Journal of microencapsulation最新文献_第6页

Synergistic effect of DR5-targeted capsules loaded with doxorubicin in drug-resistant 3D tumour spheroids. 载多柔比星dr5靶向胶囊在耐药三维肿瘤球体中的协同作用。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-11-01 Epub Date: 2025-10-14 DOI: 10.1080/02652048.2025.2570651

Daria Trushina, Anastasia Gileva, Anne Yagolovich, Marine Gasparian, Leyli Kurbanova, Sergey Burov, Tatiana Bukreeva, Tatiana Pallaeva, Vladimir Artemov, Vladimir Oleinikov, Elena Markvicheva

{"title":"Synergistic effect of DR5-targeted capsules loaded with doxorubicin in drug-resistant 3D tumour spheroids.","authors":"Daria Trushina, Anastasia Gileva, Anne Yagolovich, Marine Gasparian, Leyli Kurbanova, Sergey Burov, Tatiana Bukreeva, Tatiana Pallaeva, Vladimir Artemov, Vladimir Oleinikov, Elena Markvicheva","doi":"10.1080/02652048.2025.2570651","DOIUrl":"10.1080/02652048.2025.2570651","url":null,"abstract":"Aim: To develop polyelectrolyte multilayer capsules (PMC) loaded with doxorubicin (DOX) and modified with the DR5-B protein to overcome drug resistance in MCF-7 breast cancer cells.Methods: The capsules were prepared by layer-by-layer (LbL) assembly followed by thermal shrinking, DOX encapsulation and DR5-B surface modification. The capsules were characterised using scanning electron microscopy (SEM), dynamic light scattering (DLS), and UV-Vis spectrophotometry. Cellular uptake was assessed by confocal microscopy, flow cytometry, and fluorimetry. Cytotoxicity was evaluated by MTT-test in 2D and 3D in vitro models.Results: Mean capsule size was 320 ± 90 nm (PDI 0.39), mean ζ-potential was +29 ± 5 mV. The encapsulation efficiencies (ЕЕ) of DOX and DR5-B were 85 ± 7% and 80 ± 4%, with loading capacities (LC) of 9 ± 2 w/w% and 145 ± 40 w/w%, respectively. Shrunken capsules exhibited 3.5-fold higher internalisation than non-shrunken ones. DR5-B increased capsule accumulation by 1.8-fold. The capsules showed synergistic cytotoxicity in DR5-B-resistant MCF-7 spheroids (IC50 227 ± 13 ng/mL), being non-toxic to fibroblasts.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"736-751"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoemulsions for topical delivery: formulation, applications and recent advances. 局部递送纳米乳剂：配方、应用和最新进展。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-11-01 Epub Date: 2025-07-22 DOI: 10.1080/02652048.2025.2531778

Rajvi Shah, Jimil Gandhi, Monit Shah, Prerna Tiwari, Bharat Chaudhary, Vidhi Shah

引用次数: 0

Ultrasound-responsive hybrid liposome-polymer nanoparticles for enhanced stability and cytotoxicity of chemotherapeutic agent. 超声响应的混合脂质体-聚合物纳米颗粒增强化疗药物的稳定性和细胞毒性。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-11-01 Epub Date: 2025-10-17 DOI: 10.1080/02652048.2025.2570650

