油酸包埋纳米二氧化铈对链脲佐菌素诱导的妊娠糖尿病小鼠模型的影响。

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI:10.1080/02652048.2024.2423629

Huili Yang, Yujun An, Juan Meng, Xiaomei Lv

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引用次数: 0

摘要

目的：制备纳米二氧化铈包封油酸（CeO2 NPs-OA）并评价其治疗妊娠期糖尿病（GDM）的疗效。方法：采用热分解法制备CeO2纳米粒子。TEM， XRD和FTIR证实了颗粒。stz诱导的NIH 3T3体外研究评估了其抗氧化、抗癌、抗糖尿病和抗炎特性。用STZ诱导怀孕小鼠进行体内研究，检测抗糖尿病活性、氧化应激和血脂异常。结果：CeO2 NPs-OA呈球形结构，分布均匀。PDI为0.5，ζ电位为- 44±2 mV。DPPH和ABTS的抗氧化活性分别为40%和39.21%。CeO2 NPs-OA对糖尿病的抑制作用为500 μg/mL。体内研究证实通过降低MDA (p。stz诱导模型的组织病理学分析显示毛细血管，CeO2 NPs-OA减少。结论：CeO2 NPs-OA具有治疗GDM和改善母婴健康的作用。

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Fabrication of nano-ceria encapsulated with oleic acid to attenuate gestational diabetes mellitus in streptozotocin-induced diabetic pregnant mice model.

Aim: The study aims to fabricate and evaluate Nano-ceria encapsulated oleic acid (CeO₂ NPs-OA) to treat gestational diabetes mellitus (GDM).

Methods: The CeO₂ NPs was synthesised by thermal decomposition. TEM, XRD, and FTIR confirms particles. In vitro studies on STZ-induced NIH 3T3 assessed antioxidant, anticancer, antidiabetic, and anti-inflammatory properties. In vivo studies were performed on pregnant mice induced with STZ, examined antidiabetic activity, oxidative stress, and dyslipidemia.

Results: The CeO₂ NPs-OA had a spherical structure and uniform distribution. A PDI of 0.5 with a zeta-potential of - 44 ± 2 mV. The DPPH and ABTS exhibit 40% and 39.21% antioxidant activity. The CeO₂ NPs-OA inhibits diabetes at 500 μg/mL. The in vivo studies confirmed the reduction in oxidative stress by reducing MDA (p < 0.05). The histopathological analysis of the STZ-induced model shows capillary, which CeO₂ NPs-OA reduced.

Conclusion: CeO₂ NPs-OA shows promise for treating GDM and improving maternal and foetal health.

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.