Journal Francais D Ophtalmologie最新文献

{"title":"Long-term multimodal imaging and microperimetric assessment of hydroxychloroquine-induced cystoid macular edema.","authors":"F Bezci Aygün, D Alyan, N Rustemova, S Kadayıfçılar","doi":"10.1016/j.jfo.2025.104489","DOIUrl":"https://doi.org/10.1016/j.jfo.2025.104489","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotony maculopathy after canaloplasty and goniotomy.","authors":"S L Chang, M Wong, C X Zheng","doi":"10.1016/j.jfo.2025.104490","DOIUrl":"https://doi.org/10.1016/j.jfo.2025.104490","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presumed solitary circumscribed retinal astrocytic proliferation: Imaging with SS-OCT and SS-OCTA.","authors":"D Tetik, A K Gündüz","doi":"10.1016/j.jfo.2025.104481","DOIUrl":"https://doi.org/10.1016/j.jfo.2025.104481","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Évaluation de l’épaisseur maculaire chez le sujet drépanocytaire homozygote SS à la tomographie par cohérence optique à Yaoundé","authors":"K.D. Sina , N.C. Nanfack , B. Chetcha , M.G. Nguepi , V. Nguepnang , G. Kagmeni , N.C. Domngang","doi":"10.1016/j.jfo.2025.104472","DOIUrl":"10.1016/j.jfo.2025.104472","url":null,"abstract":"<div><h3>Objectif</h3><div>Le but de cette étude était de décrire les modifications maculaires observées grâce à la tomographie par cohérence optique chez les patients drépanocytaires homozygotes SS.</div></div><div><h3>Méthodologie</h3><div>Dans cette étude transversale, l’épaisseur maculaire de 42 patients (77 yeux) drépanocytaires SS a été comparée quadrant par quadrant à celle de 82 sujets (148 yeux) non drépanocytaires. Les mesures ont été faites grâce au SD-OCT 3D Maestro Topcon puis cartographiées sur les 9 quadrants de la grille maculaire établie par l’Early Treatment Diabetic Retinopathy Study. Les variables étudiées étaient : l’âge, le genre, le nombre de crises vaso-occlusives annuelles, le traitement prophylactique, l’acuité visuelle corrigée de loin et de près, la rétinopathie drépanocytaire, les épaisseurs maculaire moyenne, centrale (fovéolaire), temporale interne, nasale interne, supérieure interne, inférieure interne, supérieure externe, inférieure externe, nasale externe, temporale externe. Les différences étaient considérées comme statistiquement significatives pour les valeurs de <em>p</em> < 0,05.</div></div><div><h3>Résultats</h3><div>L’épaisseur maculaire moyenne était de 271,3<!--> <!-->±<!--> <!-->20,9<!--> <!-->μm chez les drépanocytaires homozygotes SS contre 272,4<!--> <!-->±<!--> <!-->20,9<!--> <!-->μm chez les patients non drépanocytaires (<em>p</em> <!-->=<!--> <!-->0,891). L’épaisseur maculaire moyenne diminuait avec l’âge ; pour un an de plus, un amincissement maculaire de 0,72<!--> <!-->μm était observé. Le taux d’amincissement maculaire central était de 40,26 %. Il existait un amincissement significatif chez les drépanocytaires dans les quadrants nasal externe (<em>p</em> <!-->=<!--> <!-->0,05), temporal externe (<em>p</em> <!-->=<!--> <!-->0,002) et inférieur interne (<em>p</em> <!-->=<!--> <!-->0,02). Le nombre de crises vaso-occlusives était associé de manière non significative à ces amincissements.</div></div><div><h3>Conclusion</h3><div>La tomographie par cohérence optique pourrait contribuer à objectiver l’atteinte maculaire infraclinique chez le drépanocytaire homozygote SS.</div></div><div><h3>Objective</h3><div>To describe tomographic macular changes in homozygous SS sickle cell patients.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, the macular thickness of 42 patients (77 eyes) with sickle cell SS was compared quadrant by quadrant with that of 82 subjects (148 eyes) without sickle cell disease. The measurements were performed using the Topcon Maestro SD-OCT 3D and then mapped onto the 9 quadrants of the macular grid established by the Early Treatment Diabetic Retinopathy Study. The studied variables were: age, gender, number of annual vaso-occlusive events; prophylactic treatment, visual acuity corrected for distance and near, sickle cell retinopathy; mean macular thickness, mean central (foveolar), and mean temporal inner, nasal inner, superior inner, inferior inner, superior","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 5","pages":"Article 104472"},"PeriodicalIF":1.