Nutrition & Metabolism最新文献

{"title":"The effects of a home-based resistance training programme on body composition and muscle function during weight loss in people living with overweight or obesity: a randomised controlled pilot trial.","authors":"Ahmad Binmahfoz, Lynsey Johnston, Emma Dunning, Cindy M Gray, Stuart R Gray","doi":"10.1186/s12986-025-00986-1","DOIUrl":"10.1186/s12986-025-00986-1","url":null,"abstract":"<p><strong>Background: </strong>Obesity continues to grow as a public health concern and although dietary interventions can be effective at reducing body mass and improving cardiovascular risk factors, they also result in undesirable losses of lean tissue. The aim of this randomised controlled pilot trial was to investigate the effects of a home-based resistance training exercise programme on body composition and muscle function in people living with overweight or obesity undergoing dietary weight loss.</p><p><strong>Methods: </strong>Participants (n = 48) from Glasgow were randomly assigned to either a diet-induced weight loss group (WL) or a diet plus home-based resistance training exercise group (RT + WL) for 12-weeks. Body composition, muscle strength, and physical function were assessed at baseline and post-intervention.</p><p><strong>Results: </strong>There was no effect of the resistance exercise training programme (all p > 0.05) on body composition including body mass index, total body mass, fat mass, fat free mass or muscle thickness during weight loss. However, the resistance training group showed improvements in muscle and physical function compared to the weight loss only group, resulting in higher grip strength (RT + WL: Δ2.65, 95% CI: 0.44, 4.86; WL: Δ-0.26, 95% CI: -2.04, 1.51:p = 0.046), maximal voluntary contraction force (RT + WL:Δ23.61, 95% CI: 3.39, 43.84 WL: Δ-11.95, 95% CI: -35.37, 11.48;p = 0.019), and sit-to-stand test scores (RT + WL:Δ5.9, 95% CI: 4.27, 7.53 WL: Δ1.47, 95% CI: 0.13, 2.82; p < 0.001).</p><p><strong>Conclusions: </strong>These findings suggest that incorporating home-based resistance training into weight loss programmes can preserve, or even enhance, muscle function without negatively impacting the effectiveness of dietary weight loss interventions, highlighting its potential to mitigate muscle function losses during weight loss in people living with overweight or obese.</p><p><strong>Trial registration: </strong>Name of the registry: ClinicalTrials.gov. The registration number: NCT05702840. Date of Registry: 18/01/2023. The registration title: EXerCise wEight Loss (EXCEL).</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"90"},"PeriodicalIF":4.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study.","authors":"Fang Li, Linlin Dang, Yanli Wang, Jianmin Cao","doi":"10.1186/s12986-025-00980-7","DOIUrl":"10.1186/s12986-025-00980-7","url":null,"abstract":"<p><strong>Background: </strong>Physical activity and micronutrient intake, including supplementation, have individually and synergistically shown potential benefits against diabetic nephropathy (DN), yet causality remains uncertain.</p><p><strong>Methods: </strong>This study conducted a Mendelian randomization (MR) study using summary-level data from large-scale genome-wide association studies (GWAS) involving 15 micronutrients grouped into four categories. Moderate-to-vigorous physical activity (MVPA) represented physical activity, whereas leisure screen time (LST) served as an indicator of sedentary behavior. Data for type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) with DN were sourced from the FinnGen consortium. Univariable MR analyses identified causal relationships, linkage disequilibrium score (LDSC) regression evaluated genetic correlations, and multivariable MR adjusted for 18 confounders. Mediation MR analyses explored potential mediating pathways. The primary analytical methods included inverse variance weighted (IVW) and Wald ratio estimation. Statistical rigor included variant pruning, Steiger tests for directional validity, and RadialMR to mitigate pleiotropy.