Nutrition & Metabolism最新文献

{"title":"Composite dietary antioxidant index of antioxidant vitamins and sarcopenia risk: insights from the UK biobank and NHANES cohorts.","authors":"HuiMin Liu, YuDi Xu, QingSheng Li, LingFei Yang, Xuan Yang, KaiXin Wang, Zhe Gong, Qiang Zhang, YanJie Jia","doi":"10.1186/s12986-025-00945-w","DOIUrl":"10.1186/s12986-025-00945-w","url":null,"abstract":"<p><strong>Background: </strong>The composite dietary antioxidant index (CDAI), reflecting total dietary intake of antioxidant vitamins, may indicate overall antioxidant capacity. This study examined its association with the risk of probable sarcopenia, defined by handgrip strength, in older adults.</p><p><strong>Methods: </strong>Participants aged over 60 from the UK Biobank (N = 22,921) and National Health and Nutrition Evaluation Surveys (NHANES) 2011-2014 (N = 2,641) cohorts were categorized into probable sarcopenia and non-probable sarcopenia groups. Multivariable logistic regression models assessed the associations between CDAI (both continuous and quartile) and its components (vitamin A, vitamin C, vitamin E, and carotene) with probable sarcopenia risk in cohorts, with sex subgroup and sensitivity analyses to validate results.</p><p><strong>Results: </strong>The median (interquartile range) of CDAI was -0.39 (-1.88, 1.45) in the UK Biobank and -0.57 (-1.60, 0.84) in NHANES, respectively. A higher CDAI was significantly associated with a lower risk of probable sarcopenia in both cohorts. Specifically, each one-unit increase in CDAI was associated with a 2% decrease in the odds of probable sarcopenia in the UK Biobank (OR = 0.98, 95% CI = 0.97-0.998, p = 0.027) and a 13.5% decrease in NHANES (OR = 0.865, 95% CI = 0.75-0.997, p = 0.045), after full adjustment under the Sarcopenia Definition and Outcomes Consortium (SDOC) criteria. In quartile analyses, the risk of probable sarcopenia tended to decrease across higher CDAI quartiles, although the dose-response trend was not strictly linear. In the UK Biobank, multivariable-adjusted odds ratios (95% CIs) across increasing CDAI quartiles were: Q1 (reference), Q2 = 0.87 (0.78-0.97), Q3 = 0.91 (0.81-1.01), and Q4 = 0.86 (0.77-0.96). In NHANES, the trend was more pronounced: Q1 (reference), Q2 = 0.47 (0.24-0.94), Q3 = 0.39 (0.19-0.82), and Q4 = 0.46 (0.22-0.95). Additionally, higher dietary intake of carotene, one of the key antioxidant components, was independently associated with a lower risk of probable sarcopenia in both cohorts. Subgroup analyses indicated an inverse association between CDAI and probable sarcopenia risk in females across both cohorts, whereas no significant association was observed in males. Sensitivity analyses confirmed the robustness of these findings.</p><p><strong>Conclusions: </strong>Increased dietary intake of antioxidant vitamins may reduce the risk of probable sarcopenia in older adults, emphasizing the need for targeted prevention strategies. Further research on underlying mechanisms and sex differences is warranted.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"44"},"PeriodicalIF":3.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the associations between prior weight loss and all-cause or cardiovascular mortality in non-elderly individuals with hyperuricemia: a mortality follow-up study.","authors":"Yanshan Li, Xiufang Kong, Wei Wang","doi":"10.1186/s12986-025-00930-3","DOIUrl":"10.1186/s12986-025-00930-3","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricemia, a common metabolic condition, is strongly associated with obesity and represents as an independent risk factor for elevated risk of mortality. This observational study aimed to examine the sex-specific associations of prior long-term weight loss (LTWL), defined as a sustained reduction in body weight maintained for at least 12 months, with all-cause and cardiovascular disease (CVD) mortality in non-elderly individuals with hyperuricemia.</p><p><strong>Methods: </strong>Non-elderly individuals with hyperuricemia and a historical maximum body mass index ≥ 25 kg/m² from the 1999-2018 US National Health and Nutrition Examination Survey were included. Sex-specific associations between prior LTWL (< 5%, 5-9.9%, 10-14.9%, and ≥ 15%) with all-cause and CVD mortality were investigated by weighted multivariable Cox proportional hazard regression analysis and stratified analysis.</p><p><strong>Results: </strong>Among 5,130 participants included, 505 all-cause (147 from CVD) deaths occurred during a median follow-up of 113 months. Compared with the LTWL < 5% reference group, the hazard ratios and 95% confidence intervals for the LTWL 5-9.9%, 10-14.9% and ≥ 15% groups were 1.11 (0.72-1.71), 1.34 (0.79-2.26) and 1.85 (1.14-2.92), respectively, for all-cause mortality (P for trend = 0.02) and 1.83 (0.76-4.43), 2.15 (0.76-6.10), and 3.76 (1.51-9.36), respectively, for CVD mortality (P for trend = 0.003). Significant associations between LTWL with all-cause and CVD mortality were observed exclusively in female, not male participants.