增肌干预可改善老年2型糖尿病伴肌减少性肥胖患者的糖代谢。

IF 4.1 2区 医学 Q2 NUTRITION & DIETETICS
Tingting Han, Xinyue Liang, Hongxia Liu, Mingyu Zhu, Sisi Shen, Jia Song, Hongwei Chen, Ningxin Chen, Yue Liu, Ziyi Wei, Yurong Weng, Xian Jin, Yaomin Hu
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引用次数: 0

摘要

背景:在不同体成分的老年2型糖尿病(T2DM)患者中,肌少性肥胖患者虽然体重正常,但胰岛素抵抗程度最为严重。这是公认的干预措施,包括阻力训练单独或与乳清蛋白补充相结合,下文称为肌肉建设的干预措施,是有效的增加肌肉质量和功能的老年人口。然而,这些增肌干预对老年2型糖尿病合并肌肉减少型肥胖患者糖代谢的影响尚不清楚。本研究的目的是阐明肌肉增强干预对老年2型糖尿病合并肌肉减少型肥胖患者血糖和胰岛素抵抗的影响。方法:本研究中的增肌干预措施包括单独抗阻训练和抗阻训练与乳清蛋白补充相结合。在这项随机对照试验中,老年T2DM合并肌肉减少型肥胖患者被分为三个不同的组:对照组、阻力训练组和阻力训练联合乳清蛋白补充组。肌肉增强干预进行了12周。结果:实施增肌干预可显著改善老年2型糖尿病合并肌肉减少型肥胖患者的血糖指数(HbA1c、OGTT 2小时血糖)和胰岛素抵抗水平(HOMA-IR、Gutt指数)。这些增强肌肉的干预措施增强了肌肉功能指数(握力,5次椅子站立测试)。与单独的抗阻运动相比,抗阻训练与补充乳清蛋白的组合并没有显著增强对葡萄糖代谢的有利影响。相关分析显示,肌肉力量的改善与葡萄糖代谢的增强显著相关。结论:在老年2型糖尿病合并肌肉减少型肥胖患者中,肌肉增强干预(特别是阻力运动)已被证明可以显著改善血糖控制和胰岛素抵抗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Muscle-building interventions improve glucose metabolism in elderly type 2 diabetic patients with sarcopenic obesity.

Background: Among all the elderly patients with type 2 diabetes mellitus (T2DM) of different body compositions, patients with sarcopenic obesity exhibited the most severe degree of insulin resistance despite possessing a normal body weight. It is well-established that interventions encompassing resistance training alone or in combination with whey protein supplementation, referred to hereafter as muscle-building interventions, are effective for increasing muscle mass and function in the elderly population. However, the impact of these muscle-building interventions on glucose metabolism in elderly T2DM patients with sarcopenic obesity remains unclear. The objective of this study was to elucidate the effect of muscle-building interventions on blood glucose and insulin resistance in elderly T2DM patients with sarcopenic obesity.

Methods: The muscle-building interventions in this study included resistance training alone and resistance training combined with whey protein supplementation. In this randomized controlled trial, elderly T2DM patients with sarcopenic obesity were divided into three distinct groups: the control group, the resistance training group, and the resistance training combined with whey protein supplement group. The muscle-building interventions were conducted for 12 weeks.

Results: Implementing muscle-building interventions showed significant improvements in glycemic indices (HbA1c, OGTT 2-hour plasma glucose) and insulin resistance levels (HOMA-IR, Gutt index) for elderly T2DM patients with sarcopenic obesity. These muscle-building interventions enhanced muscle functional indices (handgrip strength, 5-time chair stand test). The combination of resistance training with whey protein supplementation did not significantly enhance the favorable effects on glucose metabolism compared to resistance exercise alone. Correlation analyses revealed that improvements in muscle strength were significantly associated with enhancements in glucose metabolism.

Conclusions: In elderly T2DM patients with sarcopenic obesity, muscle-building interventions (particularly resistance exercise) have been shown to significantly improve blood glucose control and insulin resistance.

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来源期刊
Nutrition & Metabolism
Nutrition & Metabolism 医学-营养学
CiteScore
8.40
自引率
0.00%
发文量
78
审稿时长
4-8 weeks
期刊介绍: Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.
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