Sidrah Saeed, Usama Sarwar, Imran Tariq, Afreenish Amir, Abida Raza

{"title":"Ultrasound-responsive hybrid liposome-polymer nanoparticles for enhanced stability and cytotoxicity of chemotherapeutic agent.","authors":"Sidrah Saeed, Usama Sarwar, Imran Tariq, Afreenish Amir, Abida Raza","doi":"10.1080/02652048.2025.2570650","DOIUrl":"10.1080/02652048.2025.2570650","url":null,"abstract":"Aims: To develop and evaluate a biocompatible, stable, ultrasound-responsive hybrid nanocarrier for effective therapeutic outcomes.Methods: The hybrid liposome-polymer drug delivery system (hLPDS) was characterised using dynamic light scattering, photoluminescence, atomic force microscopy, Raman spectroscopy and evaluated for drug release, cytotoxicity, cell uptake, and biodistribution.Results: The hLPDS demonstrated mean diameter of 120 ± 5 nm and polydispersity index of 0.58 ± 0.83, zeta potential of 30 ± 5 mV, encapsulation efficiency of 93 ± 2.9%, loading capacity of 13 ± 1.5% (w/w) and remained stable for 90 days. The hLPDS showed 10% cell viability and lower IC50 (1.274 ± 0.32 µM) compared to free drug (1.842 ± 0.32 µM). Ultrasound at 4 MHz frequency increased drug release above 90% (w/v), enhanced cellular internalisation (p < 0.0001), and anti-proliferative effects.Conclusion: Ultrasound-triggered hLPDS exhibited enhanced cytotoxicity, cell uptake, stability, and therapeutic effect compared to liposomes and micelles alone.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"721-735"},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the antioxidant properties of unsaturated fatty acid microemulsions. 不饱和脂肪酸微乳抗氧化性能的研究。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-09-01 Epub Date: 2025-07-02 DOI: 10.1080/02652048.2025.2521062

Fan Yang, Mingjun Tang, Kun Wang, Min Ling

{"title":"Study on the antioxidant properties of unsaturated fatty acid microemulsions.","authors":"Fan Yang, Mingjun Tang, Kun Wang, Min Ling","doi":"10.1080/02652048.2025.2521062","DOIUrl":"10.1080/02652048.2025.2521062","url":null,"abstract":"To enhance the antioxidant properties of unsaturated fatty acids (UFAs), a UFAs microemulsion (UFAs-M) is prepared via direct emulsification. Its storage stability is evaluated using laser diffraction, while the antioxidant properties of both UFAs-M and free UFAs are assessed using the DPPH method. The effects of temperature and UV exposure are also investigated. Over a 90-day period, the mean particle diameter of UFAs-M ranges from 49.1 nm to 57.4 nm, with zeta potential values between -11.79 mV and -13.13 mV. The polydispersity index (PDI) ranges from 0.276 ± 0.045 to 0.319 ± 0.049. The encapsulation efficiency varies from 98.4 ± 0.59% (w/w) to 91.5 ± 0.98% (w/w), and the drug loading ranges from 0.984 ± 0.011% (w/w) to 0.862 ± 0.013% (w/w). The DPPH radical scavenging activity of UFAs-M (82.8 ± 3.15%) is significantly higher than that of UFAs (65.33 ± 0.26%). Moreover, UFAs-M exhibits superior antioxidant performance under high temperature and UV exposure. Overall, the microemulsion system enhances both the antioxidant capacity and storage stability of UFAs, showing promising potential for practical applications.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"613-622"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating neurodegeneration: challenges, pathophysiology, biomarkers, and the promise of nanocrystals-based nanotherapeutics. 导航神经退行性变：挑战，病理生理学，生物标志物，以及基于纳米晶体的纳米疗法的前景。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-09-01 Epub Date: 2025-05-26 DOI: 10.1080/02652048.2025.2507637

