Journal of microencapsulation最新文献_第8页

Herpetetrone nanosuspensions enhance drug solubility and bioavailability to improve anti-hepatic fibrosis effects. Herpetetrone纳米混悬剂提高了药物的溶解度和生物利用度，以提高抗肝纤维化的效果。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-12-01 Epub Date: 2023-11-09 DOI: 10.1080/02652048.2023.2258974

Yuji Zhong, Lingyu Hang, Fang Wang, Baode Shen, Chengying Shen, Yuye Xue, Haiqiang Jia, Liqiang Wang, Hailong Yuan

{"title":"Herpetetrone nanosuspensions enhance drug solubility and bioavailability to improve anti-hepatic fibrosis effects.","authors":"Yuji Zhong, Lingyu Hang, Fang Wang, Baode Shen, Chengying Shen, Yuye Xue, Haiqiang Jia, Liqiang Wang, Hailong Yuan","doi":"10.1080/02652048.2023.2258974","DOIUrl":"10.1080/02652048.2023.2258974","url":null,"abstract":"The aim of this study was to enhance the dissolution rate and oral bioavailability of herpetetrone (HPT) by preparing nanosuspensions (NSs) and evaluate the changes in its anti-hepatic fibrosis effect. Herpetetrone nanosuspension (HPT-NS) was prepared using the ultrasound-precipitation technique, and characterised on the basis of mean diameter, zeta potential (ZP), encapsulation efficiency percent (EE%), scanning electron microscopy (SEM), and X-ray powder diffraction (XRPD). In addition, the pharmacokinetics and anti-hepatic fibrosis activity were evaluated. HPT-NS prepared with the optimised formulation was found to be spherical with mean diameter of 177.48 ± 6.13 nm, polydispersity index (PDI) of 0.108 ± 0.002 and ZP of -17.28 ± 2.02 mV. The EE (m/m, %) was 83.25 ± 0.27. XRPD analyses confirmed that the amorphous state of HPT in HPT-NS remained unchanged. The dissolution rate of HPT-NS was significantly higher than that of HPT coarse suspensions (HPT-CSs). Following oral administration, Cmax and AUC0-t of HPT-NS showed a significant increase (p < 0.05). In vitro, HPT inhibited the proliferation of HSC-T6 cells and induced apoptosis by up-regulating the expression of Bax proteins and down-regulating the expression of Bcl-2 and TGF-β1 proteins. Compared with HPT-CS, HPT-NS exhibited a more pronounced anti-fibrotic effect. HPT-NS, as a new drug formulation designed to improve the solubility and bioavailability of the drug, shows promising potential in enhancing the anti-liver fibrosis effect.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"587-598"},"PeriodicalIF":3.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium alginate and chitosan co-modified fucoxanthin liposomes: preparation, bioaccessibility and antioxidant activity. 海藻酸钠和壳聚糖共修饰岩藻糖胶脂质体的制备、生物可及性和抗氧化活性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-12-01 Epub Date: 2023-11-09 DOI: 10.1080/02652048.2023.2274057

Hongchun Dong, Siyuan Wang, Cong Fu, Yanxiaofan Sun, Tuantuan Wei, Dandan Ren, Qiukuan Wang

{"title":"Sodium alginate and chitosan co-modified fucoxanthin liposomes: preparation, bioaccessibility and antioxidant activity.","authors":"Hongchun Dong, Siyuan Wang, Cong Fu, Yanxiaofan Sun, Tuantuan Wei, Dandan Ren, Qiukuan Wang","doi":"10.1080/02652048.2023.2274057","DOIUrl":"10.1080/02652048.2023.2274057","url":null,"abstract":"To improve the stability of fucoxanthin, fucoxanthin liposomes (L) were prepared by the thin-film ultrasound method, and fucoxanthin liposomes were modified with sodium alginate and chitosan by an electrostatic deposition method. The release characteristics of fucoxanthin in different types of liposomes with in vitro gastrointestinal simulation were studied. Under the optimum conditions, the results showed that the encapsulation efficiency of prepared liposomes could reach 88.56 ± 1.40% (m/m), with an average particle size of 295.27 ± 7.28 nm, a Zeta potential of -21.53 ± 2.00 mV, a polydispersity index (PDI) of 0.323 ± 0.007 and a loading capacity of 33.3 ± 0.03% (m/m). Compared with L and chitosan modified fucoxanthin liposomes (CH), sodium alginate and chitosan modified fucoxanthin liposomes (SA-CH) exhibited higher storage stability, in vitro bioaccessibility and antioxidant activity after gastrointestinal digestion. Sodium alginate and chitosan co-modified liposomes can be developed as formulations for encapsulation and delivery of functional ingredients, providing a theoretical basis for developing new fucoxanthin series products.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"649-662"},"PeriodicalIF":3.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49690962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy. 五种天然放射性保护剂的脂质体形式在减轻放射治疗中电离辐射对人类淋巴结和皮肤细胞的不良影响方面的放射性保护作用的比较。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-12-01 Epub Date: 2023-11-09 DOI: 10.1080/02652048.2023.2268705

