Journal of microencapsulation最新文献_第3页

Leflunomide nanocarriers: a new prospect of therapeutic applications. 来氟米特纳米载体：治疗应用的新前景。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-09-25 DOI: 10.1080/02652048.2024.2407373

Mariam Zewail

引用次数: 0

A comprehensive review on lipid-based nanoparticles via nose to brain targeting as a novel approach 通过鼻脑靶向这一新型方法全面评述脂基纳米粒子

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-09-17 DOI: 10.1080/02652048.2024.2404414

Huma Hameed, Saleha Faheem, Komel Younas, Muhammad Jamshaid, Nelofer Ereej, Anam Hameed, Rabia Munir, Rabia Khokhar

引用次数: 0

Interactions of human serum albumin with phosphate and Tris buffers: impact on paclitaxel binding and nanoparticles self-assembly 人血清白蛋白与磷酸盐和特里斯缓冲液的相互作用：对紫杉醇结合和纳米颗粒自组装的影响

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-09-13 DOI: 10.1080/02652048.2024.2389135

A. H. Gonzalez-Posada, M. Mesa, L. Sierra, B. Lopez

引用次数: 0

Liposomes like advanced drug carriers: from fundamentals to pharmaceutical applications. 先进药物载体脂质体：从基本原理到制药应用。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1080/02652048.2024.2376116

Huma Hameed, Mahtab Ahmad Khan, Ana Cláudia Paiva-Santos, Saleha Faheem, Aleena Khalid, Muhammad Sohaib Majid, Aiman Adnan, Fizza Rana

{"title":"Liposomes like advanced drug carriers: from fundamentals to pharmaceutical applications.","authors":"Huma Hameed, Mahtab Ahmad Khan, Ana Cláudia Paiva-Santos, Saleha Faheem, Aleena Khalid, Muhammad Sohaib Majid, Aiman Adnan, Fizza Rana","doi":"10.1080/02652048.2024.2376116","DOIUrl":"10.1080/02652048.2024.2376116","url":null,"abstract":"Aims: There are around 24 distinct lipid vesicles described in the literature that are similar to vesicular systems such as liposomes. Liposome-like structures are formed by combining certain amphiphilic lipids with a suitable stabiliser. Since their discovery and classification, self-assembled liposome-like structures as active drug delivery vehicles captured researchers' curiosity.Methodology: This comprehensive study included an in-depth literature search using electronic databases such as PubMed, ScienceDirect and Google Scholar, focusing on studies on liposome and liposomes like structure, discussed in literature till 2024, their sizes, benefits, drawback, method of preparation, characterisation and pharmaceutical applications.Results: Pharmacosomes, cubosomes, ethosomes, transethosomes, and genosomes, all liposome-like structures, have the most potential due to their smaller size with high loading capacity, ease of absorption, and ability to treat inflammatory illnesses. Genosomes are futuristic because of its affinity for DNA/gene transport, which is an area of focus in today's treatments.Conclusion: This review will critically analyse the composition, preparation procedures, drug encapsulating technologies, drug loading, release mechanism, and related applications of all liposome-like structures, highlighting their potential benefits with enhanced efficacy over each other and over traditional carriers by paving the way for exploring novel drug delivery systems in the Pharma industry.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"456-478"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of Aloe vera-coated curcumin encapsulated nanoparticles in an Alzheimer-induced mice model: behavioural, biochemical and histopathological evidence. 芦荟包裹的姜黄素封装纳米粒子在阿尔茨海默氏症诱导小鼠模型中的治疗潜力：行为、生化和组织病理学证据。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI: 10.1080/02652048.2024.2373715

Preeti Sharma, Pooja Kumari, Mansi Sharma, Rekha Sharma, Ajita Paliwal, Shriyansh Srivastava, Sumel Ashique, Mithun Bhowmick, Mohd Adnan, Reyaz Hassan Mir

