Journal of microencapsulation最新文献_第3页

Leflunomide nanocarriers: a new prospect of therapeutic applications. 来氟米特纳米载体：治疗应用的新前景。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI: 10.1080/02652048.2024.2407373

Mariam Zewail

引用次数: 0

Nano-emulsion based on Santolina chamaecyparissus essential oil potentiates the cytotoxic and apoptotic effects of Doxorubicin: an in vitro study. 基于山苍子精油的纳米乳液可增强多柔比星的细胞毒性和凋亡效应：一项体外研究。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.1080/02652048.2024.2386287

Sahar M AlMotwaa, Waad A Al-Otaibi

{"title":"Nano-emulsion based on Santolina chamaecyparissus essential oil potentiates the cytotoxic and apoptotic effects of Doxorubicin: an in vitro study.","authors":"Sahar M AlMotwaa, Waad A Al-Otaibi","doi":"10.1080/02652048.2024.2386287","DOIUrl":"10.1080/02652048.2024.2386287","url":null,"abstract":"Aim: This study was aimed at investigating the cytotoxic effect of a novel combination of doxorubicin (DOX) and nano-formulation of Santolina chamaecyparissus L. essential oil (SCEO-NANO) on hepatic (HepG2) and colon (HT29) cancer cell lines.Methods: A nano-emulsion was prepared by high-pressure homogenisation, then analysed by zetasizer and Fourier transform infrared spectroscopy. HepG2 and HT29 cells were used in in vitro tests for apoptosis detection.Results: Formulated droplet size increased in DOX@SCEO-NANO/DOX to 11.54 ± 0.02 with uniform distribution (PDI = 0.13 ± 0.01), when compared with SCEO-NANO (size: 8.91 ± 0.02 nm; PDI = 0.1 ± 0.02). In both cells, DOX@SCEO-NANO/DOX led to a considerable reduction in colony formation. Compared to DOX, apoprotein proteins were overexpressed in HepG2 cells, showing increases of 8.66-fold for caspase-3 and 4.24-fold for the Bax/Bcl-2 ratio. In HT29 cells, ROS-dependent necrosis and apoptosis were seen. Comparing DOX@SCEO-NANO/DOX versus DOX, greater levels of caspase-3 and the Bax/Bcl-2 ratio were observed.Conclusion: The DOX@SCEO-NANO/DOX formulation showed potential for targeted eradication of colon adenocarcinoma and hepatocellular carcinoma cells.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"503-518"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The assessment of pharmacokinetics and neuroprotective effect of berberine hydrochloride-embedded albumin nanoparticles via various administration routes: comparative in-vivo studies in rats. 通过不同给药途径评估盐酸小檗碱嵌入白蛋白纳米颗粒的药代动力学和神经保护作用：大鼠体内对比研究。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1080/02652048.2024.2395976

Hany G Attia, Maha E Elmataeeshy, Mohamed Aleraky, Samar R Saleh, Doaa A Ghareeb, Maha A El Demellawy, Hanan M El-Nahas, Tarek M Ibrahim