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pen ink scleral tattoo complications.","authors":"G Feltrin de Barros, L Bongiovanni, M Akaishi, C Ramos, R Cunha de Almeida, V Loduca Lima, J Z Abucham-Neto","doi":"10.1016/j.jfo.2024.104401","DOIUrl":"https://doi.org/10.1016/j.jfo.2024.104401","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":" ","pages":"104401"},"PeriodicalIF":1.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term surgical outcomes of pediatric retinal detachment associated with primary congenital glaucoma","authors":"O. Artunay, M. Ozbek, S. Ozcaliskan","doi":"10.1016/j.jfo.2025.104478","DOIUrl":"10.1016/j.jfo.2025.104478","url":null,"abstract":"<div><h3>Purpose</h3><div>Primary congenital glaucoma (PCG) is an extremely rare disease with an incidence of one in 10,000 live births. Increasing axial length due to PCG predisposes to retinal thinning and retinal detachment (RD). The present study aims to determine the long-term surgical outcomes of pediatric RD associated with PCG.</div></div><div><h3>Methods</h3><div>This was a retrospective study including pediatric patients who underwent vitrectomy with silicone oil injection for RD associated with PCG. Ocular examination reports and surgical findings of patients were analyzed to assess the anatomical and functional outcomes of the surgery.</div></div><div><h3>Results</h3><div>The study included 20 eyes of 20 children. Mean age was 10.35<!--> <!-->±<!--> <!-->3.73 years, range 5–16 years. The mean axial length was 26.10<!--> <!-->±<!--> <!-->2.19<!--> <!-->mm (range, 20.31–28.91<!--> <!-->mm). In 11 eyes, the intraocular pressure was<!--> <!--><<!--> <!-->6<!--> <!-->mmHg at the time of RD diagnosis. Visual acuity remained stable in 9 patients (45%), and 7 patients (35%) showed improvement at the final visit. The mean follow-up period was 24.55<!--> <!-->±<!--> <!-->10.01 months, range 12–48 months. During the follow-up period, 6 patients (30%) underwent surgical revision due to recurrent RD. All 14 eyes that underwent silicone oil removal demonstrated maintenance of postoperative globe preservation. In five patients, the silicone oil remained in the eye throughout the follow-up period without the need for enucleation. One patient developed phthisis bulbi.</div></div><div><h3>Conclusion</h3><div>Ocular comorbidities play a significant role in limiting final visual outcomes. Despite the poor visual prognosis of surgery, globe preservation can be achieved in such cases. Globe preservation has an important impact on patients’ quality of life and psychological and social functioning. Moreover, ambulatory vision can be preserved in most eyes.</div></div><div><h3>Objet</h3><div>Le glaucome congénital primaire (GCP) est une maladie extrêmement rare dont l’incidence est de un sur 10 000 naissances vivantes. L’augmentation de la longueur axiale due au GCP prédispose à l’amincissement de la rétine et au décollement de la rétine (DR). La présente étude vise à déterminer les résultats chirurgicaux à long terme du décollement de la rétine pédiatrique associé au PCG.</div></div><div><h3>Méthodes</h3><div>Il s’agit d’une étude rétrospective incluant des patients pédiatriques ayant subi une vitrectomie avec injection d’huile de silicone pour un DR associé à un PCG. Les comptes rendus des examens oculaires ainsi que les résultats chirurgicaux des patients ont été analysés afin d’évaluer les résultats anatomiques et fonctionnels de l’intervention chirurgicale.</div></div><div><h3>Résultats</h3><div>L’étude a porté sur 20 yeux de 20 enfants. L’âge moyen était de 10,35<!--> <!-->±<!--> <!-->3,73 ans, de 5 à 16 ans. La longueur axiale moyenne était de 26,10","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 4","pages":"Article 104478"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performances visuelles après implantation bilatérale de lentilles intraoculaires à profondeur de champ étendue AE2UV/ZOE en mini-monovision","authors":"S. Blot, M. Filattre, E. Fauviaux, B. Jany, T.H.C. Tran","doi":"10.1016/j.jfo.2025.104475","DOIUrl":"10.1016/j.jfo.2025.104475","url":null,"abstract":"<div><h3>Objectif</h3><div>Évaluer l’impact de la mini-monovision sur les performances visuelles après implantation bilatérale de LIO à profondeur de champ étendue AE2UV/ZOE™.