Ngoc-Duy Pham, Thi-Huynh-Nga Nguyen, Ngoc-Bich-Dao Vu, Thi-Ngoc-Mai Tran, Bao-Ngoc Pham, Hoang-Sinh Le, Kim-Hai Vo, Xuan-Cuong Le, Le-Bao-Ha Tran, Minh-Hiep Nguyen

{"title":"Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy.","authors":"Ngoc-Duy Pham, Thi-Huynh-Nga Nguyen, Ngoc-Bich-Dao Vu, Thi-Ngoc-Mai Tran, Bao-Ngoc Pham, Hoang-Sinh Le, Kim-Hai Vo, Xuan-Cuong Le, Le-Bao-Ha Tran, Minh-Hiep Nguyen","doi":"10.1080/02652048.2023.2268705","DOIUrl":"10.1080/02652048.2023.2268705","url":null,"abstract":"This study aims to evaluate the radioprotective effects of liposomes encapsulating curcumin (Lip-CUR), silibinin (Lip-SIL), α-tocopherol (Lip-TOC), quercetin (Lip-QUE) and resveratrol (Lip-RES) in alleviating the adverse effects of ionising irradiation on human lymphoctyes and skin cells in radiotherapy. Liposomes encapsulating the above natural radioprotectants (Lip-NRPs) were prepared by the film hydration method combined with sonication. Their radioprotective effects for the cells against X-irradiation was evaluated using trypan-blue assay and γ-H2AX assay. All prepared Lip-NRPs had a mean diameter less than 240 nm, polydispersity index less than 0.32, and zeta potential more than -23 mV. Among them, the radioprotective effect of Lip-RES was lowest, while that of Lip-QUE was highest. Lip-SIL also exhibited a high radioprotective effect despite its low DPPH-radical scavenging activity (12.9%). The radioprotective effects of Lip-NRPs do not solely depend on the free radical scavenging activity of NRPs but also on their ability to activate cellular mechanisms.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"613-629"},"PeriodicalIF":3.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysorbate 80 surface modified PLGA nanoparticles: an in-vitro evaluation of cellular uptake and cytotoxicity on neuro-2a cells. 聚山梨醇酯80表面修饰的PLGA纳米颗粒：细胞摄取和对神经-2a细胞的细胞毒性的体外评估。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-08-23 DOI: 10.1080/02652048.2023.2244095

Surbhi Sharma, Shweta Dang

{"title":"Polysorbate 80 surface modified PLGA nanoparticles: an in-vitro evaluation of cellular uptake and cytotoxicity on neuro-2a cells.","authors":"Surbhi Sharma, Shweta Dang","doi":"10.1080/02652048.2023.2244095","DOIUrl":"10.1080/02652048.2023.2244095","url":null,"abstract":"Aim: Present study focuses on the development of P80 coated PLGA Nanoparticles loaded with drugs, paroxetine (P80-Par-PLGA-NPs) and clonidine (P80-CLD-PLGA-NPs) for in-vitro evaluation of Cellular Uptake & Cytotoxicity on Neuro-2a cells.Method: P80-Par-PLGA-NPs and P80-CLD-PLGA-NPs were developed and characterised for zeta size, potential, PDI, EE%, DL%, TEM, SEM, FTIR, DSC, in-vitro release, cytotoxicity, histopathological and cell uptake studies using rhodamine loaded P80-NPs.Result: Mean particle diameter of P80-Par-PLGA-NPs and P80-CLD-PLGA-NPs was 204; 182.7 nm, ZP of -21.8; -18.72 mV and 0.275; 0.341 PDI, respectively. TEM and SEM images revealed homogenous surface morphology. In-vitro drug release showed sustained and complete release in 72 h. Cell viability (>90%) at Cmax and no cytotoxicity in histopathology was observed. Significant higher uptake (96.9%) of P80-modified-NPS was observed as compared to unmodified-NPs (81%) (p < 0.05).Conclusion: The finding clearly indicated a higher cell uptake of drugs via surface modified P80-coated PLGA-NPs as compared to unmodified particles.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"534-548"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10047753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The management of osteoarthritis symptomatology through nanotechnology: a patent review. 通过纳米技术治疗骨关节炎症状：一项专利综述。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-09-12 DOI: 10.1080/02652048.2023.2258955

Mariana Mendonça Santos, Anamaria Mendonça Santos, José Adão Carvalho Nascimento Júnior, Tatianny de Araujo Andrade, Gomathi Rajkumar, Luiza Abrahão Frank, Mairim Russo Serafini

