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Journal of microencapsulation最新文献

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Improving physicochemical characteristics and cytotoxicity of baicalin esters by liposome encapsulation. 通过脂质体封装改善黄芩苷酯的理化特性和细胞毒性。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-06-01 Epub Date: 2024-05-08 DOI: 10.1080/02652048.2024.2348462
Wei Wang, Xuan Xin, Mengmeng Zhang, Xiaofeng Li, Guanglei Zhao, Wei Dong Bai
{"title":"Improving physicochemical characteristics and cytotoxicity of baicalin esters by liposome encapsulation.","authors":"Wei Wang, Xuan Xin, Mengmeng Zhang, Xiaofeng Li, Guanglei Zhao, Wei Dong Bai","doi":"10.1080/02652048.2024.2348462","DOIUrl":"10.1080/02652048.2024.2348462","url":null,"abstract":"<p><p>The instability of ester bonds, low water solubility, and increased cytotoxicity of flavonoid glycoside esters significantly limit their application in the food industry. Therefore, the present study attempted to resolve these issues through liposome encapsulation. The results showed that baicalin butyl ester (BEC4) and octyl ester (BEC8) have higher encapsulation and loading efficiencies and lower leakage rate from liposomes than baicalin. FTIR results revealed the location of BEC4 and BEC8 in the hydrophobic layer of liposomes, which was different from baicalin. Additionally, liposome encapsulation improved the water solubility and stability of BEC4 and BEC8 in the digestive system and PBS but significantly reduced their cytotoxicity. Furthermore, the release rate of BEC4 and BEC8 from liposomes was lower than that of baicalin during gastrointestinal digestion. These results indicate that liposome encapsulation alleviated the negative effects of fatty chain introduction into flavonoid glycosides.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"312-325"},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microemulsions based on Acer truncatum seed oil and its fatty acids: fabrication, rheological property, and stability. 基于金合欢籽油及其脂肪酸的微乳剂：制造、流变特性和稳定性。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-06-01 Epub Date: 2024-05-06 DOI: 10.1080/02652048.2024.2348450
Yaqing Fan, Shuting Wang, Jiayi Yang, Ruixue Wang, Yulu Wang, Xuanhe Zhu, Zhanzhong Wang
{"title":"Microemulsions based on <i>Acer truncatum</i> seed oil and its fatty acids: fabrication, rheological property, and stability.","authors":"Yaqing Fan, Shuting Wang, Jiayi Yang, Ruixue Wang, Yulu Wang, Xuanhe Zhu, Zhanzhong Wang","doi":"10.1080/02652048.2024.2348450","DOIUrl":"10.1080/02652048.2024.2348450","url":null,"abstract":"<p><strong>Aims: </strong>To construct the microemulsion delivery system (ME) loading ATSO and NA and study their physicochemical characteristics to enhance their stability and water solubility.</p><p><strong>Methods: </strong>By plotting ternary phase diagrams, the composition and proportions of the MEs were determined. The physicochemical characteristics and stability of MEs were evaluated by mean diameter, polydispersity index (PDI), pH, electrical conductivity, transmission electron microscopy (TEM), rheological behaviour measurement, and phase inversion temperature (PIT).</p><p><strong>Results: </strong>The MEs was composed with EL-40 as a surfactant and specifically with the addition of ethanol as a cosurfactant in NA-loaded ME. The mean diameters of ATSO-loaded ME and NA-loaded ME were 39.65 ± 0.24 nm and 32.90 ± 2.65 nm, and PDI were 0.49 ± 0.01 and 0.28 ± 0.14, respectively. The TEM confirmed the spherical and smooth morphology of MEs. The rheological results indicated that MEs are dilatant fluids with the advantages of low viscosity, high fluidity, and tolerance to temperature fluctuations. The mean diameter and PDI of MEs showed no significant change after storage at 25 °C for 28 days and centrifugation.</p><p><strong>Conclusion: </strong>The prepared microemulsions could expand the application prospects of ATSO and NA products in cosmetics, medicine, foods and other fields.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"296-311"},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of various lipid carriers to study the transdermal penetration mechanism of sinomenine hydrochloride. 构建各种脂质载体，研究盐酸西诺明的透皮渗透机制。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-05-01 Epub Date: 2024-03-07 DOI: 10.1080/02652048.2024.2324810
