Nutrition & Metabolism最新文献

{"title":"The multifaceted roles of fatty acids and their dysregulation in obese mothers: potential implications for infant development.","authors":"Boqun Liu, Yuqing Liu, Chuang Zhai, Xuan Wu, Yanmei Wang, Xibi Fang","doi":"10.1186/s12986-025-01009-9","DOIUrl":"10.1186/s12986-025-01009-9","url":null,"abstract":"<p><p>The increasing global rates of obesity underscore the need to investigate its impact on infant health. Breast milk, crucial for infant nutrition, varies in composition due to maternal obesity during pregnancy. Research reveals that obese or overweight mothers tend to have higher saturated fatty acids (SFAs) levels, like palmitic and myristic acids, while stearic acid levels are lower. Monounsaturated fatty acids (MUFAs), particularly oleic acid in milk, decline in obesity. Polyunsaturated fatty acids (PUFAs), essential for infant brain and nervous system development, show imbalances in obese mothers, with an increased omega-6 (ω-6): omega-3 (ω-3) ratio and reduced levels of key ω-3 fatty acids such as α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These changes could disrupt normal immune and nervous system development in infants. This review highlights the critical impact of maternal obesity on breast milk quality.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"141"},"PeriodicalIF":4.1,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12613526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of fructose-1,6-diphosphatase 1 with the progression of diabetic kidney disease.","authors":"Ziqi Fu, Zitong Chen, Shuaibo Bian, Li Li, Suheng Geng, Jiaxin Dong, Simeng Liu, Lin Wu, Jingfeng Zhu, Honglei Guo, Ao Bian, Kang Liu, Jiafa Ren, Changying Xing, Zhimin Huang, Huijuan Mao","doi":"10.1186/s12986-025-01038-4","DOIUrl":"10.1186/s12986-025-01038-4","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Kidney Disease (DKD) is one of the most serious complications of diabetes mellitus, and a main cause of end-stage kidney disease (ESKD). The identification of clinically applicable molecular biomarkers for monitoring DKD progression has become increasingly essential. In this study, we aim to investigate the relationship between the expression of fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, and DKD.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization (MR) analysis was conducted using plasma protein quantitative trait loci data obtained from deCODE genetics and DKD genome-wide association study data acquired from the Finnish Biobank Alliance to assess the causal relationship between FBP1 and DKD. In parallel, a retrospective cohort study was performed involving 107 patients with biopsy-confirmed DKD, in which DKD progression was defined as a composite endpoint consisting of serum creatinine doubling or ESKD. For this endpoint, a predictive nomogram was subsequently developed.</p><p><strong>Results: </strong>MR results suggested that a genetically predicted higher level of circulating FBP1 was associated with a low risk of DKD (OR 0.57, 95% CI 0.33-0.98; P = 0.04) in diabetic patients. The expression level of renal FBP1 decreased with the progression of DKD pathological stage. Its expression level was positively correlated with estimated glomerular filtration rate (eGFR) (r = 0.717, P < 0.001) and expression of renal carnitine palmitoyl transferase 1 A (a rate-limiting enzyme in fatty acid oxidation) (r = 0.745, P < 0.001). During a median follow-up of 26 months, 41 (38%) patients suffered from DKD progression. Multivariate Cox regression indicated that a reduced renal expression level of FBP1 was correlated with an increased risk of DKD progression (HR 0.325, 95% CI 0.107-0.986, P = 0.047). Finally, the integration of FBP1 with 24-h urine protein and eGFR into a nomogram significantly improved the prediction of 1-year and 3-year event-free survival in DKD (C-index: 0.871 vs. 0.794, P = 0.011), demonstrating its additive prognostic value.</p><p><strong>Conclusions: </strong>Renal FBP1 might be a potential biomarker reflecting the severity of renal function and kidney progression in biopsy-proven DKD stages II to IV.