Journal of microencapsulation最新文献_第9页

Preparation and curing behaviour of microencapsulated curing agents for cold-mixed epoxy asphalt. 冷拌环氧沥青微囊化固化剂的制备及其固化性能。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-09-01 DOI: 10.1080/02652048.2023.2215316

Qiaoliang Xiong, Juntao Du, Minxin Zhang, Huina Jia, Tianjin Li, Yi Nie

{"title":"Preparation and curing behaviour of microencapsulated curing agents for cold-mixed epoxy asphalt.","authors":"Qiaoliang Xiong, Juntao Du, Minxin Zhang, Huina Jia, Tianjin Li, Yi Nie","doi":"10.1080/02652048.2023.2215316","DOIUrl":"https://doi.org/10.1080/02652048.2023.2215316","url":null,"abstract":"This study aimed to improve control over the curing behaviour of cold-mixed epoxy asphalt by using a microencapsulated curing agent (2-PZ@PC). Prepared through solvent evaporation, the 2-PZ@PC microcapsules had 2-phenylimidazole as the core material and polycarbonate as the shell material. The research examined the impact of core-shell mass ratio on microcapsule morphology and composition. Various equations, including the kinetics equation, Kissinger equation, Flynn-Wall-Ozawa, and Crane equations, were employed to assess the sustained release effect of 2-PZ@PC microcapsules on epoxy resin curing behaviour. Fluorescence microscopy and viscosity experiments were used to observe the release state of microcapsules and confirm the retardation phenomenon during construction. Optimal 2-PZ@PC microcapsules displayed a smooth spherical morphology and a maximum encapsulation rate of 32 wt% at a 1:1 core-shell ratio. The microencapsulated curing agent effectively regulated cold-mixed epoxy asphalt's curing behaviour, enhancing retention time control and application reliability.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 6","pages":"412-422"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9995401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High internal phase Pickering emulsions stabilised by ultrasound-induced soy protein-β-glucan-catechin complex nanoparticles to enhance the stability and bioaccessibility of curcumin. 超声诱导大豆蛋白-β-葡聚糖-儿茶素复合纳米颗粒稳定高内相皮克林乳状液，以提高姜黄素的稳定性和生物可及性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-09-01 DOI: 10.1080/02652048.2023.2220387

Xutao Chen, Junrong Huang, Linlin Chen, Xiaona Chen, Danxia Su, Bei Jin

{"title":"High internal phase Pickering emulsions stabilised by ultrasound-induced soy protein-β-glucan-catechin complex nanoparticles to enhance the stability and bioaccessibility of curcumin.","authors":"Xutao Chen, Junrong Huang, Linlin Chen, Xiaona Chen, Danxia Su, Bei Jin","doi":"10.1080/02652048.2023.2220387","DOIUrl":"https://doi.org/10.1080/02652048.2023.2220387","url":null,"abstract":"Aims: To evaluate the potential applications of soy protein-glucan-catechin (SGC) complexes prepared with different ultrasound times in stabilising high internal phase Pickering emulsion (HIPPE) and delivering curcumin.Methods: The SGC complexes were characterised by particle size, morphology, zeta potential, Fourier transform infra-red, and fluorescence spectroscopy. Formation and stability of curcumin emulsions were monitored by droplet size, microstructure, rheological property, lipid oxidation, and in vitro digestion.Results: Short-time ultrasound-induced complexes (SGC-U15) exhibited a small size and wettability of ∼82.5°. The chemical stability and bioaccessibility of curcumin was greatly improved by SGC-U15-stabilised HIPPEs, even after 70 days of storage, heating at 100 °C for 30 min, ultraviolet irradiation for 120 min, and in vitro digestion, owing to the formation of elastic gel-like structure at the oil/water interfaces.Conclusion: Our findings may contribute to the design of emulsion-based delivery systems using ultrasound-induced protein-polysaccharide-polyphenol complexes.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 6","pages":"456-474"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Chitooligosaccharide-catechin conjugate loaded liposome using different stabilising agents: characteristics, stability, and bioactivities. 使用不同稳定剂的壳寡糖-儿茶素偶联负载脂质体:特性、稳定性和生物活性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-09-01 DOI: 10.1080/02652048.2023.2209658