</p><p><strong>Conclusions: </strong>Prior LTWL ≥ 5% was associated with increased all-cause and CVD mortality in US non-elderly female participants with hyperuricemia. Additional prospective and longitudinal randomized clinical trials are necessary to further examine the current findings.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"43"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taurine corrects lupus CD4⁺ T cell imbalance through inhibition of mTORC1 signaling.","authors":"Saisai Huang, Yiyuan Cui, Yaqi Zhang, Hanyin Deng, Shanshan Liu, Xuebing Feng","doi":"10.1186/s12986-025-00936-x","DOIUrl":"10.1186/s12986-025-00936-x","url":null,"abstract":"<p><strong>Objective: </strong>This study was designed to explore the metabolism features in systemic lupus erythematosus (SLE) and to investigate the role and regulatory mechanism of taurine in the control of CD4⁺ T cells and the progression of SLE.</p><p><strong>Methods: </strong>Metabolomic profiles of sera from SLE patients and healthy controls (HCs) were analyzed by mass spectrometry. The therapeutic effects of taurine in vivo were observed in resiquimod (R848) induced mice, and the effects of taurine on various functions of CD4⁺ T cells were examined by flow cytometry. The effect of mTORC1 agonist MHY1485 on the regulatory capacity of taurine was examined in vitro.</p><p><strong>Results: </strong>Both untargeted metabolomics assays and independent sample validation showed that serum levels of taurine were reduced in SLE patients compared to HCs (P<0.0001), which was inversely correlated with disease activity scores (P<0.05). Taurine supplementation relieved the progression of lupus in R848 induced mice, characterized by a decrease in anti-dsDNA (P<0.01) and proteinuria (P<0.05) and a reduction in the severity of nephritis (P<0.05). And, taurine supplementation improved the differentiation of cell subsets such as Th17 (P<0.001) and Treg cells (P<0.001) in these mice. In vitro, taurine suppressed reactive oxygen species production (P<0.001), proliferation (P<0.0001) and senescence (P<0.0001) of mouse spleen cells. The level of pS6 (P<0.0001) but not AKT in CD4⁺ T was significantly decreased after taurine treatment, while mTORC1 agonists partially blocked the effect of taurine on CD4⁺ T cells.</p><p><strong>Conclusion: </strong>Taurine may play a therapeutic role by ameliorating CD4⁺ T cell abnormalities through inhibition of mTORC1 signaling in SLE.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"41"},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic profiles and prediction of failure to thrive of citrin deficiency with normal liver function based on metabolomics and machine learning.","authors":"Peiyao Wang, Duo Zhou, Lingwei Hu, Pingping Ge, Ziyan Cen, Zhenzhen Hu, Qimin He, Kejun Zhou, Benqing Wu, Xinwen Huang","doi":"10.1186/s12986-025-00928-x","DOIUrl":"10.1186/s12986-025-00928-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore metabolite pathways and identify residual metabolites during the post-neonatal intrahepatic cholestasis caused by citrin deficiency (post-NICCD) phase, while developing a predictive model for failure to thrive (FTT) using selected metabolites.</p><p><strong>Method: </strong>A case-control study was conducted from October 2020 to July 2024, including 16 NICCD patients, 31 NICCD-matched controls, 34 post-NICCD patients, and 70 post-NICCD-matched controls. Post-NICCD patients were further stratified into two groups based on growth outcomes. Biomarkers for FTT were identified using Lasso regression and random forest analysis. A non-invasive predictive model was developed, visualized as a nomogram, and internally validated using the enhanced bootstrap method. The model's performance was evaluated with receiver operating characteristic curves and calibration curves. Metabolite concentrations (amino acids, acylcarnitines, organic acids, and free fatty acids) were measured using liquid chromatography or ultra-performance liquid chromatography-tandem mass spectrometry.</p><p><strong>Results: </strong>The biosynthesis of unsaturated fatty acids was identified as the most significantly altered pathway in post-NICCD patients. Twelve residual metabolites altered during both NICCD and post-NICCD phases were identified, including: 2-hydroxyisovaleric acid, alpha-ketoisovaleric acid, C5:1, 3-methyl-2-oxovaleric acid, C18:1OH, C20:4, myristic acid, eicosapentaenoic acid, carnosine, hydroxylysine, phenylpyruvic acid, and 2-methylcitric acid. Lasso regression and random forest analysis identified kynurenine, arginine, alanine, and aspartate as the optimal biomarkers for predicting FTT in post-NICCD patients. The predictive model constructed with these four biomarkers demonstrated an AUC of 0.947.