Journal of microencapsulation最新文献_第6页

Preparation, characterisation, and pharmacodynamic study of myricetin pH-sensitive liposomes 米力西汀 pH 值敏感脂质体的制备、表征和药效学研究

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-04-15 DOI: 10.1080/02652048.2024.2337461

Chenlu Li, Mengzhe Du, Lingzhi Meng, Michael Adu-Frimpong, Caizhi Gong, Sile Zheng, Wentao Shi, Qilong Wang, Elmurat Toreniyazov, Hao Ji, Xia Cao, Jiangnan Yu, Ximing Xu

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Characterisation of a casein-/whey protein concentrate–Antarctic krill oil emulsion system and improvement of its storage stability 酪蛋白/乳清浓缩蛋白-南极磷虾油乳液体系的特性及其储存稳定性的改进

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-04-11 DOI: 10.1080/02652048.2024.2335152

Yujia Liu, Ziyang Wang, Lu Lv, Liang Wang, Deyang Li, Xiao Miao, Honglei Zhan

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Enhanced in vitro and ex vivo transdermal permeation of microemulsion gel of tapentadol hydrochloride. 增强盐酸他喷他多微乳凝胶的体外和体内透皮渗透。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.1080/02652048.2024.2319045

Nimmathota Madhavi, Heera Battu

引用次数: 0

Gelatine nanoparticles encapsulating three edible plant extracts as potential nanonutraceutical agents against type 2 diabetes mellitus. 将三种可食用植物提取物封装成明胶纳米颗粒，作为潜在的纳米保健药剂防治 2 型糖尿病。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.1080/02652048.2024.2313230

Akurange Sujeevi Dammadinna Wickramasinghe, Anoja Priyadarshani Attanayake, Pabasara Kalansuriya

{"title":"Gelatine nanoparticles encapsulating three edible plant extracts as potential nanonutraceutical agents against type 2 diabetes mellitus.","authors":"Akurange Sujeevi Dammadinna Wickramasinghe, Anoja Priyadarshani Attanayake, Pabasara Kalansuriya","doi":"10.1080/02652048.2024.2313230","DOIUrl":"10.1080/02652048.2024.2313230","url":null,"abstract":"Aim: To optimise, and characterise gelatine nanoparticles (GNPs) encapsulating plant extracts and evaluate the glucose-lowering potential.Methods: GNPs encapsulating plant extracts were prepared by desolvation method followed by adsorption. The GNPs were characterised by loading efficiency, loading capacity, particle size, zeta potential, SEM and FTIR. The glucose-lowering activity of GNPs was determined using oral glucose tolerance test in high-fat diet fed streptozotocin-induced Wistar rats.Results: Loading efficiency and capacity, particle mean diameter, and zeta potential of optimised GNPs 72.45 ± 13.03% w/w, 53.05 ± 26.16% w/w, 517 ± 48 nm and (-)23.43 ± 9.96 mV respectively. GNPs encapsulating aqueous extracts of C. grandis, S. auriculata, and ethanol 70% v/v extracts of M. koenigii showed glucose-lowering activity by 17.62%, 11.96% and 13.73% (p < 0.05) compared to the non-encapsulated extracts. FTIR analysis confirmed the encapsulation of phytoconstituents into GNPs. SEM imaging showed spherical GNPs (174 ± 46 nm).Conclusion: GNPs encapsulating plant extracts show promising potential to be developed as nanonutraceuticals against diabetes.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"94-111"},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Spray dried acerola (Malpighia emarginata DC) juice particles to produce phytochemical-rich starch-based edible films. 用喷雾干燥的金针菜（Malpighia emarginata DC）果汁颗粒生产富含植物化学成分的淀粉基食用薄膜。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-12 DOI: 10.1080/02652048.2024.2313234

Dayene Nunes Ribeiro, Kátia Cristina Borges, Kátia Nicolau Matsui, Roberta Targino Hoskin

{"title":"Spray dried acerola (Malpighia emarginata DC) juice particles to produce phytochemical-rich starch-based edible films.","authors":"Dayene Nunes Ribeiro, Kátia Cristina Borges, Kátia Nicolau Matsui, Roberta Targino Hoskin","doi":"10.1080/02652048.2024.2313234","DOIUrl":"10.1080/02652048.2024.2313234","url":null,"abstract":"This study aimed to produce spray dried acerola juice microparticles with different protein carriers to be incorporated into edible starch films. The microparticles were evaluated for solids recovery, polyphenol retention, solubility, hygroscopicity, particle size distribution, X-ray diffraction, phytochemical compounds and antioxidant activity. Acerola microparticles produced with WPI/hydrolysed collagen carriers (AWC) with higher solids recovery (53.5 ± 0.34% w/w), polyphenol retention (74.4 ± 0.44% w/w), high solubility in water (85.2 ± 0.4% w/w), total polyphenol content (128.45 ± 2.44 mg GAE/g) and good storage stability were selected to produce starch-based films by casting. As a result, cassava films with water vapour permeability of 0.29 ± 0.07 g mm/m2 h KPa, polyphenol content of 10.15 ± 0.22 mg GAE/g film and DPPH radical scavenging activity of 6.57 ± 0.13 μM TE/g film, with greater migration of polyphenol to water (6.30 ± 0.52 mg GAE/g film) were obtained. Our results show that the incorporation of phytochemical-rich fruit microparticles is a promising strategy to create biodegradable edible films.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"112-126"},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astaxanthin-loaded alginate-chitosan gel beads activate Nrf2 and pro-apoptotic signalling pathways against oxidative stress. 含虾青素的海藻酸壳聚糖凝胶珠可激活 Nrf2 和促细胞凋亡信号通路，对抗氧化应激。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.1080/02652048.2024.2319048