{"title":"The assessment of pharmacokinetics and neuroprotective effect of berberine hydrochloride-embedded albumin nanoparticles via various administration routes: comparative in-vivo studies in rats.","authors":"Hany G Attia, Maha E Elmataeeshy, Mohamed Aleraky, Samar R Saleh, Doaa A Ghareeb, Maha A El Demellawy, Hanan M El-Nahas, Tarek M Ibrahim","doi":"10.1080/02652048.2024.2395976","DOIUrl":"10.1080/02652048.2024.2395976","url":null,"abstract":"The current study aimed to evaluate the pharmacokinetics and neuroprotective effect of well-characterised berberine-bovine serum albumin (BBR-BSA) nanoparticles. BBR-BSA nanoparticles were generated by desolvation method. Entrapment efficiency, loading capacity, particle size, polydispersity index, surface morphology, thermal stability, and in-vitro release were estimated. In-vitro pharmacokinetic and tissue distribution were conducted. Their neuroprotection was evaluated against lipopolysaccharides-induced neurodegeneration. BBR-BSA nanoparticles showed satisfactory particle size (202.60 ± 1.20 nm) and entrapment efficiency (57.00 ± 1.56%). Results confirmed the formation of spheroid-thermal stable nanoparticles with a sustained drug release over 48 h. Sublingual and intranasal routes had higher pharmacokinetic plasma profiles than other routes, with Cmax values at 0.75 h (444 ± 77.79 and 259 ± 42.41 ng/mL, respectively). BBR and its metabolite distribution in the liver and kidney were higher than in plasma. Intranasal and sublingual treatment improves antioxidants, proinflammatory, amyloidogenic biomarkers, and brain architecture, protecting the brain. In conclusion, neuroinflammation and neurodegeneration may be prevented by intranasal and sublingual BBR-BSA nanoparticles.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"576-600"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles encapsulated in Abelmoschus esculentus polysaccharide-based pellets as colon targeting approach. 包裹在阿贝摩斯多糖颗粒中的纳米粒子作为结肠靶向方法。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.1080/02652048.2024.2390951

Akshita Arora, Anshul Sharma, Shamsher Singh, Rajveer Singh, Amrinder Singh, Dipti Kakkar, Nitin Sharma

{"title":"Nanoparticles encapsulated in Abelmoschus esculentus polysaccharide-based pellets as colon targeting approach.","authors":"Akshita Arora, Anshul Sharma, Shamsher Singh, Rajveer Singh, Amrinder Singh, Dipti Kakkar, Nitin Sharma","doi":"10.1080/02652048.2024.2390951","DOIUrl":"10.1080/02652048.2024.2390951","url":null,"abstract":"Aim(s): This article explores the application of mesalazine-loaded nanoparticles (MLZ-NPs) encapsulated in Abelmoschus esculentus plant polysaccharide-based pellets (MLZ-NPs-Pellets) for ulcerative colitis.Methods: MLZ-NPs were prepared and evaluated for diameter, PDI, and entrapment efficiency. In-vitro efficacy study was conducted on Caco-2 cells. MLZ-NPs were encapsulated in polysaccharides to form MLZ-NPs-Pellets and characterised for efficacy in animals and targeting efficiency in human volunteers.Results: Optimised batch of MLZ-NPs were characterised for diameter, PDI, zeta potential and entrapment efficiency which was found to be 145.42 ± 6.75 nm, 0.214 ± 0.049, -31.63 mV and 77.65 ± 2.33(%w/w) respectively. ROS, superoxide and NF-kβ were well controlled in Caco-2 cells when treated with MLZ-NPs. In-vivo data revealed that some parameters (body weight, colon length, lipid peroxidase, and glutathione) recovered significantly in the DSS-induced mice model treated with oral MLZ-NPs-Pellets. Gamma scintigraphy revealed that the formulation can effectively target the colon within 600 min.Conclusion: MLZ-NPs-Pellets can be effectively used for microbial-triggered colon targeting approach in treating ulcerative colitis.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"519-534"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI: 10.1080/02652048.2024.2394884

引用次数: 0

Self-healing microcapsule - a way towards futuristic cement: an-up-to-date-review. 自愈合微胶囊--通往未来水泥之路：最新回顾。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1080/02652048.2024.2386278

Nazia Tarannum, Manvi Singh

引用次数: 0

Microencapsulation of natural products using spray drying; an overview. 利用喷雾干燥技术对天然产品进行微胶囊化；概述。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1080/02652048.2024.2389136

Mahshid Mardani, Saeed Siahtiri, Masoud Besati, Mostafa Baghani, Majid Baniassadi, Alireza Mahdavi Nejad

