Journal of microencapsulation最新文献_第2页

Nanoparticles encapsulated in Abelmoschus esculentus polysaccharide-based pellets as colon targeting approach. 包裹在阿贝摩斯多糖颗粒中的纳米粒子作为结肠靶向方法。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.1080/02652048.2024.2390951

Akshita Arora, Anshul Sharma, Shamsher Singh, Rajveer Singh, Amrinder Singh, Dipti Kakkar, Nitin Sharma

{"title":"Nanoparticles encapsulated in Abelmoschus esculentus polysaccharide-based pellets as colon targeting approach.","authors":"Akshita Arora, Anshul Sharma, Shamsher Singh, Rajveer Singh, Amrinder Singh, Dipti Kakkar, Nitin Sharma","doi":"10.1080/02652048.2024.2390951","DOIUrl":"10.1080/02652048.2024.2390951","url":null,"abstract":"Aim(s): This article explores the application of mesalazine-loaded nanoparticles (MLZ-NPs) encapsulated in Abelmoschus esculentus plant polysaccharide-based pellets (MLZ-NPs-Pellets) for ulcerative colitis.Methods: MLZ-NPs were prepared and evaluated for diameter, PDI, and entrapment efficiency. In-vitro efficacy study was conducted on Caco-2 cells. MLZ-NPs were encapsulated in polysaccharides to form MLZ-NPs-Pellets and characterised for efficacy in animals and targeting efficiency in human volunteers.Results: Optimised batch of MLZ-NPs were characterised for diameter, PDI, zeta potential and entrapment efficiency which was found to be 145.42 ± 6.75 nm, 0.214 ± 0.049, -31.63 mV and 77.65 ± 2.33(%w/w) respectively. ROS, superoxide and NF-kβ were well controlled in Caco-2 cells when treated with MLZ-NPs. In-vivo data revealed that some parameters (body weight, colon length, lipid peroxidase, and glutathione) recovered significantly in the DSS-induced mice model treated with oral MLZ-NPs-Pellets. Gamma scintigraphy revealed that the formulation can effectively target the colon within 600 min.Conclusion: MLZ-NPs-Pellets can be effectively used for microbial-triggered colon targeting approach in treating ulcerative colitis.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"519-534"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI: 10.1080/02652048.2024.2394884

引用次数: 0

Self-healing microcapsule - a way towards futuristic cement: an-up-to-date-review. 自愈合微胶囊--通往未来水泥之路：最新回顾。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1080/02652048.2024.2386278

Nazia Tarannum, Manvi Singh

引用次数: 0

Microencapsulation of natural products using spray drying; an overview. 利用喷雾干燥技术对天然产品进行微胶囊化；概述。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1080/02652048.2024.2389136

Mahshid Mardani, Saeed Siahtiri, Masoud Besati, Mostafa Baghani, Majid Baniassadi, Alireza Mahdavi Nejad

{"title":"Microencapsulation of natural products using spray drying; an overview.","authors":"Mahshid Mardani, Saeed Siahtiri, Masoud Besati, Mostafa Baghani, Majid Baniassadi, Alireza Mahdavi Nejad","doi":"10.1080/02652048.2024.2389136","DOIUrl":"10.1080/02652048.2024.2389136","url":null,"abstract":"Aims: This study examines microencapsulation as a method to enhance the stability of natural compounds, which typically suffer from inherent instability under environmental conditions, aiming to extend their application in the pharmaceutical industry.Methods: We explore and compare various microencapsulation techniques, including spray drying, freeze drying, and coacervation, with a focus on spray drying due to its noted advantages.Results: The analysis reveals that microencapsulation, especially via spray drying, significantly improves natural compounds' stability, offering varied morphologies, sizes, and efficiencies in encapsulation. These advancements facilitate controlled release, taste modification, protection from degradation, and extended shelf life of pharmaceutical products.Conclusion: Microencapsulation, particularly through spray drying, presents a viable solution to the instability of natural compounds, broadening their application in pharmaceuticals by enhancing protection and shelf life.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"649-678"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of double-loaded bitter ginseng derivative B21-DOX liposomes co-modified with SP94 and BR2 ligand and its in vitro anti-hepatocarcinogenic effect. SP94和BR2配体共同修饰的双载体苦参衍生物B21-DOX脂质体的制备及其体外抗肝癌作用