{"title":"The management of osteoarthritis symptomatology through nanotechnology: a patent review.","authors":"Mariana Mendonça Santos, Anamaria Mendonça Santos, José Adão Carvalho Nascimento Júnior, Tatianny de Araujo Andrade, Gomathi Rajkumar, Luiza Abrahão Frank, Mairim Russo Serafini","doi":"10.1080/02652048.2023.2258955","DOIUrl":"10.1080/02652048.2023.2258955","url":null,"abstract":"Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"475-490"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10216637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, systematic optimisation and biofilm disruption activity of eugenol-based nanosized emulsions stabilised with Tween 80. 吐温80稳定丁香酚基纳米乳液的开发、系统优化和生物膜破坏活性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-08-11 DOI: 10.1080/02652048.2023.2244094

Chandra Lekha Putta, Syed Nazrin Ruhina Rahman, Payel Chakraborty, Tamilvanan Shunmugaperumal

{"title":"Development, systematic optimisation and biofilm disruption activity of eugenol-based nanosized emulsions stabilised with Tween 80.","authors":"Chandra Lekha Putta, Syed Nazrin Ruhina Rahman, Payel Chakraborty, Tamilvanan Shunmugaperumal","doi":"10.1080/02652048.2023.2244094","DOIUrl":"10.1080/02652048.2023.2244094","url":null,"abstract":"The aims of this study were to systematically optimise a formula for eugenol emulsions via face-centered central composite design and to assess the activity against two-different bacterial strains (Staphylococcus aureus and Propionibacterium acnes) present at planktonic and biofilm forms. The molecular interaction of excipients, mean particle size (MPS) including zeta potential (ZP), drug entrapment efficiency (DEE) and in vitro drug release of optimised emulsions was done using FT-IR, Malvern Zetasizer, ultracentrifugation technique and membrane-free dissolution model, respectively. The emulsions consisted of 151.3 ± 1.45 nm MPS, -21.3 ± 1.25 mV ZP and 93.98 ± 1.41% DEE values. On storage of emulsions at 25 °C for 3 months, the value of DEE was found to be 72.12 ± 2.82%. The Tween 80 emulsifier film coverage onto the dispersed eugenol droplets of emulsions delayed significantly the drug release (12%-19%) compared to the drug release occurred from pure eugenol. The treatment of planktonic S. aureus and P. acnes with diluted eugenol emulsions showed the minimum inhibitory concentration and minimum bactericidal concentration values at 1.25-2.5 mg/ml whereas it occurred at 10 mg/ml for pure eugenol. Treating the biofilms with eugenol emulsions (1-2 mg/ml) yielded 59-70% minimum biofilm eradication concentration but 10 mg/ml pure eugenol showed 60%. Hence, the eugenol emulsions displayed antibacterial activity and could be projected as an antibiofilm or biofilm disruption agent.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"517-533"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microencapsulation of Bacillus subtilis and oat β-glucan and their application as a synbiotic in fish feed. 枯草芽孢杆菌和燕麦β-葡聚糖的微胶囊化及其作为合生素在鱼类饲料中的应用。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-06-08 DOI: 10.1080/02652048.2023.2220394

Angélica Priscila do Carmo Alves, Amanda do Carmo Alves, Rodney Alexandre Ferreira Rodrigues, Brunno da Silva Cerozi, José Eurico Possebon Cyrino

{"title":"Microencapsulation of Bacillus subtilis and oat β-glucan and their application as a synbiotic in fish feed.","authors":"Angélica Priscila do Carmo Alves, Amanda do Carmo Alves, Rodney Alexandre Ferreira Rodrigues, Brunno da Silva Cerozi, José Eurico Possebon Cyrino","doi":"10.1080/02652048.2023.2220394","DOIUrl":"10.1080/02652048.2023.2220394","url":null,"abstract":"To improve survival during storage and exposure to adverse conditions, Bacillus subtilis was microencapsulated with oat β-glucan by spray-drying technology. The characterisation of the microcapsules was designed to compare free and microencapsulated cells through exposure to simulated gastric fluids (SGF) throughout storage for 90 days at different temperatures. The characterisation included analysis of efficiency, morphology, moisture, water activity, hygroscopicity, particle size, and zeta potential. The microcapsules presented a particle size of 1.5 ± 0.34 μm and an encapsulation efficiency of 77.9 ± 3.06%. After SGF, the survival of microencapsulated cells was 8.4 ± 0.07 log CFU mL-1 while that of free cells was 7.6 ± 0.06 log CFU mL-1. After 90 days of storage, only microencapsulated cells remained above 6 log-unit of viability. In conclusion, spray-drying technique combined with the addition of oat β-glucan proved to be an efficient method to protect B. subtilis under storage and SGF with potential application in fish feed.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"491-501"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9588418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tacrolimus loaded nanostructured lipid carriers using Moringa oleifera seed oil: design, optimization and in-vitro evaluations. 使用辣木籽油负载他克莫司的纳米结构脂质载体：设计、优化和体外评价。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-07-05 DOI: 10.1080/02652048.2023.2231075

