{"title":"Comparing the Effectiveness and Safety of Intravenous Levetiracetam and Phenobarbital as First-Line Therapies for Neonatal Seizures: A Randomized Clinical Trial.","authors":"Nahideh Khosroshahi, Kamyar Kamrani, Muhammadhosein Moradi, Parisa Sadeghirad, Ayda Khabazi Oskouie","doi":"10.22037/ijcn.v19i2.45234","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.45234","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized clinical trial aims to evaluate and compare phenobarbital and levetiracetam effectiveness and safety in controlling neonatal seizures as first-line therapeutic options.</p><p><strong>Materials & methods: </strong>Neonates with seizure manifestations presenting to the Bahrami Hospital from March 2020 to March 2022 were enrolled in this study. Patients' data were recorded, including demographic findings, anthropometric measurements, birth characteristics, and laboratory findings. Patients were randomly divided into the phenobarbital and levetiracetam treatment groups. Outcomes defined as adverse effects, response to medication, time to start enteral feeding, and length of hospital stay were compared between the two treatment groups.</p><p><strong>Results: </strong>The current study comprises 44 neonates divided into phenobarbital and levetiracetam groups. Seizure control among the two groups was not significantly different, with levetiracetam and phenobarbital groups showing seizure control of 68.2% and 59.1%, respectively. Moreover, no significant difference was observed regarding the duration of hospitalization and time to initiate feeding. No adverse effect was reported in either group.</p><p><strong>Conclusion: </strong>This study showed no significant difference between levetiracetam and phenobarbital for neonatal seizure control.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"65-75"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender and Age Differences in Seronegative Pediatric Acute Disseminated Encephalomyelitis Profiles: Results and Insights from a Tertiary Center.","authors":"Reza Nejad Shahrokh Abadi, Farrokh Seilanian Toosi, Javad Akhoondian, Mehran Beiraghi Toosi, Farah Ashrafzadeh, Mohammadali Nahayati, Shima Shekari, Samaneh Kamali, Shima Imannezhad, Ahmad Sohrab Niazi, Narges Hashemi","doi":"10.22037/ijcn.v19i2.46613","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.46613","url":null,"abstract":"<p><strong>Objectives: </strong>Acute disseminated encephalomyelitis (ADEM) is a rapid-onset inflammatory central nervous system (CNS) disorder in children, causing demyelination, encephalopathy, and neurological deficits, often following infections.</p><p><strong>Materials & methods: </strong>This 10-year retrospective study evaluated pediatric patients with seronegative acute disseminated encephalomyelitis (ADEM), focusing on clinical, laboratory, and imaging profiles. The various profiles were assessed to determine age- and/or sex-based differences.</p><p><strong>Results: </strong>The study reviewed 36 patients, with an average age of 6.08 years and predominantly male (61.1%). Clinical presentations included fever, nausea, vomiting, and seizures, with left facial hemiparesis being more common in girls (P-value = 0.023), while abnormal deep tendon reflexes (DTRs) and right-sided pathologies were more common in older patients (P-value < 0.05). Recent laboratory results have revealed differences between peripheral lymphocytes and polymorphonuclear (PMN) cells. Imaging revealed predominantly bilateral lesions, with older patients more likely to show lesions in the right parietal and occipital lobes (P-value = 0.01 and 0.04). Bilateral parietal lobe lesions were significantly correlated with several laboratory findings across the different subgroups. Multivariate logistic regression revealed that these findings were statistically significant in regards to peripheral PMN and lymphocytes in the age category and cerebrospinal fluid (CSF) protein in the gender category (P-value < 0.05). Additionally, girls, particularly those who were older, had significantly higher involvement of the cervical spine (P-value = 0.04 and 0.02).</p><p><strong>Conclusion: </strong>This study reveals age and sex-related differences in the clinical presentation and imaging findings of seronegative pediatric ADEM, showcasing the various demographic factors in patient profiles.