Journal of microencapsulation最新文献_第4页

Encapsulation of anti-VEGF nanobody into niosome nanoparticles: a novel approach to enhance circulation half life and efficacy. 将抗vegf纳米体包封到纳米粒中：一种提高循环半衰期和疗效的新方法。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1080/02652048.2024.2443435

Mohsen Chiani, Raha Abedini, Reza Ahangari-Cohan, Mahdi Behdani, Seyed Mahmoud Barzi, Nastaran Mohseni, Fatemeh Kazemi-Lomedasht

{"title":"Encapsulation of anti-VEGF nanobody into niosome nanoparticles: a novel approach to enhance circulation half life and efficacy.","authors":"Mohsen Chiani, Raha Abedini, Reza Ahangari-Cohan, Mahdi Behdani, Seyed Mahmoud Barzi, Nastaran Mohseni, Fatemeh Kazemi-Lomedasht","doi":"10.1080/02652048.2024.2443435","DOIUrl":"10.1080/02652048.2024.2443435","url":null,"abstract":"This study aimed to encapsulate an anti-VEGF nanobody (Nb) within niosome nanoparticles (NNPs) to enhance its circulation half life. Key parameters such as encapsulation efficiency, stability, Nb release, cytotoxicity, and cell migration inhibition in HUVEC cells were evaluated, along with pharmacokinetic studies in mice. Nb-loaded NNPs (Nb-NNPs) were successfully prepared with an encapsulation efficiency of 78.3 ± 3.2% and demonstrated stability over one month. In vitro assays revealed that Nb-NNPs enhanced cytotoxicity and significantly reduced cell migration in HUVEC cells compared to free Nb (P < 0.05). Pharmacokinetic studies in mice demonstrated a dramatically reduced elimination rate constant (0.025 h-1 vs. 0.843 h-1) and an extended terminal half life (27.721 h vs. 0.822 h), indicating slower clearance and prolonged systemic presence. In conclusion, these findings underscore the potential of Nb-NNPs to provide sustained and potent therapeutic effects, contributing valuable insights for advancing targeted therapeutic strategies.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"132-141"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimisation and evaluation of long circulating Ru-SLNs carrier for targeting melanoma cells. 靶向黑色素瘤细胞的长循环ru - sln载体的优化与评价。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1080/02652048.2024.2443436

Hitesh Kumar Dewangan, Kamal Shah, Anil Kumar Vadaga, Manisha Veer, Perwez Alam

{"title":"Optimisation and evaluation of long circulating Ru-SLNs carrier for targeting melanoma cells.","authors":"Hitesh Kumar Dewangan, Kamal Shah, Anil Kumar Vadaga, Manisha Veer, Perwez Alam","doi":"10.1080/02652048.2024.2443436","DOIUrl":"10.1080/02652048.2024.2443436","url":null,"abstract":"The aim of study was to prepared and evaluated rutin-loaded solid-lipid-nanoparticles (Ru-SLNs) gel for treatment of melanoma cells. SLNs were prepared by ultrasonication method through optimisation and evaluated their mean-diameter, PDI, zeta-potential, morphology, entrapment-efficiency, drug-loading, interaction by FTIR, in vitro skin permeation, stability, antioxidant/MTT assay and fluorescence microscopic. Further developed Ru-SLNs was incorporated into gel and characterised their physicochemical properties, drug contents, in vitro diffusion, ex vivo permeation and retention studies in human cadaver skin. Optimised Ru-SLNs batch showed 556.4 ± 2.6 nm mean-diameter, -21.9 mV zeta-potential, 94.8 ± 04% entrapment-efficiency, 62.3 ± 29% loading, and 86.63% release after 6 hrs. MTT assay showed, Ru-SLNs have 15.37 times more effectiveness against melanoma cells, while fluorescence microscopy confirmed the cellular uptake over time. Gel based Ru-SLNs, have reduction in flux across skin, indicating a sustained release of rutin and higher retention within the deeper epidermis layer. Finally, Ru-SLNs based gel exhibited promising potential and effectively targeting to skin's epidermal layer for melanoma cells.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"107-119"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimisation of albendazole delivery and assessment of anticancer potential in hepatocellular carcinoma (HepG2 cells) using surface modified nanostructured lipid carriers. 利用表面修饰的纳米结构脂质载体优化阿苯达唑在肝细胞癌（HepG2细胞）中的递送和抗癌潜力评估。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1080/02652048.2025.2451848