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"139"},"PeriodicalIF":4.1,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12613888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction of early-onset myocardial infarction using plasma proteomics, conventional risk factors, and polygenic risk score.","authors":"Zhong-Yue Liu, Fei Fang, Yu-Wen Qian, Ji-Mei Gu, Jun-Yu Zhao, Jie-Qiong Lyu, Meng-Yuan Miao, Hai-Peng Wang, Cai-Long Chen, Guo-Chong Chen","doi":"10.1186/s12986-025-01040-w","DOIUrl":"10.1186/s12986-025-01040-w","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"138"},"PeriodicalIF":4.1,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12613587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal mid-pregnancy long-chain polyunsaturated fatty acid profile is associated with pregestational body mass index and neonatal anthropometric measures at birth among non-obese pregnancies: results from two Italian multicenter cohorts.","authors":"Francesca Parisi, Chiara Mandò, Chiara Novielli, Gaia Maria Anelli, Roberta Cazzola, Fabrizia Lisso, Laura Sarno, Elisabetta Marelli, Chiara Lubrano, Patrizio Giovanni Maria Antonazzo, Irene Cetin","doi":"10.1186/s12986-025-01034-8","DOIUrl":"10.1186/s12986-025-01034-8","url":null,"abstract":"<p><strong>Background: </strong>Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential nutrients for feto-placental development. We aimed to evaluate the associations between maternal pregestational BMI, mid-pregnancy LC-PUFA status, and delivery outcomes in non-obese pregnancies.</p><p><strong>Methods: </strong>This was a secondary analysis of two Italian cohorts including healthy non-obese women with singleton spontaneous pregnancies previously studied for maternal nutritional habits, multivitamin supplementation, blood biomarkers and infant biometry/measures. In the present analysis, included women were stratified according to pregestational BMI (normal weight (NW) versus overweight (OW) groups). Fasting venous blood samples were collected between 24 and 34 gestational weeks for fatty acid (FA) analysis. Pregnancy outcomes were recorded at delivery. Multi-adjusted generalized linear models were applied to first assess the associations between BMI-based groups and mid-pregnancy LC-PUFA concentrations, and second to evaluate the associations between the LC-PUFA profile and pregnancy outcomes.</p><p><strong>Results: </strong>283 pregnancies were included. The OW group showed lower eicosapentaenoic acid (EPA) levels (β= -0.09; 95%CI= -0.16; -0.03) and a higher arachidonic acid/EPA ratio (β = 8.06; 95%CI = 0.00; 16.3) compared with the NW group in multi-adjusted models. After excluding women with gestational diabetes mellitus (n = 13), a significant association between LC-PUFA status and birth weight was also proved with increased birth weights in case of lower LC-PUFA n-6/n-3 ratio (β= -78.9; 95%CI= -148.5; -9.2) and higher docosahexaenoic acid (DHA) (β = 26.5; 95%CI = 0.4; 52.6), total LC-PUFA n-3 (β = 22.9; 95%CI = 0.7; 45.1) and n-3 index (β = 24.9; 95%CI = 0.03; 49.8). A positive association was further detected between LC-PUFA n-6 and neonatal ponderal index (β = 0.01; 95%CI = 0.00; 0.02). No associations were detected between LC-PUFAs and gestational age at delivery.</p><p><strong>Conclusions: </strong>These findings underscore significant associations between maternal pregestational BMI and mid-pregnancy LC-PUFA n-3 and n-6 status, with further associations with birth weight and neonatal ponderal index. Our results suggest that LC-PUFA n-3 and n-6 series may serve as valuable clinical biomarkers, particularly among OW women, and may act as predictors of intrauterine growth.</p><p><strong>Trial registration: </strong>NCT04438928.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"137"},"PeriodicalIF":4.1,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12613336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food intake is associated with altered glucose homeostasis in young adults with a history of overweight or obesity: a longitudinal study.","authors":"Yiping Li, Elizabeth Costello, Sarah Rock, William B Patterson, Zhanghua Chen, Frank Gilliland, Michael I Goran, Tanya L Alderete, Jesse A Goodrich, David V Conti, Nikos Stratakis, Leda Chatzi","doi":"10.1186/s12986-025-01036-6","DOIUrl":"10.1186/s12986-025-01036-6","url":null,"abstract":"<p><strong>Background: </strong>Ultra-processed foods (UPFs), often high in sodium, sugar, and unhealthy fats, compose more than half of total dietary energy consumption in the United States. A diet composed of a high amount of UPFs can contribute to glucose dysregulation and insulin resistance, which may lead to prediabetes and type 2 diabetes (T2D). However, few studies have assessed the associations between UPFs and T2D or obesity in young people. The goal of this study is to examine associations between UPF consumption and prediabetes and related biomarkers in youth.