Journal of Biophotonics最新文献_第2页

Correction to “Toward Informative Representations of Blood-Based Infrared Spectra via Unsupervised Deep Learning” 更正“通过无监督深度学习实现基于血液的红外光谱的信息表示”。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-12 Epub Date: 2025-11-06 DOI: 10.1002/jbio.70172

引用次数: 0

Magnetic-Plasmonic Au@Fe3O4 Nanostars Induced Non-Apoptotic Cell Death During Photothermal Therapy 磁等离子体Au@Fe3O4纳米星在光热治疗期间诱导非凋亡细胞死亡。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-12 Epub Date: 2025-11-06 DOI: 10.1002/jbio.202500397

S. E. Pshenichnikov, A. A. Anikin, A. V. Motorzhina, M. Albino, V. V. Malashchenko, L. S. Litvinova, V. V. Rodionova, C. Sangregorio, L. V. Panina, K. V. Levada

{"title":"Magnetic-Plasmonic Au@Fe3O4 Nanostars Induced Non-Apoptotic Cell Death During Photothermal Therapy","authors":"S. E. Pshenichnikov, A. A. Anikin, A. V. Motorzhina, M. Albino, V. V. Malashchenko, L. S. Litvinova, V. V. Rodionova, C. Sangregorio, L. V. Panina, K. V. Levada","doi":"10.1002/jbio.202500397","DOIUrl":"10.1002/jbio.202500397","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we present our previously fabricated star-shaped magnetic–plasmonic Au@Fe<sub>3</sub>O<sub>4</sub> nanostars as promising agents for photothermal therapy. The nanostars exhibit a photothermal conversion efficiency of ~60% at a concentration of 25 μg/mL under 808 nm laser irradiation. WST-1 analysis revealed that Au@Fe<sub>3</sub>O<sub>4</sub> nanostars moderately reduced the viability of human hepatocarcinoma Huh7 cells after 24 h exposure at concentrations of 1, 5, and 10 μg/mL, accompanied by notable morphological alterations. Flow cytometry demonstrated that treatment with 5 μg/mL nanostars followed by 20 min of laser irradiation resulted in 79% elimination of cancer cells. Furthermore, photothermal therapy increased cellular granularity, with highly granulated cells comprising 23% of the population compared to 4% in untreated controls. The viability of these highly granulated cells decreased to 17% post-treatment. Interestingly, photothermal therapy reduced the proportion of apoptotic cells among Huh7 subpopulations relative to the overall number of dead cells.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lightweight Spectral-MLP for Hyperspectral Differentiation of Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma 轻型光谱- mlp在肝内胆管癌和肝细胞癌高光谱鉴别中的应用。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-12 Epub Date: 2025-11-30 DOI: 10.1002/jbio.202500545

Qingyuan Zhang, Hao Wang, Ying Pian, Qichao Yang, Xuping Zhang

{"title":"Lightweight Spectral-MLP for Hyperspectral Differentiation of Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma","authors":"Qingyuan Zhang, Hao Wang, Ying Pian, Qichao Yang, Xuping Zhang","doi":"10.1002/jbio.202500545","DOIUrl":"10.1002/jbio.202500545","url":null,"abstract":"<div>\u0000 \u0000 <p>Accurate differentiation between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) remains challenging due to overlapping imaging features. We propose a hyperspectral imaging (HSI)–based diagnostic framework using a lightweight Spectral-MLP network for label-free tumor classification. Seventy-nine liver specimens were analyzed after spectral calibration, noise-band removal, and normalization within 450–900 nm. Spectral analysis revealed distinct differences in hemoglobin-related bands (540–580 nm) and lipid/water absorption regions (760–850 nm), corresponding to vascular and stromal variations between ICC and HCC. The proposed Spectral-MLP achieved 93.6% accuracy, 93.1% sensitivity, 94.0% specificity, and an AUC of 0.965, comparable to deeper models but with higher efficiency. These findings demonstrate that hyperspectral data combined with a simple neural network can effectively distinguish ICC from HCC and suggest that the lightweight Spectral-MLP framework has the potential to provide interpretable, real-time, and clinically deployable decision support for optical pathological diagnosis.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Effects of Intense Terahertz Waves at 2.88 THz on Breast Cancer and Melanoma Cells 2.88太赫兹强太赫兹波对乳腺癌和黑色素瘤细胞的生物学效应。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-12 Epub Date: 2025-11-21 DOI: 10.1002/jbio.202500307