{"title":"Microencapsulation of natural products using spray drying; an overview.","authors":"Mahshid Mardani, Saeed Siahtiri, Masoud Besati, Mostafa Baghani, Majid Baniassadi, Alireza Mahdavi Nejad","doi":"10.1080/02652048.2024.2389136","DOIUrl":"10.1080/02652048.2024.2389136","url":null,"abstract":"Aims: This study examines microencapsulation as a method to enhance the stability of natural compounds, which typically suffer from inherent instability under environmental conditions, aiming to extend their application in the pharmaceutical industry.Methods: We explore and compare various microencapsulation techniques, including spray drying, freeze drying, and coacervation, with a focus on spray drying due to its noted advantages.Results: The analysis reveals that microencapsulation, especially via spray drying, significantly improves natural compounds' stability, offering varied morphologies, sizes, and efficiencies in encapsulation. These advancements facilitate controlled release, taste modification, protection from degradation, and extended shelf life of pharmaceutical products.Conclusion: Microencapsulation, particularly through spray drying, presents a viable solution to the instability of natural compounds, broadening their application in pharmaceuticals by enhancing protection and shelf life.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"649-678"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of double-loaded bitter ginseng derivative B21-DOX liposomes co-modified with SP94 and BR2 ligand and its in vitro anti-hepatocarcinogenic effect. SP94和BR2配体共同修饰的双载体苦参衍生物B21-DOX脂质体的制备及其体外抗肝癌作用

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1080/02652048.2024.2390955

Lin Jing, Jiajia Zhang, Lili Li, Simei Luo, Zijun Tang, Xu Liu, Yonglong Zhong, Mingqing Yuan

{"title":"Preparation of double-loaded bitter ginseng derivative B21-DOX liposomes co-modified with SP94 and BR2 ligand and its in vitro anti-hepatocarcinogenic effect.","authors":"Lin Jing, Jiajia Zhang, Lili Li, Simei Luo, Zijun Tang, Xu Liu, Yonglong Zhong, Mingqing Yuan","doi":"10.1080/02652048.2024.2390955","DOIUrl":"10.1080/02652048.2024.2390955","url":null,"abstract":"Aim: To construct a novel liposomal drug delivery system co-modified with SP94 and BR2 ligands, encapsulating both the bitter ginseng derivative B21 and doxorubicin (DOX), to achieve superior anti-tumour efficacy and reduced toxic side effects.Methods: Liposomes were prepared using an organic phase reaction method, with B21 encapsulated in the lipid phase and DOX in the aqueous phase. The liposomes were further modified with SP94 and BR2 peptides. The characterisations, cytotoxicity, and in vitro targeting effects were assessed through various methods including ultraviolet spectrophotometry, high-performance liquid chromatography, nano-size analysis, ultrafiltration centrifugation, dialysis, transmission electron microscopy, flow cytometry, Methylthiazolyldiphenyl-tetrazolium bromide assay, confocal laser scanning microscopy, transwell assay, and tumorsphere assay.Results: SP94/BR2-B21/DOX-LP liposomes were spherical with an average diameter of 120.87 ± 1.00 nm, a polydispersity index (PDI) of 0.223 ± 0.006, and a surface charge of -23.1 ± 1.27 mV. The encapsulation efficiencies for B21 and DOX were greater than 85% and 97% (mg/mg), respectively. The results indicated that SP94/BR2-B21/DOX-LP exhibited enhanced targeting and cytotoxicity compared to single-ligand modified and unmodified liposomes, with the combined encapsulation of B21 and DOX showing synergistic anti-hepatocarcinogenic effects.Conclusion: SP94/BR2-B21/DOX-LP liposomes represent a promising targeted drug delivery system for hepatocellular carcinoma, offering improved membrane penetration, enhanced therapeutic efficacy, and reduced systemic toxicity.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"535-546"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders. 姜黄提取物负载壳聚糖微粒治疗胃肠道疾病的潜力。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1080/02652048.2024.2390958

Pimonsri Mittraparp-Arthorn, Suwipa Ungphaiboon, Chutha Takahashi Yupanqui, Sirikan Suwannasin, Chutikan Wijukkul, Niwan Tanmanee, Teerapol Srichana

