Iranian Journal of Child Neurology最新文献

{"title":"A Graph-Based Statistical Approach to Identifying Functional Connectivity Networks in Patients with Traumatic Brain Injury.","authors":"Samaneh Talebi, Fatemeh Pourmotahari, Keyvan Olazadeh, Hamid Alavi Majd, Seyyed Mohammad Tabatabaei","doi":"10.22037/ijcn.v19i1.44921","DOIUrl":"10.22037/ijcn.v19i1.44921","url":null,"abstract":"<p><strong>Objectives: </strong>Traumatic brain injury (TBI) is one of the most common types of brain injuries associated with cognitive impairments. Functional magnetic resonance imaging (fMRI) studies can provide a unique opportunity to examine brain connectivity patterns and understand the neural substrates of cognitive outcomes following traumatic injury. Therefore, this study aims to determine changes in functional connectivity patterns in patients with TBI compared to healthy individuals using two graph models, adaptive dense subgraph discovery (ADSD) and variance component.</p><p><strong>Materials & methods: </strong>This study used fMRI data downloaded from https://openneuro.org. These data included 14 patients with TBI aged between 18 and 36 and 12 healthy individuals (female: N=6, male: N=6) aged between 19 and 52. Out of the 74 regions examined, a cluster of 18 regions related to TBI was identified using the ADSD model. Subsequently, these identified regions were used as input for the variance component model to investigate changes in connectivity patterns.</p><p><strong>Results: </strong>Functional connectivity between an 18-brain region cluster, such as the Rectus (Left, Right), Supp_Motor_Area (Left, Right), and Middle Cingulum (Left, Right), differed between the patient and healthy groups. Based on the analysis of functional connectivity between pairs of brain regions, 153 connections between pairs of brain regions were compared in the two groups, out of which 63 connections showed significant differences between the two groups. Compared to other regions, Supp_Motor_Area_Right and Rectus_Left had more connections.</p><p><strong>Conclusion: </strong>The study's results indicate that the functional connectivity between the Cingulum, Hippocampus, Fusiform, Supp_Motor_Area, and Precentral regions differs between the two groups. Since these regions are involved in processes such as memory, learning, spatial orientation, face recognition, coordination, and motor control, changes in their functional connectivity may lead to impairments in these areas.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"65-77"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-seizure Medication Induced Cognitive Impairment in Children with Epilepsy: A Narrative Review.","authors":"Negin Armide, Meisam Babaei","doi":"10.22037/ijcn.v19i2.46371","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.46371","url":null,"abstract":"<p><p>Several circumstances, including the etiology of epilepsy, its early onset, recurrent seizures, and the use of anti-seizure medications (ASMs), can lead to cognitive impairment in people with epilepsy. Studies indicate that the etiology of epilepsy may be more closely associated with cognitive problems than the ASMs. However, considering long-term treatment in pediatrics and their developing nervous systems, it is critical to understand the cognitive effects of each anti-seizure medication. Significant methodological challenges exist in studying the cognitive effects of ASMs. Accordingly, this review aims to give a broad overview of recent studies on cognitive impairment caused by first- and second-generation ASMs.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"9-25"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rafiq Syndrome: Old Variant in MAN1B1 Gene and Some New Phenotypic Features.","authors":"Nezir Özgün, Merve Saka Güvenç","doi":"10.22037/ijcn.v19i1.42376","DOIUrl":"10.22037/ijcn.v19i1.42376","url":null,"abstract":"<p><p>Rafiq syndrome is a congenital disorder of glycosylation type II that develops due to mutations in the Mannosidase Alpha Class 1B Member 1 (MAN1B1) gene encoding α 1,2-mannosidase. In the literature, 45 patients have been reported to date. This study presents a patient with some phenotypic traits that differ from previously reported patients with Rafiq syndrome.Since the patient was not diagnosed despite detailed examinations, whole exome sequencing was performed. The patientss' homozygous c.1000 C>T (p.Arg334Cys) pathogenic variant was detected in the MAN1B1 gene (NM_016219.5), which was consistent with Rafiq syndrome. Our patient's clinical findings were mainly similar to those of previously reported patients. However, our patient had feeding difficulty that started to improve after the fifth month and persistent hyperekplexia . Feeding difficulty and hyperekplexia concomitant to MAN1B1 gene mutation are reported for the first time. More extensive case series are needed to understand whether these findings are part of the syndrome or incidental comorbid conditions.