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1080/02652048.2024.2390955

Lin Jing, Jiajia Zhang, Lili Li, Simei Luo, Zijun Tang, Xu Liu, Yonglong Zhong, Mingqing Yuan

{"title":"Preparation of double-loaded bitter ginseng derivative B21-DOX liposomes co-modified with SP94 and BR2 ligand and its in vitro anti-hepatocarcinogenic effect.","authors":"Lin Jing, Jiajia Zhang, Lili Li, Simei Luo, Zijun Tang, Xu Liu, Yonglong Zhong, Mingqing Yuan","doi":"10.1080/02652048.2024.2390955","DOIUrl":"10.1080/02652048.2024.2390955","url":null,"abstract":"Aim: To construct a novel liposomal drug delivery system co-modified with SP94 and BR2 ligands, encapsulating both the bitter ginseng derivative B21 and doxorubicin (DOX), to achieve superior anti-tumour efficacy and reduced toxic side effects.Methods: Liposomes were prepared using an organic phase reaction method, with B21 encapsulated in the lipid phase and DOX in the aqueous phase. The liposomes were further modified with SP94 and BR2 peptides. The characterisations, cytotoxicity, and in vitro targeting effects were assessed through various methods including ultraviolet spectrophotometry, high-performance liquid chromatography, nano-size analysis, ultrafiltration centrifugation, dialysis, transmission electron microscopy, flow cytometry, Methylthiazolyldiphenyl-tetrazolium bromide assay, confocal laser scanning microscopy, transwell assay, and tumorsphere assay.Results: SP94/BR2-B21/DOX-LP liposomes were spherical with an average diameter of 120.87 ± 1.00 nm, a polydispersity index (PDI) of 0.223 ± 0.006, and a surface charge of -23.1 ± 1.27 mV. The encapsulation efficiencies for B21 and DOX were greater than 85% and 97% (mg/mg), respectively. The results indicated that SP94/BR2-B21/DOX-LP exhibited enhanced targeting and cytotoxicity compared to single-ligand modified and unmodified liposomes, with the combined encapsulation of B21 and DOX showing synergistic anti-hepatocarcinogenic effects.Conclusion: SP94/BR2-B21/DOX-LP liposomes represent a promising targeted drug delivery system for hepatocellular carcinoma, offering improved membrane penetration, enhanced therapeutic efficacy, and reduced systemic toxicity.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"535-546"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders. 姜黄提取物负载壳聚糖微粒治疗胃肠道疾病的潜力。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1080/02652048.2024.2390958

Pimonsri Mittraparp-Arthorn, Suwipa Ungphaiboon, Chutha Takahashi Yupanqui, Sirikan Suwannasin, Chutikan Wijukkul, Niwan Tanmanee, Teerapol Srichana

{"title":"The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders.","authors":"Pimonsri Mittraparp-Arthorn, Suwipa Ungphaiboon, Chutha Takahashi Yupanqui, Sirikan Suwannasin, Chutikan Wijukkul, Niwan Tanmanee, Teerapol Srichana","doi":"10.1080/02652048.2024.2390958","DOIUrl":"10.1080/02652048.2024.2390958","url":null,"abstract":"Aim: To develop turmeric extract-loaded chitosan microparticles for treating gastrointestinal disorders.Methods: The microparticles were prepared using a spray-drying process, optimised the characteristics by biomarker loading, and encapsulation efficiency, and assessed for bioactivities related to gastrointestinal diseases.Results: The optimised microparticles were spherical, with a mean diameter of 2.11 ± 0.34 µm, a SPAN of 4.46 ± 0.68, a zeta potential of +37.6 ± 0.2 mV, loading of 15.7% w/w curcuminoids, 5.4% w/w ar-turmerone, and encapsulation efficiency of 63.26 ± 1.62% w/w curcuminoids and 43.75 ± 1.33% w/w ar-turmerone. Encapsulation of turmeric extract improved release at 6 h by 20 times and mucoadhesion by 3.6 times. The microparticles exhibited high acid-neutralising capacity (1.64 ± 0.34 mEq/g) and inhibited nitric oxide production about twice as effectively as the turmeric extract, while maintaining antioxidant and antibacterial activities.Conclusion: Encapsulation of turmeric extract in chitosan microparticles effectively enhanced therapeutic potential for gastrointestinal disorders.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"547-563"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic enhancement of chlorophenols removal using eco-friendly alginate@montmorillonite hybrid bio-capsules: insights from encapsulation and kinetic release studies. 使用环保型海藻酸盐@蒙脱石混合生物胶囊协同提高氯苯酚的去除率：从封装和动力学释放研究中获得的启示。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1080/02652048.2024.2395968