</p><p><strong>Methods: </strong>Young adults (age 17-22, n = 85) with a history of overweight or obesity from the Metabolic and Asthma Incidence Research (Meta-AIR) study, a subset of the Children's Health Study, were enrolled between 2014 and 2018 and returned for a second visit between 2020 and 2022. Participants completed two 24-hour dietary recalls and an oral glucose tolerance test at each visit. Food items were categorized as either an UPF or non-UPF according to NOVA classification guidelines. The proportion of the diet composed of UPFs was calculated for each participant. Regression models were used to assess relationships of UPF consumption at baseline and change between visits with markers of glucose homeostasis at follow-up, adjusting for demographics, physical activity, and total energy intake.</p><p><strong>Results: </strong>A 10%-point increase in UPF consumption between visits was associated with a 51% (OR: 1.51, 95% Cl: 1.04, 2.31) higher odds of having prediabetes and 158% (OR: 2.58, 95% CI: 1.43, 5.85) higher odds of impaired glucose tolerance at follow-up. Higher baseline UPF consumption was significantly positively associated with 2-hour insulin ([Formula: see text] = 45.11, 95% CI: 22.42, 67.80) and insulin area under the curve ([Formula: see text] = 63.56, 95% CI: 34.95, 92.17) at follow-up.</p><p><strong>Conclusion: </strong>UPF consumption may increase the risk for T2D among young adults. Our findings suggest that limiting UPF consumption could be an important strategy for T2D prevention in this population.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"135"},"PeriodicalIF":4.1,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12604416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between hepatic fibrosis indicators and subclinical carotid atherosclerosis in the population with metabolic dysfunction-associated steatotic liver disease under 50 years old.","authors":"Shuai Zhang, Hao Liang, Jun Liu, Ye Zhu","doi":"10.1186/s12986-025-01039-3","DOIUrl":"10.1186/s12986-025-01039-3","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) and subclinical carotid atherosclerosis (SCA) share common roots in systemic inflammation and metabolic dysregulation. Hepatic fibrosis mirrors the intensity of these disturbances; however, its association with SCA in younger adults remains unclear.</p><p><strong>Methods: </strong>A total of 14 567 MASLD patients were enrolled from the health examination center of Northern Jiangsu People's Hospital. Participant stratification into SCA and non-SCA groups was based on carotid ultrasound findings. Variable selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO) regression. The associations between the selected indicators and SCA risk were subsequently evaluated through multivariate logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, receiver operating characteristic (ROC) curves, and mediation analysis.</p><p><strong>Results: </strong>Both LASSO and multivariate logistic regression analyses demonstrated that elevated NAFLD Fibrosis Score (NFS) and Fibrosis-4 (FIB-4) levels were positively correlated with the prevalence of SCA in patients with MASLD (P for trend < 0.001). Mediation analysis indicated that the Red-cell Distribution Width-to-Albumin Ratio (RAR) significantly mediated this association, with the mediated proportion ranging from 28.6% to 44.6% (P < 0·05). Subgroup analysis identified a significant interaction between age and the association of both fibrosis scores with SCA (P for interaction < 0.05). Subsequently, RCS analysis demonstrated significant positive non-linear associations between NFS/FIB-4 and SCA risk specifically in patients aged under 50 years (P for non-linear < 0.001). The area under the ROC curve (AUC) indicated that both scores had fair predictive value for SCA in this younger subgroup.</p><p><strong>Conclusion: </strong>This study confirms that elevated NFS and FIB-4 levels are significantly associated with an increased risk of SCA in MASLD patients, demonstrating a distinct non-linear relationship and fair predictive value, particularly in individuals under 50 years of age.