three-fold cross-validation, Random Forest model was the most suitable for distinguishing the two dietary patterns. Finally, Shapely Additive exPlanations (SHAP) were explored to perform a weighted explanatory analysis on the Random Forest model, and the contribution of each metabolite to the model was calculated. Results indicated that Ganoderenic Acid C is the potential biomarkers to distinguish the two dietary patterns. Our work provides new insights for metabolic biomarker analysis and lays a theoretical foundation for the selection of a healthieir dietary lifestyle.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"21 1","pages":"106"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}