Walid Anwar, Abdulsalam M Kassem, Ayman Salama, Mohamed F Zidan, Ahmed H Ibrahim, Ibrahim A Elbahwy, Elsaied H Barakat, Tarek M Faris, Maged K Elsayad, Ahmed M Samy, Mahmoud M A Elsayed, Abdelaziz E Abdelaziz

{"title":"Optimisation of albendazole delivery and assessment of anticancer potential in hepatocellular carcinoma (HepG2 cells) using surface modified nanostructured lipid carriers.","authors":"Walid Anwar, Abdulsalam M Kassem, Ayman Salama, Mohamed F Zidan, Ahmed H Ibrahim, Ibrahim A Elbahwy, Elsaied H Barakat, Tarek M Faris, Maged K Elsayad, Ahmed M Samy, Mahmoud M A Elsayed, Abdelaziz E Abdelaziz","doi":"10.1080/02652048.2025.2451848","DOIUrl":"10.1080/02652048.2025.2451848","url":null,"abstract":"This study evaluated albendazole (ABZ) nanostructured lipid carriers (NLCs) for hepatocellular carcinoma treatment. ABZ-NLCs were prepared using emulsification-ultrasonication and optimised using a Box-Behnken design. Independent variables-lipids concentration (X1), surfactant concentration (X2), and sonication duration (X3)-were assessed for their effect on mean diameter (Y1), PDI (Y2), and entrapment efficiency (Y3). The optimised formulation exhibited a mean diameter of 166.13 ± 3.72 nm, a PDI of 0.17 ± 0.01, a zeta potential of -39.86 ± 1.84 mV, an entrapment efficiency of 94.25 ± 6.12%, and a loading capacity of 99.93 ± 7.15 mg/g. Following chitosan coating (ABZ-CS-NLCs), all parameters were maintained, and the zeta potential developed to +24.61 ± 1.32 mV, improving cellular interaction. The cytotoxicity assays revealed that ABZ-CS-NLCs were more effective than uncoated NLCs and free ABZ, with an IC50 value of 8.89 μM in HepG2 cells. Overall, ABZ-CS-NLCs demonstrate a promising and effective delivery platform for targeted hepatic cancer therapy.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"161-176"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, QbD-based optimisation, in-vivo pharmacokinetics, and ex-vivo evaluation of Eudragit^® RS 100 loaded flurbiprofen nanoparticles for oral drug delivery. 用于口服给药的 Eudragit® RS 100 负载氟比洛芬纳米颗粒的开发、基于 QbD 的优化、体内药代动力学和体外评估。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-01-01 Epub Date: 2024-11-16 DOI: 10.1080/02652048.2024.2427294

Shilpa Mandpe, Eknath Kole, Vishal Parate, Aniruddha Chatterjee, Arun Mujumdar, Jitendra Naik

{"title":"Development, QbD-based optimisation, in-vivo pharmacokinetics, and ex-vivo evaluation of Eudragit® RS 100 loaded flurbiprofen nanoparticles for oral drug delivery.","authors":"Shilpa Mandpe, Eknath Kole, Vishal Parate, Aniruddha Chatterjee, Arun Mujumdar, Jitendra Naik","doi":"10.1080/02652048.2024.2427294","DOIUrl":"10.1080/02652048.2024.2427294","url":null,"abstract":"This study aims to develop and evaluate flurbiprofen-loaded polymeric nanoparticles to achieve sustained drug release, enhancing therapeutic efficacy and minimising dosing frequency for improved patient outcomes. Flurbiprofen-loaded polymeric nanoparticles were prepared using a tubular microreactor and spray drying, optimised via Box-Behnken Design. Characterisation included particle size, encapsulation efficiency, in vitro and in vivo drug release, and techniques like FTIR, DSC, XRD, and SEM. Statistical analysis ensured robust formulation optimisation and evaluation of performance. The optimised batch of flurbiprofen-loaded polymeric nanoparticles was characterised for mean diameter, PDI, zeta potential, drug release, and EE% were found to be 306.1 ± 6.00 nm, 0.184 ± 0.02 Mw, -23.6 ± 1.51 mV, 85.46 ± 0.53% and 92.31 ± 0.84 (% w/w) respectively. Pharmacokinetic analysis further confirmed the sustained release, extending up to 12 hours and enhancing permeation compared to the pure flurbiprofen. Sustained release of flurbiprofen-loaded polymeric nanoparticles significantly enhances therapeutic effectiveness for inflammatory conditions.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-13"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent updates of carotenoid encapsulation by spray-drying technique. 利用喷雾干燥技术封装类胡萝卜素的最新进展。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-01-01 Epub Date: 2024-11-23 DOI: 10.1080/02652048.2024.2430643

