Journal of microencapsulation最新文献

{"title":"Recent developments in sustained-release and targeted drug delivery applications of solid lipid nanoparticles.","authors":"Hanaa Ali Hussein, Fatin L Khaphi, Ramachandran Sivaramakrishnan, Sivamani Poornima, Mohd Azmuddin Abdullah","doi":"10.1080/02652048.2025.2495290","DOIUrl":"10.1080/02652048.2025.2495290","url":null,"abstract":"<p><p>Solid Lipid Nanoparticles (SLNs) are versatile nano-carriers for wide range of applications. The advantages of SLNs include ease of preparation, low toxicity, high active compound bioavailability, flexibility of incorporating hydrophilic and lipophilic drugs, and feasibility of large-scale production. This review provides an overview on the preparation methods of the SLNs, the micro and nanostructure characteristics of the SLNs, and the different factors influencing sustained release and targeted drug delivery. The applications in agriculture and environment, cosmetics, wound healing, malarial treatment, gene therapy and nano-vaccines, and cancer therapy, are elaborated. The mechanisms such as passive, active, and co-delivery are discussed. The issues, challenges and the way forward with ionisable SLNs for delivery of gene and vaccines, RAS-targeted therapy, and bioactive compounds, are highlighted. In combination with multiple compounds and the potential for integration with nature/bio-based solutions, SLNs are proven to be effective, and practical for diverse applications.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"472-502"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhalable microparticles embedding hyaluronic acid-coated chitosan nanoparticles: fabrication and evaluation for preferential accumulation of montelukast in the lung.","authors":"Faqir Ullah, Fahad Y Sabei, Kifayat Ullah Shah, Awaji Y Safhi, Mohammed Ali Bakkari, Osama A Madkhali, Ahmed H Albariqi, Muhammad Danish Saeed, Muhammad Ramzan","doi":"10.1080/02652048.2025.2500537","DOIUrl":"10.1080/02652048.2025.2500537","url":null,"abstract":"<p><p>The study aimed to prepare nanoembedded microparticles for pulmonary delivery of montelukast. The nanoparticles were synthesised by ionic gelation method and characterised for physicochemical properties. The nanoembedded microparticles fabricated via freeze drying method were evaluated for their physicochemical properties, drug release, aerodynamic performance and pharmacokinetic parameters in male <i>Sprague Dawley</i> rats. The hyaluronic-coated chitosan nanoparticles with particle size of 276.221 ± 08.232 nm, PDI of 0.397 ± 0.007, zeta potential of 14.101 ± 0.107 mV, drug content of 22.781 ± 1.002 µg/mg, and a triangular structure were embedded within microparticles. The sustained release of montelukast from nanoembedded microparticles was attributed to slow dissolution of chitosan at lung pH. The lactose-embedded nanoparticles had higher fine particle fraction (FPF: 31.37 ± 1.29) as compared to mannitol-embedded nanoparticles (FPF: 25.053 ± 0.93) due to spherical compact structure. The microparticles have lower AUC_0-t (835-856 µg.h/ml) compared to montelukast solution (1488 µg.h/ml), confirming preferential accumulation of microparticles in the lung.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"519-530"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spray-dried micellar dry powder inhalation of curcumin for lung-targeted delivery in non-small cell lung cancer therapy.","authors":"Shraddha S Ghodke, K M G Taylor, Satyanarayana Somavarapu","doi":"10.1080/02652048.2025.2495246","DOIUrl":"10.1080/02652048.2025.2495246","url":null,"abstract":"<p><p>A spray-dried DPI formulation was developed to enhance solubility, stability, and pulmonary delivery of curcumin-loaded CS-HA dual-coated micelles for lung cancer therapy. Curcumin was encapsulated in Pluronic F68 micelles via thin-film hydration and coated with CS-HA to improve colloidal stability and cellular interaction. The micellar suspension was spray-dried using lactose and L-leucine as dispersibility enhancers. Formulation characterisation was conducted using DLS to determine mean diameter and PDI, zeta potential analysis, and HPLC for drug loading and encapsulation efficiency, along with TEM. Spray-dried formulations were further characterised by SEM, laser diffraction (Sympatec), FTIR, and XRPD. <i>In vitro</i> aerosol characterisation was performed using NGI. The micelles exhibited a mean diameter of 209 nm, PDI of 0.21, zeta potential of -14 mV, encapsulation efficiency of 50-90%, and loading capacity of 5.6% (w/w). XRPD and FTIR confirmed amorphous conversion and stability. The optimized DPI showed favourable aerodynamic properties for targeted pulmonary delivery in NSCLC.