</div></div><div><h3>Méthodes</h3><div>Il s’agit d’une étude prospective monocentrique incluant 60 patients qui ont été opérés de cataracte bilatérale. Deux groupes de patients ont été constitués : un ciblé pour une mini-monovision et le second ciblé pour l’emmétropie. L’acuité visuelle en vision de loin, intermédiaire et de près, l’indépendance aux lunettes et la satisfaction des patients ont été comparés à 1 mois postopératoire.</div></div><div><h3>Résultats</h3><div>Le groupe mini-monovision comprenait 29 patients et le groupe emmétropie 31 patients. Les acuités visuelles moyennes non corrigées intermédiaires (0,08 vs 0,19 logMAR, <em>p</em> <!-->=<!--> <!-->0,043) et de près (0,29 vs 0,53, <em>p</em> <!--><<!--> <!-->0,001) du groupe mini-monovision sont significativement meilleures que celle du groupe emmétrope. Les acuités visuelles binoculaires de loin sont inférieures à 0,0 logMAR dans les deux groupes, sans différence statistiquement significative. Le niveau de dépendance aux lunettes est statistiquement plus élevé dans le groupe emmétropie pour les activités à distance intermédiaire et de près (43 % vs 21 % ; 93 % vs 43 % respectivement ; <em>p</em> <!--><<!--> <!-->0,05). Les scores de satisfaction des patients pour la vision de près non corrigée étaient meilleurs dans le groupe mini-monovision (6,25 contre 3,17 ; <em>p</em> <!--><<!--> <!-->0,001).</div></div><div><h3>Conclusion</h3><div>L’approche mini-monovision dans l’implantation bilatérale de LIO ZOE™ permet de meilleures performances visuelles en vision intermédiaire et de près, sans dégradation de la vision de loin avec des niveaux élevés de satisfaction des patients.</div></div><div><h3>Objective</h3><div>To evaluate the impact of mini-monovision on visual performance after bilateral implantation of AE2UV/ZOE™ extended depth of focus IOLs.</div></div><div><h3>Methods</h3><div>This is a single-center prospective study including 60 patients who underwent bilateral cataract surgery. Patients were divided into 2 groups: with mini-monovision targeted for group 1 and emmetropia targeted for group 2. Distance, intermediate and near vision, spectacle independence and patient satisfaction were assessed 1 month after surgery.</div></div><div><h3>Results</h3><div>The mini-monovision group included 29 patients and the emmetropia group 31 patients. Mean uncorrected intermediate (0.08 vs. 0.19 logMAR, <em>P</em> <!-->=<!--> <!-->0.043) and near (0.29 vs. 0.53, <em>P</em> <!--><<!--> <!-->0.001) visual acuity in the mini-monovision group were significantly better. Binocular distance visual acuity was less than 0.0 logMAR for both groups, without statistically significant difference. The level of spectacle dependence is statistically higher in the emmetropia group for intermediate and near distance activities","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 5","pages":"Article 104475"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of subthreshold micropulse laser therapy for chronic central serous chorioretinopathy: Navigated vs. non-navigated approach","authors":"M. Karapapak, E. Özal, S. Ermiş, S.A. Özal","doi":"10.1016/j.jfo.2025.104483","DOIUrl":"10.1016/j.jfo.2025.104483","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the efficacy of navigated subthreshold micropulse laser (NSML) compared to subthreshold micropulse laser (SML) without navigation in the management of chronic central serous chorioretinopathy (CSCR).</div></div><div><h3>Materials and methods</h3><div>This retrospective study included patients diagnosed with chronic CSCR who underwent either NSML or SML without navigation. Patients meeting inclusion criteria presented with serous macular detachment and leakage at the level of the retinal pigment epithelium on fundus fluorescein angiography (FFA). The NSML group underwent treatment using the Navilas® Laser System 577s Prime, operating at a wavelength of 577 nanometers. Micropulse laser application targeted the leakage areas identified on mid-phase FFA images, which were imported into the laser device and aligned with the live image using an eye tracking system. The SML without navigation group underwent treatment using the 577-nanometer yellow laser, delivered through the area centralis laser lens. Laser therapy was guided by focal leaking points and areas of hyperpermeability identified on FFA.