Gagandeep Kaur, Jay Prakash Dewangan, Anuradha Kumari, Rahul Shukla

{"title":"Navigating neurodegeneration: challenges, pathophysiology, biomarkers, and the promise of nanocrystals-based nanotherapeutics.","authors":"Gagandeep Kaur, Jay Prakash Dewangan, Anuradha Kumari, Rahul Shukla","doi":"10.1080/02652048.2025.2507637","DOIUrl":"10.1080/02652048.2025.2507637","url":null,"abstract":"Approximately 90% of drugs struggle with low solubility and non-selectivity in target-specific drug delivery. This creates a significant challenge due to the limited permeability of the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier. Poor solubility, low drug concentration at the target site, and rapid clearance via efflux transporters further restrict effective drug delivery in neurodegenerative disorders (NDDs). Nanocrystal (NC) technology offers a promising approach by producing sub-micron, carrier-free NCs with high drug payload, stabilised with stabilisers to enhance colloidal stability and shelf life. The increased surface area boosts the solubility, bioavailability, and brain permeability of hydrophobic drugs, making NCs an emerging technology for both therapeutic and diagnostic applications in neurodegenerative diseases. NCs are synthesised via top-down, bottom-up, and combinational methods, with NANOEDGE® and SmartCrystals® being some of the patented technologies. Despite the high potential of NCs in improving drug delivery to the brain, many challenges remain, including thermal instability, scalability, and long-term safety.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"547-564"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro apoptotic potential and ex vivo permeation analysis of ulipristal acetate loaded niosomes for management of uterine fibroids. 醋酸乌普利司酯负载乳小体治疗子宫肌瘤的体外凋亡电位及体外渗透分析。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.1080/02652048.2025.2507639

Priyadarshi Aparajay, Harishkumar Madhyastha, Shuvadip Bhowmik, Abhimanyu Dev

{"title":"In vitro apoptotic potential and ex vivo permeation analysis of ulipristal acetate loaded niosomes for management of uterine fibroids.","authors":"Priyadarshi Aparajay, Harishkumar Madhyastha, Shuvadip Bhowmik, Abhimanyu Dev","doi":"10.1080/02652048.2025.2507639","DOIUrl":"10.1080/02652048.2025.2507639","url":null,"abstract":"Aim: To develop and optimise a niosomal formulation of ulipristal acetate (UPA) for enhanced cytotoxicity against uterine fibroids.Methods: Quality by Design, thin film hydration, dynamic light scattering, transmission electron microscopy, cytotoxicity assays, flow cytometry, reactive oxygen species (ROS) generation analysis.Results: Optimised UPA-loaded niosomes (UPA-NS) exhibited mean diameter of 170.7 ± 3.46 nm, polydispersity index of 0.23 ± 0.02, zeta potential of -18.2 ± 2.31 mV, encapsulation efficiency of 90.57 ± 3.22%w/w and 10.65 ± 1.64%w/w loading efficiency. UPA-NS showed 89 ± 3.22%w/w drug release at pH 5.5 within 24 hours compared to 36 ± 5.44%w/w at pH 7.4. UPA-NS demonstrated 70% cytotoxicity in HEC-6 cells at 0.5 μg/mL compared to 44% for free UPA. Flow cytometry showed 23% live cells for UPA-NS vs 33% for free UPA after 16 hours. UPA-NS induced higher ROS generation than free UPA.Conclusions: The niosomal formulation enhanced the cytotoxicity and ROS-generating potential of UPA against uterine fibroid cells.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"580-592"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured lipid nanocarrier scaffold of ranolazine: preparation, optimization, in vitro and in vivo evaluations. 雷诺嗪纳米结构脂质纳米载体支架的制备、优化及体内外评价。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-09-01 Epub Date: 2025-06-21 DOI: 10.1080/02652048.2025.2521070