</p><p><strong>Conclusion: </strong>While post-NICCD patients recover clinically and biochemically, their metabolic profiles remain incompletely restored. The predictive model based on kynurenine, arginine, alanine, and aspartate provides robust diagnostic performance for detecting FTT in post-NICCD patients.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"42"},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of lean and non-lean non-alcoholic fatty liver disease: a cross-sectional study.","authors":"Mengyan Xu, Rui Gong, Jiao Xie, Sanping Xu, Shi Wang","doi":"10.1186/s12986-025-00927-y","DOIUrl":"10.1186/s12986-025-00927-y","url":null,"abstract":"<p><strong>Introduction: </strong>Non-alcoholic fatty liver disease (NAFLD) affects more than a quarter of the global population and has become the world's number one chronic liver disease, seriously jeopardizing public life and health. Despite the new terminology of metabolic dysfunction-associated steatotic liver disease (MASLD) has been proposed, the mechanisms underlying the heterogeneity across BMI stratification in non-alcoholic fatty liver disease (NAFLD) remain unclear. The aim of this study was to reveal the differences in metabolic and fibrotic characteristics between lean (BMI < 23 kg/m²) and non-lean NAFLD in an Asian population.</p><p><strong>Methods: </strong>The current study collected NAFLD patients from the physical examination population. Patients were divided into two groups by BMI to compare their clinical parameters, including lean (BMI < 23 kg/m²) and non-lean (BMI ≥ 23 kg/m²) and fibrosis subgroups (with a threshold of LSM = 8 kPa) and analyzed for risk factors by logistic regression models.</p><p><strong>Results: </strong>Of the 11,577 NAFLD patients who participated in the study, there were 916 lean and 10,661 non-lean. The non-lean group was younger than the lean group (median age 50 vs. 52 years, P < 0.001) and had a significantly higher prevalence of hypertension (28.0% vs. 18.3%), diabetes mellitus (10.1% vs. 6.1%), and liver fibrosis (9.1% vs. 5.1%) (all P < 0.001). Analysis of metabolic indexes showed that TyG, TyG-BMI, TG/HDL-C and APRI were higher in the non-lean group (all P < 0.001). Gender stratification revealed that ALT was significantly higher in the male non-lean group, while HDL-C was lower in the female non-lean group (1.35 vs. 1.47 mmol/L). Multiple regression suggested that the risk of fibrosis was independently associated with CAP values and fasting glucose, BMI, direct bilirubin, globulin, and age in the non-lean group, whereas the risk was mainly driven by GGT and ALP in the lean group.</p><p><strong>Conclusions: </strong>Non-lean NAFLD patients showed more significant metabolic disturbances and risk of liver fibrosis. Although metabolic indicators (TyG, FIB-4) have limited predictive value for liver fibrosis, they are strongly associated with metabolic risk in MASLD.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"40"},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary phytochemical index with metabolic markers, serum asymmetric dimethylarginine and atherogenic indices in patients with polycystic ovary syndrome.","authors":"Farshad Amirkhizi, Mahdiyeh Taghizadeh, Soudabeh Hamedi-Shahraki, Somayyeh Asghari","doi":"10.1186/s12986-025-00932-1","DOIUrl":"https://doi.org/10.1186/s12986-025-00932-1","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular diseases (CVD). Plant-based diets are associated with reduced CVD risk factors. This study aimed to explore the associations between dietary phytochemical index (DPI) and asymmetric dimethylarginine (ADMA), lipid profile, atherogenic indices, and other metabolic biomarkers in women with PCOS.</p><p><strong>Methods: </strong>In this cross-sectional study, 150 females aged 18-45 years diagnosed with PCOS were recruited. An interviewer-administered questionnaire was applied to gather the relevant demographic characteristics, detailed clinical information, and lifestyle habits of participants. A validated semi-quantitative food frequency questionnaire was used to assess dietary intake, and DPI was calculated accordingly. We used multiple linear regression to determine the association between serum concentrations of ADMA, total testosterone, sex hormone-binding globulin (SHBG), fasting serum glucose (FSG), insulin, and lipid profile, as well as atherogenic indices across quartiles of DPI.