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"459-471"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the synergistic impact of cocktail nanohyalurosomes encapsulating berberine and dexamethasone in managing rheumatoid arthritis: in-vitro evaluation and biological studies.","authors":"Mariam Zewail, Manal A Elsheikh, Haidy Abbas, Passent M E Gaafar","doi":"10.1080/02652048.2025.2498963","DOIUrl":"10.1080/02652048.2025.2498963","url":null,"abstract":"<p><strong>Aim: </strong>The current therapeutic approaches for rheumatoid arthritis (RA) have limited effectiveness; the present study focused on the formulation of hyalurosomes co-encapsulating dexamethasone and berberine (BER-DEX hyalurosomes).</p><p><strong>Methods: </strong>Different formulations were developed and in-vitro characterized. The optimized formulation was transdermally applied in rats with AIA model. At the end of the experiment, histopathological examination and evaluation of inflammatory biomarkers were conducted.</p><p><strong>Results: </strong>Entrapment efficiency of 81.14 ± 2.36% for DEX and 92.69 ± 1.58% for BER was achieved with a sustained release for 24h for both drugs. TNF-α, IL7, MMP9, and HO levels decreased by 2.7, 2.4, 2.24, and 3.6 folds in BER-DEX hyalurosomes compared to the positive control group. Histopathological assessment revealed that BER-DEX hyalurosomes showed normal joint structure comparable to the negative control.</p><p><strong>Conclusion: </strong>The BER-DEX hyalurosomes offered a synergistic, non-invasive nanoplatform that actively targeted CD44 receptors, provided a novel and effective strategy for localized management of RA..</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"503-518"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"siRNA-guided dual-targeting nanocarrier for breast cancer treatment.","authors":"Ebru Kilicay, Betul Sahin, Zeynep Karahaliloglu, Ekin Celik, Baki Hazer","doi":"10.1080/02652048.2025.2490041","DOIUrl":"10.1080/02652048.2025.2490041","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to develop a thermoplastic polyurethane-oleic acid-based nanosystem (TPU-Ole NPs) incorporating siRNA and curcumin (CUR) to overcome multidrug resistance in breast cancer by silencing the c-myc gene.</p><p><strong>Methods: </strong>TPU-Ole and CUR-loaded NPs were prepared via solvent evaporation and coated with poly-L-lysine (PLL) for siRNA attachment. NPs were characterised by dynamic light scattering (DLS) for mean diameter, polydispersity index (PDI), and zeta potential (ZP). Encapsulation (EE) and loading efficiencies (LE) were measured by NanoDrop. Release (pH 5.0; 7.4) and storage stability (pH 7.4) were evaluated using the eppendorf method. siRNA binding was confirmed by agarose gel electrophoresis. Gene silencing and apoptosis were assessed by RT-PCR and flow cytometry.</p><p><strong>Results: </strong>Mean diameter, PDI, and ZP of NPs were 170 ± 2 nm, 0.011 ± 0.080, and -27.5 ± 0.11 mV. EE and LE were 75 ± 0.12 and 14.2 ± 0.06%. Sustained release and good stability were observed.</p><p><strong>Conclusion: </strong>siRNA-CUR-NPs efficiently silenced c-myc and induced apoptosis in MCF-7 cells.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"437-458"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel combinational nanomedicines, liposomes, to tackle breast cancer.","authors":"Mohamed Attia, David Hill, Cheng Shu Chaw, Amal Ali Elkordy","doi":"10.1080/02652048.2025.2487031","DOIUrl":"10.1080/02652048.2025.2487031","url":null,"abstract":"<p><strong>Aims: </strong>Doxorubicin (DOX), a potent chemotherapeutic, is a commonly prescribed treatment for breast cancer, but is limited by severe organ toxicity. Therefore, more effective therapies are required. This study developed a novel DOX-liposomes (LipDOX-ALA-AA) co-loaded with alpha-lipoic-acid (ALA) and ascorbic-acid (AA) to enhance antineoplastic effect.