Chengbin Zhao, Huan Zhou, Xiao-Yu Peng, Weijun Wang, Peng Zhang, Jie Liu, Peng Li, Xianqin Luo, Biyong Ren, De-Sheng Pei

{"title":"Biological Effects of Intense Terahertz Waves at 2.88 THz on Breast Cancer and Melanoma Cells","authors":"Chengbin Zhao, Huan Zhou, Xiao-Yu Peng, Weijun Wang, Peng Zhang, Jie Liu, Peng Li, Xianqin Luo, Biyong Ren, De-Sheng Pei","doi":"10.1002/jbio.202500307","DOIUrl":"10.1002/jbio.202500307","url":null,"abstract":"<div>\u0000 \u0000 <p>Current research has shown that terahertz (THz) waves can induce some bioeffects on certain human tumor cells. These effects are significant for potential applications in future tumor treatments. However, there are limited reports on the research advancements in this field, likely due to the scarcity of powerful THz sources. Here, we preliminarily report biological effects on breast cancer and melanoma cells using a powerful THz source at 2.88 THz from a THz free-electron laser. We observed obvious morphological changes, especially the early apoptotic phenomena, in both cancer cells. Flow cytometry results further confirmed that some cancer cells had undergone early apoptosis. An evaluation of the thermal effects suggests that the apoptosis observed in both cancer cells could be mainly attributed to the non-thermal effects induced by the strong THz waves. Our findings indicate the potential for utilizing strong THz waves in non-inflammatory cancer treatment in the future.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable Low-Cost Photobiomodulation Device Enhances Migration and Adhesion in L929 Fibroblasts: In Vitro Healing Evidence 便携式低成本光生物调节装置增强L929成纤维细胞的迁移和粘附：体外愈合证据。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-12 Epub Date: 2025-11-30 DOI: 10.1002/jbio.202500517

Rebeca Barbosa da Rocha, Rodrigo Elísio de Sá, Renato Dias dos Santos, Fabrício dos Santos Machado, Wilson Rosas de Vasconcelos-Neto, Fuad Ahmad Hazime, Ana Jérsia Araújo, Vinicius Saura Cardoso, José Delano Barreto Marinho-Filho

{"title":"Portable Low-Cost Photobiomodulation Device Enhances Migration and Adhesion in L929 Fibroblasts: In Vitro Healing Evidence","authors":"Rebeca Barbosa da Rocha, Rodrigo Elísio de Sá, Renato Dias dos Santos, Fabrício dos Santos Machado, Wilson Rosas de Vasconcelos-Neto, Fuad Ahmad Hazime, Ana Jérsia Araújo, Vinicius Saura Cardoso, José Delano Barreto Marinho-Filho","doi":"10.1002/jbio.202500517","DOIUrl":"10.1002/jbio.202500517","url":null,"abstract":"<div>\u0000 \u0000 <p>Photobiomodulation shows promise in modulating complex mechanisms of chronic wound healing. Current photobiomodulation devices remain costly and technically demanding. Therefore, this study reports the development of a simple, portable and operationally and easy-to-use LED-based photobiomodulation device for the treatment of skin lesions. The design and operating parameters confirmed the device's safety and energy efficiency. In vitro LED irradiation on fibroblasts increased cell viability, without inducing proliferation. The treatment prevented cellular shrinkage, as evidenced by a higher number of smaller cells in the control group. Irradiation also enhanced cell migration at 72 and 96 h after treatment. Significantly increased adhesion to fibronectin was observed in the irradiated group, with no effect on type I collagen adhesion. Nevertheless, no significant differences were observed in the proportion of cells in the sub-G0/G1, G0/G1, S, and G2/M phases of the cell cycle. In conclusion, the LED device provides a reliable source of electromagnetic stimulation with healing effects.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy 纤维组织力学的布里渊光谱定量映射。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-11 Epub Date: 2025-11-14 DOI: 10.1002/jbio.202500489