</p><p><strong>Results: </strong>There was a negative correlation between the DPI and serum levels of ADMA (p-trend = 0.022), triglycerides (TG) (p-trend = 0.003), oxidized low-density lipoprotein cholesterol (ox-LDL) (p-trend = 0.001), insulin (p-trend = 0.045) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p-trend = 0.018). Moreover, there was a tendency for visceral adiposity index (VAI) (p-trend = 0.005) and atherogenic index of plasma (AIP) (p-trend = 0.001) to decrease as the quartile categories of DPI increased. No significant regular trend was found for serum levels of FSG, SHBG, total testosterone, other lipid profiles, and lipid accumulation product (LAP).</p><p><strong>Conclusions: </strong>These findings suggest that adherence to a phytochemical-rich diet decrease the CVD risk factors in PCOS patients.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"39"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food consumption and cardiometabolic risk in Canada: a cross-sectional analysis of the Canadian health measures survey.","authors":"Angelina Baric, Vasanti S Malik, Anthea Christoforou","doi":"10.1186/s12986-025-00935-y","DOIUrl":"https://doi.org/10.1186/s12986-025-00935-y","url":null,"abstract":"<p><strong>Background: </strong>Ultra-processed food (UPF) contributes to nearly 50% of Canadians' diets. Research in other countries has begun to implicate high intakes of UPFs and negative health outcomes, including body mass index, waist circumference, blood pressure, and unfavourable lipid profiles. There have been no population level examinations of the relationship between UPF consumption and cardiometabolic risk in Canada.</p><p><strong>Methods: </strong>Drawing on the Canadian Health Measures Survey (2016/17 and 2018/19), this study investigates the relationship between UPF consumption and cardiometabolic risk factors among Canadians (ages 19-79, n = 6517). Dietary data collected by Food Frequency Questionnaire was classified as UPF or not using the NOVA classification system which scores foods by degree of processing. Participants were grouped into quartiles based on the daily servings of UPF. Sociodemographic and lifestyle variables were collected via household questionnaire and cardiometabolic outcomes were measured during a clinic visit. Multivariable linear regression analyses separately assessed the association between cardiometabolic risk factors and UPF quartiles while adjusting for various sociodemographic and lifestyle variables. Sensitivity analyses additionally adjusted for fruit and vegetable intake (servings/day) to determine the effect of diet quality on this relationship. All analyses were weighted to ensure national representativeness.</p><p><strong>Results: </strong>UPF servings per day ranged from 1.2 in the lowest and 5.8 in the highest quartile. Compared to the lowest quartiles of UPF consumption, those in the highest were more likely to be male, in the lowest income quartile, Black or White, have lower household education, and higher physical activity and sedentary time. After adjustments, UPF consumption was positively associated with BMI, WC, diastolic BP, HBA1C, c-reactive protein, white blood cells (WBC), fasting triglycerides (TG), and fasting insulin. Fruit and vegetable intake attenuated the association for all outcomes, while BMI, WC, WBC, and TG remained significantly associated with increased UPF consumption.</p><p><strong>Conclusion: </strong>This study is the first Canadian study looking at population level intakes of UPF across various cardiometabolic risk factors and adds to the growing body of literature demonstrating the detrimental health effects associated with UPF consumption.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"37"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the association between Life's essential 8 and cardiovascular disease: a U.S.-based cross-sectional analysis.","authors":"Yi Tang, Xiaojie Chen, Yifan Zhao, Jihong Sun, Yaohui Jiang","doi":"10.1186/s12986-025-00929-w","DOIUrl":"https://doi.org/10.1186/s12986-025-00929-w","url":null,"abstract":"<p><strong>Background: </strong>This research aims to elucidate the gender differences in the association between cardiovascular disease (CVD) prevalence and Life's Essential 8 (LE8), a recently updated measure of cardiovascular health (CVH).</p><p><strong>Methods: </strong>This study included participants from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018.The scores of LE8, health behavior, health factor and each metric based on diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipid, blood glucose, and blood pressure were classified as low (0-49 points), moderate (50-79 points), and high (80-100 points). The scores of LE8, health behavior and health factor as continuous variables were also used for dose-response analysis. The main outcomes included the prevalence of CVD. The definition of CVD based on self-reported history of coronary heart disease or stroke.