</p><p><strong>Results: </strong>After false discovery rate correction, genetically predicted MVPA significantly reduced T1DM-associated DN risk [odds ratio (OR) = 0.294, 95% CI: 0.120-0.724, P_adj = 0.036], independently of renal function markers. Mediation analysis indicated body mass index mediated part of this protective effect (mediation effect: 9.42%). LDSC analysis revealed a significant negative genetic correlation between MVPA and DN risk (genetic correlation = -0.143). Suggestive associations were found between carotene and zinc levels and increased T1DM-related DN risk (OR > 1). For T2DM-related DN, higher vitamin E (γ-tocopherol) levels significantly decreased DN risk (OR = 0.261, 95% CI: 0.111-0.616, P_adj = 0.039), with suggestive protective evidence also observed for α-tocopherol (OR = 0.214, 95% CI: 0.058-0.793).</p><p><strong>Conclusion: </strong>This MR analysis confirms physical activity reduces DN risk in T1DM patients, partially through BMI-mediated mechanisms, and highlights vitamin E's protective potential in managing T2DM-related DN. These findings underline the clinical relevance of lifestyle modifications and dietary supplementation in DN prevention strategies.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"87"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study.","authors":"Detian Jiang, Yuxin Chang, Xiaowen Zhen, Xin Zhao","doi":"10.1186/s12986-025-00979-0","DOIUrl":"10.1186/s12986-025-00979-0","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"86"},"PeriodicalIF":4.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the influence of early and late time-restricted eating with energy restriction and energy restriction alone on cardiometabolic markers, metabolic hormones and appetite in adults with overweight/obesity: per-protocol analysis of a 3-month randomized clinical trial.","authors":"Bernarda Habe, Tanja Črešnovar, Ana Petelin, Saša Kenig, Nina Mohorko, Zala Jenko Pražnikar","doi":"10.1186/s12986-025-00984-3","DOIUrl":"10.1186/s12986-025-00984-3","url":null,"abstract":"","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"85"},"PeriodicalIF":4.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol, high-sensitivity C-reactive protein, and risk of incident coronary heart disease among patients with chronic kidney disease based on UK biobank.","authors":"Minghui Han, Jing Zhou, Zhenzhen Wan, Meng Chen, Mengli Yan, Wei Feng, Ge Wang, Jing Zhang, Lina Zhang, Lei Yan, Fengmin Shao, Yue Gu","doi":"10.1186/s12986-025-00982-5","DOIUrl":"10.1186/s12986-025-00982-5","url":null,"abstract":"<p><strong>Background: </strong>Patients with chronic kidney disease (CKD) exhibit elevated remnant cholesterol (RC) and high-sensitivity C-reactive protein (hs-CRP), and both of them contribute to the residual cardiovascular risk. However, the independent effects of RC and its joint effects with hs-CRP remain unknown. This study aimed to explore the associations of RC and its joint categories with hs-CRP with coronary heart disease (CHD), myocardial infarction (MI), and angina among patients with CKD.</p><p><strong>Methods: </strong>This prospective study included 21,914 participants with CKD free of CHD from UK Biobank. RC was calculated as non-high-density lipoprotein cholesterol minus measured low-density lipoprotein cholesterol. Cox models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD. Fine and Gray's model with age as the underlying timescale was used to evaluate the lifetime risks.</p><p><strong>Results: </strong>Over a median follow-up of 11.99 years, 3403 CHD cases were documented. RC was positively associated with CHD, MI, and angina in a linear manner (P _nonlinearity >0.05), with HRs (95% CIs) of 1.09 (1.06-1.13), 1.10 (1.05-1.17), and 1.13 (1.07-1.19) for per standard deviation increase. Compared with low RC/low hs-CRP, low RC/high hs-CRP and high RC/low hs-CRP had 29% (HR 1.29, 95% CI 1.19-1.39) and 44% (1.44, 1.25-1.67) increased risk of CHD, and high RC/high hs-CRP had the highest risk (1.56, 1.38-1.75). Consistent associations were also observed for MI and angina. Moreover, the cumulative CHD risk by age of 80 among high RC/high hs-CRP was much higher than that among low RC/low hs-CRP (35.17% vs. 25.27%).</p><p><strong>Conclusions: </strong>Elevated RC was linearly and positively associated with increased risk of incident CHD. Combined high RC and hs-CRP conferred the highest relative and absolute risks. Our findings highlighted the importance of targeting RC and hs-CRP combined to reduce the cardiovascular risk among patients with CKD.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"83"},"PeriodicalIF":4.