Journal of microencapsulation最新文献

Novel combinational nanomedicines, liposomes, to tackle breast cancer.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-04-04 DOI: 10.1080/02652048.2025.2487031

Mohamed Attia, David Hill, Cheng Shu Chaw, Amal Ali Elkordy

{"title":"Novel combinational nanomedicines, liposomes, to tackle breast cancer.","authors":"Mohamed Attia, David Hill, Cheng Shu Chaw, Amal Ali Elkordy","doi":"10.1080/02652048.2025.2487031","DOIUrl":"https://doi.org/10.1080/02652048.2025.2487031","url":null,"abstract":"Aims: Doxorubicin (DOX), a potent chemotherapeutic, is a commonly prescribed treatment for breast cancer, but is limited by severe organ toxicity. Therefore, more effective therapies are required. This study developed a novel DOX-liposomes (LipDOX-ALA-AA) co-loaded with alpha-lipoic-acid (ALA) and ascorbic-acid (AA) to enhance antineoplastic effect.Methods: Liposomes were fabricated using a microfluidic-system with a DSPClipid:Cholesterol ratio of 1:1 and a flow rate ratio of 5:1. Liposomes were investigated using various-techniques such-as dynamic light scattering to measure liposomes' size and charge; and UV-spectroscopy to determine DOX-encapsulation-efficiency, EE. Cytotoxicity assays used various cell-lines.Results: Data revealed that LipDOX-ALA-AA had diameter of 79.0 ± 0.3 nm, with narrow size distribution, and zeta-potential of -4.0 ± 1.2. DOX-EE exceeded 95%, drug load was 0.5 mg/105.5 mg total content, drug release followed a biphasic pattern. Cytotoxicity assay showed activity (p < 0.05) against breast cancer cell-lines with reduced nephrotoxicity compared to Doxosome.Conclusion: This novel formulation (LipDOX-ALA-AA) offers a promise in breast cancer therapy.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of antimicrobial nanotechnology using flavonoids: a systematic review. 利用黄酮类化合物绿色合成抗菌纳米技术：系统综述。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-04-04 DOI: 10.1080/02652048.2025.2487033

Cláudio Carvalho Santana Júnior, Anamaria Mendonça Santos, Ana Maria Santos Oliveira, José Adão Carvalho Nascimento Júnior, Laurent Picot, Luiza Abrahão Frank, Paula Dos Passos Menezes, Izabel Almeida Alves, Mairim Russo Serafini

{"title":"Green synthesis of antimicrobial nanotechnology using flavonoids: a systematic review.","authors":"Cláudio Carvalho Santana Júnior, Anamaria Mendonça Santos, Ana Maria Santos Oliveira, José Adão Carvalho Nascimento Júnior, Laurent Picot, Luiza Abrahão Frank, Paula Dos Passos Menezes, Izabel Almeida Alves, Mairim Russo Serafini","doi":"10.1080/02652048.2025.2487033","DOIUrl":"https://doi.org/10.1080/02652048.2025.2487033","url":null,"abstract":"Antimicrobial resistance (AMR) is a critical public health concern that arises when microorganisms evolve mechanisms to evade the effects of antibiotics, thereby rendering conventional treatments ineffective. This growing challenge underscores the urgent need for novel therapeutic approaches. Nanotechnology, particularly when combined with environmentally sustainable practices such as green synthesis, reduces the use of toxic substances and minimises waste, offering a promising solution. This review explores the green synthesis of antimicrobial nanoparticles using flavonoids-natural compounds with substantial biological activity-as reducing and stabilising agents. By systematically analysing articles from PubMed, Scopus, Web of Science, and Embase, 10 key studies were identified. The primary nanoparticles examined were metallic, including silver, gold, copper, and metallic, which demonstrated notable efficacy against pathogens such as S. aureus, E. coli, and P. aeruginosa. The results support that green-synthesised nanoparticles represent a viable strategy to combat AMR, offering an effective and eco-friendly alternative for developing antimicrobial agents.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, in vitro, and in vivo evaluation of a new nanoemulsion gel of lamotrigine for application via nasal route.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-04-02 DOI: 10.1080/02652048.2025.2482048

DaІia E Gaber, Alanood S Almurshedi, Basmah N Aldosari, Samiah Alhabardi, Randa M Zaki, Mahasen A Radwan, Xien Chen