</p><p><strong>Methods: </strong>Liposomes were fabricated using a microfluidic-system with a DSPClipid:Cholesterol ratio of 1:1 and a flow rate ratio of 5:1. Liposomes were investigated using various-techniques such-as dynamic light scattering to measure liposomes' size and charge; and UV-spectroscopy to determine DOX-encapsulation-efficiency, EE. Cytotoxicity assays used various cell-lines.</p><p><strong>Results: </strong>Data revealed that LipDOX-ALA-AA had diameter of 79.0 ± 0.3 nm, with narrow size distribution, and zeta-potential of -4.0 ± 1.2. DOX-EE exceeded 95%, drug load was 0.5 mg/105.5 mg total content, drug release followed a biphasic pattern. Cytotoxicity assay showed activity (<i>p</i> < 0.05) against breast cancer cell-lines with reduced nephrotoxicity compared to Doxosome.</p><p><strong>Conclusion: </strong>This novel formulation (LipDOX-ALA-AA) offers a promise in breast cancer therapy.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"368-391"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular treatment of osteoarthritis using novel biocompatible etoricoxib chitosan-hyaluronate hybrid microparticles.","authors":"Khaled E Abuelella, Hend Abd-Allah, Sara M Soliman, Mona M A Abdel-Mottaleb","doi":"10.1080/02652048.2025.2490033","DOIUrl":"10.1080/02652048.2025.2490033","url":null,"abstract":"<p><strong>Aim: </strong>The current study aimed to develop and evaluate Etoricoxib (ETX) loaded polyelectrolyte microparticles (PEMPs) for intra-articular delivery in osteoarthritis management.</p><p><strong>Methods: </strong>PEMPs were prepared by the electrostatic interactions between hyaluronic acid (HA) and chitosan (CS). The optimum formulation was characterized for encapsulation efficiency, particle size (PS), zeta potential (ZP), drug release, stability, TEM, FTIR, DSC and in vivo anti-inflammatory activity.</p><p><strong>Results: </strong>The optimum formulation (ME4/TPP0.25) demonstrated spherical particles with a PS of 1.56 ± 0.04 µm, a PDI value of 0.29 ± 0.05, ZP of +35.26 ± 0.9 mV, and EE% of 94.7 ± 0.24% and loading capacity of 11.7 ± 0.16% (w/w). In vivo studies demonstrated that ME4/TPP0.25 significantly suppressed knee joint swelling, and significantly reduced the levels of catabolic and inflammatory mediators (ALP and IL-6) compared to drug alone.</p><p><strong>Conclusion: </strong>These results suggest that the optimum ETX-loaded PEMPs could be a promising formulation for knee osteoarthritis management.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"421-435"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Cyclodextrin-functionalized nanocarriers for bromocriptine: development, evaluation and histopathological studies.","authors":"Muhammad Ahsan Waqar, Iqra Noor Khan, Shabab Zahra, Farwa Shaheen, Saba Noureen, Shakeel Ahmad, Muhammad Irfan Siddique, Muhammad Nadeem Alvi","doi":"10.1080/02652048.2025.2487034","DOIUrl":"10.1080/02652048.2025.2487034","url":null,"abstract":"<p><p>Bromocriptine (BCM), a dopaminergic agonist used in Parkinson's disease treatment, has poor oral bioavailability due to extensive first-pass metabolism and limited gastrointestinal absorption. This study aimed to develop a β-cyclodextrin-functionalized bromocriptine nanoemulsion (oil-in-water) to enhance drug solubility, stability, and bioavailability while facilitating direct brain delivery via the intranasal route. The formulation was designed to overcome systemic metabolic barriers, improve drug permeation across the blood-brain barrier, and ensure sustained therapeutic effects with minimal systemic side effects. Nano-emulsions were prepared using high-shear homogenization. Characterization was performed using scanning electron microscopy (SEM) for morphological analysis. Globule size and zeta potential were measured using Malvern Zetasizer. Fourier Transform Infrared Spectroscopy (FTIR) was used for structural analysis, while X-ray diffraction (XRD) assessed crystallinity. Differential Scanning Calorimetry (DSC) was conducted for thermal analysis. Drug content and <i>in-vitro</i> drug release were evaluated using UV-visible spectroscopy. Stability studies were performed using centrifugation