Nutrition & Metabolism最新文献

{"title":"The effectiveness and safety of specific dietary supplements in modulating uric acid levels, oxidative stress, and lipid metabolism in patients: a network meta-analysis of 13 interventions.","authors":"Guancheng Ye, Chunping Liu, Xiaojia Zheng, Jinying Fang, Cunxiang Xie, Mingxuan Liu, Yiwen Wang, Luming Zhao, Hailong Wang","doi":"10.1186/s12986-025-00977-2","DOIUrl":"https://doi.org/10.1186/s12986-025-00977-2","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricemia and gout have garnered increasing attention as significant health concerns in recent years, often associated with damage to multiple bodily systems. Consequently, the reduction of uric acid levels has become particularly crucial. The utilization of dietary supplements presents potential adjunctive treatment options for individuals with gout. Certain dietary supplements are purported to aid in the reduction of uric acid levels and are highly preferred by patients due to their affordability, ease of use, and accessibility. The aim of this article was to compare the efficacy and safety of dietary supplements in modulating uric acid, oxidative stress, and lipid metabolism in patients with hyperuricemia or gout, using a comprehensive network meta-analysis (NMA) approach.</p><p><strong>Methodology: </strong>A comprehensive search was performed across both Chinese and English databases to identify randomized controlled trials (RCTs) examining the efficacy of dietary supplements in reducing uric acid levels. Network meta-analysis was conducted using Stata 16.0 software, while RevMan 5.3 software was employed to assess the quality of the literature and evaluate the risk of bias.</p><p><strong>Result: </strong>A total of 30 RCTs, encompassing 44,972 patients, were conducted. The findings of the study indicated that folic acid (mean difference [MD] = -57.62 μmol/L, 95% confidence interval [CI] [-107.14, -8.1]) and probiotics (MD = -42.52 μmol/L, 95% CI [-81.95, -3.09]) significantly reduced uric acid levels compared to conventional therapy. Furthermore, Vitamin C (MD = -0.92 nmmol/ml, 95% CI [-1.54, -0.31]) and Vitamin E (MD = -1.05 nmmol/ml, 95% CI [-2.01, -0.1]) were effective in reducing oxidative stress-related malondialdehyde (MDA) levels. In terms of lipid metabolism improvement, DKB114 (MD = -0.45 mmol/L, 95% CI [-0.9, -0.001]) and curcumin (MD = -0.54 mmol/L, 95% CI [-0.89, -0.18]) demonstrated statistically significant reductions in low-density lipoprotein (LDL) levels. Analysis of subgroups revealed that administration of 500 mg of vitamin C resulted in a significant reduce in uric acid levels when compared to conventional treatment (MD =  - 21.67 μmol/L, 95% CI [- 43.01, - 0.33]), indicating statistically significant differences. The safety profile of all dietary supplements has generally been demonstrated to be favorable.</p><p><strong>Conclusion: </strong>Dietary supplements hold significant potential for managing gout and hyperuricemia, as well as improving patients' metabolic status. Future research should focus on larger-scale studies to further explore these findings.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"80"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analyses the effect of Bifidobacterium longum subsp. longum BL21 supplementation on overweight and obese subjects: a randomized, double-blind, placebo-controlled study.","authors":"Xiaoya Wang, Zefeng Xing, Rui Wang, Guoming Zhang, Guodong Liu, Zhen Li, Lixiang Li","doi":"10.1186/s12986-025-00969-2","DOIUrl":"10.1186/s12986-025-00969-2","url":null,"abstract":"<p><strong>Background: </strong>Bifidobacterium longum subsp. longum BL21 has demonstrated promise in alleviating gut microbiota disturbances and metabolic regulation in high-fat diet-induced obesity and type 2 diabetes mellitus models. However, the effect of probiotic B. longum BL21 on overweight and obese individuals remain unclear.</p><p><strong>Methods: </strong>A randomized, double-blind, placebo-controlled trial was performed, and 66 adult individuals were assigned to receive either BL 21 (2*10¹⁰ colony-forming units per day along with 3 g of maltodextrin) or placebo (3 g of maltodextrin daily) for 8 weeks. Multi-omics analyses were employed to evaluate the impact of the B. longum strain BL21 on gut microbiota, serum metabolomics, body weight and lipids profiles in overweight and obese participants.