Journal of microencapsulation最新文献_第2页

Development and optimization of quercetin and β-sitosterol co-loaded transethosomes for melanoma skin cancer. 槲皮素和β-谷甾醇共载转运体治疗黑色素瘤皮肤癌的开发与优化。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-08-01 Epub Date: 2026-09-09 DOI: 10.1080/02652048.2026.2708819

Teena Patidar, Suman Ramteke

引用次数: 0

Nano-liposomal encapsulation of isorhamnetin to enhance bioavailability and anticancer efficacy. 纳米脂质体包封异鼠李素提高生物利用度和抗癌功效。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-08-01 Epub Date: 2026-08-22 DOI: 10.1080/02652048.2026.2669802

Forough Parandak, Shahram Pourseyedi, Azadeh Lohrasbi-Nejad, Sara Abedini

引用次数: 0

Microencapsulation of spirulina using spray-drying technique: impact on morphological and structural characteristics. 喷雾干燥技术对螺旋藻微胶囊化：对形态和结构特征的影响。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-08-01 DOI: 10.1080/02652048.2026.2709765

Hema Deupa, Priyanka Shankar, Pankaj Panwar

{"title":"Microencapsulation of spirulina using spray-drying technique: impact on morphological and structural characteristics.","authors":"Hema Deupa, Priyanka Shankar, Pankaj Panwar","doi":"10.1080/02652048.2026.2709765","DOIUrl":"10.1080/02652048.2026.2709765","url":null,"abstract":"Spirulina's valuable properties are often overshadowed by its off-flavour. This study demonstrates that microencapsulation using maltodextrin as wall material effectively addresses these challenges. The encapsulated spirulina (ES1) exhibited good encapsulation efficiency (49.70%) and yield (40.55%), with low wettability (0.08 ± 0.03gmin-1) and hygroscopicity (6.16 ± 0.18%). Significant composition changes were observed in ES1, including total lipids (6.22 ± 0.50g 100 g-1), carbohydrates (51.97 ± 0.75g 100 g-1), moisture (6.42 ± 0.24g 100 g-1), protein (31.59 ± 0.11g 100 g-1), ash (3.78 ± 0.85g 100 g-1) and water activity (0.23 ± 0.01Aw). Phytopigments, such as chlorophyll a (32.02 ± 0.15 mg/g), chlorophyll b (23.12 ± 0.30 mg/g), total carotenoids (3.13 ± 0.00 mg/g), c-phycocyanin (17.78 ± 0.26 mg/g), as well as vitamin B9 (0.5937 ± 0.52 µg/g) and antioxidant activity (25.21 ± 3.29%), were well retained. The microcapsules displayed a mean particle size of 2.18 ± 2.91 µm with a PDI of 0.795 ± 0.03. Morphological and structural analyses (SEM-EDS, FTIR, XRD, UV-Vis) confirmed electrostatic interactions within the wall matrix, promoting amorphization and stability. Overall, spray-drying microencapsulation of spirulina with maltodextrin effectively improved storage stability by lowering water activity.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"409-424"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levofloxacin-encapsulated engineered elastosomes for targeted trans-tympanic delivery: comprehensive evaluation across in vitro, microbiological, ex vivo, and in vivo models. 左氧氟沙星包封工程弹性体靶向跨鼓室递送：跨体外，微生物，离体和体内模型的综合评估。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-08-08 DOI: 10.1080/02652048.2026.2712989

