Journal of microencapsulation最新文献_第10页

Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion. 透明质酸水凝胶包埋胡椒碱脂质体作为预防术后腹膜粘连的有效平台。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2194415

Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri

{"title":"Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion.","authors":"Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri","doi":"10.1080/02652048.2023.2194415","DOIUrl":"https://doi.org/10.1080/02652048.2023.2194415","url":null,"abstract":"This study aimed to prepare piperine (PIP) loaded liposomes in hyaluronic acid (HA) hydrogel to provide a hybrid superstructure for postoperative adhesion prevention. Liposomes were prepared using thin-film hydration method. The optimised formulation was characterised by size, SEM, TEM, FTIR, encapsulation efficiency (EE)% (w/w), and release pattern. Liposome-in-hydrogel formulation was investigated by rheology, SEM, and release studies. The efficacy was evaluated in a rat peritoneal abrasion model. EE% (w/w) increased with increasing lipid concentration from 10 to 30; however, a higher percentage of Chol reduced EE% (w/w). The optimised liposome (EE: 68.10 ± 1.71% (w/w), average diameter: 513 ± 8 nm, PDI: 0.15 ± 0.04) was used for hydrogel embedding. No sign of adhesion in 5/8 rats and no collagen deposition confirmed the in vivo effectiveness of the optimised formulation. Overall, providing a sustained delivery of PIP, the developed liposome-in-hydrogel formulation can be a promising carrier to prevent postoperative adhesion.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"279-301"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dry powder formulation of azithromycin for COVID-19 therapeutics. 阿奇霉素干粉制剂用于COVID-19治疗。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2175924

Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu

{"title":"Dry powder formulation of azithromycin for COVID-19 therapeutics.","authors":"Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu","doi":"10.1080/02652048.2023.2175924","DOIUrl":"https://doi.org/10.1080/02652048.2023.2175924","url":null,"abstract":"Azithromycin is an antibiotic proposed as a treatment for the coronavirus disease 2019 (COVID-19) due to its immunomodulatory activity. The aim of this study is to develop dry powder formulations of azithromycin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocomposite microparticles for pulmonary delivery to improve the low bioavailability of azithromycin. Double emulsion method was used to produce nanoparticles, which were then spray dried to form nanocomposite microparticles. Encapsulation efficiency and drug loading were analysed, and formulations were characterised by particle size, zeta potential, morphology, crystallinity and in-vitro aerosol dispersion performance. The addition of chitosan changed the neutrally-charged azithromycin only formulation to positively-charged nanoparticles. However, the addition of chitosan also increased the particle size of the formulations. It was observed in the NGI® data that there was an improvement in dispersibility of the chitosan-related formulations. It was demonstrated in this study that all dry powder formulations were able to deliver azithromycin to the deep lung regions, which suggested the potential of using azithromycin via pulmonary drug delivery as an effective method to treat COVID-19.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"217-232"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9510311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of anti-arthritic activity of lipid matrix encased berberine in rheumatic animal model. 类风湿动物模型中脂质基质包膜小檗碱抗关节炎活性的评价。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2194414

Neelu Singh, Amit Kumar Pandey, Ravi Raj Pal, Alka, Poonam Parashar, Priya Singh, Nidhi Mishra, Dinesh Kumar, Ritu Raj, Sukhveer Singh, Shubhini A Saraf