</p><p><strong>Results: </strong>Following the intervention, both the BL21 group (1.22 ± 2.78, P = 0.02) and placebo group (0.98 ± 2.06, P = 0.01) demonstrated significant body weight reductions, with no statistically significant intergroup difference observed (P = 0.81). Notably, only the BL21 group exhibited a significant reduction in triglyceride levels compared to baseline (0.21 ± 1.09, P = 0.04). Microbiota analysis indicated that BL21 intervention significantly changed the β-diversity at week 8 compared with placebo group. The genera of Parasutterella, Parabacteroides, Blautia, Dorea, Butyricicoccus enriched in BL21 group. Metabolomics results indicated that sphingolipid metabolism, biotin metabolism and protein digestion and absorption were the top altered pathway in BL21 group compared with placebo group after intervention.</p><p><strong>Conclusion: </strong>B. longum subsp. longum BL21 may be a beneficial candidate to modulate the gut microbiota and triglyceride metabolism of overweight and obese individuals.</p><p><strong>Trial registration: </strong>Clinical trial registration number: NCT06140641. Date of registration: November 17, 2023.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"79"},"PeriodicalIF":3.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 supplementation and cardiometabolic risk factors in obese/overweight children and adolescents: a GRADE assessed systematic review and meta-analysis.","authors":"Vali Musazadeh, Mahsa Mahmoudinezhad, Pedram Pam, Sanaz Brazandeh, Fatemeh Faramarzi, Yousef Mohammadpour, Amir Hossein Faghfouri, Shahsanam Gheibi","doi":"10.1186/s12986-025-00952-x","DOIUrl":"10.1186/s12986-025-00952-x","url":null,"abstract":"<p><strong>Background: </strong>Omega-3 polyunsaturated fatty acids (ɷ3 PUFA), have been proposed as a supplement to improve cardiometabolic risk factors in obese/overweight children and adolescents. However, findings evidence remains inconsistent. This meta-analysis aimed to assess the effects of ɷ-3 PUFA supplementation on cardiometabolic risk factors in obese/overweight children and adolescents.</p><p><strong>Methods: </strong>A systematic review of PubMed, Embase, Scopus, Web of Science, Cochrane Library, and Google Scholar up to January 2024 was searched. Data were pooled using a random-effects model to calculate Weighted mean differences (WMDs) and 95% Confidence intervals (CIs).</p><p><strong>Results: </strong>Nine studies with 595 participants were included. The meta-analysis revealed that ɷ-3 PUFA supplementation significantly reduced Body mass index (BMI) (WMD = -0.39 kg/m²; 95% CI: -0.72, -0.05, I² = 0.0%, P = 0.497), triglyceride (TG) (WMD = -23.54 mg/dl, 95% CI: -42.90, -4.18, I² = 89.2%, P < 0.001), and Homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = -0.38, 95% CI: -0.67, -0.10, I² = 53.6%, P = 0.071). However, ɷ-3 PUFA supplementation did not significantly affect weight, BMI-Z score, Fasting blood sugar (FBS), insulin, Total cholesterol (TC), Low-density lipoprotein- cholesterol (LDL-C), and High-density lipoprotein-cholesterol (HDL-C). Moreover, subgroup analysis elucidated that ɷ-3 supplementation has more pronounced effects in higher doses (> 1500 mg/ day) in term of BMI, LDL-c, TG. The quality of the included studies was assessed using the Cochrane risk-of-bias tool (RoB 2), which identified eight studies as having a high risk of bias. Additionally, the GRADE assessment indicated a high quality of evidence for BMI, HOMA-IR, TG and moderate quality for weight, FBS, TC, LDL-c, and HDL-c values.</p><p><strong>Conclusions: </strong>The current meta-analysis revealed that ɷ3 PUFA supplementation beneficial effect on BMI, HOMA-IR, and TG levels. No favorable effect of ɷ3 PUFA supplementation on weight, BMI z-score, TC, LDL-C, HDL-C, FBS and insulin was observed.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"78"},"PeriodicalIF":3.