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"121-126"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Evaluation of a Computerized Auditory Training Program to Enhance Binaural Listening Skills in Children with Specific Learning Disabilities.","authors":"Marziyeh Moallemi, Nariman Rahbar, Mohsen Ahadi, Mohammad Maarefvand","doi":"10.22037/ijcn.v19i2.46670","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.46670","url":null,"abstract":"<p><strong>Objectives: </strong>Binaural processing deficits are commonly observed in children with specific learning disabilities (SLD). These deficits can significantly hinder learning, specifically in noisy environments, making rehabilitating binaural processing crucial. This study aimed to implement an auditory training program based on binaural interaction tasks at the brainstem level in children with learning disabilities who exhibit binaural processing issues and to assess its effectiveness.</p><p><strong>Materials & methods: </strong>A sample of fourteen children diagnosed with SLD was randomly divided into intervention (n=7) and control groups (n=7). The intervention group participated in a 12-week auditory training program based on binaural interaction. The training exercises were designed with modifications to a test battery classified as assessments of binaural interaction. Pre- and post-intervention assessments included masking level difference and Persian auditory recognition of words-in-noise tests.</p><p><strong>Results: </strong>The Wilcoxon signed-rank test showed a statistically significant change in the masking level difference and Persian auditory recognition of words-in-noise results from pre- to post-intervention within the intervention group. Additionally, a nonparametric analysis of covariance indicated a significant difference in post-intervention outcomes between the two groups, with both assessments showing a meaningful effect from the rehabilitation (p < 0.05).</p><p><strong>Conclusion: </strong>This study's findings suggest that computerized auditory training focused on binaural interactions may effectively address binaural processing challenges in children with SLD. Further research is recommended to confirm these initial findings and explore the benefits of binaural auditory training for social communication in this population.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"119-129"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New-Onset Refractory Status Epilepticus and Febrile Infection-Related Epilepsy Syndrome Cases in Children: A Retrospective Cohort Study in South of Iran.","authors":"Hamid Nemati, Atena Modanlou, Eslam Shorafae, Razie Taghizade, Soroor Inaloo","doi":"10.22037/ijcn.v19i1.43172","DOIUrl":"10.22037/ijcn.v19i1.43172","url":null,"abstract":"<p><strong>Objectives: </strong>Epilepsy is one of the most common health problems in Iran. Considering this issue, the present study aimed to investigate New-Onset Refractory Status Epilepticus (NORSE) and Febrile Infection-Related Epilepsy Syndrome (FIRES) cases in children and evaluate the neurological outcome, referring to the special care department of Namazi Hospital, Shiraz, Iran.</p><p><strong>Materials & methods: </strong>Eight hundred seventy-three patients with status epilepticus (SE) referred to the medical centers of Shiraz Medical Sciences University were retrospectively examined from September 2021 to December 2022. After obtaining consent, the patients completed the questionnaire based on the literature review. Research data were collected and analyzed using SPSS version 23 software, t-test, Pearson correlation, and chi-square statistical methods.</p><p><strong>Results: </strong>The obtained results revealed that out of 873 patients with SE, 140 patients had inclusion criteria for NORSE and FIRSE (63 had NORSE, and 30 had FIRSE). The developmental status of the patient was good in 26.4% of cases and had minimal complications in 21.4% of cases. Mortality in the studied subjects was 33.6% (47 patients), and seizures were controlled in 63 patients (64.9). Furthermore, the results showed that the cause of epilepsy in 47 people (33.6%) of the investigated people was infection/inflammation. Furthermore, no correlation was observed between the gender and age of the patients and the investigated outcomes (p-value>0.05). Only in seizure control, a significant difference was observed between the females and males (p-value<0.05).</p><p><strong>Conclusion: </strong>This study concluded that the rate of NORSE and FIRES in the examined children is high. Moreover, one-third of these patients will not have a chance to survive. The results of the present study emphasize the need for more comprehensive studies in this field.