{"title":"The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders.","authors":"Pimonsri Mittraparp-Arthorn, Suwipa Ungphaiboon, Chutha Takahashi Yupanqui, Sirikan Suwannasin, Chutikan Wijukkul, Niwan Tanmanee, Teerapol Srichana","doi":"10.1080/02652048.2024.2390958","DOIUrl":"10.1080/02652048.2024.2390958","url":null,"abstract":"Aim: To develop turmeric extract-loaded chitosan microparticles for treating gastrointestinal disorders.Methods: The microparticles were prepared using a spray-drying process, optimised the characteristics by biomarker loading, and encapsulation efficiency, and assessed for bioactivities related to gastrointestinal diseases.Results: The optimised microparticles were spherical, with a mean diameter of 2.11 ± 0.34 µm, a SPAN of 4.46 ± 0.68, a zeta potential of +37.6 ± 0.2 mV, loading of 15.7% w/w curcuminoids, 5.4% w/w ar-turmerone, and encapsulation efficiency of 63.26 ± 1.62% w/w curcuminoids and 43.75 ± 1.33% w/w ar-turmerone. Encapsulation of turmeric extract improved release at 6 h by 20 times and mucoadhesion by 3.6 times. The microparticles exhibited high acid-neutralising capacity (1.64 ± 0.34 mEq/g) and inhibited nitric oxide production about twice as effectively as the turmeric extract, while maintaining antioxidant and antibacterial activities.Conclusion: Encapsulation of turmeric extract in chitosan microparticles effectively enhanced therapeutic potential for gastrointestinal disorders.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"547-563"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic enhancement of chlorophenols removal using eco-friendly alginate@montmorillonite hybrid bio-capsules: insights from encapsulation and kinetic release studies. 使用环保型海藻酸盐@蒙脱石混合生物胶囊协同提高氯苯酚的去除率：从封装和动力学释放研究中获得的启示。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1080/02652048.2024.2395968

Kamal Essifi, Mohamed Brahmi, Abdelghani Boussetta, Hassan Charii, Anass Ait Benhamou, Ali El Bachiri, Samira Salhi, Rachid Brahmi, Amine Moubarik, Abdesselam Tahani

{"title":"Synergistic enhancement of chlorophenols removal using eco-friendly alginate@montmorillonite hybrid bio-capsules: insights from encapsulation and kinetic release studies.","authors":"Kamal Essifi, Mohamed Brahmi, Abdelghani Boussetta, Hassan Charii, Anass Ait Benhamou, Ali El Bachiri, Samira Salhi, Rachid Brahmi, Amine Moubarik, Abdesselam Tahani","doi":"10.1080/02652048.2024.2395968","DOIUrl":"10.1080/02652048.2024.2395968","url":null,"abstract":"This study investigates the synergistic effects of alginate@montmorillonite (Alg@Mt) hybrid microcapsules for enhancing water purification, focusing on improving the encapsulation of hydrophobic contaminants. Alg@Mt microcapsules were prepared through ionotropic gelation. Characterisation was performed using SEM-EDX, FTIR, XRD, and TGA. Encapsulation efficiency (EE), loading capacity (LC), and release behaviour were also examined. Alg@Mt microcapsules effectively removed phenol and its chlorinated derivatives from water. Incorporating Na-Mt improved structural and thermal properties, EE, and LC. Increasing the clay content to 60% (w/w) raised the EE of phenol and its more hydrophobic derivative, 2,4,6-trichlorophenol, from 39.74 ± 3.1% (w/w) and 63.91 ± 2% (w/w) to 60.56 ± 1.6% (w/w) and 82.28 ± 2.3% (w/w), respectively, with more controlled release rates, following Fickian diffusion mechanism. EE increased with phenolic substances hydrophobicity, while LC and release rates were inversely related. This approach is promising for removing hydrophobic contaminants from water.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"601-619"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0