Rajat Garg, Anuj Garg

引用次数: 0

Diruthenium(II-III)-ibuprofen-loaded chitosan-based microparticles and nanoparticles systems: encapsulation, characterisation, anticancer activity of the nanoformulations against U87MG human glioma cells. Diruthenium（II-III）-布洛芬负载的壳聚糖基微粒和纳米颗粒系统：纳米制剂对U87MG人神经胶质瘤细胞的封装、表征和抗癌活性。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-11-01 Epub Date: 2023-09-12 DOI: 10.1080/02652048.2023.2258967

Hanif Ur-Rehman, Bárbara Fornaciari, Samara R Alves, Alison Colquhoun, Denise de Oliveira Silva

{"title":"Diruthenium(II-III)-ibuprofen-loaded chitosan-based microparticles and nanoparticles systems: encapsulation, characterisation, anticancer activity of the nanoformulations against U87MG human glioma cells.","authors":"Hanif Ur-Rehman, Bárbara Fornaciari, Samara R Alves, Alison Colquhoun, Denise de Oliveira Silva","doi":"10.1080/02652048.2023.2258967","DOIUrl":"10.1080/02652048.2023.2258967","url":null,"abstract":"The aim of this work was to investigate novel formulations containing diruthenium(II-III)-ibuprofen (RuIbp) metallodrug encapsulated into the chitosan (CT) biopolymer. Microparticles (RuIbp/CT MPs, ∼ 1 µm) were prepared by spray-drying, and RuIbp/CT-crosslinked nanoparticles (NPs) by ionic gelation (RuIbp/CT-TPP, TPP = tripolyphosphate (1), RuIbp/CT-TPP-PEG, PEG = poly(ethyleneglycol (2)) or pre-gel/polyelectrolyte complex method (RuIbp/CT-ALG, ALG = alginate (3)). Ru analysis was conducted by energy dispersive x-ray fluorescence or inductively coupled plasma atomic emission spectroscopy, and physicochemical characterisation by powder x-ray diffraction, electronic absorption and FTIR spectroscopies, electrospray ionisation mass spectrometry, thermal analysis, scanning electron, transition electron and atomic force microscopies, and dynamic light scattering. The RuIbp-loaded nanosystems exhibited encapsulation efficiency ∼ 20-37%, drug loading∼ 10-20% (w/w), hydrodynamic diameter (nm): 103.2 ± 7.9 (1), 91.7 ± 12.6 (2), 270.2 ± 58.4 (3), zeta potential (mV): +(47.7 ± 2.8) (1), +(49.2 ± 3.6) (2), -(28.2 ± 2.0) (3). Nanoformulation (1) showed the highest cytotoxicity with increased efficacy in relation to the RuIbp free metallodrug against U87MG human glioma cells.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"549-565"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10564676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual drug loaded polypeptide delivery systems for cancer therapy. 用于癌症治疗的双载药多肽递送系统。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2023-10-12 DOI: 10.1080/02652048.2023.2270064

Natalia Zashikhina, Erik Gandalipov, Apollinariia Dzhuzha, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh

{"title":"Dual drug loaded polypeptide delivery systems for cancer therapy.","authors":"Natalia Zashikhina, Erik Gandalipov, Apollinariia Dzhuzha, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh","doi":"10.1080/02652048.2023.2270064","DOIUrl":"10.1080/02652048.2023.2270064","url":null,"abstract":"The present study was aimed to prepare and examine in vitro novel dual-drug loaded delivery systems. Biodegradable nanoparticles based on poly(L-glutamic acid-co-D-phenylalanine) were used as nanocarriers for encapsulation of two drugs from the paclitaxel, irinotecan, and doxorubicin series. The developed delivery systems were characterised with hydrodynamic diameters less than 300 nm (PDI < 0.3). High encapsulation efficiencies (≥75%) were achieved for all single- and dual-drug formulations. The release studies showed faster release at acidic pH, with the release rate decreasing over time. The release patterns of the co-encapsulated forms of substances differed from those of the separately encapsulated drugs, suggesting differences in drug-polymer interactions. The joint action of encapsulated drugs was analysed using the colon cancer cells, both for the dual-drug delivery sytems and a mixture of single-drug formulations. The encapsulated forms of the drug combinations demonstrated comparable efficacy to the free forms, with the encapsulation enhancing solubility of the hydrophobic drug paclitaxel.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-19"},"PeriodicalIF":3.9,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2