Vsevolod Cheburkanov, Sujeong Jung, Mikhail Y. Berezin, Vladislav V. Yakovlev

{"title":"Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy","authors":"Vsevolod Cheburkanov, Sujeong Jung, Mikhail Y. Berezin, Vladislav V. Yakovlev","doi":"10.1002/jbio.202500489","DOIUrl":"10.1002/jbio.202500489","url":null,"abstract":"<p>Fibrosis is a pathological scarring process that disrupts tissue architecture, and is characterized by excessive extracellular matrix (ECM) deposition, leading to tissue stiffening and impaired organ function. Accurate quantification and spatial mapping of fibrotic tissue mechanics are critical for diagnosis, monitoring disease progression, and evaluating therapeutic responses. Here, we employ Brillouin microspectroscopy, a non-invasive, label-free optical technique, to quantify the mechanical properties of human fibrotic tissue in in situ. We show that Brillouin spectroscopy distinguishes fibrotic tissue from healthy tissue on the basis of localized differences in the complex longitudinal modulus and enables real-time monitoring of dynamic alterations in viscoelastic properties during fibrogenesis. To our knowledge, this is the first demonstration of Brillouin spectroscopy for in situ characterization of fibrosis and wound healing in a human model. These findings underscore Brillouin microspectroscopy's potential application as a promising diagnostic and monitoring tool for fibrotic diseases.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling Protein Citrullination in Extracellular Vesicles by Single-Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy 用直接随机光学重建显微镜单分子检测分析细胞外囊泡中的瓜氨酸化蛋白。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-11 Epub Date: 2025-11-27 DOI: 10.1002/jbio.202500483

Sarah R. Needham, Benjamin M. Davis, Pinar Uysal-Onganer, Daniel J. Rolfe, Mariya Hristova, Igor Kraev, Jameel M. Inal, Sigrun Lange

{"title":"Profiling Protein Citrullination in Extracellular Vesicles by Single-Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy","authors":"Sarah R. Needham, Benjamin M. Davis, Pinar Uysal-Onganer, Daniel J. Rolfe, Mariya Hristova, Igor Kraev, Jameel M. Inal, Sigrun Lange","doi":"10.1002/jbio.202500483","DOIUrl":"10.1002/jbio.202500483","url":null,"abstract":"<p>Extracellular vesicles (EVs) are critical in cellular communication and pathological biomarkers. Post-translationally deiminated/citrullinated proteins are reported in EV cargoes by LC–MS/MS but it is unknown in which EV sub-types they are exported, as part of EVs' intraluminal cargo or on the EV surface. Here, dSTORM super-resolution microscopy is used to co-localise total citrullinated proteins (pan-Cit), and citrullinated histone H3 (CitH3) to EV subtypes of three cancer cell lines, captured by tetraspanin trio (TT) or phosphatidylserine (PS). Permeabilised and non-permeabilised EVs are analysed with a Bayesian framework using beta-distributed posteriors for binomial outcomes. Pan-Cit and CitH3 labelling is confirmed in EVs as intraluminal cargo and on the EV surface, with higher levels detected in the permeabilized EVs. Pan-Cit staining is higher in TT-bound EVs, but CitH3 staining higher in PS-bound EVs. This study expands the landscape of EV-associated post-translational modifications with translational potential for EV-citrullinome based liquid biopsy tools.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Identification and Characterization of Pathogenic Bacteria Isolates Using Fluorescence Excitation Spectroscopy and Spectral Deconvolution 利用荧光激发光谱和光谱反褶积快速鉴定和鉴定病原菌分离物。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-11 Epub Date: 2025-11-24 DOI: 10.1002/jbio.202500408

Anandh Sundaramoorthy, Bharanidharan Ganesan, Aruna Prakasarao, Singaravelu Ganesan