and freeze-thaw methods. Docking studies and Histopathological evaluation were also performed of the prepared formulations. Morphological studies revealed nano-sized globular particles with a mean diameter of 117.2 nm and a low polydispersity index (PDI 0.810), indicating uniformity. The nanoemulsion exhibited a zeta potential of -10.5 mV, ensuring colloidal stability. The encapsulation efficiency (EE%) of the optimized formulation (F4) was 95.36(% w/w,) with a drug load of approximately 9.5(% w/w). <i>In-vitro</i> drug release reached 85.65%, with permeation release of 78.44% and 70.13% ex-vivo. The formulation remained stable under freeze-thaw and centrifugation conditions. Cell toxicity assessments demonstrated excellent biocompatibility, with no significant cytotoxic effects observed in histopathological evaluations. This nanoemulsion presents a promising alternative to oral bromocriptine for Parkinson's treatment.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"406-420"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose-based hydrogels enhanced with bioactive molecules for optimal chronic diabetic wound management.","authors":"Mahtab Ghasemi Toudeshkchouei, Hassan Abdoos, Jafar Ai, M S Nourbakhsh","doi":"10.1080/02652048.2025.2480598","DOIUrl":"10.1080/02652048.2025.2480598","url":null,"abstract":"<p><p>Hydrogels are three-dimensional structures that replicate natural tissues' extracellular matrix (ECM). They are essential for transporting exudates, gases, and moisture and facilitating cellular interactions in tissue engineering and wound healing. The choice of primary material in designing the scaffold is necessary to be paid more attention rather than common sources, including plant fibres like cotton, bamboo, and algae, as well as bacterial and marine-derived materials. Among them, cellulose-based polymers are especially valued for their biocompatibility and ability to promote wound healing. Chronic diabetic wounds pose unique treatment challenges, such as necrosis and infection risks. Consequently, a growing interest is in incorporating bioactive molecules into cellulose-based hydrogels. This article investigates how these infused hydrogels enhance the healing process in chronic diabetic wounds, examining various loading and crosslinking techniques alongside their clinical applications. It also discusses the benefits and limitations of bioactive molecules and their interactions with hydrogels to improve treatment strategies.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"313-336"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> and <i>in vivo</i> PK/PD evaluation of glibenclamide nanosponges.","authors":"Marwa G Zaima, Shadeed Gad, Hany M Ibrahim","doi":"10.1080/02652048.2025.2483805","DOIUrl":"10.1080/02652048.2025.2483805","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to develop glibenclamide (GLC)-loaded nanosponges (NS) using β-cyclodextrin to improve dissolution rate and oral bioavailability of GLC.</p><p><strong>Methods: </strong>Blank NS were produced using solvent technique with varying ratios of β-cyclodextrin and carbonyl-diimidazole. The hyper-crosslinked β-cyclodextrin was dispersed in de-ionized water, and then lyophilised. The GLC-loaded-NS were prepared using different ratios of GLC to the previously developed NS_1:4 and evaluated for particle size, zeta potential, TEM, SEM, DSC, PXRD, FTIR, loading efficiency, pharmacokinetically, pharmacodynamically, histologically and effect of storage.</p><p><strong>Results: </strong>GLC:NS_1:4 showed highest solubility (46.36 ± 2.44%w/v), entrapment efficiency (36.1 ± 0.57%w/v), particle size 352 ± 6.1 nm and Z-potential -25.3 ± 0.3 mV. GLC:NS_1:4 exhibited porous, spherical nanoparticles, with confirmed drug encapsulation. In-vitro and in-vivo evaluations demonstrated an initial burst followed by sustained drug release, reducing blood glucose levels by 79.6 ± 0.43%. The effect of storage revealed no significant changes after 3 months.</p><p><strong>Conclusion: </strong>GLC-NS complexation improved oral bioavailability and extended drug release, suggesting better patient compliance.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"352-367"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}