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"77-91"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Accuracy of MRI and CT Scan Features in Differentiation of Pediatric Ependymoma from Medulloblastoma.","authors":"Sam Mirfendereski, Neda Mansouri","doi":"10.22037/ijcn.v19i1.42100","DOIUrl":"10.22037/ijcn.v19i1.42100","url":null,"abstract":"<p><strong>Objectives: </strong>The study aims to compare the diagnostic accuracy of MRI and CT scan features in differentiating medulloblastoma from ependymoma, two similar pediatric brain tumors.</p><p><strong>Materials & methods: </strong>This retrospective cross-sectional study was conducted on all pediatric patients with posterior fossa tumors admitted to teaching hospitals affiliated with Isfahan University of Medical Sciences from 2017 to 2022. Forty-three patients with posterior fossa tumors were identified, and seven patients were excluded due to diagnoses other than medulloblastoma or ependymoma. Tumor morphology on MRI, tumor density on CT scan, and apparent diffusion coefficient (ADC) values were assessed to differentiate medulloblastoma from ependymoma.</p><p><strong>Results: </strong>Histopathologic diagnosis was medulloblastoma in 21 patients (60%) and ependymoma in 14 patients (40%). Mean ADC values in medulloblastoma and ependymoma cases were 0.67±0.19 (range= 0.50-1.25) and 1.22±0.29 (range=0.67-1.72), showing a significant statistical difference between the two groups (p-value=0.000). The ADC cut-off point of 0.9825 was associated with 90% sensitivity and 92.9% specificity for differentiation of ependymoma from medulloblastoma.</p><p><strong>Conclusion: </strong>While tumor morphology on MRI and other studied parameters are unreliable for differentiating medulloblastoma and ependymoma, ADC values may provide a potential diagnostic tool. Further studies are needed to confirm the utility of DWI and other advanced MRI techniques in differentiating these tumors.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"55-63"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ala Torabi, Reza Shervin Badv, Masoud Mohammadpour, Fatemeh Zamani, Masoumeh Sadat Sadeghzadeh, Neda Pak
{"title":"Haberland Syndrome (Encephalocraniocutaneous Lipomatosis): A Case Report and Review of Literature.","authors":"Ala Torabi, Reza Shervin Badv, Masoud Mohammadpour, Fatemeh Zamani, Masoumeh Sadat Sadeghzadeh, Neda Pak","doi":"10.22037/ijcn.v19i1.37492","DOIUrl":"10.22037/ijcn.v19i1.37492","url":null,"abstract":"<p><p>Encephalocraniocutaneous lipomatosis (ECCL), also known as Haberland syndrome, is a rare, nonhereditary, nonprogressive congenital neurocutaneous syndrome with underlying ectodermal dysgenesis. The classic triad of this syndrome is central nervous system (CNS), ocular, and cutaneous involvement as unilateral lipomatous lesions of the scalp, neck, and face with ipsilateral brain anomalies and ipsilateral ocular choristoma. Herein, this study reports a case of a 2-year-old boy presented with status epilepticus for the first time. Intraspinal lipoma, arachnoid cyst, cerebral hemiatrophy, asymmetric hydrocephaly, choristoma, and corneal clouding were noted. This case fulfilled Moog's clinical criteria for diagnosis of Haberland syndrome. Additionally, this study introduces linear and whorled nevoid hypermelanosis and cerebral periventricular white matter hyperintensity as novel manifestations of this syndrome.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"127-133"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impacts of hippotherapy simulation on balance, postural control, and spasticity of thigh adductor muscles in children with spastic bilateral Cerebral Palsy: A single-blind clinical trial study.","authors":"Kiana Ramezani, Minoo Kalantari, Marzieh Pashmdarfard, Alireza Akbarzadeh Baghba, Ghodrat Khavari","doi":"10.22037/ijcn.v19i1.46567","DOIUrl":"10.22037/ijcn.v19i1.46567","url":null,"abstract":"<p><strong>Objectives: </strong>Cerebral Palsy (CP) is a group of movement disorders. A recently proposed occupational therapy approach to reduce spasticity and improve balance and postural control is Hippotherapy Simulation (HS). The present study attempts to investigate how HS impacts balance, postural control, and spasticity of adductor muscles in children with spastic bilateral CP.</p><p><strong>Materials & methods: </strong>Thirty-one children with bilateral spastic CP, five to nine years old, were selected via availability sampling and divided into the intervention group (n=16) and the control (n=15) through stratified block randomization. Assessment tools, including Pediatric Balance Scale (PBS), Trunk Control Measurement Scale (TCMS), Modified Ashworth Scale (MAS), Gross Motor Function Measure (GMFM), Pediatric Evaluation of Disability Inventory (PEDI), and goniometry, were completed by an assessor unaware of the children's grouping.