Enhanced in vitro and ex vivo transdermal permeation of microemulsion gel of tapentadol hydrochloride.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI:10.1080/02652048.2024.2319045

Nimmathota Madhavi, Heera Battu

引用次数: 0

Abstract

Aim of the current study is to develop a microemulsion gel for transdermal delivery of tapentadol hydrochloride. Microemulsion was developed using phase diagram and subjected to assay, globule size, PDI, zeta potential, TEM and in vitro drug release studies. The optimized microemulsion was converted into gel using carbopol 934 NF and evaluated for viscosity, spreadability, in vitro, ex vivo, FTIR, DSC, stability and skin irritation studies. The mean globule size, PDI, zeta potential and in vitro drug release of microemulsion were found 247.3 nm, 0.298, -17.6 mV and 98.42% respectively. In vitro and ex vivo drug release of gel was found 92.2% and 88.6% in 24 h. Viscosity and spreadability results indicated ease of application and no incompatibility was observed from FTIR studies. The skin irritation studies showed absence of erythema. Key findings from the current research concluded that microemulsion gel was suitable for effective transdermal delivery.

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增强盐酸他喷他多微乳凝胶的体外和体内透皮渗透。

本研究旨在开发一种用于盐酸他喷他多透皮给药的微乳凝胶。利用相图开发了微乳液，并对其进行了化验、球形大小、PDI、ZETA电位、TEM和体外药物释放研究。使用 carbopol 934 NF 将优化后的微乳剂转化为凝胶，并对其粘度、铺展性、体外、体内、傅立叶变换红外光谱、DSC、稳定性和皮肤刺激性进行了评估。结果发现，微乳液的平均球形尺寸、PDI、zeta 电位和体外药物释放率分别为 247.3 nm、0.298、-17.6 mV 和 98.42%。凝胶的体外和体内药物释放率在 24 小时内分别为 92.2% 和 88.6%。粘度和铺展性结果表明其易于应用，傅立叶变换红外光谱研究也没有发现不相容性。皮肤刺激性研究表明没有红斑。当前研究的主要结论是，微乳液凝胶适用于有效的透皮给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.