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary nitrate and nitrite from plant sources with digestive system cancer risk: a systematic review and meta-analysis.","authors":"Bangce Long, Chenglin Jiang, Zhongjian Liu, Ping Wan, Qiang Guo","doi":"10.1186/s12986-025-00973-6","DOIUrl":"10.1186/s12986-025-00973-6","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have indicated that dietary nitrate intake from plant sources offers numerous health benefits. However, the relationships between the intake of plant-derived nitrates and nitrites and the risk of digestive system cancers (DSCs) remain unclear. This study aimed to quantify the associations between dietary nitrate and nitrite from plant sources and the risk of DSCs via a systematic review and meta-analysis.</p><p><strong>Methods: </strong>We conducted extensive literature searches of the PubMed, Embase, Scopus, Web of Science, CINAHL, Cochrane Library, CNKI, VIP, Wanfang, and CBM databases up to April 2024. STATA 14.0 was applied for meta-regression and meta-analysis, and fixed or random effects models were used to calculate the pooled relative risks and 95% confidence intervals. Sensitivity and subgroup analyses were conducted to explore sources of heterogeneity.</p><p><strong>Results: </strong>Our analysis included 13 articles with a total of 897,585 participants, which included 10 different types of digestive tumors. The pooled results indicated no significant association between high (median: >134.9 mg/day) [RR = 0.92; 95% CI (0.82-1.03); P = 0.14] or moderate (median: 83.0-133.1 mg/day) [RR = 0.95; 95% CI (0.89-1.02); P = 0.186] nitrate intake and DSCs. Similarly, neither high (median: >0.91 mg/day) [RR = 0.91; 95% CI (0.84-1.00); P = 0.05] nor moderate (median: 0.75 mg/day) [RR = 0.96; 95% CI (0.89-1.04); P = 0.355] nitrite intake was correlated with DSCs. However, a negative association was observed between nitrate or nitrite intake and DSCs when the data were stratified by subgroup variables such as study type, sex, region, antioxidant intake, and fibre intake. A meta-regression dose‒response analysis revealed that the risk of gastric cancer was negatively associated with the median intake of plant-derived nitrates [slope= -0.0047 per mg/day; 95% CI (-0.0086--0.0008); P = 0.022].</p><p><strong>Conclusions: </strong>Plant-derived nitrate and nitrite intakes were not significantly associated with DSCs. This relationship may be affected by subgroup variables, and a dose‒response analysis indicated that higher nitrate intake was linked to a reduced risk of gastric cancer.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"84"},"PeriodicalIF":4.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention.","authors":"Alexandra M Johnstone, Emiliano Albanese, Daniel R Crabtree, Boushra Dalile, Stefanie Grabrucker, Jenna M Gregory, Giuseppe Grosso, Adrian Holliday, Catherine Hughes, Catherine Itsiopoulos, John Mamo, Claire McEvoy, Phyo Kyaw Myint, Leticia Radin Pereira, David Vauzour, Mario Siervo","doi":"10.1186/s12986-025-00981-6","DOIUrl":"10.1186/s12986-025-00981-6","url":null,"abstract":"<p><p>An international expert panel convened to evaluate nutrition-based approaches to brain health and dementia prevention. This consensus statement integrates perspectives from lived experiences, mechanistic evidence, epidemiology, and clinical interventions. Nutrition plays a crucial role in brain health throughout life and in cognitive decline pathogenesis, particularly through the food-gut-brain axis. Intervention effectiveness varies across the health promotion, prevention, treatment, and maintenance spectrum due to methodological differences and individual responses to nutritional interventions.The Mediterranean and MIND dietary patterns show promise for maintaining cognitive function across studies. Multi-domain interventions like FINGER effectively combine dietary modifications with lifestyle changes to delay dementia onset in at-risk older adults. These findings align with mechanistic evidence on the food-gut-brain axis in maintaining optimal brain health by preventing neurodegeneration. Key mechanisms include gut microbiota composition and function, blood-brain barrier integrity, endothelial and mitochondrial dysfunction, insulin resistance, oxidative stress, and inflammatory processes.Research priorities include standardizing cognitive assessment methodologies, developing early intervention strategies, and implementing integrated precision nutrition and lifestyle approaches. Incorporating patients' and caregivers' lived experiences in research co-production was identified as essential to support those with lived experience. The panel concluded that future directions should combine population and individual-level preventive approaches while addressing challenges in sustaining healthy behavioral changes and understanding the complex interplay between diet, lifestyle, and genetic factors in brain health and dementia prevention. Experts emphasized the need for both standardized methodologies and personalized interventions to account for individual variability in nutritional responses and facilitate effective prevention strategies across diverse populations.