{"title":"Design, in vitro, and in vivo evaluation of a new nanoemulsion gel of lamotrigine for application via nasal route.","authors":"DaІia E Gaber, Alanood S Almurshedi, Basmah N Aldosari, Samiah Alhabardi, Randa M Zaki, Mahasen A Radwan, Xien Chen","doi":"10.1080/02652048.2025.2482048","DOIUrl":"https://doi.org/10.1080/02652048.2025.2482048","url":null,"abstract":"Aims: This study aimed to enhance the bioavailability and therapeutic efficacy of lamotrigine (LMG), an antiepileptic drug with low solubility, by formulating it into a nasal nanoemulsion (NE) for effective epilepsy control. Methods: LMG was incorporated into a nasal nanoemulsion (LMG-NE) using a 32 factorial design via spontaneous emulsification method. LMG-NEs were characterised for drug loading (DL), entrapment efficiency (EE%), particle size, microscopic examination, rheological profile, phosphatidylcholine liposome uptake, in vitro release, anticonvulsant activity, and in vivo pharmacokinetics. Results: The optimal formulation exhibited a DL of 79.03 ± 0.5 (w/w), an EE% of 80.2 ± 3.0%, a mean diameter of 182.78 ± 22.76 nm, and a zeta potential of 0.60 ± 0.04 mV. LMG was rapidly released, with 91.87% ± 4.54% of drug was released within 2 hours. The area under the curve (AUC0-24) showed a 1.84-fold increase compared to standard formulations. Conclusion: LMG-NE presents a promising alternative for epilepsy treatment, potentially reducing peripheral side effects and improving therapeutic outcomes.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro and in vivo PK/PD evaluation of glibenclamide nanosponges.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-27 DOI: 10.1080/02652048.2025.2483805

Marwa G Zaima, Shadeed Gad, Hany M Ibrahim

{"title":"In vitro and in vivo PK/PD evaluation of glibenclamide nanosponges.","authors":"Marwa G Zaima, Shadeed Gad, Hany M Ibrahim","doi":"10.1080/02652048.2025.2483805","DOIUrl":"https://doi.org/10.1080/02652048.2025.2483805","url":null,"abstract":"Aim: This study aimed to develop glibenclamide (GLC)-loaded nanosponges (NS) using β-cyclodextrin to improve dissolution rate and oral bioavailability of GLC.Methods: Blank NS were produced using solvent technique with varying ratios of β-cyclodextrin and carbonyl-diimidazole. The hyper-crosslinked β-cyclodextrin was dispersed in de-ionized water, and then lyophilised. The GLC-loaded-NS were prepared using different ratios of GLC to the previously developed NS1:4 and evaluated for particle size, zeta potential, TEM, SEM, DSC, PXRD, FTIR, loading efficiency, pharmacokinetically, pharmacodynamically, histologically and effect of storage.Results: GLC:NS1:4 showed highest solubility (46.36 ± 2.44%w/v), entrapment efficiency (36.1 ± 0.57%w/v), particle size 352 ± 6.1 nm and Z-potential -25.3 ± 0.3 mV. GLC:NS1:4 exhibited porous, spherical nanoparticles, with confirmed drug encapsulation. In-vitro and in-vivo evaluations demonstrated an initial burst followed by sustained drug release, reducing blood glucose levels by 79.6 ± 0.43%. The effect of storage revealed no significant changes after 3 months.Conclusion: GLC-NS complexation improved oral bioavailability and extended drug release, suggesting better patient compliance.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-16"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic combinatorial delivery system based on nanoliposome encapsulating doxorubicin and sorafenib for broad-spectrum cancer treatment.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-24 DOI: 10.1080/02652048.2025.2480597

Farwa Nurjis, Usama Sarwar, Joham Sarfraz Ali, Mahnoor Fayyaz, Faiza Munir, Shaheen Shahzad

{"title":"Synergistic combinatorial delivery system based on nanoliposome encapsulating doxorubicin and sorafenib for broad-spectrum cancer treatment.","authors":"Farwa Nurjis, Usama Sarwar, Joham Sarfraz Ali, Mahnoor Fayyaz, Faiza Munir, Shaheen Shahzad","doi":"10.1080/02652048.2025.2480597","DOIUrl":"https://doi.org/10.1080/02652048.2025.2480597","url":null,"abstract":"A novel combination delivery approach entrapping Sorafenib inside a nanoliposome bilayer and Doxorubicin within the aqueous core to achieve the broad-spectrum synergistic chemotherapeutic effect. DOX-SOR liposomes were synthesized by thin film hydration and characterized using UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy, Dynamic Light Scattering, Fluorescence, and Scanning Electron Microscopy, followed by cytotoxicity assessments. Nanoliposomes demonstrated effective loading and encapsulation of Doxorubicin (10.23% ± 0.65 and 89.65% ± 0.52) and Sorafenib (10.42% ± 0.50 and 85.35% ± 0.72) with a 165 nm ± 1.34 mean diameter, -15.2 ± 1.78 zeta potential, and 75% ± 1.92 of cumulative release. In vitro analysis of nanoliposomes demonstrated biocompatibility up to 250 µg/mL concentration (p < 0.05), enhanced intracellular localization in Hep2c cell lines, 91% ± 1.72 cytotoxic effects (p < 0.0001) with IC50 up to 127µg/mL, 21% ± 0.89 cell viability with 85% apoptosis (p < 0.0001) using flow cytometer. This study presents a promising treatment approach using a multidrug-loaded nanoliposomes for broad-spectrum synergistic chemotherapy.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-13"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose-based hydrogels enhanced with bioactive molecules for optimal chronic diabetic wound management.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-23 DOI: 10.1080/02652048.2025.2480598