Ajay Mittal, Avtar Singh, Hui Hong, Soottawat Benjakul

{"title":"Chitooligosaccharide-catechin conjugate loaded liposome using different stabilising agents: characteristics, stability, and bioactivities.","authors":"Ajay Mittal, Avtar Singh, Hui Hong, Soottawat Benjakul","doi":"10.1080/02652048.2023.2209658","DOIUrl":"https://doi.org/10.1080/02652048.2023.2209658","url":null,"abstract":"Aim: To determine the optimum condition for preparing chitooligosaccharide-catechin conjugate (COS-CAT) liposomes using different stabilising agents.Methods: COS-CAT liposomes (0.1-1%, w/v) were prepared using soy phosphatidylcholine (SPC) (50-200 mM) and glycerol or cholesterol (25-100 mg). Encapsulation efficiency (EE), loading capacity (LC), physicochemical characteristics, FTIR spectra, thermal stability, and structure of COS-CAT liposomes were assessed.Results: COS-CAT loaded liposome stabilised by cholesterol (COS-CAT-CHO) showed higher stability as shown by the highest EE (76.81%) and LC (4.57%) and the lowest zeta potential (ZP) (-76.51 mV), polydispersity index (PDI) (0.2674) and releasing efficiency (RE) (53.54%) (p < 0.05). COS-CAT-CHO showed the highest retention and relative remaining bioactivities of COS-CAT under various conditions (p < 0.05). FTIR spectra revealed the interaction between the choline group of SPC and -OH groups of COS-CAT. Phase transition temperature of COS-CAT-CHO was shifted to 184 °C, which was higher than others (p < 0.05).Conclusion: SPC and cholesterol-based liposome could be used as a promising vesicle for maintaining bioactivities of COS-CAT.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 6","pages":"385-401"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion. 透明质酸水凝胶包埋胡椒碱脂质体作为预防术后腹膜粘连的有效平台。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2194415

Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri

{"title":"Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion.","authors":"Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri","doi":"10.1080/02652048.2023.2194415","DOIUrl":"https://doi.org/10.1080/02652048.2023.2194415","url":null,"abstract":"This study aimed to prepare piperine (PIP) loaded liposomes in hyaluronic acid (HA) hydrogel to provide a hybrid superstructure for postoperative adhesion prevention. Liposomes were prepared using thin-film hydration method. The optimised formulation was characterised by size, SEM, TEM, FTIR, encapsulation efficiency (EE)% (w/w), and release pattern. Liposome-in-hydrogel formulation was investigated by rheology, SEM, and release studies. The efficacy was evaluated in a rat peritoneal abrasion model. EE% (w/w) increased with increasing lipid concentration from 10 to 30; however, a higher percentage of Chol reduced EE% (w/w). The optimised liposome (EE: 68.10 ± 1.71% (w/w), average diameter: 513 ± 8 nm, PDI: 0.15 ± 0.04) was used for hydrogel embedding. No sign of adhesion in 5/8 rats and no collagen deposition confirmed the in vivo effectiveness of the optimised formulation. Overall, providing a sustained delivery of PIP, the developed liposome-in-hydrogel formulation can be a promising carrier to prevent postoperative adhesion.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"279-301"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dry powder formulation of azithromycin for COVID-19 therapeutics. 阿奇霉素干粉制剂用于COVID-19治疗。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2175924

Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu

{"title":"Dry powder formulation of azithromycin for COVID-19 therapeutics.","authors":"Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu","doi":"10.1080/02652048.2023.2175924","DOIUrl":"https://doi.org/10.1080/02652048.2023.2175924","url":null,"abstract":"Azithromycin is an antibiotic proposed as a treatment for the coronavirus disease 2019 (COVID-19) due to its immunomodulatory activity. The aim of this study is to develop dry powder formulations of azithromycin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocomposite microparticles for pulmonary delivery to improve the low bioavailability of azithromycin. Double emulsion method was used to produce nanoparticles, which were then spray dried to form nanocomposite microparticles. Encapsulation efficiency and drug loading were analysed, and formulations were characterised by particle size, zeta potential, morphology, crystallinity and in-vitro aerosol dispersion performance. The addition of chitosan changed the neutrally-charged azithromycin only formulation to positively-charged nanoparticles. However, the addition of chitosan also increased the particle size of the formulations. It was observed in the NGI® data that there was an improvement in dispersibility of the chitosan-related formulations. It was demonstrated in this study that all dry powder formulations were able to deliver azithromycin to the deep lung regions, which suggested the potential of using azithromycin via pulmonary drug delivery as an effective method to treat COVID-19.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"217-232"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9510311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of anti-arthritic activity of lipid matrix encased berberine in rheumatic animal model. 类风湿动物模型中脂质基质包膜小檗碱抗关节炎活性的评价。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2194414

Neelu Singh, Amit Kumar Pandey, Ravi Raj Pal, Alka, Poonam Parashar, Priya Singh, Nidhi Mishra, Dinesh Kumar, Ritu Raj, Sukhveer Singh, Shubhini A Saraf