{"title":"Assessment of anti-arthritic activity of lipid matrix encased berberine in rheumatic animal model.","authors":"Neelu Singh, Amit Kumar Pandey, Ravi Raj Pal, Alka, Poonam Parashar, Priya Singh, Nidhi Mishra, Dinesh Kumar, Ritu Raj, Sukhveer Singh, Shubhini A Saraf","doi":"10.1080/02652048.2023.2194414","DOIUrl":"https://doi.org/10.1080/02652048.2023.2194414","url":null,"abstract":"The purpose of this study was to evaluate the drug delivery and therapeutic potential of berberine (Br) loaded nanoformulation in rheumatoid arthritis (RA)-induced animal model. The Br-loaded NLCs (nanostructured lipid carriers) were prepared employing melt-emulsification process, and optimised through Box-Behnken design. The prepared NLCs were assessed for in-vitro and in-vivo evaluations. The optimised NLCs exhibited a mean diameter of 180.2 ± 0.31 nm with 88.32 ± 2.43% entrapment efficiency. An enhanced anti-arthritic activity with reduced arthritic scores to 0.66 ± 0.51, reduction in ankle diameter to 5.80 ± 0.27 mm, decline in paw withdrawal timing, and improvements in walking behaviour were observed in the Br-NLCs treated group. The radiographic images revealed a reduction in bone and cartilage deformation. The Br-NLCs showed promising results in the management of RA disease, can be developed as an efficient delivery system at commercial levels, and may be explored for clinical application after suitable experiments in the future.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"263-278"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Co-delivery of paclitaxel and etoposide prodrug by human serum albumin and PLGA nanoparticles: synergistic cytotoxicity in brain tumour cells. 人血清白蛋白和PLGA纳米颗粒共同递送紫杉醇和依托泊苷前药:脑肿瘤细胞的协同细胞毒性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2188943

Tatyana Kovshova, Sergey Mantrov, Svetlana Boiko, Julia Malinovskaya, Maria Merkulova, Nadezhda Osipova, Natalia Moiseeva, Mikhail Akimov, Polina Dudina, Ivan Senchikhin, Yulia Ermolenko, Svetlana Gelperina

{"title":"Co-delivery of paclitaxel and etoposide prodrug by human serum albumin and PLGA nanoparticles: synergistic cytotoxicity in brain tumour cells.","authors":"Tatyana Kovshova, Sergey Mantrov, Svetlana Boiko, Julia Malinovskaya, Maria Merkulova, Nadezhda Osipova, Natalia Moiseeva, Mikhail Akimov, Polina Dudina, Ivan Senchikhin, Yulia Ermolenko, Svetlana Gelperina","doi":"10.1080/02652048.2023.2188943","DOIUrl":"https://doi.org/10.1080/02652048.2023.2188943","url":null,"abstract":"The aims of this study were to develop co-delivery systems of paclitaxel (PTX) and etoposide prodrug (4'-O-benzyloxycarbonyl-etoposide, ETP-cbz) based on non-cross-linked human serum albumin (HSA) and poly(lactide-co-glycolide) nanoparticles and to evaluate the synergistic potential of these drugs in vitro. The nanoformulations were prepared by the high-pressure homogenisation technique and characterised using DLS, TEM, SEM, AFM, HPLC, CZE, in-vitro release, and cytotoxicity in human and murine glioma cells. All nanoparticles had 90-150 nm in size and negative ζ-potentials. The Neuro2A cells were the most sensitive to both HSA- and PLGA-based co-delivery systems (IC50 0.024 µM and 0.053 µM, respectively). The drugs' synergistic effect (combination index < 0.9) was observed in the GL261 cells for both types of co-delivery formulations and in the Neuro2A cells for the HSA-based system. These nanodelivery systems may be useful to improve combination chemotherapy for brain tumour treatment. To our knowledge, this is the first report describing the non-cross-linked HSA-based co-delivery nanosuspension which was prepared using nab™ technology.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"246-262"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9510843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Encapsulation of Ruta essential oil in chitosan and alginate matrices as an ecological alternative for the control of nematodes. 壳聚糖和海藻酸盐基质包封Ruta精油作为防治线虫的生态替代品。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2188939

Duvan Fernando Castillo, Rubén Albeiro Sánchez-Andica, Brayan Fernando Enriquez, Jaime Restrepo, Martha Isabel Páez-Melo