</p><p><strong>Results: </strong>After the intervention, the average total scores of all variables in the HS group significantly exceeded those in the control group (P<0.01). However, no significant differences were observed between the groups at follow-up, underlining the necessity of providing long-term or recurrent interventions to maintain improvements in gross motor function. This approach also constructively influenced postural control and mitigated the spasticity of adductor thigh muscles.</p><p><strong>Conclusion: </strong>This study showed the multimodal effect of simulated hippotherapy combined with occupational therapy routine exercises on the physical performance of children with bilateral spastic CP.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"79-96"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ataxia Telangiectasia with Giant Suprasellar Arachnoid Cyst - A Case Report and a Brief Review.","authors":"Mahmoud Reza Ashrafi, Ali Nikkhah, Morteza Heidari, Golazin ShahbodaghKhan, Roya Sinaei, Solmaz Aziz-Ahari, Hossein Yousefimanesh","doi":"10.22037/ijcn.v19i2.45580","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.45580","url":null,"abstract":"<p><p>Ataxiatelangiectasia (A-T) is an infrequent genetic neurodegenerative disorder inherited autosomal recessively. It is mainly characterized by early-onset progressive cerebellar ataxia and dilated capillaries in the oculocutaneous regions especially conjunctivae so-called telangiectasia. A-T is a multisystem disorder and requires multi-disciplinary approach to management. Diagnosis is difficult in some cases because presentation is not in the same manner and showing a phenotypic spectrum. In atypical cases serum immunoglobulins and alfa fetoprotein are normal and telangiectasia is absent. We present a 5.5-year-old boy with progressive cerebellar ataxia and history of repeated sino-pulmonary infections that was homozygote for ataxia-telangiectasia mutated gene and had a giant arachnoid cyst in left hemisphere. It is important to keep in mind those cases with ataxia and repeated sino-pulmonary infections may be ataxia telangectasia patients. Genetic study is helpful and confirms the diagnosis by showing ataxia-telangiectasia mutated gene.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"143-147"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katayoon Razjouyan, Abbas Babazadeh Dezfoly, Rozita Davari Ashtiani, Mojgan Khademi, Fariba Arabgol, Mohammad Javad Nasiri, Nahid Piri, Mohammad Ali Miri
{"title":"Investigating the Prevalence of Neurological Soft Signs in Children with Autism Spectrum Disorder and their Siblings: A Cross-Sectional Study.","authors":"Katayoon Razjouyan, Abbas Babazadeh Dezfoly, Rozita Davari Ashtiani, Mojgan Khademi, Fariba Arabgol, Mohammad Javad Nasiri, Nahid Piri, Mohammad Ali Miri","doi":"10.22037/ijcn.v19i1.44589","DOIUrl":"10.22037/ijcn.v19i1.44589","url":null,"abstract":"<p><strong>Objectives: </strong>Autism is determined by children's inability to communicate with others through language. More studies have shown that neurological soft signs (NSS) can be one of the symptoms of psychiatric disorders, including schizophrenia. However, complete and proven evidence regarding the role of NSS in the pathogenesis of autism has not been determined. For this purpose, this research investigated the prevalence of NSS in children with autism spectrum and their siblings and compared it with the control group.</p><p><strong>Materials & methods: </strong>The current study was cross-sectional. In this study, thirty-two children aged 7-17 who had been referred to the pediatric psychiatry clinics of Imam Hossein Hospital and the Autism Charitable Association in Tehran, Iran, were entered; they were diagnosed with an autism disorder by a child and adolescent psychiatrist based on the DSM-5 diagnostic criteria. Furthermore, thirty-two siblings of children with autism in the age group of 7-17 years who did not have any neurological and mental disorders were included; thirty-two healthy individuals (controls) who did not have any disorders were evaluated with the K-SADS checklist. Gilliam Autism Rating Scale 3rd Edition (GARS-3) was also used to confirm the diagnosis and severity of the disease.</p><p><strong>Results: </strong>The results showed that the incidence of NSS in the patient group was higher than in the other two groups, which was statistically significant (p<0.05). Furthermore, the results indicated that these signs had a high diagnostic value in identifying patients from healthy people.