{"title":"Assessment of anti-arthritic activity of lipid matrix encased berberine in rheumatic animal model.","authors":"Neelu Singh, Amit Kumar Pandey, Ravi Raj Pal, Alka, Poonam Parashar, Priya Singh, Nidhi Mishra, Dinesh Kumar, Ritu Raj, Sukhveer Singh, Shubhini A Saraf","doi":"10.1080/02652048.2023.2194414","DOIUrl":"https://doi.org/10.1080/02652048.2023.2194414","url":null,"abstract":"The purpose of this study was to evaluate the drug delivery and therapeutic potential of berberine (Br) loaded nanoformulation in rheumatoid arthritis (RA)-induced animal model. The Br-loaded NLCs (nanostructured lipid carriers) were prepared employing melt-emulsification process, and optimised through Box-Behnken design. The prepared NLCs were assessed for in-vitro and in-vivo evaluations. The optimised NLCs exhibited a mean diameter of 180.2 ± 0.31 nm with 88.32 ± 2.43% entrapment efficiency. An enhanced anti-arthritic activity with reduced arthritic scores to 0.66 ± 0.51, reduction in ankle diameter to 5.80 ± 0.27 mm, decline in paw withdrawal timing, and improvements in walking behaviour were observed in the Br-NLCs treated group. The radiographic images revealed a reduction in bone and cartilage deformation. The Br-NLCs showed promising results in the management of RA disease, can be developed as an efficient delivery system at commercial levels, and may be explored for clinical application after suitable experiments in the future.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"263-278"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Co-delivery of paclitaxel and etoposide prodrug by human serum albumin and PLGA nanoparticles: synergistic cytotoxicity in brain tumour cells. 人血清白蛋白和PLGA纳米颗粒共同递送紫杉醇和依托泊苷前药:脑肿瘤细胞的协同细胞毒性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2188943

Tatyana Kovshova, Sergey Mantrov, Svetlana Boiko, Julia Malinovskaya, Maria Merkulova, Nadezhda Osipova, Natalia Moiseeva, Mikhail Akimov, Polina Dudina, Ivan Senchikhin, Yulia Ermolenko, Svetlana Gelperina

{"title":"Co-delivery of paclitaxel and etoposide prodrug by human serum albumin and PLGA nanoparticles: synergistic cytotoxicity in brain tumour cells.","authors":"Tatyana Kovshova, Sergey Mantrov, Svetlana Boiko, Julia Malinovskaya, Maria Merkulova, Nadezhda Osipova, Natalia Moiseeva, Mikhail Akimov, Polina Dudina, Ivan Senchikhin, Yulia Ermolenko, Svetlana Gelperina","doi":"10.1080/02652048.2023.2188943","DOIUrl":"https://doi.org/10.1080/02652048.2023.2188943","url":null,"abstract":"The aims of this study were to develop co-delivery systems of paclitaxel (PTX) and etoposide prodrug (4'-O-benzyloxycarbonyl-etoposide, ETP-cbz) based on non-cross-linked human serum albumin (HSA) and poly(lactide-co-glycolide) nanoparticles and to evaluate the synergistic potential of these drugs in vitro. The nanoformulations were prepared by the high-pressure homogenisation technique and characterised using DLS, TEM, SEM, AFM, HPLC, CZE, in-vitro release, and cytotoxicity in human and murine glioma cells. All nanoparticles had 90-150 nm in size and negative ζ-potentials. The Neuro2A cells were the most sensitive to both HSA- and PLGA-based co-delivery systems (IC50 0.024 µM and 0.053 µM, respectively). The drugs' synergistic effect (combination index < 0.9) was observed in the GL261 cells for both types of co-delivery formulations and in the Neuro2A cells for the HSA-based system. These nanodelivery systems may be useful to improve combination chemotherapy for brain tumour treatment. To our knowledge, this is the first report describing the non-cross-linked HSA-based co-delivery nanosuspension which was prepared using nab™ technology.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"246-262"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9510843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Encapsulation of Ruta essential oil in chitosan and alginate matrices as an ecological alternative for the control of nematodes. 壳聚糖和海藻酸盐基质包封Ruta精油作为防治线虫的生态替代品。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-06-01 DOI: 10.1080/02652048.2023.2188939

Duvan Fernando Castillo, Rubén Albeiro Sánchez-Andica, Brayan Fernando Enriquez, Jaime Restrepo, Martha Isabel Páez-Melo