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"82"},"PeriodicalIF":4.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High dietary live microbe intake associated with reduced depressive symptoms in gastrointestinal disease patients: findings from a cross-sectional study.","authors":"Cheng Zhang, Ming-Hui Ma, Ke Li, Shu-Ning Xu, Ying Liu","doi":"10.1186/s12986-025-00976-3","DOIUrl":"10.1186/s12986-025-00976-3","url":null,"abstract":"<p><strong>Background: </strong>Depression and gastrointestinal disease are prevalent conditions that often coexist, significantly impacting daily life and productivity. Recent studies suggest a potential link between the intake of dietary live microbe and the alleviation of depressive symptoms. However, the relationship between live microbe consumption and depressive symptoms in patients suffering from gastrointestinal diseases remains unexplored.</p><p><strong>Methods: </strong>This study included participants with gastrointestinal diseases from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2018. We utilized weighted multivariate logistic regression, subgroup analyses, and restricted cubic spline (RCS) analyses to investigate the association between live microbe consumption and depression. Additionally, the eXtreme Gradient Boosting (XGBoost) algorithm was implemented to develop a predictive model for depression based on individual characteristics.</p><p><strong>Results: </strong>Of the 2,195 individuals, 472 (21.5%) exhibited depressive symptoms (PHQ-9 ≥ 10). Our findings indicate an inverse relationship between the live microbe intake and the incidence of depression in individuals with gastrointestinal diseases. In the most comprehensively adjusted model, patients with the highest level of microbe intake exhibited a 66.1% or 52.9% reduced risk of depressive symptoms compared to those with the minimal intake. An L-shaped dose-response relationship was observed in the RCS analysis (non-linear P = 4e-04). The XGBoost model demonstrated effective prediction capabilities for depression, with an area under the curve (AUC) of 0.897 (95% CI: 0.869-0.925).</p><p><strong>Conclusions: </strong>This study provides evidence of an inverse, non-linear association between dietary live microbe and depression in individuals with gastrointestinal diseases, suggesting that higher intake levels may offer protective effects against depressive symptoms.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"81"},"PeriodicalIF":4.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness and safety of specific dietary supplements in modulating uric acid levels, oxidative stress, and lipid metabolism in patients: a network meta-analysis of 13 interventions.","authors":"Guancheng Ye, Chunping Liu, Xiaojia Zheng, Jinying Fang, Cunxiang Xie, Mingxuan Liu, Yiwen Wang, Luming Zhao, Hailong Wang","doi":"10.1186/s12986-025-00977-2","DOIUrl":"10.1186/s12986-025-00977-2","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricemia and gout have garnered increasing attention as significant health concerns in recent years, often associated with damage to multiple bodily systems. Consequently, the reduction of uric acid levels has become particularly crucial. The utilization of dietary supplements presents potential adjunctive treatment options for individuals with gout. Certain dietary supplements are purported to aid in the reduction of uric acid levels and are highly preferred by patients due to their affordability, ease of use, and accessibility. The aim of this article was to compare the efficacy and safety of dietary supplements in modulating uric acid, oxidative stress, and lipid metabolism in patients with hyperuricemia or gout, using a comprehensive network meta-analysis (NMA) approach.