{"title":"Therapeutic potential of Aloe vera-coated curcumin encapsulated nanoparticles in an Alzheimer-induced mice model: behavioural, biochemical and histopathological evidence.","authors":"Preeti Sharma, Pooja Kumari, Mansi Sharma, Rekha Sharma, Ajita Paliwal, Shriyansh Srivastava, Sumel Ashique, Mithun Bhowmick, Mohd Adnan, Reyaz Hassan Mir","doi":"10.1080/02652048.2024.2373715","DOIUrl":"10.1080/02652048.2024.2373715","url":null,"abstract":"Objective: The main purpose of the present study was to evaluate the therapeutic efficacy of Aloe vera-coated curcumin encapsulated nanoparticles in mitigating Alzheimer's disease progression in mice, by examining behavioural changes, biochemical markers, and histopathological alterations, thus elucidating its potential as a treatment strategy.Methods: The green synthesis method was used to synthesise this nanoformulation, which was then characterised using a variety of techniques, including percentage encapsulation efficacy, UV-visible spectroscopy, DLS, FT-IR, FESEM, and EDX. Several in-vivo assessments, including behavioural evaluations, dose optimisation studies, oxidative stress marker estimation, and histological studies, were conducted to determine the potential therapeutic impact of nanoformulation on the Alzheimer-induced mice model.Results: The synthesised nanoparticles show a mean diameter of 76.12 nm ±1.23, a PDI of 0.313 ± 0.02, a zeta potential of 6.27 ± 0.65 mV, and the percentage encapsulation efficiency between 90% and 95% indicating good stability of synthesised nanoformulation. With the help of Morris water maze, Y-maze, and novel object recognition assay, the learning capacity and memory were assessed, and the results show that the synthesised nanoformulation significantly decreased the transfer latency to reach baited arm or to the hidden platform within 7 days.Conclusion: The formulation demonstrated significant biochemical benefits and remarkable cognitive advantages, establishing it as a prospective therapeutic intervention option that is both safe and effective.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"403-418"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-targeting liposomes modified with BTP-7 and pHA for combined delivery of TCPP and TMZ to enhance the anti-tumour effect in glioblastoma cells. 用 BTP-7 和 pHA 修饰的双靶向脂质体联合递送 TCPP 和 TMZ，以增强对胶质母细胞瘤细胞的抗肿瘤作用。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1080/02652048.2024.2376114

Lili Li, Lin Jing, Zijun Tang, Jingguo Du, Yonglong Zhong, Xu Liu, Mingqing Yuan

{"title":"Dual-targeting liposomes modified with BTP-7 and pHA for combined delivery of TCPP and TMZ to enhance the anti-tumour effect in glioblastoma cells.","authors":"Lili Li, Lin Jing, Zijun Tang, Jingguo Du, Yonglong Zhong, Xu Liu, Mingqing Yuan","doi":"10.1080/02652048.2024.2376114","DOIUrl":"10.1080/02652048.2024.2376114","url":null,"abstract":"Aim: To construct a novel nano-carrier with dual ligands to achieve superior anti-tumour efficacy and lower toxic side effects.Methods: Liposomes were prepared by thin film hydration method. Ultraviolet, high performance liquid chromatography, nano-size analyser, ultrafiltration centrifugation, dialysis, transmission electron microscope, flow cytometry, Cell Counting Kit-8, confocal laser scanning microscopy, transwell, and tumorsphere assay were used to study the characterisations, cytotoxicity, and in vitro targeting of dg-Bcan targeting peptide (BTP-7)/pHA-temozolomide (TMZ)/tetra(4-carboxyphenyl)porphyrin (TCPP)-Lip.Results: BTP-7/pHA-TMZ/TCPP-Lip was a spheroid with a mean diameters of 143 ± 3.214 nm, a polydispersity index of 0.203 ± 0.025 and a surface charge of -22.8 ± 0.425 mV. The drug loadings (TMZ and TCPP) are 7.40 ± 0.23% and 2.05 ± 0.03% (mg/mg); and the encapsulation efficiencies are 81.43 ± 0.51% and 84.28 ± 1.64% (mg/mg). The results showed that BTP-7/pHA-TMZ/TCPP-Lip presented enhanced targeting and cytotoxicity.Conclusion: BTP-7/pHA-TMZ/TCPP-Lip can specifically target the tumour cells to achieve efficient drug delivery, and improve the anti-tumour efficacy and reduces the systemic toxicity.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"419-433"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancements in microspheres mediated targeted delivery for therapeutic interventions in osteoarthritis. 以微球为介质的骨关节炎靶向给药疗法的最新进展。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-09-01 Epub Date: 2024-07-05 DOI: 10.1080/02652048.2024.2373723