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary antioxidants and mortality in early-stage CKM syndrome: insights from NHANES.","authors":"Lincheng Duan, Hong Yang, Zhuoyang Chen, Junxin Zhao, Jingyi Yang, Dingjun Cai","doi":"10.1186/s12986-025-00974-5","DOIUrl":"10.1186/s12986-025-00974-5","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"77"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of skipping breakfast, lunch or dinner on subsequent postprandial blood glucose levels among healthy young adults.","authors":"Chisato Kanazawa, Yuki Shimba, Saki Toyonaga, Fuzuki Nakamura, Toshio Hosaka","doi":"10.1186/s12986-025-00975-4","DOIUrl":"10.1186/s12986-025-00975-4","url":null,"abstract":"<p><p>Meal skipping has become increasingly common in modern society due to changes in lifestyle. While the adverse effects of skipping breakfast on postprandial glucose levels have been well established, less is known about the impact of skipping lunch or dinner on these levels. The aim of this study is to determine the effect of skipping breakfast, lunch, and dinner consecutively on postprandial glucose levels in healthy subjects. Thirteen healthy young adults were enrolled and instructed to consume meals freely at designated times while maintaining detailed food intake records. Participants then followed a controlled protocol in which one of the three meals was skipped for two consecutive days in a specified order, with interstitial glucose continuously monitored. Skipping lunch on both days significantly increased postprandial glucose levels at the subsequent dinner by 1.6 mmol/L compared to when lunch was consumed and breakfast was skipped (p < 0.001). In contrast, skipping dinner or breakfast did not result in significant changes in postprandial glucose levels at the following meal. We thus observed skipping each of these three meals to have different effects on subsequent postprandial blood glucose levels in the healthy subjects. Most notably, skipping lunch leads to increased postprandial blood glucose levels at dinner.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"76"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Hydroxybutyrate, a metabolite in sustaining neuronal cell vitality: a mendelian randomization and in vitro experimentation.","authors":"Xiaoling Hu, Yu Lin, Kaiwen Huang, HuiLin Xu, Changmei Huang Fu, Jiayin Ou, Xiude Fan, Zhe Li, Jiansong Fang, Shuhuan Fang","doi":"10.1186/s12986-025-00960-x","DOIUrl":"10.1186/s12986-025-00960-x","url":null,"abstract":"<p><strong>Background: </strong>Recent research has implicated mitochondrial DNA copy number (mtDNA-CN) and Tau protein levels in the blood as potential biomarkers for early Alzheimer's disease (AD) risk assessment, correlating with metabolite profiles. However, intermediary metabolites mediating these associations remain elusive.</p><p><strong>Methods: </strong>Employing a two-sample and a mediation Mendelian randomization (MR) analysis of the IEU OpenGWAS database, involving 383,476 participants from a genome-wide association study (GWAS) and an exome-wide association study (ExWAS), we identified intermediary metabolites linking mtDNA-CN and Tau.Meanwhile, the effects of mediating metabolites on HT22 cell viability and its mitochondrial morphology were also assessed in conjunction with in vitro experiments.</p><p><strong>Results: </strong>Our study revealed an association of mtDNA-CN on Tau (OR = 3.102, 95% CI: 1.016-9.472, P = 0.047), as well as on other 31 metabolites such as 3-Hydroxybutyrate (3HB), Docosahexaenoic acid (DHA), Acetate, Albumin, Apolipoprotein A-I (APOA1), and so on. Notably, 3HB was further implicated in a relationship with Tau (OR = 6.030, 95% CI: 1.054-34.491, P = 0.043), acting as a mediator between mtDNA-CN and Tau. In vitro experiments demonstrated that 3HB positively sustained HT22 cell viability by MTT assay and mitigated mitochondrial swelling under low glucose conditions, as observed via HIS-SIM. In Western blot (WB) and quantitative real-time PCR (qPCR) assays, phosphorylation levels of Tau at serine 262 (p-Tau262) and serine 396 (p-Tau396) were tended to decline following 3HB intervention. Additionally, a positive correlation was identified between 3HB concentration and mtDNA-CN.</p><p><strong>Conclusions: </strong>These findings underscore the potential of 3HB as a biomarker and mediator in early AD risk assessment. Moreover, 3HB's ability to enhance cell viability, maintain mitochondrial morphology, decrease phosphorylated Tau protein expression and increase mtDNA-CN under stressful conditions, suggesting its therapeutic potential in improving the imbalance of energy metabolism in the AD brain.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"75"},"PeriodicalIF":3.