Mahtab Ghasemi Toudeshkchouei, Hassan Abdoos, Jafar Ai, M S Nourbakhsh

{"title":"Cellulose-based hydrogels enhanced with bioactive molecules for optimal chronic diabetic wound management.","authors":"Mahtab Ghasemi Toudeshkchouei, Hassan Abdoos, Jafar Ai, M S Nourbakhsh","doi":"10.1080/02652048.2025.2480598","DOIUrl":"https://doi.org/10.1080/02652048.2025.2480598","url":null,"abstract":"Hydrogels are three-dimensional structures that replicate natural tissues' extracellular matrix (ECM). They are essential for transporting exudates, gases, and moisture and facilitating cellular interactions in tissue engineering and wound healing. The choice of primary material in designing the scaffold is necessary to be paid more attention rather than common sources, including plant fibres like cotton, bamboo, and algae, as well as bacterial and marine-derived materials. Among them, cellulose-based polymers are especially valued for their biocompatibility and ability to promote wound healing. Chronic diabetic wounds pose unique treatment challenges, such as necrosis and infection risks. Consequently, a growing interest is in incorporating bioactive molecules into cellulose-based hydrogels. This article investigates how these infused hydrogels enhance the healing process in chronic diabetic wounds, examining various loading and crosslinking techniques alongside their clinical applications. It also discusses the benefits and limitations of bioactive molecules and their interactions with hydrogels to improve treatment strategies.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on nanoformulations with FDA approved drugs for female reproductive cancer.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-20 DOI: 10.1080/02652048.2025.2474457

Mahima Raj, Abha Meena, Richa Seth, Anurag Mathur, Suaib Luqman

{"title":"An update on nanoformulations with FDA approved drugs for female reproductive cancer.","authors":"Mahima Raj, Abha Meena, Richa Seth, Anurag Mathur, Suaib Luqman","doi":"10.1080/02652048.2025.2474457","DOIUrl":"https://doi.org/10.1080/02652048.2025.2474457","url":null,"abstract":"Female reproductive cancers, including ovarian, cervical, breast, gestational trophoblastic and endometrial cancer, present significant challenges in therapy and patient prognosis. Conventional chemotherapy often lacks selectivity, leading to systemic toxicity and reduced treatment efficacy. Nanotechnology has emerged as a promising approach to improve drug delivery and therapeutic outcomes. Encapsulation of FDA-approved drugs within nanocarriers such as liposomes, polymeric nanoparticles, and lipid nanoparticles enables controlled drug release, reduces off-target effects, and enhances drug accumulation at tumor sites. This targeted delivery minimizes damage to healthy tissues and improves patient survival rates. Additionally, nanoformulations facilitate combination therapy, overcoming drug resistance and maximizing therapeutic efficacy. Despite promising results, challenges like scalability, reproducibility, and regulatory approvals hinder widespread clinical applications. Developing personalized nanoformulations tailored to individual patient profiles offers potential for precision cancer therapy. This study explores the role of nanoformulations in enhancing the therapeutic potential of FDA-approved drugs for treating female reproductive cancers.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-34"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel formulation of curcumin-loaded chlorhexidine drug combined with gold nanoparticles for effective therapeutic agent against urinary tract infections.

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI: 10.1080/02652048.2025.2457667