Sadek Ahmed, Ali Fayez, Heba Attia, Doaa Ahmed El-Setouhy

{"title":"Levofloxacin-encapsulated engineered elastosomes for targeted trans-tympanic delivery: comprehensive evaluation across in vitro, microbiological, ex vivo, and in vivo models.","authors":"Sadek Ahmed, Ali Fayez, Heba Attia, Doaa Ahmed El-Setouhy","doi":"10.1080/02652048.2026.2712989","DOIUrl":"10.1080/02652048.2026.2712989","url":null,"abstract":"Aim: This study aimed to develop and optimise Levofloxacin-Encapsulated Engineered Elastosomes (LEEE) as a non-invasive nanocarrier to improve trans-tympanic drug delivery and therapeutic efficacy in acute otitis media (AOM).Methods: LEEE were formulated using cholesterol, surfactant, edge activator, and terpene via thin-film hydration and optimised with a 2³ factorial design. Vesicles were characterised for particle size, zeta potential, entrapment efficiency, rheology, morphology, ex-vivo permeation, confocal laser scanning microscopy, antibacterial activity, biofilm inhibition, and in-vivo histopathology.Results: The optimised LEEE (desirability = 0.980) exhibited a mean particle size of 100.41 ± 3.39 nm, entrapment efficiency of 86.11 ± 3.41%w/w, and zeta potential of -24.75 ± 5.02 mV. Morphology revealed uniform spherical vesicles, and rheological studies confirmed pseudoplastic behaviour. The formulation showed biphasic sustained release, enhanced tympanic membrane penetration, strong antibacterial and anti-biofilm activity, and excellent biocompatibility.Conclusions: LEEE represent a safe and effective non-invasive nanoplatform with potential to enhance drug delivery and therapeutic outcomes in AOM.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"389-408"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic synthesised PEGylated ascorbic acid-conjugated silver nanocarriers effectively downregulate oncogenes in invasive ductal carcinoma cells. 微流控合成聚乙二醇化抗坏血酸共轭银纳米载体有效下调浸润性导管癌细胞的癌基因。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-07-25 DOI: 10.1080/02652048.2026.2704961

Ayesha Aftab, Bashir Ahmad, Shazia Bashir, Qaisar Mansoor, Hafiz Muhammad Jafar Hussain

{"title":"Microfluidic synthesised PEGylated ascorbic acid-conjugated silver nanocarriers effectively downregulate oncogenes in invasive ductal carcinoma cells.","authors":"Ayesha Aftab, Bashir Ahmad, Shazia Bashir, Qaisar Mansoor, Hafiz Muhammad Jafar Hussain","doi":"10.1080/02652048.2026.2704961","DOIUrl":"10.1080/02652048.2026.2704961","url":null,"abstract":"Aim: We aim to formulate highly stabilised nanocarriers for the downregulation of oncogenes in IDC cells.Methods: A microfluidic system was operated for the synthesis of silver-tripolyphosphate nanoparticles (AgTPP-NPs) functionalised with polyethylene-glycol (PEG). They were characterised by UV-Vis spectroscopy, DLS, SEM, FTIR, and EDX. Biological evaluation included DPPH, MTT, clonogenesis, qRT-PCR, and western blot against MCF and MDA-MB-231.Results: AgTPP-NPs remained stable for 24 months, and particle size increased slightly from 78 ± 22nm to 88 ± 18nm over this period. PEGylation resulted in tuned (64 ± 15 nm) PEGylated ascorbic acid-conjugated-AgTPP (PAAT) nanocarriers, which have a significant (p < 0.0001) antioxidant property of 74.4% at 160 µg/mL (IC50=11.3 µg/mL). PAAT nanocarriers exhibited cytotoxicity of 81%. PAAT demonstrated a significant (p < 0.0001) downregulation of MYC and CCNE1 in IDC cells, validated by western blot analysis.Conclusion: Our study highlights the long-term stability of AgTPP-NPs, and PEGylation enhances the efficacy of AgTPP-NPs in terms of cytotoxicity and downregulation of oncogenes in IDC cells.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"425-446"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of yacon (Smallanthus sonchifolius) in encapsulation processes for functional and prebiotic applications: A systematic review and bibliometric analysis. 在功能性和益生元的包封工艺中使用雪莲：系统综述和文献计量学分析。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-07-09 DOI: 10.1080/02652048.2026.2700574

Amanda Fernandes Oliveira De Souza, Leandro Fragoso Lins, Thaynna Leocádio Trajano Lacerda Sousa, Evellyn Mayara Dias Carvalho Da Silva, Maria Taciana Holanda Cavalcanti, Ana Lúcia Figueiredo Porto, Raquel Pedrosa Bezerra