Patrícia Griep, Luana Gayeski, Rosicler Colet, Jamile Zeni, Eunice Valduga

引用次数: 0

Preparation and optimisation of solid lipid nanoparticles of rivaroxaban using artificial neural networks and response surface method. 利用人工神经网络和响应面法制备利伐沙班固体脂质纳米颗粒并进行优化。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-01-01 Epub Date: 2025-01-05 DOI: 10.1080/02652048.2024.2437362

Fatemeh Ghorbannejad Nashli, Sareh Aghajanpour, Ali Farmoudeh, Seyed Sajad Hosseini Balef, Meshkat Torkamanian, Alireza Razavi, Hamid Irannejad, Pedram Ebrahimnejad

{"title":"Preparation and optimisation of solid lipid nanoparticles of rivaroxaban using artificial neural networks and response surface method.","authors":"Fatemeh Ghorbannejad Nashli, Sareh Aghajanpour, Ali Farmoudeh, Seyed Sajad Hosseini Balef, Meshkat Torkamanian, Alireza Razavi, Hamid Irannejad, Pedram Ebrahimnejad","doi":"10.1080/02652048.2024.2437362","DOIUrl":"10.1080/02652048.2024.2437362","url":null,"abstract":"Aims: This study aimed to improve rivaroxaban delivery by optimising solid lipid nanoparticles (SLN) for minimal mean diameter and maximal entrapment efficiency (EE), enhancing solubility, bioavailability, and the ability to cross the blood-brain barrier.Methods: A central composite design was employed to synthesise 32 SLN formulations. Response surface methodology (RSM) and artificial neural networks (ANN) models predicted mean diameter and EE based on five independent variables.Results: The optimised SLN formulation achieved a mean particle diameter of 159.8 ± 15.2 nm, with a Polydispersity index of 0.46, a zeta potential of -28.8 mV, and an EE of 74.3% ± 5.6%. The ANN model showed superior accuracy for both mean diameter and EE, outperforming the RSM model. Structural integrity and stability were confirmed by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR).Conclusion: The high accuracy of the ANN model highlights its potential in optimising pharmaceutical formulations and improving SLN-based drug delivery systems.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"70-82"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing the power of novel drug delivery systems for effective delivery of apigenin: an updated review. 利用新型药物输送系统的力量有效输送芹菜素：最新综述。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1080/02652048.2024.2437375

Vanshita, Tanu Rawal, Hemant Bhati, Keshav Bansal

{"title":"Harnessing the power of novel drug delivery systems for effective delivery of apigenin: an updated review.","authors":"Vanshita, Tanu Rawal, Hemant Bhati, Keshav Bansal","doi":"10.1080/02652048.2024.2437375","DOIUrl":"10.1080/02652048.2024.2437375","url":null,"abstract":"Phytochemicals as dietary components are being extensively explored in order to prevent and treat a wide range of diseases. Apigenin is among the most studied flavonoids found in significant amount in fruits (oranges), vegetables (celery, parsley, onions), plant-based beverages (beer, tea, wine) and herbs (thyme, chamomile, basil, oregano) that has recently gained interest due to its promising pharmacological effects. However, the poor solubility and extended first pass metabolism of apigenin limits its clinical use. Various advantages have been demonstrated by nanocarrier-based platforms in the delivery of hydrophobic drugs like apigenin to diseased tissues. Apigenin nanoformulations have been reported to have better stability, high encapsulation efficiency, prolonged circulation time, sustained release, enhanced accumulation at targeted sites and better therapeutic efficacy. An overview of the major nanocarriers based delivery including liposomes, niosomes, solid lipid nanoparticles, micelles, dendrimers etc., is described. This review sheds insight into the therapeutic effects and advanced drug delivery strategies for the delivery of apigenin.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"83-106"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid nanocarrier-based bigel of Piper betel oil for analgesic and anti-inflammatory applications. 基于脂质纳米载体的胡椒槟榔油镇痛消炎应用。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1080/02652048.2024.2430651

Bhabani Sankar Satapathy, Abhishek Mishra, Kritika Mohanty, Snigdha Pattnaik, Shyamalendu Tripathy, Biswabhusan Biswal