Jian Kang, Yanqing Tong

{"title":"Novel formulation of curcumin-loaded chlorhexidine drug combined with gold nanoparticles for effective therapeutic agent against urinary tract infections.","authors":"Jian Kang, Yanqing Tong","doi":"10.1080/02652048.2025.2457667","DOIUrl":"10.1080/02652048.2025.2457667","url":null,"abstract":"Aim: This study investigates a novel treatment for urinary tract infections (UTIs) caused by Staphylococcus aureus, Escherichia coli, and Klebsiella pathogenic bacterial strains.Methods: The Cur/Chx/Au composite matrix was synthesised in one pot by solution reduction and examined for functional groups and surface morphology by FT-IR, UV-DRS, HR-TEM, and TGA. In vitro, microbial growth inhibition evaluation and pathogen biofilm studies assessed the composite's antibacterial capacity.Results: Cur/Chx/Au exhibit mean diameter from 30 ± 5.2 nm, PDI 0.50 ± 0.05, and a zeta potential of -9.56 ± 1.84. The inhibition zones for S. aureus and E. coli were 16 ± 1.2 mm and 14 ± 0.8 mm, respectively, with an anti-inflammatory inhibition rate of 89.96%. The composite material's biocompatibility was further tested utilising in-vitro MTT, cell proliferation, and wound scratch assays in NHI 3T3 cells.Conclusion: Our findings demonstrate that the combination of Cur/Chx/Au composite matrix is a promising formulation for UTI treatment.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"177-190"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and characterization of medicinal plant-based extracellular vesicles as nano delivery systems for ascorbic acid. 抗坏血酸纳米递送系统药用植物细胞外囊泡的分离与表征。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1080/02652048.2024.2443430

Zainab Muhammad, Suleiman A Muhammad, Abdullahi Y Abbas, Mohammed Achor, Samson A Adeyemi, Yahya E Choonara, Yusuf Saidu, Lawal S Bilbis

{"title":"Isolation and characterization of medicinal plant-based extracellular vesicles as nano delivery systems for ascorbic acid.","authors":"Zainab Muhammad, Suleiman A Muhammad, Abdullahi Y Abbas, Mohammed Achor, Samson A Adeyemi, Yahya E Choonara, Yusuf Saidu, Lawal S Bilbis","doi":"10.1080/02652048.2024.2443430","DOIUrl":"10.1080/02652048.2024.2443430","url":null,"abstract":"Aim: Plant-derived extracellular vesicles (EVs) are natural nanovesicles for drug delivery. This study isolated and characterised EVs from medicinal plants as delivery vehicles.Methods: Precipitation method was employed for the isolation and characterised using DLS, SEM, and TEM. The encapsulation efficiency (EE) and antioxidant activity of ascorbic acid (AA)-EVs were evaluated.Results: The total yields of lyophilised vesicles per weight of the sample were 6.0, 8.6 and 9.2 mg/g for garlic, turmeric and ginger, respectively. Mean size of garlic-derived EVs, ginger-derived EVs, and turmeric-derived EVs were 101.0 ± 6.7, 226.4 ± 62.2 and 90.7 ± 2.5 nm, respectively. The zeta potential of the EVs was between -33.2 ± 10.9 and -28.8 ± 8.43 mV. Spherical morphology of the nanovesicles was confirmed by SEM and TEM. The EE of the EVs was between 78.1 ± 2.8% and 87.2 ± 1.4%.Conclusion: Overall, the antioxidant activity of AA-loaded EVs was better compared to free AA. This study provides evidence that these medicinal plants are rich sources for developing nanotherapeutics.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"120-131"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the antimicrobial and anticancer potential of a modified silver nanoparticle-impregnated carrier system. 一种改性纳米银浸渍载体体系的抗菌和抗癌潜力评价。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1080/02652048.2024.2443437

Ebru Kilicay, Ebru Erdal, Özge Kübra Karadag, Baki Hazer

{"title":"Evaluation of the antimicrobial and anticancer potential of a modified silver nanoparticle-impregnated carrier system.","authors":"Ebru Kilicay, Ebru Erdal, Özge Kübra Karadag, Baki Hazer","doi":"10.1080/02652048.2024.2443437","DOIUrl":"10.1080/02652048.2024.2443437","url":null,"abstract":"This study aimed to develop silver nanoparticles embedded in poly(ricinoleic acid)-poly(methyl methacrylate)-poly(ethylene glycol) (AgNPsPRici-PMMA-PEG) nanoparticles (NPs) containing caffeic acid (Caff) and tetracycline hydrochloride (TCH) for treating infections and cancer in bone defects. The block copolymers were synthesised via free radical polymerisation. NPs were prepared using the solvent evaporation method and characterised by FTIR, HNMR, SEM, DSC, TGA, and DLS. Drug loading (LE), encapsulation efficiency (EE), antimicrobial activity, cytotoxicity, and in vitro release studies were conducted. The NPs exhibited a size of 198 ± 2.89 nm, a narrow size distribution (PDI < 0.1), and a zeta potential of -27.5 ± 0.13 mV. The EE of Caff were 73 ± 0.09% w/w and 78 ± 0.32% w/w. Caff NPs showed prolonged release (69 ± 0.23% w/w), cytotoxicity with the cell viability of 66.85 ± 10.51% in SaOS cells, and antimicrobial zones ranging from 1.5 ± 0.3 to 4.2 ± 0.2 mm. TCH-Caff-AgNPsPRici-PMMA-PEG NPs exhibited promising therapeutic potential for infection and cancer treatment in bone defects.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"142-160"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0