{"title":"Encapsulation of Ruta essential oil in chitosan and alginate matrices as an ecological alternative for the control of nematodes.","authors":"Duvan Fernando Castillo, Rubén Albeiro Sánchez-Andica, Brayan Fernando Enriquez, Jaime Restrepo, Martha Isabel Páez-Melo","doi":"10.1080/02652048.2023.2188939","DOIUrl":"https://doi.org/10.1080/02652048.2023.2188939","url":null,"abstract":"Controlled release formulations of Ruta essential oil obtained by ionic gelation were developed. The presence of rue essential oil in the alginate and chitosan capsules was evidenced by Fourier transform infrared spectroscopy and differential scanning calorimetry. Release studies revealed that in acidic conditions (pH 4.2), the CHS-REO particles reached a Sw of 240% (w/w) in 30 days and 101% (w/w) for ALG-REO particles, generating a RR of 23.7% for CHS-REO and 20.4% for ALG-REO. On the other hand, at pH 6.8 it favored the Sw for ALG-REO 840% (w/w) and therefore the RR (45.6%) and disfavored the Sw of CHS-REO generating low RR (16.9%). Encapsulated rue essential oil showed equal or superior nematicidal activity against the nematode Melodogyne ssp., compared to free oil and a synthetic nematicide such as Carbofuran, without having a phytotoxic effect on the plant. This study revealed that REO encapsulated in biopolymeric matrices can be used as new nematicide formulations.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"233-245"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9462049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microencapsulation of β-carotene using barley residue proteins from beer waste as coating material. 以啤酒渣大麦蛋白为包衣材料制备β-胡萝卜素微胶囊化。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2183277

Ana Cristina Freitas De Oliveira Meira, Larissa Carolina De Morais, Jayne De Abreu Figueiredo, Lizzy Ayra Alcântara Veríssimo, Diego Alvarenga Botrel, Jaime Vilela De Resende

{"title":"Microencapsulation of β-carotene using barley residue proteins from beer waste as coating material.","authors":"Ana Cristina Freitas De Oliveira Meira, Larissa Carolina De Morais, Jayne De Abreu Figueiredo, Lizzy Ayra Alcântara Veríssimo, Diego Alvarenga Botrel, Jaime Vilela De Resende","doi":"10.1080/02652048.2023.2183277","DOIUrl":"https://doi.org/10.1080/02652048.2023.2183277","url":null,"abstract":"This study aimed to produce and characterise microparticles produced from barley residue proteins (BRP) enriched with β-carotene. The microparticles were obtained by freeze-drying five emulsion formulations with 0.5% w/w whey protein concentrate and different concentrations of maltodextrin and BRP (0, 1.5, 3.0, 4.5 and 6.0% w/w), with the dispersed phase consisting of corn oil enriched with β-carotene. The mixtures were mechanically mixed and sonicated, the formed emulsions were freeze-drying. The microparticles obtained were tested for encapsulation efficiency, humidity, hygroscopicity, apparent density, scanning electron microscopy (SEM), accelerated stability and bioaccessibility. Microparticles produced with the emulsion containing 6% w/w BRP had lower moisture content (3.47 ± 0.05%), higher encapsulation efficiency (69.11 ± 3.36%), bioaccessibility value of 84.1% and greater β-carotene protection against thermal degradation. SEM analysis showed that microparticles had sizes ranging from 74.4 to 244.8 µm. These results show that BRP are viable for the microencapsulation of bioactive compounds by freeze-drying.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 3","pages":"171-185"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model. 含叶磷脂体的蛇舌草提取物的开发和评价:用于治疗啮齿动物神经性疼痛模型的临床前方法。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2188938

Nitin Kumar, Radha Goel, Monika Singh, Neeraj Kant Sharma, Praveen Kumar Gaur, Pradeep Kumar Sharma