{"title":"Lipid nanocarrier-based bigel of Piper betel oil for analgesic and anti-inflammatory applications.","authors":"Bhabani Sankar Satapathy, Abhishek Mishra, Kritika Mohanty, Snigdha Pattnaik, Shyamalendu Tripathy, Biswabhusan Biswal","doi":"10.1080/02652048.2024.2430651","DOIUrl":"10.1080/02652048.2024.2430651","url":null,"abstract":"Present study reports analgesic and anti-inflammatory potential of Piper betel (L.) leaf oil loaded lipid nanocarrier (BLNs)-embedded bigel. BLNs were developed by solvent evaporation technique and were characterised by FESEM, Cryo-TEM, mean diameter, zeta potential, loading efficiency, etc. BLNs embedded bigel (BLNs-G) was evaluated for analgesic and anti-inflammatory efficacy in rat model. Data showed spherical BLNs with intact lamellarity, 138.2 ± 1.08 nm mean diameter, 0.182 PDI, -46.6 ± 0.61 mV zeta potential, 76.2 ± 2.1% (w/w) loading efficiency and a sustained release in vitro. BLNs-G was homogenous with satisfied viscosity (40 734 ± 1.7 cps), spreadability (8.3 ± 1.5 g.cm sec-1), extrudability (91.33 ± 1.3% w/w) along with a sustained permeation ex vivo. Significant analgesic and anti-inflammatory action were depicted by BLNs-G (1% w/w) in rat model (p ˂ 0.05) within 30 minutes post topical application. In silico docking study revealed high affinity of major phytoactive components with key analgesic/inflammatory mediators. Further pre-clinical investigations are warranted for futuristic clinical application of BLNs-G.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"47-69"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spray-dried chitosan oligosaccharide microparticles with polyvinyl alcohol-based dispersions for improved gefitinib solubility. 喷雾干燥壳聚糖寡糖微颗粒与聚乙烯醇基分散体可提高吉非替尼的溶解度。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1080/02652048.2024.2428359

Shubham B Ahir, Bhaskar Vallamkonda, Ranadheer Reddy Challa, Nishant Chopade, Prashant K Deshmukh, Mahesh P More

{"title":"Spray-dried chitosan oligosaccharide microparticles with polyvinyl alcohol-based dispersions for improved gefitinib solubility.","authors":"Shubham B Ahir, Bhaskar Vallamkonda, Ranadheer Reddy Challa, Nishant Chopade, Prashant K Deshmukh, Mahesh P More","doi":"10.1080/02652048.2024.2428359","DOIUrl":"10.1080/02652048.2024.2428359","url":null,"abstract":"The aim of research is to enhance the solubility of crystalline gefitinib (GF), a poorly water-soluble drug, by developing drug delivery systems using chitosan oligosaccharide (COS) particle engineering. Fabrication utilizes ionic gelation followed by spray drying. The preliminary evaluations such as Uv-Vis, FTIR, DSC followed by advanced techniques like SEM and invitro drug release characteristics was performed along with solubility study. The spray-dried particles measured a mean diameter of 3.18 ± 0.5 microns, %EE as well as load w/w improved from 63.25 ± 2.1% and 37.98 ± 1.5% w/w (COS nanoparticles) to 78.15 ± 2.6% and 45.34 ± 1.6% w/w (engineered microparticles), respectively. The zeta potential and in vitro studies demonstrated 41 ± 3.5 mV and 92 ± 2.1% (w/w) release suggest long-term stability and prolonged release. This novel engineering approach effectively enhances GF solubility and surface characteristics, offering promising potential for improving delivery characteristics.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"14-25"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in microneedle technology: current status and next-generation innovations. 微针技术的进步：现状与下一代创新。

IF 3 4区医学

Journal of microencapsulation Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1080/02652048.2024.2418613

Siddhant Kumar, Rahul Shukla

{"title":"Advancements in microneedle technology: current status and next-generation innovations.","authors":"Siddhant Kumar, Rahul Shukla","doi":"10.1080/02652048.2024.2418613","DOIUrl":"10.1080/02652048.2024.2418613","url":null,"abstract":"Microneedle technology is a pivotal component of third-generation transdermal drug delivery systems featuring tiny needles that create temporary microscopic channels in the stratum corneum which facilitate drug penetration in the dermis. This review offers a detailed examination of the current types of microneedles, including solid, coated, dissolving, hollow, and swelling microneedles, along with their preparation techniques as well as their benefits and challenges. Use of 3D printing technology is especially gaining significant attention due to its ability to achieve the high dimensional accuracy required for precise fabrication. Additionally, its customisability presents significant potential for exploring new designs and creating personalised microneedles products. Furthermore, this review explores next generation microneedles, especially stimuli-responsive microneedle, bioinspired microneedle and microneedles combined with other transdermal technology like sonophoresis, electroporation and iontophoresis. Regulatory aspects, characterisation techniques, safety considerations, and cost factors have also been addressed which are crucial for translation from lab to the market.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"782-803"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0