{"title":"Encapsulation of Ruta essential oil in chitosan and alginate matrices as an ecological alternative for the control of nematodes.","authors":"Duvan Fernando Castillo, Rubén Albeiro Sánchez-Andica, Brayan Fernando Enriquez, Jaime Restrepo, Martha Isabel Páez-Melo","doi":"10.1080/02652048.2023.2188939","DOIUrl":"https://doi.org/10.1080/02652048.2023.2188939","url":null,"abstract":"Controlled release formulations of Ruta essential oil obtained by ionic gelation were developed. The presence of rue essential oil in the alginate and chitosan capsules was evidenced by Fourier transform infrared spectroscopy and differential scanning calorimetry. Release studies revealed that in acidic conditions (pH 4.2), the CHS-REO particles reached a Sw of 240% (w/w) in 30 days and 101% (w/w) for ALG-REO particles, generating a RR of 23.7% for CHS-REO and 20.4% for ALG-REO. On the other hand, at pH 6.8 it favored the Sw for ALG-REO 840% (w/w) and therefore the RR (45.6%) and disfavored the Sw of CHS-REO generating low RR (16.9%). Encapsulated rue essential oil showed equal or superior nematicidal activity against the nematode Melodogyne ssp., compared to free oil and a synthetic nematicide such as Carbofuran, without having a phytotoxic effect on the plant. This study revealed that REO encapsulated in biopolymeric matrices can be used as new nematicide formulations.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 4","pages":"233-245"},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9462049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microencapsulation of β-carotene using barley residue proteins from beer waste as coating material. 以啤酒渣大麦蛋白为包衣材料制备β-胡萝卜素微胶囊化。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2183277

Ana Cristina Freitas De Oliveira Meira, Larissa Carolina De Morais, Jayne De Abreu Figueiredo, Lizzy Ayra Alcântara Veríssimo, Diego Alvarenga Botrel, Jaime Vilela De Resende

{"title":"Microencapsulation of β-carotene using barley residue proteins from beer waste as coating material.","authors":"Ana Cristina Freitas De Oliveira Meira, Larissa Carolina De Morais, Jayne De Abreu Figueiredo, Lizzy Ayra Alcântara Veríssimo, Diego Alvarenga Botrel, Jaime Vilela De Resende","doi":"10.1080/02652048.2023.2183277","DOIUrl":"https://doi.org/10.1080/02652048.2023.2183277","url":null,"abstract":"This study aimed to produce and characterise microparticles produced from barley residue proteins (BRP) enriched with β-carotene. The microparticles were obtained by freeze-drying five emulsion formulations with 0.5% w/w whey protein concentrate and different concentrations of maltodextrin and BRP (0, 1.5, 3.0, 4.5 and 6.0% w/w), with the dispersed phase consisting of corn oil enriched with β-carotene. The mixtures were mechanically mixed and sonicated, the formed emulsions were freeze-drying. The microparticles obtained were tested for encapsulation efficiency, humidity, hygroscopicity, apparent density, scanning electron microscopy (SEM), accelerated stability and bioaccessibility. Microparticles produced with the emulsion containing 6% w/w BRP had lower moisture content (3.47 ± 0.05%), higher encapsulation efficiency (69.11 ± 3.36%), bioaccessibility value of 84.1% and greater β-carotene protection against thermal degradation. SEM analysis showed that microparticles had sizes ranging from 74.4 to 244.8 µm. These results show that BRP are viable for the microencapsulation of bioactive compounds by freeze-drying.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 3","pages":"171-185"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model. 含叶磷脂体的蛇舌草提取物的开发和评价:用于治疗啮齿动物神经性疼痛模型的临床前方法。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-05-01 DOI: 10.1080/02652048.2023.2188938

Nitin Kumar, Radha Goel, Monika Singh, Neeraj Kant Sharma, Praveen Kumar Gaur, Pradeep Kumar Sharma

{"title":"Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model.","authors":"Nitin Kumar, Radha Goel, Monika Singh, Neeraj Kant Sharma, Praveen Kumar Gaur, Pradeep Kumar Sharma","doi":"10.1080/02652048.2023.2188938","DOIUrl":"https://doi.org/10.1080/02652048.2023.2188938","url":null,"abstract":"Purpose: The study was aimed to encapsulate Hedyotis corymbosa extract (HCE) into phytosomes to improve its therapeutic efficacy in neuropathic pain by enhancing the bioavailability of chief chemical constituent Hedycoryside -A (HCA).Methods: For preparing phytosomes complexes (F1, F2, and F3), HCE and phospholipids were reacted in disparate ratio. F2 was chosen to assess its therapeutic efficacy in neuropathic pain induced by partial sciatic nerve ligation. Nociceptive threshold and oral bioavailability were also estimated for F2.Results: Particle size, zeta potential and entrapment efficiency for F2 were analysed as 298.1 ± 1.1 nm, -3.92 ± 0.41 mV and 72.12 ± 0.72% respectively. F2 gave enhanced relative bioavailability (158.92%) of HCA along with a greater neuroprotective potential showing a significant antioxidant effect and augmentation (p < 0.05) in nociceptive threshold with the diminution in damage to nerves.Conclusion: F2 is an optimistic formulation for enhancing the HCE delivery for the effective treatment of neuropathic pain.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"40 3","pages":"186-196"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0