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"15-23"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse Clinical manifestations of Cobalamin C Metabolism Disorders.","authors":"Hosein Eslamiyeh","doi":"10.22037/ijcn.v19i2.45047","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.45047","url":null,"abstract":"<p><p>Cobalamin, commonly known as vitamin B12, is a crucial micronutrient synthesized predominantly by a few microorganisms. In the human body, Vitamin B12 (Cobalamin) is essential for DNA synthesis and is required as a cofactor for functioning two crucial enzymes, methylmalonyl-CoA mutase and methionine synthase. The deficiency in these cobalamin-derivated coenzymes leads to enzyme activity dysfunction and an accumulation of their respective substrates, methylmalonic acid, and homocysteine,harming the brain and many other organs. Furthermore, deficiency in this micronutrient can lead to a wide spectrum of hematologic and neuropsychiatric disorders. In addition to vitamin B12 deficiency, some genetic disorders block the intracellular processing of Cobalamin to its cofactors and lead to symptoms somewhat similar to vitamin B12 deficiency. These disorders are called Cobalamin metabolism disorders. Many of them are reversible when diagnosed early and treated promptly. This group's most common and well-understood disease is Cobalamin C (CblC) metabolism disorder. This case series report aimed to provide a comprehensive overview of diverse clinical presentations within the spectrum of CblC metabolism disorder and the introduction of two cases of late-onset presentation with ataxia and repeated seizures as the first manifestation of the disorder. Few case reports are available, specifically in children, describing cerebellar ataxia and seizure as the first manifestations of late-onset CblC metabolism disorder. Additionally, this report sought to contribute to the existing literature by highlighting potential areas for timely recognition and targeted clinical and therapeutic interventions, thereby enhancing the comprehensive care and support for individuals affected by CblC metabolism disorder.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"131-141"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Validity of the Bayley Screening and the Bayley-III in Persian-Speaking Children.","authors":"Farin Soleimani, Fatemeh Hassanati, Zahra Ghorbanpour, Mohsen Vahedi, Nadia Azari, Adis Kraskian, Zahra Nobakht","doi":"10.22037/ijcn.v18i3.43167","DOIUrl":"https://doi.org/10.22037/ijcn.v18i3.43167","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to determine the concurrent validity of the Bayley-III and the Bayley screening in Persian-speaking children. Measuring child development with the Bayley-III can be time-consuming and expensive. Accordingly, this research seeks to assess the accuracy of the Bayley screening as a measure of developmental delay for high-risk infants by age group.</p><p><strong>Materials & methods: </strong>Concurrent validity between raw Bayley screening scores and Bayley-III scores was assessed by administering to 403 1-42 month-old children. The cut score of 1.0 standard deviation below the mean of two tests was calculated using the Bayley-III as the criterion measure. This study used 70% of the sensitivity and specificity cut scores to measure validity. In addition, the study calculated the Pearson and Cohen's kappa correlation for the association between the two measures.</p><p><strong>Results: </strong>The sensitivity of cognitive, receptive, and expressive communication, fine, and gross motor scales of Bayley screening were 70.7, 81.4, 67.7, 60.7, and 58.1, respectively. Specificity values varied narrower, from 87.8% to 100%. The Cohen's kappa coefficient in all age groups was substantial. The Pearson correlation between two test scores is significant for all scales, although the coefficients are over 0.884. The sensitivity and specificity have no specific trends with children's age, and the best sensitivity concurrence on the two tests was in the 1-12 months old age range.</p><p><strong>Conclusion: </strong>The study supports the concurrent validity of the Bayley screening, showing an assertive and significant association between Bayley screening and Bayley-III in Persian-speaking children.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"51-64"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Electrodiagnostic Findings and Cerebrospinal Fluid Changes in Children with Guillain-Barre syndrome.","authors":"Maryam Noory, Kambiz Eftekhari, Hosein Shabani-Mirzaee, Mohammad Barzegar, Armen Malekiantaghi","doi":"10.22037/ijcn.v19i1.44703","DOIUrl":"10.22037/ijcn.v19i1.44703","url":null,"abstract":"<p><strong>Objectives: </strong>Guillain-Barré syndrome (GBS) involves the peripheral nervous system developed by infections or immune conditions. Cerebrospinal fluid (CSF) analysis and electrodiagnostic tests are essential diagnostic methods for GBS. However, limited data are available on how the findings from these methods relate to each other. This study aimed to evaluate changes in CSF analysis and electrodiagnostic tests in pediatrics with GBS.