Ayush Rohila, Rahul Shukla

引用次数: 0

Droplet-based microfluidics: an efficient high-throughput portable system for cell encapsulation. 基于液滴的微流控技术：一种高效的高通量便携式细胞封装系统。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-09-01 Epub Date: 2024-07-30 DOI: 10.1080/02652048.2024.2382744

Hengameh Dortaj, Ali Mohammad Amani, Lobat Tayebi, Negar Azarpira, Mahtab Ghasemi Toudeshkchouei, Ashraf Hassanpour-Dehnavi, Neda Karami, Milad Abbasi, Atefeh Najafian-Najafabadi, Zeinab Zarei Behjani, Ahmad Vaez

{"title":"Droplet-based microfluidics: an efficient high-throughput portable system for cell encapsulation.","authors":"Hengameh Dortaj, Ali Mohammad Amani, Lobat Tayebi, Negar Azarpira, Mahtab Ghasemi Toudeshkchouei, Ashraf Hassanpour-Dehnavi, Neda Karami, Milad Abbasi, Atefeh Najafian-Najafabadi, Zeinab Zarei Behjani, Ahmad Vaez","doi":"10.1080/02652048.2024.2382744","DOIUrl":"10.1080/02652048.2024.2382744","url":null,"abstract":"One of the goals of tissue engineering and regenerative medicine is restoring primary living tissue function by manufacturing a 3D microenvironment. One of the main challenges is protecting implanted non-autologous cells or tissues from the host immune system. Cell encapsulation has emerged as a promising technique for this purpose. It involves entrapping cells in biocompatible and semi-permeable microcarriers made from natural or synthetic polymers that regulate the release of cellular secretions. In recent years, droplet-based microfluidic systems have emerged as powerful tools for cell encapsulation in tissue engineering and regenerative medicine. These systems offer precise control over droplet size, composition, and functionality, allowing for creating of microenvironments that closely mimic native tissue. Droplet-based microfluidic systems have extensive applications in biotechnology, medical diagnosis, and drug discovery. This review summarises the recent developments in droplet-based microfluidic systems and cell encapsulation techniques, as well as their applications, advantages, and challenges in biology and medicine. The integration of these technologies has the potential to revolutionise tissue engineering and regenerative medicine by providing a precise and controlled microenvironment for cell growth and differentiation. By overcoming the immune system's challenges and enabling the release of cellular secretions, these technologies hold great promise for the future of regenerative medicine.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"479-501"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sweet tea extract encapsulated by different wall material combinations with improved physicochemical properties and bioactivity stability. 不同壁材组合封装的甜茶提取物具有更好的理化特性和生物活性稳定性。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI: 10.1080/02652048.2024.2357779

Qingyue Deng, Lishu Han, Chengjiang Tang, Yue Ma, Shuibing Lao, Douyong Min, Xiaoling Liu, Hongrui Jiang