{"title":"Rapid Identification and Characterization of Pathogenic Bacteria Isolates Using Fluorescence Excitation Spectroscopy and Spectral Deconvolution","authors":"Anandh Sundaramoorthy, Bharanidharan Ganesan, Aruna Prakasarao, Singaravelu Ganesan","doi":"10.1002/jbio.202500408","DOIUrl":"10.1002/jbio.202500408","url":null,"abstract":"<div><p>Bacterial detection and identification are crucial tasks in today's world due to increasing casualties and severity caused by bacteria in hospital-acquired infections, food-borne infections, etc. This warrants an urgent need for rapid detection and identification of different bacterial strains. Fluorescence spectroscopy is a widely used technique for bacteria characterization owing to its high sensitivity, real-time, and simple measurement capabilities. In this work, fluorescence excitation spectra of 200 bacteria isolates belonging to eight different species were acquired under identical conditions with 25 isolates per species. The fluorescence excitation spectra were subjected to spectral deconvolution to extract four Gaussian components viz., tryptophan in protein under buried and exposed conditions, nucleic acids and anthranilic acid. Linear discriminant analysis applied to normalized fluorescence excitation spectra of 200 samples classified the bacterial strains with 100% accuracy using leave-one-out cross-validation.</p></div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue Autofluorescence is Correlated With Intima and Media Thickness in Atherosclerotic Human Aorta 动脉粥样硬化人主动脉组织自身荧光与内膜和中膜厚度相关。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-11 Epub Date: 2025-11-12 DOI: 10.1002/jbio.202500274

William Lewis, Walfre Franco

{"title":"Tissue Autofluorescence is Correlated With Intima and Media Thickness in Atherosclerotic Human Aorta","authors":"William Lewis, Walfre Franco","doi":"10.1002/jbio.202500274","DOIUrl":"10.1002/jbio.202500274","url":null,"abstract":"<div><p>This study identifies fluorescence excitation-emission pairs correlated with atherosclerotic pathology in an ex vivo human aorta. Fluorescence spectroscopy, wide-field fluorescence imaging, gross pathologic and histologic evaluation of ex vivo cadaveric human aorta are performed. A matrix of Pearson correlation coefficients are determined for the relationship between relevant histologic features and fluorescence intensity for 427 excitation-emission pairs. A multiple linear regression analysis indicates that tryptophan and elastin fluorescence intensity predicts 58% of the variance in intima thickness (R-squared = 0.588, <i>F</i>(2, 18) = 12.8, <i>p</i> = 0.0003), and 48% of the variance in media thickness (R-squared = 0.483, <i>F</i>(2, 18) = 8.42, <i>p</i> = 0.002). Excluding lesions identified as necrotic lipid cores on histology from analysis, a combination of tyrosine, tryptophan, collagen and elastin autofluorescence predicted 86.0% of the variance in intima thickness (R-squared = 0.8598, <i>F</i>(4, 13) = 19.9, <i>p</i> = 1.87 × 10<sup>−5</sup>) and 51.8% of the variance in media thickness (R-squared = 0.518, <i>F</i>(4, 13) = 3.49, <i>p</i> = 0.0382).</p></div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optomechanical Racetrack Cantilever Biosensor: Bridging Chemical and Cellular Detection 光机械赛道悬臂式生物传感器：桥接化学和细胞检测。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2026-03-11 Epub Date: 2025-11-19 DOI: 10.1002/jbio.202500494

Chaitra Shri Krishnappa, Ugra Mohan Roy, Malathi Sathish

{"title":"Optomechanical Racetrack Cantilever Biosensor: Bridging Chemical and Cellular Detection","authors":"Chaitra Shri Krishnappa, Ugra Mohan Roy, Malathi Sathish","doi":"10.1002/jbio.202500494","DOIUrl":"10.1002/jbio.202500494","url":null,"abstract":"<div><p>A novel optomechanical biosensor architecture integrating an optomechanical racetrack–cantilever biosensor with a flexible cantilever is designed for simultaneous detection of chemical and cellular analytes. Pressure loads induced by glucose, dopamine, and MCF-7 cancer cells were modeled as mechanical deflections transduced into resonance wavelength shifts. Finite element simulations in ANSYS and COMSOL were validated against analytical beam theory with deviations below 1%. Distinct resonance signatures were observed for chemical and cellular analytes, demonstrating the capacity for analyte discrimination. PDMS cantilevers exhibited mean sensitivities of approximately 1.69 pm/kPa and maximum responses of 5.34 pm/kPa, whereas SiO<sub>2</sub> devices showed negligible sensitivity. These results demonstrate, through finite-element simulations and analytical modeling, the proof-of-concept operation of a racetrack–cantilever optomechanical biosensor. The study highlights key trends and limitations rather than providing an exhaustive experimental explanation, thereby offering a design foundation for future fabrication and validation.</p></div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0