Mengyao Cui, Yaqing Li, Jing Li, Nini Jia, Wenxuan Cao, Zhengguang Li, Xiang Li, Xiaoqin Chu
{"title":"Construction of various lipid carriers to study the transdermal penetration mechanism of sinomenine hydrochloride.","authors":"Mengyao Cui, Yaqing Li, Jing Li, Nini Jia, Wenxuan Cao, Zhengguang Li, Xiang Li, Xiaoqin Chu","doi":"10.1080/02652048.2024.2324810","DOIUrl":"10.1080/02652048.2024.2324810","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the transdermal mechanisms and compare the differences in transdermal delivery of Sinomenine hydrochloride (SN) between solid lipid nanoparticles (SLN), liposomes (LS), and nanoemulsions (NE).</p><p><strong>Methods: </strong>SN-SLN, SN-LS and SN-NE were prepared by ultrasound, ethanol injection and spontaneous emulsification, respectively. FTIR, DSC, in vitro skin penetration, activation energy (Ea) analysis were used to explore the mechanism of drug penetration across the skin.</p><p><strong>Results: </strong>The particle size and encapsulation efficiency were 126.60 nm, 43.23 ± 0.48%(w/w) for SN-SLN, 224.90 nm, 78.31 ± 0.75%(w/w) for SN-LS, and 83.22 nm, 89.01 ± 2.16%(w/w) for SN-LS. FTIR and DSC showed the preparations had various levels of impacts on the stratum corneum's lipid structure which was in the order of SLN > NE > LS. Ea values of SN-SLN, SN-LS, and SN-NE crossing the skin were 2.504, 1.161, and 2.510 kcal/mol, respectively.</p><p><strong>Conclusion: </strong>SLN had a greater degree of alteration on the skin cuticle, which allows SN to permeate skin more effectively.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"157-169"},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbeads as carriers for Bacillus pumilus: a biofertilizer focus on auxin production. 微珠作为枯草芽孢杆菌的载体：以生产辅酶为重点的生物肥料。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-05-01 Epub Date: 2024-03-12 DOI: 10.1080/02652048.2024.2324812
Solange V Benítez, Rocio Carrasco, Juan D Giraldo, Mauricio Schoebitz
{"title":"Microbeads as carriers for <i>Bacillus pumilus</i>: a biofertilizer focus on auxin production.","authors":"Solange V Benítez, Rocio Carrasco, Juan D Giraldo, Mauricio Schoebitz","doi":"10.1080/02652048.2024.2324812","DOIUrl":"10.1080/02652048.2024.2324812","url":null,"abstract":"<p><p>The study aimed to develop a solid biofertilizer using <i>Bacillus pumilus</i>, focusing on auxin production to enhance plant drought tolerance. Methods involved immobilising <i>B. pumilus</i> in alginate-starch beads, focusing on microbial concentration, biopolymer types, and environmental conditions. The optimal formulation showed a diameter of 3.58 mm ± 0.18, a uniform size distribution after 15 h of drying at 30 °C, a stable bacterial concentration (1.99 × 10<sup>9</sup> CFU g<sup>-1</sup> ± 1.03 × 10<sup>9</sup> over 180 days at room temperature), a high auxin production (748.8 µg g<sup>-1</sup> ± 10.3 of IAA in 7 days), and a water retention capacity of 37% ± 4.07. In conclusion, this new formulation of alginate + starch + L-tryptophan + <i>B. pumilus</i> has the potential for use in crops due to its compelling water retention, high viability in storage at room temperature, and high auxin production, which provides commercial advantages.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"170-189"},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethosomes: a potential nanovesicular carrier to enhancing the drug delivery against skin barriers. 乙硫体：一种潜在的纳米囊状载体，可增强皮肤屏障的给药效果。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-05-01 Epub Date: 2024-03-08 DOI: 10.1080/02652048.2024.2326085
Huma Hameed, Saleha Faheem, Mahtab Ahmad Khan, Anam Hameed, Nelofer Ereej, Hafsa Ihsan