</div></div><div><h3>Results</h3><div>A total of 34 patients underwent NSML, while 36 patients received SML without navigation. Both groups were similar in terms of demographic and clinical characteristics. No statistically significant difference was found in visual and anatomical outcomes between the NSML and SML groups at 1 and 3 months post-treatment (<em>P</em> <!-->><!--> <!-->0.05). However, favorable outcomes were observed in both groups, with a cumulative probability of successful treatment reaching 73.5% in the NSML group and 63.8% in the SML group. Notably, no adverse events were reported in either group.</div></div><div><h3>Conclusion</h3><div>Both NSML and SML without navigation demonstrate efficacy and safety in treating CSCR, with improvements in visual and anatomical outcomes observed during the 3-month follow-up period. NSML emerges as a promising treatment option for facilitating the resolution of subretinal fluid in patients with chronic CSCR.</div></div><div><h3>Contexte</h3><div>Évaluer l’efficacité du laser à micropulsations sous-seuil avec navigation (LMSN) par rapport au laser à micropulsations sous-seuil (SML) sans navigation dans la prise en charge de la choriorétinopathie séreuse centrale chronique (CSCR).</div></div><div><h3>Matériel et méthodes</h3><div>Cette étude rétrospective a inclus des patients diagnostiqués avec une choriorétinopathie centrale séreuse chronique qui ont subi soit un LMSN, soit un SML sans navigation. Les patients répondant aux critères d’inclusion présentaient un décollement maculaire séreux et une fuite au niveau de l’épithélium pigmentaire rétinien à l’angiographie à la fluorescéine du fond d’œil (AFF). Le groupe LMSN a été traité à l’aide du Navilas® Laser System 577s Prime, fonctionnant à une longueur d’onde de 577 nanomètres. L’application du laser à micropulsati","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 5","pages":"Article 104483"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amniotic membrane transplantation in the treatment of macular hole secondary to neuroretinitis","authors":"M.K. Erol ,&nbsp;B. Gedik ,&nbsp;E. Suren","doi":"10.1016/j.jfo.2025.104474","DOIUrl":"10.1016/j.jfo.2025.104474","url":null,"abstract":"<div><div>This case report aims to demonstrate the use of amniotic membrane transplantation (AMT) as a treatment for a refractory full-thickness macular hole (FTMH) that developed secondary to neuroretinitis. A 14-year-old girl presented to our hospital with a complaint of blurred vision persisting for one week. The patient was diagnosed with neuroretinitis due to cat scratch disease with a FTMH that developed secondarily. A pars plana vitrectomy, internal limiting membrane (ILM) peel, and ILM transplantation were performed. The FTMH did not close completely. The third surgery was performed using the AMT method, which resulted in the successful closure of the FTMH. This is the first case report documenting the treatment of refractory FTMH secondary to neuroretinitis using AMT. It can be suggested that inflammation plays a role in the pathophysiology of FTMH secondary to neuroretinitis. We consider AMT to be an effective method in the treatment of resistant FTMH.</div></div><div><div>Ce cas montre l’utilisation de la transplantation de membrane amniotique (AMT) comme traitement d’un trou maculaire de pleine épaisseur (FTMH) réfractaire développé secondairement à une neurorétinite. Une jeune fille de 14 ans s’est présentée à notre hôpital avec une vision floue persistant depuis une semaine. Le diagnostic était celui de neurorétinite due à la maladie des griffes du chat et à un FTMH qui s’est développé secondairement. Une vitrectomie par la pars plana, un pelage de la membrane limitante interne (ILM) et une transplantation d’ILM ont été réalisés. La FTMH n’a pas complètement fermé. La troisième intervention chirurgicale a été réalisée selon la méthode AMT, ce qui a permis la fermeture du FTMH. Il s’agit du premier cas documentant le traitement par AMT du FTMH réfractaire secondaire à la neurorétinite. On peut suggérer que l’inflammation joue un rôle dans la physiopathologie du FTMH se développant secondairement à la neurorétinite. Nous considérons également que l’AMT est une méthode efficace dans le traitement du FTMH résistant.