Kamal Essifi, Mohamed Brahmi, Abdelghani Boussetta, Hassan Charii, Anass Ait Benhamou, Ali El Bachiri, Samira Salhi, Rachid Brahmi, Amine Moubarik, Abdesselam Tahani

{"title":"Synergistic enhancement of chlorophenols removal using eco-friendly alginate@montmorillonite hybrid bio-capsules: insights from encapsulation and kinetic release studies.","authors":"Kamal Essifi, Mohamed Brahmi, Abdelghani Boussetta, Hassan Charii, Anass Ait Benhamou, Ali El Bachiri, Samira Salhi, Rachid Brahmi, Amine Moubarik, Abdesselam Tahani","doi":"10.1080/02652048.2024.2395968","DOIUrl":"10.1080/02652048.2024.2395968","url":null,"abstract":"This study investigates the synergistic effects of alginate@montmorillonite (Alg@Mt) hybrid microcapsules for enhancing water purification, focusing on improving the encapsulation of hydrophobic contaminants. Alg@Mt microcapsules were prepared through ionotropic gelation. Characterisation was performed using SEM-EDX, FTIR, XRD, and TGA. Encapsulation efficiency (EE), loading capacity (LC), and release behaviour were also examined. Alg@Mt microcapsules effectively removed phenol and its chlorinated derivatives from water. Incorporating Na-Mt improved structural and thermal properties, EE, and LC. Increasing the clay content to 60% (w/w) raised the EE of phenol and its more hydrophobic derivative, 2,4,6-trichlorophenol, from 39.74 ± 3.1% (w/w) and 63.91 ± 2% (w/w) to 60.56 ± 1.6% (w/w) and 82.28 ± 2.3% (w/w), respectively, with more controlled release rates, following Fickian diffusion mechanism. EE increased with phenolic substances hydrophobicity, while LC and release rates were inversely related. This approach is promising for removing hydrophobic contaminants from water.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"601-619"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in microneedle technology: current status and next-generation innovations. 微针技术的进步：现状与下一代创新。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-10-30 DOI: 10.1080/02652048.2024.2418613

Siddhant Kumar, Rahul Shukla

{"title":"Advancements in microneedle technology: current status and next-generation innovations.","authors":"Siddhant Kumar, Rahul Shukla","doi":"10.1080/02652048.2024.2418613","DOIUrl":"https://doi.org/10.1080/02652048.2024.2418613","url":null,"abstract":"Microneedle technology is a pivotal component of third-generation transdermal drug delivery systems featuring tiny needles that create temporary microscopic channels in the stratum corneum which facilitate drug penetration in the dermis. This review offers a detailed examination of the current types of microneedles, including solid, coated, dissolving, hollow, and swelling microneedles, along with their preparation techniques as well as their benefits and challenges. Use of 3D printing technology is especially gaining significant attention due to its ability to achieve the high dimensional accuracy required for precise fabrication. Additionally, its customisability presents significant potential for exploring new designs and creating personalised microneedles products. Furthermore, this review explores next generation microneedles, especially stimuli-responsive microneedle, bioinspired microneedle and microneedles combined with other transdermal technology like sonophoresis, electroporation and iontophoresis. Regulatory aspects, characterisation techniques, safety considerations, and cost factors have also been addressed which are crucial for translation from lab to the market.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-22"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of poly(ε-caprolactone) microspheres on population pharmacokinetic/pharmacodynamic model of a simple coumarin. 聚（ε-己内酯）微球对一种简单香豆素的群体药代动力学/药效学模型的影响

