The management of osteoarthritis symptomatology through nanotechnology: a patent review.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-09-12 DOI:10.1080/02652048.2023.2258955

Mariana Mendonça Santos, Anamaria Mendonça Santos, José Adão Carvalho Nascimento Júnior, Tatianny de Araujo Andrade, Gomathi Rajkumar, Luiza Abrahão Frank, Mairim Russo Serafini

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Abstract

Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.

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通过纳米技术治疗骨关节炎症状：一项专利综述。

骨关节炎被认为是一种退行性关节疾病，其特征是炎症、慢性疼痛和功能受限。纳米技术在药物递送系统中的日益发展为骨关节炎的治疗提供了新的思路和方法。这篇综述旨在评估在骨关节炎治疗中使用纳米技术开发创新、治疗策略和替代方案的专利。结果显示，2015年至2021年11月，欧洲专利局和世界知识产权组织在线数据库中存放的专利。共确定651项专利进行初步评估，并选择16项进行全面阅读和讨论。评估的专利集中在骨关节炎治疗的关节内途径、口服途径和局部途径上。关节内途径的专利数较高，其次分别是口服途径和局部途径。新技术的发展使我们能够展望骨关节炎治疗的前景。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.