</div></div>","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 5","pages":"Article 104474"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ChatGPT-4o, Google Gemini 1.5 Pro, Microsoft Copilot Pro, and Ophthalmologists in the management of uveitis and ocular inflammation: A comparative study of large language models","authors":"S. Demir","doi":"10.1016/j.jfo.2025.104468","DOIUrl":"10.1016/j.jfo.2025.104468","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;The aim of this study was to compare the latest large language models (LLMs) ChatGPT-4o, Google Gemini 1.5 Pro and Microsoft Copilot Pro developed by three different companies, with each other and with a group of ophthalmologists, to reveal the strengths and weaknesses of LLMs against each other and against ophthalmologists in the field of uveitis and ocular inflammation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Using a personal OphthoQuestions (&lt;span&gt;&lt;span&gt;www.ophthoquestions.com&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;) account, a total of 100 questions from 201 questions on uveitis and ocular inflammation out of a total of 4551 questions on OphthoQuestions, including questions involving multimodal imaging, were included in the study using the randomization feature of the website. In November 2024, ChatGPT-4o, Microsoft Copilot Pro, and Google Gemini 1.5 Pro were asked the same 100 questions: 80 multiple-choice and 20 open-ended questions. Each question was categorized as either true or false. A statistical comparison of the accuracy rates was performed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Among the 100 questions, ChatGPT-4o, Google Gemini 1.5 Pro, Microsoft Copilot Pro, and the human group (ophthalmologists) answered 80 (80.00%), 81 (81.00%), 80 (80.00%) and 72 (72.00%) questions, respectively, correctly. In the statistical comparisons between the groups for multiple-choice questions, no significant difference was found between the correct and incorrect response rates of the three LLMs and the human group (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.207, Cochran's Q test). In the statistical comparisons of responses to open-ended questions, there was no significant difference between the correct and incorrect response rates of the three LLMs and the human group (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.392, Cochran's Q test).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Although ChatGPT-4o, Google Gemini 1.5 Pro , and Microsoft Copilot Pro answered higher percentages of questions correctly than the human group, the LLMs were not statistically superior to each other or to the human group in the management of uveitis and ocular inflammation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectif&lt;/h3&gt;&lt;div&gt;L’objectif de cette étude était de comparer les derniers grands modèles de langage (LLM) ChatGPT-4o, Google Gemini 1.5 Pro et Microsoft Copilot Pro développés par trois sociétés différentes, entre eux et avec un groupe d’ophtalmologistes, afin de révéler les forces et les faiblesses des LLM les uns par rapport aux autres et par rapport aux ophtalmologistes dans le domaine de l’uvéite et de l’inflammation oculaire.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthodes&lt;/h3&gt;&lt;div&gt;Par l’usage d’un compte personnel OphthoQuestions (&lt;span&gt;&lt;span&gt;www.ophthoquestions.com&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;), un total de 100 questions parmi 201 questions sur l’uvéite et l’inflammation oculaire sur un total de 4551 questions sur OphthoQuestions, y compris les questions impliquant l’imagerie multimodale, ont été inc","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 4","pages":"Article 104468"},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}