{"title":"Use of yacon (Smallanthus sonchifolius) in encapsulation processes for functional and prebiotic applications: A systematic review and bibliometric analysis.","authors":"Amanda Fernandes Oliveira De Souza, Leandro Fragoso Lins, Thaynna Leocádio Trajano Lacerda Sousa, Evellyn Mayara Dias Carvalho Da Silva, Maria Taciana Holanda Cavalcanti, Ana Lúcia Figueiredo Porto, Raquel Pedrosa Bezerra","doi":"10.1080/02652048.2026.2700574","DOIUrl":"10.1080/02652048.2026.2700574","url":null,"abstract":"This systematic and bibliometric review aims to evaluate the use of yacon in the encapsulation of bioactives and to identify research hotspots in this field over the last 10 years. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Out of an initial pool of 770 articles, only six original studies published in English between 2015 and 2024 were selected. Most of the included studies focused on yacon encapsulated as juice or extract using the spray-drying technique. The encapsulation efficiency reported in these studies ranged from 41.5% to 85.49%, with particle size <100μm. The findings indicated that encapsulation did not compromise the antioxidant activity of the compounds. The bibliometric analysis highlighted keyword co-occurrence and co-authorship networks. This review demonstrated that encapsulation and wall materials effectively preserve bioactive compounds, supporting the potential of encapsulated yacon for prebiotic functional applications.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"491-505"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lurasidone hydrochloride-loaded microparticle-based long-acting injectable: formulation optimisation, characterisation, and payload release kinetics-a proof of concept study. 盐酸鲁拉西酮装载微颗粒的长效注射剂：配方优化，表征和有效载荷释放动力学-概念研究的证明。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-08-13 DOI: 10.1080/02652048.2026.2708740

Gaurav Awasthi, Parth Patel, Keerti Jain

{"title":"Lurasidone hydrochloride-loaded microparticle-based long-acting injectable: formulation optimisation, characterisation, and payload release kinetics-a proof of concept study.","authors":"Gaurav Awasthi, Parth Patel, Keerti Jain","doi":"10.1080/02652048.2026.2708740","DOIUrl":"10.1080/02652048.2026.2708740","url":null,"abstract":"Lurasidone hydrochloride is a promising antipsychotic agent. The currently marketed formulation (Latuda®) of lurasidone hydrochloride exhibits extremely poor bioavailability and requires daily dosing. Current research focuses on the development and optimisation of a lurasidone hydrochloride-loaded poly(lactic-co-glycolic acid) microparticle-based long-acting depot formulation. The optimised batch of microparticles showed 32.81 ± 1.46 µm particle size, 95.74 ± 3.19% an entrapment efficiency, and a drug loading of 27.68 ± 0.95%. The morphological examination showed the buckling effect on the surface of microparticles, resembling the appearance of a golf ball, and DSC revealed amorphisation and successful encapsulation of lurasidone hydrochloride. The in vitro release study was performed for real-time and accelerated conditions, which showed the triphasic drug release pattern and followed the Hixon-Crowell release kinetic model. The real-time study showed 80.26 ± 3.84% drug release within 90 days. Overall, the results of this research work furnished a strong basis for further development of lurasidone hydrochloride microparticle-based long-acting injectables at a large scale.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"373-388"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and properties of fucoxanthin-loaded emulsion gel microspheres. 岩藻黄素乳液凝胶微球的制备及性能研究。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-07-21 DOI: 10.1080/02652048.2026.2703075

Fengjie Xing, Wei Zhang, Yuantao Chen, Guodong Zhang, Xiaochen Wang, Xin Zhou, Dongjie Duan, Xin Zheng, Hao Zhang