{"title":"Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model.","authors":"Nitin Kumar, Radha Goel, Monika Singh, Neeraj Kant Sharma, Praveen Kumar Gaur, Pradeep Kumar Sharma","doi":"10.1080/02652048.2023.2188938","DOIUrl":"https://doi.org/10.1080/02652048.2023.2188938","url":null,"abstract":"Purpose: The study was aimed to encapsulate Hedyotis corymbosa extract (HCE) into phytosomes to improve its therapeutic efficacy in neuropathic pain by enhancing the bioavailability of chief chemical constituent Hedycoryside -A (HCA).Methods: For preparing phytosomes complexes (F1, F2, and F3), HCE and phospholipids were reacted in disparate ratio. F2 was chosen to assess its therapeutic efficacy in neuropathic pain induced by partial sciatic nerve ligation. Nociceptive threshold and oral bioavailability were also estimated for F2.Results: Particle size, zeta potential and entrapment efficiency for F2 were analysed as 298.1 ± 1.1 nm, -3.92 ± 0.41 mV and 72.12 ± 0.72% respectively. F2 gave enhanced relative bioavailability (158.92%) of HCA along with a greater neuroprotective potential showing a significant antioxidant effect and augmentation (p < 0.05) in nociceptive threshold with the diminution in damage to nerves.Conclusion: F2 is an optimistic formulation for enhancing the HCE delivery for the effective treatment of neuropathic pain.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 3","pages":"186-196"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impregnation of polyethylene terephthalate (PET) grafts with BMP-2 loaded functional nanoparticles for reconstruction of anterior cruciate ligament. 载BMP-2功能纳米颗粒浸渍聚对苯二甲酸乙二醇酯(PET)移植物重建前交叉韧带。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2188940

Zeynep Karahaliloglu, Batur Ercan, Baki Hazer

引用次数: 0

Core-shell micro/nanocapsules: from encapsulation to applications. 核壳微/纳米胶囊:从封装到应用。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2178538

Eslam Elkalla, Sumera Khizar, Mohamad Tarhini, Noureddine Lebaz, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari

{"title":"Core-shell micro/nanocapsules: from encapsulation to applications.","authors":"Eslam Elkalla, Sumera Khizar, Mohamad Tarhini, Noureddine Lebaz, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari","doi":"10.1080/02652048.2023.2178538","DOIUrl":"https://doi.org/10.1080/02652048.2023.2178538","url":null,"abstract":"Encapsulation is the way to wrap or coat one substance as a core inside another tiny substance known as a shell at micro and nano scale for protecting the active ingredients from the exterior environment. A lot of active substances, such as flavours, enzymes, drugs, pesticides, vitamins, in addition to catalysts being effectively encapsulated within capsules consisting of different natural as well as synthetic polymers comprising poly(methacrylate), poly(ethylene glycol), cellulose, poly(lactide), poly(styrene), gelatine, poly(lactide-co-glycolide)s, and acacia. The developed capsules release the enclosed substance conveniently and in time through numerous mechanisms, reliant on the ultimate use of final products. Such technology is important for several fields counting food, pharmaceutical, cosmetics, agriculture, and textile industries. The present review focuses on the most important and high-efficiency methods for manufacturing micro/nanocapsules and their several applications in our life.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 3","pages":"125-156"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9262466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E. 含维生素C和维生素E的抗氧化协同体系的构建与评价。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2183276

Ran Tao, Qianyu Zhang, Jialing Duan, Ran Chen, Liyun Yao, Ruiteng Zhang, Gang Dong, Huali Chen

{"title":"Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E.","authors":"Ran Tao, Qianyu Zhang, Jialing Duan, Ran Chen, Liyun Yao, Ruiteng Zhang, Gang Dong, Huali Chen","doi":"10.1080/02652048.2023.2183276","DOIUrl":"https://doi.org/10.1080/02652048.2023.2183276","url":null,"abstract":"Aims: The aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed.Methods: Vitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast Blue method. The concentration of VE was determined by high performance liquid chromatography (HPLC). Vitamin antioxidant capacity in vitro and in vivo was determined using β-carotene bleaching.Results: VCVE-MVL with particle diameter of 848.55 ± 0.29 nm and SPAN of 0.16 ± 0.11 were obtained. The encapsulation efficiency of VC reached 48.51% (w/w)±0.15. Compared with VC/VE solution, VCVE-MVL had a higher permeation efficiency. In addition, the in vitro and ex-vivo antioxidant tests verified the adequate antioxidant activity of VCVE-MVL.Conclusions: In conclusion, the antioxidant synergistic system we constructed and demonstrated its potential applications in the cosmetics industry.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 3","pages":"157-170"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9263115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0