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"136"},"PeriodicalIF":4.1,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12604223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ashwagandha (Withania somnifera L.) supplementation on serum lipid concentrations and anthropometric parameters in adults with overweight and obesity: a double-blind, placebo-controlled pilot study.","authors":"Juan Manuel Ballesteros-Torres, Alejandra Vázquez-Aguilar, Ivan Luzardo-Ocampo, Anayansi Escalante-Aburto, Cindy Joanna Caballero-Prado","doi":"10.1186/s12986-025-01028-6","DOIUrl":"10.1186/s12986-025-01028-6","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obesity are widespread in Mexico, often linked to dyslipidemia and higher cardiovascular risk. The search for safe and effective treatments has promoted interest in natural supplements such as Ashwagandha (Withania somnifera), recognized for its adaptogenic and potential lipid-lowering properties.</p><p><strong>Objective: </strong>To assess the impact of Ashwagandha supplementation on serum lipid profiles and anthropometric parameters in Mexican adults with overweight and obesity.</p><p><strong>Methods: </strong>A double-blind, randomized, placebo-controlled pilot clinical trial was carried out with 43 adults (n = 17 in the control group and n = 21 in the intervention group) over 40 days. Participants followed a monitored diet and received one daily capsule containing 500 mg of Ashwagandha or a placebo, in addition to a guided unrestricted dietary plan. Anthropometric and biochemical measurements were taken at baseline and after the intervention. In silico analysis was also performed to examine the binding affinity of Ashwagandha bioactive compounds to key proteins involved in lipid metabolism.</p><p><strong>Results: </strong>Ashwagandha supplementation did not produce statistically significant changes in body weight, body mass index (BMI), or waist circumference (WC). However, significant reductions were observed in triglyceride and VLDL-c levels (p = 0.0082 and p = 0.0321, respectively). In silico results supported these findings, showing favorable interactions between compounds such as withanolide A and lipid metabolism targets, including AMPK, CETP, and LPL.</p><p><strong>Conclusions: </strong>Ashwagandha supplementation improved serum lipid profiles in adults with overweight and obesity, suggesting potential lipid-lowering effects when combined with a prescribed dietary plan. Also, it was possible to elucidate some metabolic pathways in which Ashwagandha composition has an influence on producing the reported effects. Further long-term studies with controlled dietary intake are needed to confirm these findings and clarify the underlying molecular mechanisms.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"134"},"PeriodicalIF":4.1,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12595879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145471479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and kidney aging: insights into current research.","authors":"Yalda Rahbar Saadat, Abolfazl Barzegari, Zahra Saadatian, Soheila Montazersaheb, Sepideh Zununi Vahed","doi":"10.1186/s12986-025-01032-w","DOIUrl":"10.1186/s12986-025-01032-w","url":null,"abstract":"<p><p>Aging induces structural and functional alterations in the kidneys, including changes in renal morphology and progressive decline in renal function. During aging, the gut microbiota undergoes profound shifts in composition and activity, transitioning from predominantly commensal to more pathogenic communities. Renal dysfunction further exacerbates this process by reducing toxin clearance and promoting the accumulation of uremic metabolites, which disrupt gut microbial balance. In turn, gut dysbiosis impairs kidney function, creating a self-perpetuating cycle of microbial imbalance and renal damage. Hence, breaking this vicious cycle of dysbiosis and kidney damage is important. This review sheds light on the bidirectional relationship between gut microbiota and kidney aging. It also highlights the potential of microbiota-targeted interventions to restore microbial balance and delay the onset of age-related issues.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"133"},"PeriodicalIF":4.1,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12593916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediterranean diet and acne vulgaris: a systematic review and meta-analysis.","authors":"Sari Taha, Marah Shakhshir, Sa'ed H Zyoud","doi":"10.1186/s12986-025-01033-9","DOIUrl":"10.1186/s12986-025-01033-9","url":null,"abstract":"<p><strong>Introduction: </strong>Acne vulgaris is chronic skin condition with considerable physical, psychological, social, and economic impacts. Adherence to Western diets with a high glycemic index and dairy content has been linked to acne. However, the associations between acne and the Mediterranean diet (MD), a non-Western diet, have not been reviewed. This review aimed to examine the associations between adherence to the MD and the development and severity of acne vulgaris.