Hamieh Goshtasbi, Elaheh Dalir Abdolahinia, Marziyeh Fathi, Ali Movafeghi, Hossein Omidian, Jaleh Barar, Yadollah Omidi

{"title":"Astaxanthin-loaded alginate-chitosan gel beads activate Nrf2 and pro-apoptotic signalling pathways against oxidative stress.","authors":"Hamieh Goshtasbi, Elaheh Dalir Abdolahinia, Marziyeh Fathi, Ali Movafeghi, Hossein Omidian, Jaleh Barar, Yadollah Omidi","doi":"10.1080/02652048.2024.2319048","DOIUrl":"10.1080/02652048.2024.2319048","url":null,"abstract":"Oxidative stress (OS) plays a crucial role in disease development. Astaxanthin (ATX), a valuable natural compound, may reduce OS and serve as a treatment for diseases like neurodegenerative disorders and cancer. Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates antioxidant enzymes and OS management. We evaluated ATX's antioxidant activity via Alg-CS/ATX gel beads in vitro. ATX-encapsulated alginate-chitosan (Alg-CS/ATX) gel beads were synthesized and structurally/morphologically characterized by SEM, FT-IR, and XRD. Their biological effects were examined in human umbilical vein endothelial cells (HUVECs) treated with H2O2 through MTT assay, Annexin V/PI, cell cycle studies, and western blotting. Alg-CS effectively carried ATX, with high capacity and reduced pore size. Alg-CS/ATX displayed an 84% encapsulation efficiency, maintaining stability for 30 days. In vitro studies showed a 1.4-fold faster release at pH 5.4 than at neutral pH, improving ATX's therapeutic potential. HUVECs treated with Alg-CS/ATX showed enhanced viability via increased Nrf2 expression. Alg-CS gel beads exhibit significant potential as a biocompatible vehicle for delivering ATX to combat OS with considerable opportunity for clinical applications.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"140-156"},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production and investigation of Pickering emulsion stabilised by casein-Qodume Shirazi (Alyssum homolocarpum) seed gum complex particles: gastrointestinal digestion. 酪蛋白-白子籽胶复合颗粒稳定皮克林乳的制备与研究:胃肠消化。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-01-17 DOI: 10.1080/02652048.2023.2282987

Atena Modiri-Dovom, Akram Arianfar, Sara Naji-Tabasi, Vahid Hakimzadeh

{"title":"Production and investigation of Pickering emulsion stabilised by casein-Qodume Shirazi (Alyssum homolocarpum) seed gum complex particles: gastrointestinal digestion.","authors":"Atena Modiri-Dovom, Akram Arianfar, Sara Naji-Tabasi, Vahid Hakimzadeh","doi":"10.1080/02652048.2023.2282987","DOIUrl":"10.1080/02652048.2023.2282987","url":null,"abstract":"Recently, there has been growing research interests in designing Pickering emulsions. In this work, Alyssum homolocarpum seed gum (AHSG) and casein protein (CP) nanoparticles (NPs) fabricated as Pickering stabilizers. AHSG (0.0, 0.05, 0.10, and 0.15% (w/w))-CP (2% (w/w)) nanoparticles were fabricated and their properties were investigated (mean diameter, morphology, zeta potential, Fourier transform infra-red, and contact angle). Formation and stability of Pickering emulsion (Pes) stabilized by AHSG-CP NPs were monitored by mean diameter, rheological properties, and in vitro digestion. AHSG-CP Nps exhibited a small size (107.75 ± 0.42-201.52 ± 0.70 nm) and had wettability between 64.94 ± 3.44° and 70.92 ± 7.64°. The stability of PEs was greatly improved by 0.05AHSG-CP NPs, even after 30 days of storage, centrifugation, and in vitro digestion, owing to the reinforcement of particle structure at the oil/water interfaces.This study demonstrates that 0.05% (w/w) AHSG-CP NP showed the highest stability during storage and against gastrointestinal digestion which showed its suitability as a fat reducer emulsion structure.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"79-93"},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new approach for the treatment of Alzheimer's disease: insulin-quantum dots. 治疗阿尔茨海默病的新方法:胰岛素量子点。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-01-01 Epub Date: 2024-01-10 DOI: 10.1080/02652048.2023.2282968