Kiran D Patil, Yogeeta O Agrawal

{"title":"Nanostructured lipid nanocarrier scaffold of ranolazine: preparation, optimization, in vitro and in vivo evaluations.","authors":"Kiran D Patil, Yogeeta O Agrawal","doi":"10.1080/02652048.2025.2521070","DOIUrl":"10.1080/02652048.2025.2521070","url":null,"abstract":"The present study aimed to develop and optimise Ranolazine-loaded Nanostructured Lipid Carriers (RNZ-NLCs) to overcome the poor oral bioavailability and rapid clearance associated with Ranolazine, thereby improving its therapeutic efficacy. RNZ-NLCs were prepared using the hot high-pressure homogenisation technique and optimised using a 2³ factorial design. Characterisation techniques included dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infra-red spectroscopy (FTIR), in vitro drug release profiling, and pharmacokinetic analysis in rats. The optimised RNZ-NLCs exhibited a mean diameter of 205.8 nm, a polydispersity index (PDI) of 0.318, a surface charge (Zeta potential) of -22.4 mV and drug loading of 8.01% w/w. DSC and XRD studies confirmed the transformation of Ranolazine into an amorphous state, and FTIR indicated no chemical interaction with excipients. In vitro release studies showed a sustained release profile, with 65% drug release at 12 hours and 90% at 24 hours, fitting the Korsmeyer-Peppas model. Long-term storage stability studies over 90 days revealed no significant changes in particle characteristics. Pharmacokinetic evaluation in rats showed that RNZ-NLCs increased the Cmax to 18.621 µg/mL (from 9.413 µg/mL for free RNZ), delayed Tmax to 4 h (from 2 h), and enhanced AUC0-∞ to 217.02 µg·h/mL (from 32.06 µg·h/mL). Additionally, mean residence time (MRT) and elimination half-life (t1/2) were extended to 11.83 h and 6.81 h, respectively. RNZ-NLCs significantly improved the pharmacokinetic profile and storage stability of Ranolazine, indicating their potential as a promising delivery system for enhancing oral bioavailability and therapeutic efficacy.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"623-634"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and optimisation of esculin-loaded chitosan microspheres for intravitreal injection. 玻璃体内注射用载内皮素壳聚糖微球的研制与优化。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-09-01 Epub Date: 2025-06-17 DOI: 10.1080/02652048.2025.2515840

Ning He, Danqing Wu, Rui Luo, Ziqin Cao, Shuang Shan, Qingsong Fei, Jiabao Wu, Shaoyun Bai

{"title":"Development and optimisation of esculin-loaded chitosan microspheres for intravitreal injection.","authors":"Ning He, Danqing Wu, Rui Luo, Ziqin Cao, Shuang Shan, Qingsong Fei, Jiabao Wu, Shaoyun Bai","doi":"10.1080/02652048.2025.2515840","DOIUrl":"10.1080/02652048.2025.2515840","url":null,"abstract":"This study was to prepare the esculin-loaded chitosan microspheres for intravitreal injection and explore the feasibility of the treatment of macular degeneration. The microspheres were fabricated using an emulsification crosslinking technique. The drug loading, encapsulation efficiency, and mean particle diameter of the optimised esculin-loaded chitosan microspheres were 8.03 ± 1.30%, 93.03 ± 2.16%, and 4.81 ± 1.60 μm, respectively. The thermal stability evaluation at 25 °C demonstrated consistent particle diameter maintenance, with microspheres retaining sizes of 4.73 ± 1.75 μm and 4.89 ± 1.55 μm after 15 and 30 days' storage periods, respectively. The in vitro release profile demonstrated 80% cumulative drug release from the microspheres over a 72 h period. Subsequent pharmacokinetic analysis revealed significantly enhanced parameters in the vitreous humour following intravitreal administration, with the half-life (t1/2) reaching 879.88 ± 44.00 min and the area under curve (AUC) attaining 150.18 ± 2.28 × 103 mg·min/mL. Intravitreal injection of esculin-loaded chitosan microspheres offers a promising drug delivery system for the treatment of macular degeneration.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"593-612"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pH-controlled release properties of chitosan-gold nanoparticles encapsulated nobiletin to induce apoptosis through PI3K/AKT/mTOR signalling pathway on gastric cancer cell lines. 壳聚糖金纳米颗粒包埋诺比叶素的ph调控释放特性通过PI3K/AKT/mTOR信号通路诱导胃癌细胞凋亡。

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-09-01 Epub Date: 2025-05-31 DOI: 10.1080/02652048.2025.2507638