{"title":"Ethosomes: a potential nanovesicular carrier to enhancing the drug delivery against skin barriers.","authors":"Huma Hameed, Saleha Faheem, Mahtab Ahmad Khan, Anam Hameed, Nelofer Ereej, Hafsa Ihsan","doi":"10.1080/02652048.2024.2326085","DOIUrl":"10.1080/02652048.2024.2326085","url":null,"abstract":"<p><p>Ethosomes, which are liposomes like structures, mainly composed primarily of ethanol, have attracted considerable attention due to their potential to enhance the drug permeation via skin. The article discusses the formulation and preparation methods of ethosomes, offering insights into the various factors that influence their size, shape, and stability. Moreover, it explores the techniques used to assess the physicochemical properties of ethosomes and their impact on drug delivery effectiveness. The article also elucidates the mechanism by which ethosomes enhance skin permeation, emphasising their ability to modify the lipid structure and fluidity of the stratum corneum. Additionally, the review investigates the applications of ethosomes in diverse drug delivery scenarios, including the delivery of small molecules, peptides, and phytoconstituents. It highlights the potential of ethosomes to improve drug bioavailability, extend drug release, and achieve targeted delivery to specific skin layers or underlying tissues.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"204-225"},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements and prospects of lipid-based nanoparticles: dual frontiers in cancer treatment and vaccine development. 脂基纳米粒子的进展和前景：癌症治疗和疫苗开发的双重前沿。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-05-01 Epub Date: 2024-04-01 DOI: 10.1080/02652048.2024.2326091
Ibrahim Shaw, George Frimpong Boafo, Yimer Seid Ali, Yang Liu, Ronald Mlambo, Songwen Tan, Chuanpin Chen
{"title":"Advancements and prospects of lipid-based nanoparticles: dual frontiers in cancer treatment and vaccine development.","authors":"Ibrahim Shaw, George Frimpong Boafo, Yimer Seid Ali, Yang Liu, Ronald Mlambo, Songwen Tan, Chuanpin Chen","doi":"10.1080/02652048.2024.2326091","DOIUrl":"10.1080/02652048.2024.2326091","url":null,"abstract":"<p><p>Cancer is a complex heterogeneous disease that poses a significant public health challenge. In recent years, lipid-based nanoparticles (LBNPs) have expanded drug delivery and vaccine development options owing to their adaptable, non-toxic, tuneable physicochemical properties, versatile surface functionalisation, and biocompatibility. LBNPs are tiny artificial structures composed of lipid-like materials that can be engineered to encapsulate and deliver therapeutic agents with pinpoint accuracy. They have been widely explored in oncology; however, our understanding of their pharmacological mechanisms, effects of their composition, charge, and size on cellular uptake, tumour penetration, and how they can be utilised to develop cancer vaccines is still limited. Hence, we reviewed LBNPs' unique characteristics, biochemical features, and tumour-targeting mechanisms. Furthermore, we examined their ability to enhance cancer therapies and their potential contribution in developing anticancer vaccines. We critically analysed their advantages and challenges impeding swift advancements in oncology and highlighted promising avenues for future research.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"226-254"},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pulmonary protective potential of vanillic acid-loaded TPGS-liposomes: modulation of miR-217/MAPK/NF-κb signalling pathway 负载香草酸的TPGS-脂质体的肺保护潜力：调控miR-217/MAPK/NF-κb信号通路
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-04-22 DOI: 10.1080/02652048.2024.2335166
Nabila M. Sweed, Mai A. Zaafan, Mahitab H. El-Bishbishy, Marwa H.S. Dawoud
{"title":"The pulmonary protective potential of vanillic acid-loaded TPGS-liposomes: modulation of miR-217/MAPK/NF-κb signalling pathway","authors":"Nabila M. Sweed, Mai A. Zaafan, Mahitab H. El-Bishbishy, Marwa H.S. Dawoud","doi":"10.1080/02652048.2024.2335166","DOIUrl":"https://doi.org/10.1080/02652048.2024.2335166","url":null,"abstract":"The aim is to investigate the possible pulmonary protective effect of vanillic acid (VA) in liposome-TPGS nanoparticles, to overcome VA’s poor bioavailability. VA was successfully extracted. Liposo...","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"33 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140634463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, characterisation, and pharmacodynamic study of myricetin pH-sensitive liposomes 米力西汀 pH 值敏感脂质体的制备、表征和药效学研究
