Spray-dried micellar dry powder inhalation of curcumin for lung-targeted delivery in non-small cell lung cancer therapy.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2025-05-05 DOI:10.1080/02652048.2025.2495246

Shraddha S Ghodke, K M G Taylor, Satyanarayana Somavarapu

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引用次数: 0

Abstract

A spray-dried DPI formulation was developed to enhance solubility, stability, and pulmonary delivery of curcumin-loaded CS-HA dual-coated micelles for lung cancer therapy. Curcumin was encapsulated in Pluronic F68 micelles via thin-film hydration and coated with CS-HA to improve colloidal stability and cellular interaction. The micellar suspension was spray-dried using lactose and L-leucine as dispersibility enhancers. Formulation characterisation was conducted using DLS to determine mean diameter and PDI, zeta potential analysis, and HPLC for drug loading and encapsulation efficiency, along with TEM. Spray-dried formulations were further characterised by SEM, laser diffraction (Sympatec), FTIR, and XRPD. In vitro aerosol characterisation was performed using NGI. The micelles exhibited a mean diameter of 209 nm, PDI of 0.21, zeta potential of -14 mV, encapsulation efficiency of 50-90%, and loading capacity of 5.6% (w/w). XRPD and FTIR confirmed amorphous conversion and stability. The optimized DPI showed favourable aerodynamic properties for targeted pulmonary delivery in NSCLC.

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喷雾干燥胶束干粉吸入姜黄素在非小细胞肺癌治疗中的肺靶向递送。

开发了一种喷雾干燥DPI配方，以提高姜黄素负载CS-HA双包被胶束的溶解度，稳定性和肺输送，用于肺癌治疗。将姜黄素通过薄膜水化包被Pluronic F68胶束，并包被CS-HA，以提高胶体稳定性和细胞相互作用。采用乳糖和l -亮氨酸作为分散剂对胶束悬浮液进行喷雾干燥。采用DLS法测定平均直径和PDI， zeta电位分析，HPLC法测定载药量和包封效率，TEM进行表征。喷雾干燥的配方进一步通过SEM，激光衍射（Sympatec）， FTIR和XRPD进行表征。用NGI进行了体外气溶胶表征。胶束的平均直径为209 nm， PDI为0.21，zeta电位为-14 mV，包封效率为50-90%，负载容量为5.6% （w/w）。XRPD和FTIR证实了非晶转换和稳定性。优化后的DPI具有良好的空气动力学特性，可用于非小细胞肺癌的靶向肺输送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.