Hongyi Qing, Ping Xie, Zhenjiang Wu, Wenhai Fan, Yuanxiao Liang, Xiulian Xu

{"title":"The pH-controlled release properties of chitosan-gold nanoparticles encapsulated nobiletin to induce apoptosis through PI3K/AKT/mTOR signalling pathway on gastric cancer cell lines.","authors":"Hongyi Qing, Ping Xie, Zhenjiang Wu, Wenhai Fan, Yuanxiao Liang, Xiulian Xu","doi":"10.1080/02652048.2025.2507638","DOIUrl":"10.1080/02652048.2025.2507638","url":null,"abstract":"Context: Gastric cancer (GC) remains a major health concern with limited effective therapies. Nanotechnology-based drug delivery systems offer targeted and efficient treatment strategies.Objective: This study aimed to develop chitosan-coated gold nanoparticles loaded with Nobiletin (Ch-AuNPs-NB) and evaluate their anticancer potential by targeting the PI3K/AKT/mTOR signaling pathway in GC.Materials and MethodsCh-AuNPs were synthesized by NaBH4 reduction and loaded with Nobiletin using nanoprecipitation. Characterization was done using UV-Vis, FTIR, XRD, DLS, and TEM. Drug loading, encapsulation efficiency, and pH-responsive release were assessed.Results: Ch-AuNPs-NB (∼120 nm, PDI 0.247, +51 mV) showed enhanced drug loading (15%) and encapsulation efficiency (90.4%) at higher NB concentrations. The formulation demonstrated pH-responsive release over 72 hours and stability for 60 days.Discussion and conclusion: Ch-AuNPs-NB inhibited the PI3K/AKT/mTOR pathway, induced apoptosis, and arrested the cell cycle in AGS cells, highlighting its potential as a targeted GC therapy.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"565-579"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing linagliptin-loaded novasomes as a neuroprotectant for Alzheimer's disease: in-vitro characterisation, statistical optimisation and ex-vivo permeation study. 重新利用利格列汀负载的novassomes作为阿尔茨海默病的神经保护剂：体外表征，统计优化和离体渗透研究

IF 3.2 4区医学

Journal of microencapsulation Pub Date : 2025-08-01 Epub Date: 2025-05-07 DOI: 10.1080/02652048.2025.2500542

Michael M Farag, Nevine S Abdelmalak, Shahira F El Menshawe, Asmaa S Omara, Doaa S Hamad

{"title":"Repurposing linagliptin-loaded novasomes as a neuroprotectant for Alzheimer's disease: in-vitro characterisation, statistical optimisation and ex-vivo permeation study.","authors":"Michael M Farag, Nevine S Abdelmalak, Shahira F El Menshawe, Asmaa S Omara, Doaa S Hamad","doi":"10.1080/02652048.2025.2500542","DOIUrl":"10.1080/02652048.2025.2500542","url":null,"abstract":"Aim: Linagliptin (LGP) has poor oral bioavailability due to P-gp efflux and first-pass metabolism. This study aimed to develop LGP-loaded novasomes (LGP-NVS) for intranasal brain delivery.Methods: LGP-NVS were prepared via thin film hydration and optimised using a Box-Behnken design, varying cholesterol, stearic acid, and span-80 levels. Fifteen formulations were evaluated for particle size, entrapment efficiency, zeta potential, and drug release. The optimised formula underwent further surface, compatibility, permeability, and stability studies.Results: The optimised formula showed high entrapment (84.22% ± 1.68%), small particle size (239.35 ± 15.20 nm), plausible zeta potential (-30.25 ± 1.23 mV), polydispersity index (0.32 ± 0.058), and controlled release (66.85 ± 2.25% after 8 h). Transmission electron microscopy demonstrated uniform size. Stability was maintained over three months. Ex-vivo permeation studies showed 1.39-fold higher permeation through camel nasal mucosa compared to drug solution.Conclusion: Intranasal LGP-NVS might be an auspicious therapeutic avenue for the combat of Alzheimer's disease.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"531-545"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0