{"title":"Preparation and properties of fucoxanthin-loaded emulsion gel microspheres.","authors":"Fengjie Xing, Wei Zhang, Yuantao Chen, Guodong Zhang, Xiaochen Wang, Xin Zhou, Dongjie Duan, Xin Zheng, Hao Zhang","doi":"10.1080/02652048.2026.2703075","DOIUrl":"10.1080/02652048.2026.2703075","url":null,"abstract":"Fucoxanthin, a marine carotenoid, suffers from poor stability under light and heat, limiting its use in functional foods. To address this, we developed a multilayer emulsion-based gel microsphere system for enhanced protection and controlled intestinal delivery. Microspheres were fabricated using whey protein, corn oil with 5% fucoxanthin, and chitosan-sodium alginate shells, followed by Ca2+ cross-linking. Using Box-Behnken design, optimal conditions were determined: whey protein 2.3%, oil/water ratio 4:16, chitosan 2.0%, alginate 2.6%, and Ca2+ 4%, achieving 77.37% encapsulation efficiency. The system achieved targeted release: only 38.9% fucoxanthin was released during 12-h simulated intestinal digestion, versus 13.25% passive degradation of free fucoxanthin. Microspheres also improved photostability (73.89% vs. 46.55% retention) and preserved antioxidant activity (75.84% scavenging retention). These findings demonstrate that the multilayer microsphere system effectively overcomes fucoxanthin's stability limitations, offering a platform for site-specific delivery of hydrophobic bioactives.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"447-459"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical review of microencapsulation methods, mechanisms, and applications. 对微胶囊化方法、机制和应用的综述。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-06-01 Epub Date: 2026-08-14 DOI: 10.1080/02652048.2026.2712984

Zarnab Gul, Daiva Milašienė

{"title":"A critical review of microencapsulation methods, mechanisms, and applications.","authors":"Zarnab Gul, Daiva Milašienė","doi":"10.1080/02652048.2026.2712984","DOIUrl":"10.1080/02652048.2026.2712984","url":null,"abstract":"Across industries, the demand for high-performance and environmentally responsible products is reshaping the design of functional materials. Microencapsulation, a technique that entrains active agents within microscopic shells, has emerged as an effective strategy to protect, stabilise, and control the release of sensitive compounds. Initially developed for specialised applications, it is now widely used in pharmaceuticals, food technology, cosmetics, agriculture, textiles, and advanced materials. This review presents an overview of microencapsulation technologies, covering core-shell structures, material selection, and major fabrication methods such as coacervation, solvent evaporation, spray drying, layer-by-layer assembly, and co-extrusion. The influence of processing conditions, capsule morphology, and release mechanisms on encapsulation efficiency and performance is critically discussed. In addition, current challenges including durability, scalability, and environmental concerns are highlighted. The review also outlines emerging research directions, particularly the development of biodegradable polymers, solvent-free processes, and stimuli-responsive systems for sustainable and advanced functional applications.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"460-490"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rationally engineered essential oil-loaded nanocarriers for acne vulgaris: integrating multiscale molecular modeling, machine learning, and response surface optimization. 合理设计精油负载纳米载体治疗寻常痤疮：整合多尺度分子建模、机器学习和响应面优化。

IF 3.1 4区医学

Journal of microencapsulation Pub Date : 2026-05-01 Epub Date: 2026-07-03 DOI: 10.1080/02652048.2026.2695092

Wajid Zaman, Niamat Ullah, Adnan Amin

{"title":"Rationally engineered essential oil-loaded nanocarriers for acne vulgaris: integrating multiscale molecular modeling, machine learning, and response surface optimization.","authors":"Wajid Zaman, Niamat Ullah, Adnan Amin","doi":"10.1080/02652048.2026.2695092","DOIUrl":"10.1080/02652048.2026.2695092","url":null,"abstract":"Background: Acne vulgaris is a prevalent inflammatory dermatosis in which Cutibacterium acnes, Staphylococcus epidermidis, and, to a lesser extent, Staphylococcus aureus play central pathogenic roles. Conventional therapies (retinoids, antibiotics, corticosteroids) are limited by resistance, irritation, and suboptimal long-term efficacy.Objective and methodology: Essential oils (EOs) exhibit diverse biological activities, yet their clinical translation is constrained by volatility, physicochemical instability and poor follicular penetration. This review systematically examines EO-loaded nano-delivery systems including nanogels, liposomes, solid lipid nanoparticles and nanostructured lipid carriers as strategies to enhance overall release. Special emphasis is placed on multiscale in silico tools and statistical optimisation approaches for rational formulation engineering. Representative case studies and current insights into nano-toxicity and safety assessment are critically appraised to guide future clinical translation.Conclusion: Advancing priorities including personalised dermatology frameworks, microbiome-responsive, folliculotropic EO nanocarriers and integrated computational approaches will accelerate the development of scalable, and patient-centered EO based nanoformulations for acne.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"282-313"},"PeriodicalIF":3.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0