Nutrition & Metabolism最新文献

{"title":"Cardiometabolic health and all-cause and cause-specific mortality in the general US adult population.","authors":"Chuxian Guo, Xiaomei Hu, Shaojie Han, Bin Li, Huimin Zhu, Panpan Li, Lei Xu, Zenghui Zhang, Jun Guo","doi":"10.1186/s12986-026-01085-5","DOIUrl":"https://doi.org/10.1186/s12986-026-01085-5","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food intakes based on degree of processing and metabolic dysfunction-associated steatotic liver disease (MASLD): the Tehran Lipid and Glucose Study (TLGS).","authors":"Nazanin Moslehi, Farhad Hosseinpanah, Parvin Mirmiran, Fereidoun Azizi","doi":"10.1186/s12986-026-01106-3","DOIUrl":"https://doi.org/10.1186/s12986-026-01106-3","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of weight recurrence after bariatric surgery.","authors":"Rajiv Kumar Yadav, Ye Zhang, You Lv, Songyang Liu, Jiaxing Yang, Yao Wang, Xiaokun Gang","doi":"10.1186/s12986-026-01115-2","DOIUrl":"https://doi.org/10.1186/s12986-026-01115-2","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beetroot juice and vitamin C co-supplementation enhances anaerobic performance and reduces post-exercise glycemia in wrestlers: a randomized, double-blind, placebo-controlled crossover trial.","authors":"Maedeh Nojoumi, Ali Jafari, Alireza Hosseini Kakhki, Ali Jafarzadeh Esfehani, Hossein Rafiei, Chad Kerksick, Oluwatoyosi Owoeye, Reza Rezvani","doi":"10.1186/s12986-026-01103-6","DOIUrl":"https://doi.org/10.1186/s12986-026-01103-6","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative correlation between microRNA and insulin sensitivity gene expression in adipose tissue: potential implications for diabetes and neurodegenerative diseases.","authors":"Jakub Podraza, Michał Wąsowski, Marta Izabela Jonas, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka, Alina Kuryłowicz","doi":"10.1186/s12986-026-01113-4","DOIUrl":"https://doi.org/10.1186/s12986-026-01113-4","url":null,"abstract":"<p><strong>Background: </strong>Obesity-related adipose tissue dysfunction leads to a chronic inflammatory state affecting distant organs and tissues. This metabolic inflammation has a detrimental impact on the expression of genes related to glucose metabolism, leading to systemic insulin resistance, which also affects the central nervous system and contributes to cognitive decline. Adipose tissue-derived microRNAs (miRNAs) have been implicated in this phenomenon. This study aimed to investigate whether the expression of genes critical for both insulin action and neuronal metabolism (APP, SOCS3, PTPN1, PTPN2) is altered in the adipose tissue of patients with obesity due to miRNA interference, predisposing them directly to the development of insulin resistance and metabolic inflammation, while indirectly leading to a decline in cognitive function.</p><p><strong>Methods: </strong>The expression of mRNAs of the above-mentioned genes, selected adipokines (interleukins 1β, 6, 8, 15, tumor necrosis factor-alpha, resistin, adiponectin) and miRNAs was measured by real-time PCR in adipose tissue of 75 patients with obesity, 19 patients who successfully reduced body mass after metabolic surgery and 25 normal weight subjects, stratified by insulin sensitivity and diabetic status. The results were correlated with patients' clinical and biochemical parameters.</p><p><strong>Results: </strong>mRNA levels of genes promoting insulin sensitivity, APP and PTPN2, were significantly (p < 0.05) decreased in adipose tissue from patients with obesity, in both visceral (VAT) and subcutaneous (SAT) depots. After stratification by the triglyceride/high-density lipoprotein ratio (an indirect marker of insulin sensitivity), we found that individuals diagnosed with insulin resistance had lower VAT and SAT APP and PTPN2 mRNA levels, whereas APP expression was significantly decreased in VAT from patients with both obesity and type 2 diabetes compared to normoglycemic individuals with obesity, too. We also observed significant positive correlations between the mRNA levels of these genes and the expression of the above-mentioned adipokines. Finally, we analysed the levels of miRNAs targeting the mRNAs of the genes studied and observed significant negative correlations between APP mRNA levels and hsa-miR-579-5p and hsa-miR-142-3p, and between PTPN2 mRNA levels and hsa-miR-142-3p.</p><p><strong>Conclusion: </strong>Adipose tissues of patients with obesity are characterised by altered expression of genes that are key for both insulin action and neuronal metabolism, and miRNAs may be involved in this phenomenon. However, due to the descriptive nature of our experiments, these results require verification in functional studies.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of \"exercise snacks\" during prolonged sitting on hemodynamics and peripheral vascular function: a three-level meta-analysis.","authors":"Hai Wang, Yuanbo Chang, Hao Wang, Kaiyue Diao, Shiqi Sun","doi":"10.1186/s12986-026-01120-5","DOIUrl":"https://doi.org/10.1186/s12986-026-01120-5","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between DASH diet adherence and mortality in non-diabetic adults with and without chronic kidney disease.","authors":"Shang-Feng Tsai, Wei-Ju Liu, Yu-Jung Lin, Chia-Lin Lee","doi":"10.1186/s12986-026-01118-z","DOIUrl":"https://doi.org/10.1186/s12986-026-01118-z","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isocaloric-restricted traditional Jiangnan diet combined with physical exercise on non-alcoholic fatty liver disease: a randomized controlled trial.","authors":"Yan Wu, Lei Li, Xiancui Zhang, Yan Xu, Jing Xu, Zhen Wang","doi":"10.1186/s12986-026-01105-4","DOIUrl":"https://doi.org/10.1186/s12986-026-01105-4","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paeoniflorin: a natural candidate for the treatment of metabolic diseases.","authors":"Minghao Ji, Haoyang Gao, Xiaotong Ma, Wei Dai, Jiabin Wu, Weihua Xiao","doi":"10.1186/s12986-026-01091-7","DOIUrl":"https://doi.org/10.1186/s12986-026-01091-7","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic inflexibility mediates the association between type 2 diabetes and impaired post-exercise heart rate recovery: a mediation analysis.","authors":"Yutao Liu, Jiahui Wu, Nan Li, Suhui Zhang, Yan Feng, Ying Zhang, Yong Shao","doi":"10.1186/s12986-026-01114-3","DOIUrl":"https://doi.org/10.1186/s12986-026-01114-3","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}