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of diet, sleep, and metabolomic pathways on Glaucoma subtypes: insights from Mendelian randomization and cross-sectional analyses.","authors":"Zhang Shengnan, Wang Tao, Zhang Yanan, Sun Chao","doi":"10.1186/s12986-025-00967-4","DOIUrl":"10.1186/s12986-025-00967-4","url":null,"abstract":"<p><strong>Background: </strong>Glaucoma is a leading cause of irreversible blindness, influenced by systemic and lifestyle factors. This study investigates the causal relationships between dietary habits, sleep traits, amino acids, metabolites, and inflammatory factors with glaucoma subtypes using Mendelian randomization (MR) and validates findings through cross-sectional analysis.</p><p><strong>Methods: </strong>MR analysis assessed the causal effects of 226 dietary factors, 11 sleep traits, 20 amino acids, 1400 metabolites, and 91 inflammatory factors on five glaucoma subtypes (NTG, POAG, PACG, NVG, XFG). Mediation MR analysis explored the role of amino acids and inflammatory factors in these relationships. Validation was conducted using NHANES cross-sectional data.</p><p><strong>Results: </strong>High-fat, high-calorie diets increased glaucoma risk, while antioxidant-rich foods and better sleep quality reduced it. Key mediators included proline, tyrosine, IL-1 A, and PDL1. NHANES data confirmed lower intake of vitamins A and C, higher water consumption among glaucoma patients, and significant sleep-related associations.</p><p><strong>Conclusion: </strong>Our findings highlight the role of balanced diets and optimized sleep patterns in glaucoma prevention and management. This study provides evidence for targeted lifestyle interventions focusing on metabolic and inflammatory pathways to mitigate glaucoma risk.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"74"},"PeriodicalIF":3.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between empirically driven dietary patterns and cardiometabolic disease risk factors: a cross-sectional analysis in disease-free adults.","authors":"Arife Yilmaz, Michelle Weech, Vasiliki Bountziouka, Kim G Jackson, Julie A Lovegrove","doi":"10.1186/s12986-025-00965-6","DOIUrl":"10.1186/s12986-025-00965-6","url":null,"abstract":"<p><strong>Background: </strong>Although links between dietary patterns (DPs) and cardiometabolic disease (CMD) risk markers have been identified in UK populations, these studies often rely on less quantitative measures of dietary assessment and include only a limited number of risk markers.</p><p><strong>Objective: </strong>This cross-sectional analysis aimed to identify DP in self-reported disease-free adults using weighed diet diaries and explore relationships with a broad range of CMD risk factors and diet quality.</p><p><strong>Methods: </strong>Data were collated from five studies conducted in adults living in the UK (2009-2019) and DPs were a posteriori extracted from habitual dietary intake data using principal component analysis. Associations between quartiles (Q) of adherence to the DPs with CMD risk markers, nutrient intakes and the Alternative Healthy Eating Index (AHEI-2010) were evaluated using ANCOVA.</p><p><strong>Results: </strong>In our cohort [n = 646, 58.4% female, mean (SD) age 44 (14) years, and body mass index (BMI) 25.2 (4.0) kg/m²] two DPs explained 12% of the variance in habitual food intake. Highest adherence to DP1 (Q4), characterised by diets rich in fermented dairy, fruits, vegetables, wholegrains, nuts/seeds, unsaturated fats/oils and milk and lower in red meat dishes and processed meat, was associated with a lower BMI, waist circumference, diastolic blood pressure, fasting triacylglycerol, non-high-density lipoprotein-cholesterol, remnant-like particle-cholesterol, and total cholesterol:HDL-C ratio and a higher HDL-C and AHEI-2010 score versus Q1 (all P ≤ 0.006). In contrast, Q4 vs Q1 of DP2, high in refined carbohydrates, milk and unsaturated fats/oils and low in cruciferous vegetables/spinach, and nuts/seeds, was only associated with a lower HDL-C (P = 0.006) and AHEI-2010 score (P < 0.001).</p><p><strong>Conclusions: </strong>In disease-free adults, greater adherence to DP1, which broadly aligned with UK food-based dietary guidelines, was favourably associated with diet quality and CMD risk markers. Our findings could contribute to the evidence base for future food-based dietary recommendations, particularly highlighting the importance of fermented dairy foods.