</p><p><strong>Conclusion: </strong>In general, using the NSS score in patients with autism can be considered a prediction factor compared to their siblings. In addition, the score had no effect on the prediction between sibling and control subjects.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"25-35"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High Succinate peak in Magnetic Resonance Spectroscopy: A Diagnostic Clue for the Leukoencephalopathy Result from Succinate Dehydrogenase Deficiencies.","authors":"Habibe Koc Ucar, Leman Tekin Orgun, Ebru Arhan, Ayse Serdaroglu, Kursad Aydin","doi":"10.22037/ijcn.v19i1.35156","DOIUrl":"10.22037/ijcn.v19i1.35156","url":null,"abstract":"<p><p>The Succinate Dehydrogenase (SDH) enzyme is known as Complex-II in the electron transport chain. This study reports the clinical and molecular investigations of three pediatric patients (two of whom are siblings), with histochemical and biochemical evidence of a severe, isolated complex II deficiency due to SDH gene mutations. The patients presented with severe hypotonia, developmental delay, spasticity, macrocephaly, and megalencephaly. Magnetic Resonance Imaging (MRI) revealed signal changes in the frontal, temporal, parietal, occipital cerebral, and cerebellar white matter, corpus striatum, thalamus, substantia nigra, inferior olivary nucleus, pyramidal tracts at the level of the pons and posterior limb of the internal capsule. Other typical findings involved a high succinate peak at 2.42 ppm and lactate peak at 1.3 ppm in Magnetic Resonance Spectroscopy (MRS). The siblings presented due to compound heterozygous c.143A>T (p. Asp48Val) and c.308T>C (p. Met103Thr) SDHB mutations, while the other patient presented due to compound heterozygous c.1754G>A (p. Arg585Gln) and c.1786G>C (p. Asp596His) SDHA mutation. The demonstration of succinate peak, particularly MRS, is highly diagnostic regarding SDH deficiency. MRS should be a standard part of routine radiological exams when there is a suspicion of a neurometabolic disease, especially mitochondrial disorders. Additionally, employing Next-Generation Sequencing (NGS) is advisable for patients as it allows for accurate diagnosis without requiring invasive procedures like muscle biopsies.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"97-105"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Hossein Asadi, Saeed Changizi-Ashtiyani, Saeed Amini
{"title":"Causes of Neonatal Stroke: Ibn Thalaj's (Died in 975 AD) Viewpoints.","authors":"Mohammad Hossein Asadi, Saeed Changizi-Ashtiyani, Saeed Amini","doi":"10.22037/ijcn.v19i1.37978","DOIUrl":"10.22037/ijcn.v19i1.37978","url":null,"abstract":"<p><p>Although stroke has long been recognized as an adult health problem that causes significant morbidity and mortality, it is also an important cause of brain injury in infants and children. The present article deals with this issue from the perspective of medical history. Physicians have tried throughout history to diagnose and treat this disease. One of the physicians who first accurately described this disease was Ibn Thalaj, who died in 975 AD. The hypotheses that he has raised about the causes of neonatal stroke, along with his recommendations for prevention and treatment, are intriguing. Exploring these hypotheses highlights the ongoing human endeavor to comprehend and combat diseases.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"9-13"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Horner Syndrome Following Permcath Insertion in a Child with End-Stage Renal Disease: A Case Report.","authors":"Masoumeh Mohkam, Shiva Fatollahierad, Farzad Ahmadabadi, Mitra Khalili","doi":"10.22037/ijcn.V19i2.44855","DOIUrl":"https://doi.org/10.22037/ijcn.V19i2.44855","url":null,"abstract":"<p><p>Horner syndrome, characterized by the triad of unilateral ptosis, miosis, and anhidrosis, typically arises following a stroke, surgical interventions in the neck and chest, or trauma. Horner syndrome is rare in children. This study presents the case of a 9-year-old girl with End-Stage Renal Disease (ESRD) caused by renal hypodysplasia. After permcath insertion, she developed a severe headache and anisocoria, followed by ptosis and a progressively expanding neck hematoma. Physical examination and MRI of the neck revealed that Horner syndrome, caused by hematoma formation following permcath placement, was the diagnosis. Supportive interventions were implemented, leading to significant improvement in Horner syndrome over a six-month period. Complications from permcath insertion can be a cause of Horner syndrome.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"153-158"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}