{"title":"Sweet tea extract encapsulated by different wall material combinations with improved physicochemical properties and bioactivity stability.","authors":"Qingyue Deng, Lishu Han, Chengjiang Tang, Yue Ma, Shuibing Lao, Douyong Min, Xiaoling Liu, Hongrui Jiang","doi":"10.1080/02652048.2024.2357779","DOIUrl":"10.1080/02652048.2024.2357779","url":null,"abstract":"Aim: To prepare sweet tea extract microcapsules (STEMs) via a spray-drying by applying different wall material formulations with maltodextrin (MD), inulin (IN), and gum arabic (GA). Methods: The microcapsules were characterised by yield, encapsulation efficiency (EE), particle size, sensory evaluation, morphology, attenuated total reflectance-Fourier transform infra-red spectroscopy and in vitro digestion studies. Results: The encapsulation improved the physicochemical properties and bioactivity stability of sweet tea extract (STE). MD5IN5 had the highest yield (56.33 ± 0.06% w/w) and the best EE (e.g. 88.84 ± 0.36% w/w of total flavonoids). MD9GA1 obtained the smallest particle size (642.13 ± 4.12 nm). MD9GA1 exhibited the highest retention of bioactive components, inhibition of α-glucosidase (96.85 ± 0.55%), α-amylase (57.58 ± 0.99%), angiotensin-converting enzyme (56.88 ± 2.20%), and the best antioxidant activity during in vitro gastrointestinal digestion. Conclusion: The encapsulation of STE can be an appropriate way for the valorisation of STE with improved properties.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"360-374"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encapsulation of Alpinia leaf essential oil in nanophytosome-embedded gel as novel strategy to treat periodontal infections: evaluation of antimicrobial effectiveness, pharmacokinetic, in vitro-ex vivo correlation and in silico studies. 将阿尔卑斯叶精油封装在纳米叶绿体嵌入凝胶中作为治疗牙周感染的新策略：抗菌效果评估、药代动力学、体内外相关性和硅学研究。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI: 10.1080/02652048.2024.2354234

Bhabani Sankar Satapathy, Abhishek Mishra, Sangram Keshari Biswal, Snigdha Pattnaik, Reena Parida, Biswabhusan Biswal, Tapan Kumar Shaw

{"title":"Encapsulation of Alpinia leaf essential oil in nanophytosome-embedded gel as novel strategy to treat periodontal infections: evaluation of antimicrobial effectiveness, pharmacokinetic, in vitro-ex vivo correlation and in silico studies.","authors":"Bhabani Sankar Satapathy, Abhishek Mishra, Sangram Keshari Biswal, Snigdha Pattnaik, Reena Parida, Biswabhusan Biswal, Tapan Kumar Shaw","doi":"10.1080/02652048.2024.2354234","DOIUrl":"10.1080/02652048.2024.2354234","url":null,"abstract":"Aim: The work reports a novel nanophytosomal gel encapsulating Alpinia galanga (L.) Willd leaf essential oil to treat periodontal infections.Methods: Alpinia oil-loaded nanophytosomes (ANPs) were formulated by lipid layer hydration technique and were evaluated by FESEM, cryo-TEM, loading efficiency, zeta potential, particle size, release profile etc. Selected ANPs-loaded gel (ANPsG) was evaluated by both in vitro and in vivo methods.Results: Selected ANPs were spherical, unilamellar, 49.32 ± 2.1 nm size, 0.45 PDI, -46.7 ± 0.8 mV zeta potential, 9.8 ± 0.5% (w/w) loading, 86.4 ± 3.02% (w/w) loading efficiency with sustained release profile. ANPsG showed good spreadability (6.8 ± 0.3 gm.cm/sec), extrudability (79.33 ± 1.5%), viscosity (36522 ± 0.82 cps), mucoadhesive strength (44.56 ± 3.5 gf) with sustained ex vivo release tendency. Satisfied ZOI and MIC was observed for ANPsG against periodontal bacteria vs. standard/control. ANPsG efficiently treated infection in ligature induced periodontitis model. Key pharmacokinetic parameters like AUC, MRT, Vd were enhanced for ANPsG.Conclusion: ANPsG may be investigated for futuristic clinical studies.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"327-344"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0