Gamze Camlik, Besa Bilakaya, Yildiz Ozsoy, Ismail Tuncer Degim

引用次数: 0

Quality by design endorsed atorvastatin-loaded nanostructured lipid carriers embedded in pH-responsive gel for melanoma. 设计质量认可了在ph反应凝胶中嵌入阿托伐他汀纳米结构脂质载体用于黑色素瘤。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-01-01 Epub Date: 2024-01-10 DOI: 10.1080/02652048.2023.2282971

Deepkumar Bagasariya, Kondasingh Charankumar, Saurabh Shah, Paras Famta, Valencia Fernandes, Syed Shahrukh, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava

{"title":"Quality by design endorsed atorvastatin-loaded nanostructured lipid carriers embedded in pH-responsive gel for melanoma.","authors":"Deepkumar Bagasariya, Kondasingh Charankumar, Saurabh Shah, Paras Famta, Valencia Fernandes, Syed Shahrukh, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava","doi":"10.1080/02652048.2023.2282971","DOIUrl":"10.1080/02652048.2023.2282971","url":null,"abstract":"Aim: Our aim was to repurpose atorvastatin for melanoma by encapsulating in a nanostructured lipid carrier matrix to promote tumour cell internalisation and skin permeation. pH-responsive chitosan gel was employed to restrict At-NLCs in upper dermal layers.Methods: We utilised a quality by design approach for encapsulating At within the NLC matrix. Further, cellular uptake and cytotoxicity was evaluated along with pH-responsive release and ex vivo skin permeation.Results: Cytotoxicity assay showed 3.13-fold enhanced cytotoxicity on melanoma cells compared to plain drug with nuclear staining showing apoptotic markers. In vitro, release studies showed 5.9-fold rapid release in chitosan gel matrix at pH 5.5 compared to neutral pH.Conclusions: At-NLCs prevented precipitation, promoted skin permeation, and SK-MEL 28 cell internalisation. The localisation of NLCs on the upper dermal layer due to electrostatic interactions of skin with chitosan gel diminished the incidence of untoward systemic effects.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"27-44"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and bioactivity assessment of Coccinia grandis L. extract encapsulated alginate nanoparticles as an antidiabetic drug lead. 抗糖尿病药物铅包封藻酸盐纳米颗粒的合成及生物活性评价。

IF 3.9 4区医学

Journal of microencapsulation Pub Date : 2024-01-01 Epub Date: 2024-01-10 DOI: 10.1080/02652048.2023.2282964

Nayomi Deshani De Silva, Anoja Priyadarshani Attanayake, Desiree Nedra Karunaratne, Liyanage Dona Ashanti Menuka Arawwawala, Geethi Kaushalya Pamunuwa

{"title":"Synthesis and bioactivity assessment of Coccinia grandis L. extract encapsulated alginate nanoparticles as an antidiabetic drug lead.","authors":"Nayomi Deshani De Silva, Anoja Priyadarshani Attanayake, Desiree Nedra Karunaratne, Liyanage Dona Ashanti Menuka Arawwawala, Geethi Kaushalya Pamunuwa","doi":"10.1080/02652048.2023.2282964","DOIUrl":"10.1080/02652048.2023.2282964","url":null,"abstract":"Aim: This study aimed to prepare, characterise, and evaluate the antidiabetic activity of Coccinia grandis (L.) extracts encapsulated alginate nanoparticles.Methods: Alginate nanoparticles were prepared using the ionic gelation method and characterised by encapsulation efficiency %w/w, loading capacity %w/w, particle size analysis, zeta potential, Fourier transform infra-red spectroscopy (FTIR), and scanning electron microscopy (SEM). In vitro antidiabetic activity was also evaluated.Results: Encapsulation efficiency %w/w, loading capacity %w/w, mean diameter, zeta potential of C. grandis encapsulated alginate nanoparticles ranged from 10.51 ± 0.51 to 62.01 ± 1.28%w/w, 0.39 ± 0.04 to 3.12 ± 0.11%w/w, 191.9 ± 76.7 to 298.9 ± 89.6 nm, -21.3 ± 3.3 to -28.4 ± 3.4 mV, respectively. SEM and FTIR confirmed that particles were in nano range with spherical shape and successful encapsulation of plant extracts into an alginate matrix. The antidiabetic potential of aqueous extract of C. grandis encapsulated alginate nanoparticles (AqCG-ANP) exhibited inhibition in α-amylase, α-glucosidase and dipeptidyl peptidase IV enzymes of 60.8%c/c, 19.1%c/c, and 30.3%c/c, respectively, compared to the AqCG.Conclusion: The AqCG-ANP exerted promising antidiabetic potential as an antidiabetic drug lead.","PeriodicalId":16391,"journal":{"name":"Journal of microencapsulation","volume":" ","pages":"1-17"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0