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-10-26 DOI: 10.1080/02652048.2024.2418606

Paola A Cárdenas, Izabel Almeida Alves, Bibiana Verlindo De Araujo, Diana Marcela Aragón

{"title":"Effect of poly(ε-caprolactone) microspheres on population pharmacokinetic/pharmacodynamic model of a simple coumarin.","authors":"Paola A Cárdenas, Izabel Almeida Alves, Bibiana Verlindo De Araujo, Diana Marcela Aragón","doi":"10.1080/02652048.2024.2418606","DOIUrl":"https://doi.org/10.1080/02652048.2024.2418606","url":null,"abstract":"This study aims to evaluated the impact of poly(ε-caprolactone) (PCL) microspheres on the pharmacokinetics and pharmacodynamics (PopPK/PD) of 6-methylcoumarin (6MC). For this, PCL microspheres loaded with 6MC were prepared using the emulsification-evaporation method. Particle size, zeta potential, drug loading, and entrapment efficiency were characterised by dynamic light scattering and UV spectrophotometry. In vitro release and pharmacokinetics in Wistar rats were assessed for free and encapsulated 6MC. Anti-inflammatory activity was evaluated using the carrageenan-induced paw edoema model, with PopPK and PopPK/PD models developed. Microspheres showed diameters between 2.9 and 7.1 µm, zeta potentials of -10 to -15 mV, and drug loading of 0.24 mg/mg. Encapsulation efficiency was 45.5% to 75.9%. PopPK models showed enhanced absorption and distribution, with increased anti-inflammatory potency of encapsulated 6MC. PCL microspheres significantly improved the pharmacokinetic and pharmacodynamic profiles of 6MC, enhancing its therapeutic potential for lipophilic drugs.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable polymeric nanocomposite containing phloretin for enhanced oral bioavailability and improved myocardial ischaemic recovery. 生物可降解聚合物纳米复合材料，含有可提高口服生物利用度和改善心肌缺血恢复的酞丁胺。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-10-21 DOI: 10.1080/02652048.2024.2418608

Prasanti Sharma, Trishna Bal, Sandeep Kumar Singh, Neelima Sharma

{"title":"Biodegradable polymeric nanocomposite containing phloretin for enhanced oral bioavailability and improved myocardial ischaemic recovery.","authors":"Prasanti Sharma, Trishna Bal, Sandeep Kumar Singh, Neelima Sharma","doi":"10.1080/02652048.2024.2418608","DOIUrl":"https://doi.org/10.1080/02652048.2024.2418608","url":null,"abstract":"Aim: The study aimed to enhance phloretin's oral absorption and systemic availability through nanoencapsulation within biodegradable polymers, improving its anti-oxidant and cardioprotective potential.Methods: Phloretin-loaded polymeric nanocomposites were prepared using ionic gelation and optimised for yield, encapsulation, loading, particle size, PdI and zeta potential. The formulation was characterised by FTIR, XRD, FESEM and MS. In-vitro drug release, stability, pharmacokinetics, biodistribution, anti-oxidant capacity, haemolysis and both in-vitro and in-vivo assessments were conducted in an ischaemia-induced rat model.Results: The average particle size, zeta potential, encapsulation and drug loading of the optimised nanoparticles were 105.8 ± 1.92 nm, -41.5 ± 1.10 mV, 92.36 ± 0.01% and 18.47 ± 0.38%, respectively. Nano-phloretin enhanced oral bioavailability, anti-oxidant capacity. In-vivo, it reduced myocardial infarct size by ∼46% versus ∼13% for free phloretin, showing significant cardiomyocyte protection and ROS suppression.Conclusion: The study demonstrates polymer-based nanoparticles as effective oral drug delivery systems capable of enhancing both systemic bioavailability and therapeutic efficacy of the encapsulated drug.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-16"},"PeriodicalIF":3.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0