</p><p><strong>Materials & methods: </strong>The present study retrospectively evaluated electrodiagnostic tests and CSF changes in pediatrics with GBS who were admitted to Tabriz Hospital, Iran, from 2010 to 2020 due to CBS. Patients' data, including age, gender, CSF analysis, and electrodiagnostic test results, were recorded from the patients' files. Electrodiagnostic data included pace and amplitude of tibial, median, peroneal, sural, ulnar nerves, nerve conduction velocity (NCV), F-wave, and motor unit action potential (MUAP). The significance level was considered less than 0.05.</p><p><strong>Results: </strong>The mean age of patients was 4.83±2.72 years, and 54.6% were boys. The most common type of GBS involvement was demyelinating type. No gender differences were found between involved nerves unless the ulnar nerve was significantly more involved in girls (P-value: 0.012). The obtained findings indicated no significant relationship between electrodiagnostic tests and CSF protein (P-value: 0.439).</p><p><strong>Conclusion: </strong>No association was observed between electrodiagnostic results and CSF changes in pediatrics with GBS.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"37-44"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Diabetes to Neuropathy: A Diagnostic Journey to Leigh Syndrome.","authors":"Arya Behzadi, Pooya Poormehr, Hedyeh Saneifard, Marjan Shakiba","doi":"10.22037/ijcn.v19i1.46085","DOIUrl":"10.22037/ijcn.v19i1.46085","url":null,"abstract":"<p><p>Diabetes is one of the most common chronic disorders in the world, characterized by chronic hyperglycemia. Among the rare causes of diabetes, Leigh syndrome is a rare genetic mitochondrial disorder with unusual manifestations like neurological deficits in addition to typical diabetes symptoms. This report enlightens others about the unusual presentation of diabetes in a pediatric population. The studied case is a 6-year-old girl with hypothyroidism and diabetes. Post-SARS-CoV-2 infection, she developed progressive lower limb weakness. Magnetic resonance imaging (MRI) and electromyography-nerve conduction velocity (EMG-NCV) revealed brain lesions and polyneuropathy. Genetic testing using whole exome and Sanger sequencing confirmed mitochondrial gene mutations in the MT-NDI location, diagnosing her with Leigh syndrome. Pediatric diabetic patients typically present with Type 1 diabetes mellitus (T1DM) or Type 2 diabetes mellitus (T2DM), but other causes must be considered. Leigh syndrome can manifest with neurological symptoms, requiring clinicians to recognize its diverse presentations for proper management. This case highlights the importance of considering rare etiologies for diabetes to improve the prognosis and quality of life.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 1","pages":"113-119"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Effectiveness and Safety of Intravenous Levetiracetam and Phenobarbital as First-Line Therapies for Neonatal Seizures: A Randomized Clinical Trial.","authors":"Nahideh Khosroshahi, Kamyar Kamrani, Muhammadhosein Moradi, Parisa Sadeghirad, Ayda Khabazi Oskouie","doi":"10.22037/ijcn.v19i2.45234","DOIUrl":"https://doi.org/10.22037/ijcn.v19i2.45234","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized clinical trial aims to evaluate and compare phenobarbital and levetiracetam effectiveness and safety in controlling neonatal seizures as first-line therapeutic options.</p><p><strong>Materials & methods: </strong>Neonates with seizure manifestations presenting to the Bahrami Hospital from March 2020 to March 2022 were enrolled in this study. Patients' data were recorded, including demographic findings, anthropometric measurements, birth characteristics, and laboratory findings. Patients were randomly divided into the phenobarbital and levetiracetam treatment groups. Outcomes defined as adverse effects, response to medication, time to start enteral feeding, and length of hospital stay were compared between the two treatment groups.</p><p><strong>Results: </strong>The current study comprises 44 neonates divided into phenobarbital and levetiracetam groups. Seizure control among the two groups was not significantly different, with levetiracetam and phenobarbital groups showing seizure control of 68.2% and 59.1%, respectively. Moreover, no significant difference was observed regarding the duration of hospitalization and time to initiate feeding. No adverse effect was reported in either group.</p><p><strong>Conclusion: </strong>This study showed no significant difference between levetiracetam and phenobarbital for neonatal seizure control.</p>","PeriodicalId":14537,"journal":{"name":"Iranian Journal of Child Neurology","volume":"19 2","pages":"65-75"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}