Deciphering the causality between micronutrients and esophageal cancer via Mendelian randomization.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2025-05-22 DOI:10.1186/s12986-025-00940-1

Zhuo Diao, Guangyin Peng, Yige Chen, Jun Wang, Jianjun Liu, Zhaopeng Zhang, Wei Zhang

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引用次数: 0

Abstract

Background: There is an ongoing debate about how micronutrients influence the risk of developing esophageal cancer (EC), requiring more definitive proof to ascertain their causal relationship.

Objective: The current study seeks to identify the causal relationship between 14 micronutrients and EC through Mendelian randomization (MR) methods.

Methods: We performed a two-sample MR analysis of micronutrients in relation to EC, using five different MR methodologies, chief among them the Inverse Variance Weighted method. To ascertain the direction of causal links, Steiger filtering was applied. The study culminated in a sensitivity analysis to test the robustness of the results.

Results: In the European population, iron (OR = 0.231, 95% CI: 0.073-0.727, P = 0.012) and magnesium (OR = 0.357, 95% CI: 0.143-0.894, P = 0.028) were associated with a reduced risk of EC, both showing suggestive evidence of a causal relationship. In Asian populations, however, no significant causal effects were found between the 14 micronutrients and EC. The direction of causality was validated across all results.

Conclusion: Among European populations, iron and magnesium intake is associated with a reduced risk of EC, a benefit not seen in Asian populations. Personalized strategies and region-specific advice are necessary for EC prevention and control.

查看原文本刊更多论文

通过孟德尔随机化解读微量营养素与食管癌之间的因果关系。

背景：关于微量营养素如何影响患食管癌（EC）的风险一直存在争论，需要更明确的证据来确定它们之间的因果关系。目的：本研究旨在通过孟德尔随机化（MR）方法确定14种微量营养素与EC之间的因果关系。方法：我们使用五种不同的MR方法，其中主要是逆方差加权法，对与EC相关的微量营养素进行了两样本MR分析。为了确定因果关系的方向，采用了Steiger滤波。这项研究最后进行了敏感性分析，以检验结果的稳健性。结果：在欧洲人群中，铁（OR = 0.231, 95% CI: 0.073-0.727, P = 0.012）和镁（OR = 0.357, 95% CI: 0.143-0.894, P = 0.028）与EC风险降低相关，两者都显示了因果关系的暗示证据。然而，在亚洲人群中，14种微量营养素与EC之间没有发现显著的因果关系。因果关系的方向在所有结果中都得到了验证。结论：在欧洲人群中，铁和镁的摄入与降低EC风险相关，这一益处在亚洲人群中未见。预防和控制欧共体需要个性化策略和针对特定区域的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.