</p><p><strong>Materials and methods: </strong>PubMed, Embase, and Web of Science databases were searched for studies examining the association between adherence to the MD and acne vulgaris. Data were extracted by two independent reviewers. The risk of bias was assessed using the Newcastle‒Ottawa Scale, and the quality of evidence was assessed using the GRADE tool. The Meta-analyses were conducted using a random-effects model to pool the odds ratio (OR) and correlation coefficient.</p><p><strong>Results: </strong>Five case‒control studies were included, with 765 participants, 340 cases, and 425 controls. The meta-analysis found that higher adherence to the MD was not significantly associated with lower odds of acne development (OR 0.32, CI = 0.08-1.28), with high heterogeneity (Q test p = .02, I2 = 75%). The second meta-analysis of correlational studies found a significant negative correlation between adherence to the MD and acne severity (correlation coefficient= -0.29, CI= -0.55 to -0.03), with high heterogeneity (Q test p = .008, I2 = 79%). Higher consumption of vegetables was significantly associated with lower odds of acne development (OR = 0.46, 95% CI, 0.29-0.74). The quality of evidence for the associations with both acne development and severity was low.</p><p><strong>Conclusions: </strong>This review found that higher adherence to the Mediterranean diet was significantly correlated with less severe acne, while the association with acne development was not significant. Due to the low number of studies, small sample size, and methodological limitations, more well-designed studies are needed to strengthen the evidence base.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"132"},"PeriodicalIF":4.1,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12587681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of blood pressure control in metabolic syndrome among US adults: evidence from NHANES 1999 to 2020.","authors":"Jiaming Huang, Lingrong Hu, Qingyan Ruan, Xiaoming Li, Shumin Zhao, Kaihong Chen, Liling Chen","doi":"10.1186/s12986-025-01027-7","DOIUrl":"10.1186/s12986-025-01027-7","url":null,"abstract":"<p><strong>Background: </strong>Metabolic Syndrome (MetS) involves several cardiovascular risk factors, with hypertension being a critical component that significantly impacts cardiovascular outcomes. As guidelines support blood pressure control in populations with high cardiovascular risk factors, we evaluated BP control in MetS patients.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of probability samples of adults aged ≥ 18 years with MetS from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020 to assess changes in BP control. MetS was identified by meeting at least three of the following criteria: (1) waist circumference ≥ 102 cm in men and ≥ 88 cm in women; (2) fasting glucose ≥ 100 mg/dl; (3) BP ≥ 130/85 mmHg; (4) triglycerides ≥ 150 mg/dl; and (5) high-density lipoprotein cholesterol (HDL-C) < 40 mg/dl in men and < 50 mg/dl in women. BP control was defined as systolic BP < 130 mmHg and diastolic BP < 80 mmHg. All analyses accounted for differences between survey years, complex sampling design, and survey weights.</p><p><strong>Results: </strong>From 1999-2002 to 2015-2020, the prevalence of MetS increased from 19% to 24% (P < 0.001). Among MetS patients, the proportion of those self-reporting hypertension or taking BP medications increased from 65% in 1999-2002 to 72% in 2015-2020 (P = 0.001). Over time, both the use and quantity of antihypertensive medications increased significantly, and according to current guidelines, BP control among MetS patients has improved significantly. Similar trends were observed across subgroups stratified by gender, diabetes status, and CKD status.</p><p><strong>Conclusion: </strong>BP management in MetS patients showed significant improvement from 1999 to 2020, with increasing control rates despite fluctuations.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"131"},"PeriodicalIF":4.1,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145445603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}