Exercise-induced metabolomics and its association with metabolic health in adolescents.

IF 4.1 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2025-05-22 DOI:10.1186/s12986-025-00946-9

Xiaoyuan Guo, Zhibo Zhou, Yutong Wang, Huishan Sun, Shanshan Liu, Yiling He, Hanze Du, Hongbo Yang, Huijuan Zhu, Mei Zhang, Bo Ban, Shi Chen, Hui Pan

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引用次数: 0

Abstract

Background: While exercise training has been shown to improve various aspects of adolescent metabolic health, such as blood pressure, insulin resistance, and dyslipidemia, the underlying metabolic mechanisms remain poorly understood. No study has examined the metabolomic changes to identify potential mechanisms and explore biomarkers that predict exercise benefits in adolescents.

Methods: We used propensity score matching to select 54 pairs of adolescents (ages 12-14 years) with and without long-term exercise training. Body mass index (BMI), waist circumference (WC) and metabolic indicators including blood pressure, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and triglycerides (TGs) were assessed at enrollment and 1-year follow-up. Untargeted metabolomics was analyzed at enrollment. The associations between metabolites and clinical metabolic indicators were tested.

Results: Metabolomic analysis revealed 73 differential metabolites between exercise and non-exercise groups, with 59 metabolites associated with metabolic health indicators. Among them, a group of eicosanoids were consistently upregulated and negatively associated with diastolic blood pressure (DBP), HOMA-IR, or TGs, suggesting their potential roles in exercise-related improvements. Receiver operating characteristic analysis showed better predictive performance for exercise benefits on DBP and TGs using papaverine and azelaic acid compared to BMI and WC.

Conclusions: Adolescents with long-term exercise are associated with improved metabolic health. Metabolomic profiles provide novel insights into the underlying mechanisms and offer useful biomarkers for predicting exercise benefits.

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青少年运动诱导代谢组学及其与代谢健康的关系

背景：虽然运动训练已被证明可以改善青少年代谢健康的各个方面，如血压、胰岛素抵抗和血脂异常，但其潜在的代谢机制仍然知之甚少。目前还没有研究检查代谢组学变化，以确定潜在的机制，并探索预测青少年运动益处的生物标志物。方法：采用倾向评分匹配的方法，对54对12-14岁的青少年进行和不进行长期运动训练。在入组和1年随访时评估体重指数（BMI）、腰围（WC）和代谢指标，包括血压、胰岛素抵抗稳态模型评估（HOMA-IR）和甘油三酯（tg）。在入组时分析非靶向代谢组学。检测代谢物与临床代谢指标之间的关系。结果：代谢组学分析显示，运动组和非运动组之间存在73种代谢物差异，其中59种代谢物与代谢健康指标相关。其中，一组类二十烷酸持续上调，并与舒张压（DBP）、HOMA-IR或tg呈负相关，表明它们在运动相关改善中的潜在作用。受试者工作特征分析显示，与BMI和WC相比，使用罂粟碱和壬二酸对DBP和TGs的运动益处有更好的预测效果。结论：青少年长期运动与改善代谢健康有关。代谢组学概况为潜在机制提供了新的见解，并为预测运动益处提供了有用的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.