</p><p><strong>Results: </strong>A total of 23,307 individuals were included in this analysis. Participants with CVD had significantly lower LE8 scores compared to those without CVD, and females demonstrated higher CVH levels compared to males including total LE8 scores and the scores of diet, nicotine exposure, blood lipid, blood glucose, and blood pressure (P < 0.05). Moreover, the LE8 score demonstrated a non-linear association with CVD in both males and females (all P-values for non-linearity were < 0.001). Furthermore, compared to the low LE8 level, a high LE8 level was associated with a 78% decreased risk of CVD in males (HR: 0.22, 95% CI: 0.16-0.31) and an 83% decreased risk in females (HR: 0.17, 95% CI: 0.11-0.26). Consistently, compared to low levels of health behaviors and health factors, higher levels were significantly associated with a decreased risk of CVD in both males and females (All P < 0.001). Additionally, the area under the curve (AUC) for the total LE8 score in CVD discrimination was significantly higher in females than in males (P < 0.001).</p><p><strong>Conclusion: </strong>Higher CVH scores were associated with a lower risk of CVD, especially in females. These findings highlight the need for gender-specific preventive strategies in CVH promotion, with a particular focus on improving LE8 scores in high-risk populations.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"38"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and dermatological diseases: association and treatment.","authors":"Jiali Xia, Li Ding, Guoyan Liu","doi":"10.1186/s12986-025-00924-1","DOIUrl":"https://doi.org/10.1186/s12986-025-00924-1","url":null,"abstract":"<p><p>Metabolic syndrome (MetS) is a clinical syndrome associated with cardiovascular disease, diabetes, obesity, and dyslipidemia. Its primary features include dyslipidemia, hypertension, abdominal obesity, and insulin resistance (IR). Recently, research has revealed that MetS is not only a manifestation of internal metabolic disturbances but is also closely associated with various dermatological conditions, including inflammatory skin diseases, autoimmune skin diseases, and skin tumors. These studies have clarified the complex mechanisms underlying the interaction between MetS and these skin diseases, including IR, chronic inflammatory responses, and oxidative stress. This review summarizes the association between MetS and related dermatological conditions and their shared physiological mechanisms. It aims to provide clinicians with new therapeutic strategies and preventive measures to improve the treatment outcomes and quality of life of patients with skin conditions.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"36"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory potential, genetic predisposition, and incidence of Crohn's disease and ulcerative colitis.","authors":"Ji-Mei Gu, Miao Zhao, Jie Zhu, Hao-Wei Tao, Xiao-Ping Shao, Li-Qiang Qin, Yang-Yang Ge, Guo-Chong Chen","doi":"10.1186/s12986-025-00934-z","DOIUrl":"https://doi.org/10.1186/s12986-025-00934-z","url":null,"abstract":"<p><strong>Background: </strong>Evidence for a potential link between dietary inflammatory potential and inflammatory bowel disease is limited, and the moderating role of genetic susceptibility remains to be assessed.</p><p><strong>Objective: </strong>To evaluate energy-adjusted dietary inflammatory index (E-DII) for the associations with incident Crohn's disease (CD) and ulcerative colitis (UC) and the role of genetic susceptibility.</p><p><strong>Methods: </strong>A total of 205,706 UK Biobank participants who were aged 39-72 years and had no known CD or UC at baseline (2006-2010) were included. The E-DII score was calculated based on energy-adjusted average intakes of 33 food or nutrient items derived from up to five 24-hour dietary recalls. Multivariable Cox regression models were used estimate hazard ratios (HRs) with 95% confidence interval (CI) for incident CD and UC.</p><p><strong>Results: </strong>During a median 12.3 years of follow-up, 382 incident CD and 798 incident UC cases were ascertained. A higher E-DII score was not associated with risk of CD (HR _{Q4 VS. Q1} = 1.28, 95% CI: 0.94-1.74; P-trend = 0.09) or UC (HR _{Q4 VS. Q1} = 1.10, 95% CI: 0.90-1.36; P-trend = 0.17). There was an interaction between the E-DII and the polygenic risk score (PRS) for CD on incident CD (P-interaction = 0.023), with an association only among participants with a high PRS (HR _{Q4 VS. Q1} = 1.64, 95% CI: 1.03-2.61) (P-interaction = 0.023). As compared with the participants with a low PRS for CD and a low E-DII score, participants with high levels of both scores had a particularly higher risk of CD (HR = 3.12; 95% CI: 1.74-5.60).</p><p><strong>Conclusions: </strong>The association of dietary inflammatory potential with incident CD appears to be amplified by high genetic susceptibility to CD.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"35"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}