姜黄提取物负载壳聚糖微粒治疗胃肠道疾病的潜力。

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI:10.1080/02652048.2024.2390958

Pimonsri Mittraparp-Arthorn, Suwipa Ungphaiboon, Chutha Takahashi Yupanqui, Sirikan Suwannasin, Chutikan Wijukkul, Niwan Tanmanee, Teerapol Srichana

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引用次数: 0

摘要

目的：开发用于治疗胃肠道疾病的姜黄提取物壳聚糖微粒：方法：采用喷雾干燥工艺制备微颗粒，通过生物标志物负载和封装效率优化微颗粒特性，并评估与胃肠道疾病相关的生物活性：结果：优化后的微粒呈球形，平均直径为 2.11 ± 0.34 µm，SPAN 为 4.46 ± 0.68，zeta 电位为 +37.6 ± 0.2 mV，姜黄素含量为 15.7%（湿重），姜黄萜酮含量为 5.4%（湿重），封装效率为 63.26 ± 1.62%（湿重），姜黄萜酮含量为 43.75 ± 1.33%（湿重）。包封姜黄提取物后，6 小时的释放率提高了 20 倍，粘附性提高了 3.6 倍。微颗粒表现出较高的酸中和能力（1.64 ± 0.34 mEq/g），抑制一氧化氮产生的效果是姜黄提取物的两倍，同时还保持了抗氧化和抗菌活性：结论：将姜黄提取物封装在壳聚糖微粒中可有效提高对胃肠道疾病的治疗潜力。

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The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders.

Aim: To develop turmeric extract-loaded chitosan microparticles for treating gastrointestinal disorders.

Methods: The microparticles were prepared using a spray-drying process, optimised the characteristics by biomarker loading, and encapsulation efficiency, and assessed for bioactivities related to gastrointestinal diseases.

Results: The optimised microparticles were spherical, with a mean diameter of 2.11 ± 0.34 µm, a SPAN of 4.46 ± 0.68, a zeta potential of +37.6 ± 0.2 mV, loading of 15.7% w/w curcuminoids, 5.4% w/w ar-turmerone, and encapsulation efficiency of 63.26 ± 1.62% w/w curcuminoids and 43.75 ± 1.33% w/w ar-turmerone. Encapsulation of turmeric extract improved release at 6 h by 20 times and mucoadhesion by 3.6 times. The microparticles exhibited high acid-neutralising capacity (1.64 ± 0.34 mEq/g) and inhibited nitric oxide production about twice as effectively as the turmeric extract, while maintaining antioxidant and antibacterial activities.

Conclusion: Encapsulation of turmeric extract in chitosan microparticles effectively enhanced therapeutic potential for gastrointestinal disorders.

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.