</p><p><strong>Methodology: </strong>A comprehensive search was performed across both Chinese and English databases to identify randomized controlled trials (RCTs) examining the efficacy of dietary supplements in reducing uric acid levels. Network meta-analysis was conducted using Stata 16.0 software, while RevMan 5.3 software was employed to assess the quality of the literature and evaluate the risk of bias.</p><p><strong>Result: </strong>A total of 30 RCTs, encompassing 44,972 patients, were conducted. The findings of the study indicated that folic acid (mean difference [MD] = -57.62 μmol/L, 95% confidence interval [CI] [-107.14, -8.1]) and probiotics (MD = -42.52 μmol/L, 95% CI [-81.95, -3.09]) significantly reduced uric acid levels compared to conventional therapy. Furthermore, Vitamin C (MD = -0.92 nmmol/ml, 95% CI [-1.54, -0.31]) and Vitamin E (MD = -1.05 nmmol/ml, 95% CI [-2.01, -0.1]) were effective in reducing oxidative stress-related malondialdehyde (MDA) levels. In terms of lipid metabolism improvement, DKB114 (MD = -0.45 mmol/L, 95% CI [-0.9, -0.001]) and curcumin (MD = -0.54 mmol/L, 95% CI [-0.89, -0.18]) demonstrated statistically significant reductions in low-density lipoprotein (LDL) levels. Analysis of subgroups revealed that administration of 500 mg of vitamin C resulted in a significant reduce in uric acid levels when compared to conventional treatment (MD =  - 21.67 μmol/L, 95% CI [- 43.01, - 0.33]), indicating statistically significant differences. The safety profile of all dietary supplements has generally been demonstrated to be favorable.</p><p><strong>Conclusion: </strong>Dietary supplements hold significant potential for managing gout and hyperuricemia, as well as improving patients' metabolic status. Future research should focus on larger-scale studies to further explore these findings.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"80"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analyses the effect of Bifidobacterium longum subsp. longum BL21 supplementation on overweight and obese subjects: a randomized, double-blind, placebo-controlled study.","authors":"Xiaoya Wang, Zefeng Xing, Rui Wang, Guoming Zhang, Guodong Liu, Zhen Li, Lixiang Li","doi":"10.1186/s12986-025-00969-2","DOIUrl":"10.1186/s12986-025-00969-2","url":null,"abstract":"<p><strong>Background: </strong>Bifidobacterium longum subsp. longum BL21 has demonstrated promise in alleviating gut microbiota disturbances and metabolic regulation in high-fat diet-induced obesity and type 2 diabetes mellitus models. However, the effect of probiotic B. longum BL21 on overweight and obese individuals remain unclear.</p><p><strong>Methods: </strong>A randomized, double-blind, placebo-controlled trial was performed, and 66 adult individuals were assigned to receive either BL 21 (2*10¹⁰ colony-forming units per day along with 3 g of maltodextrin) or placebo (3 g of maltodextrin daily) for 8 weeks. Multi-omics analyses were employed to evaluate the impact of the B. longum strain BL21 on gut microbiota, serum metabolomics, body weight and lipids profiles in overweight and obese participants.</p><p><strong>Results: </strong>Following the intervention, both the BL21 group (1.22 ± 2.78, P = 0.02) and placebo group (0.98 ± 2.06, P = 0.01) demonstrated significant body weight reductions, with no statistically significant intergroup difference observed (P = 0.81). Notably, only the BL21 group exhibited a significant reduction in triglyceride levels compared to baseline (0.21 ± 1.09, P = 0.04). Microbiota analysis indicated that BL21 intervention significantly changed the β-diversity at week 8 compared with placebo group. The genera of Parasutterella, Parabacteroides, Blautia, Dorea, Butyricicoccus enriched in BL21 group. Metabolomics results indicated that sphingolipid metabolism, biotin metabolism and protein digestion and absorption were the top altered pathway in BL21 group compared with placebo group after intervention.</p><p><strong>Conclusion: </strong>B. longum subsp. longum BL21 may be a beneficial candidate to modulate the gut microbiota and triglyceride metabolism of overweight and obese individuals.</p><p><strong>Trial registration: </strong>Clinical trial registration number: NCT06140641. Date of registration: November 17, 2023.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"79"},"PeriodicalIF":3.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}