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-04-15 DOI: 10.1080/02652048.2024.2337461
Chenlu Li, Mengzhe Du, Lingzhi Meng, Michael Adu-Frimpong, Caizhi Gong, Sile Zheng, Wentao Shi, Qilong Wang, Elmurat Toreniyazov, Hao Ji, Xia Cao, Jiangnan Yu, Ximing Xu
{"title":"Preparation, characterisation, and pharmacodynamic study of myricetin pH-sensitive liposomes","authors":"Chenlu Li, Mengzhe Du, Lingzhi Meng, Michael Adu-Frimpong, Caizhi Gong, Sile Zheng, Wentao Shi, Qilong Wang, Elmurat Toreniyazov, Hao Ji, Xia Cao, Jiangnan Yu, Ximing Xu","doi":"10.1080/02652048.2024.2337461","DOIUrl":"https://doi.org/10.1080/02652048.2024.2337461","url":null,"abstract":"Myricetin (MYR) was incorporated into pH-sensitive liposomes in order to improve its bioavailability and anti-hyperuricemic activity.The MYR pH-sensitive liposomes (MYR liposomes) were prepared usi...","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"243 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of a casein-/whey protein concentrate–Antarctic krill oil emulsion system and improvement of its storage stability 酪蛋白/乳清浓缩蛋白-南极磷虾油乳液体系的特性及其储存稳定性的改进
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-04-11 DOI: 10.1080/02652048.2024.2335152
Yujia Liu, Ziyang Wang, Lu Lv, Liang Wang, Deyang Li, Xiao Miao, Honglei Zhan
{"title":"Characterisation of a casein-/whey protein concentrate–Antarctic krill oil emulsion system and improvement of its storage stability","authors":"Yujia Liu, Ziyang Wang, Lu Lv, Liang Wang, Deyang Li, Xiao Miao, Honglei Zhan","doi":"10.1080/02652048.2024.2335152","DOIUrl":"https://doi.org/10.1080/02652048.2024.2335152","url":null,"abstract":"To develop Antarctic krill oil emulsions with casein and whey protein concentrate (WPC) and study their physicochemical properties and storage stability.Emulsions were prepared by homogenisation an...","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":"36 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced in vitro and ex vivo transdermal permeation of microemulsion gel of tapentadol hydrochloride. 增强盐酸他喷他多微乳凝胶的体外和体内透皮渗透。
IF 3.9 4区 医学
Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.1080/02652048.2024.2319045
Nimmathota Madhavi, Heera Battu
{"title":"Enhanced <i>in vitro</i> and <i>ex vivo</i> transdermal permeation of microemulsion gel of tapentadol hydrochloride.","authors":"Nimmathota Madhavi, Heera Battu","doi":"10.1080/02652048.2024.2319045","DOIUrl":"10.1080/02652048.2024.2319045","url":null,"abstract":"<p><p>Aim of the current study is to develop a microemulsion gel for transdermal delivery of tapentadol hydrochloride. Microemulsion was developed using phase diagram and subjected to assay, globule size, PDI, zeta potential, TEM and <i>in vitro</i> drug release studies. The optimized microemulsion was converted into gel using carbopol 934 NF and evaluated for viscosity, spreadability, <i>in vitro</i>, <i>ex vivo</i>, FTIR, DSC, stability and skin irritation studies. The mean globule size, PDI, zeta potential and <i>in vitro</i> drug release of microemulsion were found 247.3 nm, 0.298, -17.6 mV and 98.42% respectively. <i>In vitro</i> and <i>ex vivo</i> drug release of gel was found 92.2% and 88.6% in 24 h. Viscosity and spreadability results indicated ease of application and no incompatibility was observed from FTIR studies. The skin irritation studies showed absence of erythema. Key findings from the current research concluded that microemulsion gel was suitable for effective transdermal delivery.</p>","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"127-139"},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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