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"73"},"PeriodicalIF":3.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the gut microbiotic composition and dietary patterns in hypertensive elderly patients: a cross-sectional study.","authors":"Hsi-Cheng Hung, Yuan-Yuan Lin, Wan-Jung Tien, Yu-Yoh Chen, Suh-Ching Yang","doi":"10.1186/s12986-025-00963-8","DOIUrl":"10.1186/s12986-025-00963-8","url":null,"abstract":"<p><strong>Background: </strong>Many studies on gut microbiota and hypertension have not focused on detailed dietary intake and eating habits, especially in older adults. This cross-sectional study aimed to examine the gut microbiota profiles of hypertensive elderly individuals in relation to their dietary patterns and nutrient intake.</p><p><strong>Methods: </strong>Twenty hypertensive patients and 21 age-matched healthy controls (aged 65-80 years) were recruited from Cathay General Hospital (Taipei, Taiwan). Data collected included anthropometric measurements, blood pressure, blood biochemical analyses, and dietary intake (24-h recall and food frequency questionnaires) and fecal microbiotic composition (via 16S rRNA sequencing).</p><p><strong>Results: </strong>Hypertensive patients had significantly higher BMI, waist circumference, and systolic blood pressure. They also showed lower levels of Bacteroides caccae and Barnesiella, and higher levels of Enterobacteriaceae, Enterobacter, Acidaminococcus, and Bacteroides plebeius. Bacteroides caccae abundance was negatively correlated with the intake of saturated fats, sodium, staple foods (e.g., bread, steamed buns, noodles), nut oils, and seasonings.</p><p><strong>Conclusions: </strong>Hypertensive patients showed distinct gut microbiota profiles, with lower levels of Bacteroides caccae and Barnesiella, and higher levels of Enterobacteriaceae-related taxa. The abundance of Bacteroides caccae was negatively associated with the intake of saturated fats, sodium, and staple foods, suggesting a link between diet, gut microbiota, and hypertension.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"71"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary factors and risk for endometriosis: a Mendelian randomization analysis.","authors":"Xia Zhang, Qiaomei Zheng, Lihong Chen","doi":"10.1186/s12986-025-00970-9","DOIUrl":"10.1186/s12986-025-00970-9","url":null,"abstract":"<p><strong>Aims: </strong>Observational studies have reported an association between dietary factors and endometriosis, but the causality remains unknown. The study aimed to investigate the potential causal association between dietary factors and endometriosis using Mendelian randomization (MR).</p><p><strong>Methods: </strong>We performed a two-sample MR analysis to investigate the effects of 18 diet-related exposure factors (alcoholic drinks per week, alcohol intake frequency, processed meat intake, poultry intake, beef intake, non-oily fish intake, oily fish intake, pork intake, lamb/mutton intake, bread intake, cheese intake, cooked vegetable intake, tea intake, fresh fruit intake, cereal intake, salad/raw vegetable intake, coffee intake, dried fruit intake) on the risk of endometriosis using summary statistics from the genome-wide association study (GWAS). The inverse variance weighted (IVW) method was used to deduce the causal association between dietary factors and endometriosis, and sensitivity analyses were further performed.</p><p><strong>Results: </strong>Processed meat intake (OR = 0.550; 95%CI:0.314-0.965; p = 0.037) and salad / raw vegetable intake (OR = 0.346; 95%CI:0.127-0.943; p = 0.038) were discovered as protective factors for endometriosis. Heterogeneity test revealed no significant heterogeneity (processed meat intake: p_IVW=0.607, p_MR-Egger=0.548; salad / raw vegetable intake: p_IVW=0.678, p_MR-Egger=0.620). MR-Egger regression test didn't support any evidence for horizontal pleiotropy (processed meat intake: p for intercept = 0.865; salad / raw vegetable intake: p for intercept = 0.725). No causal relationship was found between other dietary intakes and endometriosis.</p><p><strong>Conclusion: </strong>These findings suggest that processed meat intake and salad/raw vegetable intake are associated with a decreased risk of endometriosis, but further investigation is required.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"72"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}